Profile

Rachel Adria Katzenellenbogen, MD

Rachel Adria Katzenellenbogen, MD

Adolescent Medicine

On staff since July 2006

Academic Title: Assistant Professor, Pediatrics-Section of Adolescent Medicine

Research Center: Center for Global Infectious Disease Research

"Adolescence is a time of transition — a time when teenagers begin to decide who they are and what they want to become. As adults, we often look back at our lives and wish we had made smarter choices about our health, education and relationships. In my work with adolescents, I am focused on helping to highlight and define the range of choices they can make. The choices are theirs, and they are ones that should be made thoughtfully, deliberately and with a goal in mind. Seeing adolescents recognize the power they have in making their own choices and being in charge of their own lives is wonderful to witness. "

Rachel Katzenellenbogen, MD, is attending physician in adolescent medicine at Seattle Children’s Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her clinical interests include adolescent gynecology and STD management as well as general preventive medicine.

Katzenellenbogen conducts NIH-sponsored research on high-risk human papillomavirus infection, which is linked to cervical cancer and is the most common sexually transmitted infection.  For more information, please visit: http://www.seattlechildrens.org/katzenellenbogenlab/.   

Making A Difference

  • Significant Recruits of 2010

    2010 was a banner year for recruiting at Seattle Children’s Research Institute as several nationally recognized researchers chose to continue their life’s work in Seattle. ... cont.

Overview

Board Certification(s)

Pediatrics
Adolescent Medicine

Medical/Professional School

Johns Hopkins University School of Medicine, Baltimore

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Adolescent Medicine, University of Washington, Seattle
University of Washington, Seattle

Research Description

Human papillomavirus (HPV) is the most common sexually transmitted infection, affecting more than 75 percent of the adult population. HPV is categorized as high-risk or low-risk, based on its association with cancer. Through dysregulation of normal cellular function, high-risk HPV blocks signals for DNA damage, programmed cell death, and cellular arrest, all as a part of its viral life cycle. I am studying the mechanism by which high-risk HPV activates telomerase, and enzyme found normally in stem cells and almost categorically activated in cancers, in order to understand how HPV drives cells to become malignant.

Lab URL

http://www.seattlechildrens.org/research/global-infectious-disease-research/katzenellenbogen-lab/

Research Focus Area

Infectious Disease, Virology

Publications

  • Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA
    NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
    Journal of virology , 2013 Dec. : 87(24)13741-50
  • Xu M, Katzenellenbogen RA, Grandori C, Galloway DA
    An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.
    Virology , 2013 Nov. : 446(1-2)17-24
  • Wong CA, Taylor JA, Wright JA, Opel DJ, Katzenellenbogen RA
    Missed opportunities for adolescent vaccination, 2006-2011.
    The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2013 Oct. : 53(4)492-7
  • Holder NA, Katzenellenbogen R, Middleman AB
    Human papillomavirus vaccines: factors that affect vaccine knowledge and delivery.
    The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2013 Sept. : 53(3)423-5
  • Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA
    Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes.
    Journal of virology , 2010 Dec. : 12934-44
  • Xu M, Katzenellenbogen RA, Grandori C, Galloway DA
    NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.
    Journal of virology , 2010 Nov. : 11461-9
  • Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA
    NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.
    Journal of virology , 2009 July : 6446-56
  • Howie HL, Katzenellenbogen RA, Galloway DA
    Papillomavirus E6 proteins.
    Virology , 2009 Feb. : 324-34
  • Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, Gewin LC, Gafken PR, Galloway DA
    NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
    Journal of virology , 2007 Apr, : 3786-96
  • Richardson LP, Katzenellenbogen R
    Childhood and adolescent depression: the role of primary care providers in diagnosis and treatment.
    Current problems in pediatric and adolescent health care , 2005 Jan. : 6-24

Research Funding

Grant Title Grantor Amount Award Date
HPV E6 and NFX1-123 in differentiation, cell regulation, and cancer - R01 CA172742-01A1 NIH/NCI $207,500 annual directs June 4, 2014 - May 31, 2019
Regulation of telomerase by NFX1 NIH/NCI $596,490.00 July 1, 2008
Telomerase Regulation by HPV E6, NFX1-123, and PABPCs NIH/NIAID $95,600.00 March 1, 2008