Paritosh C. Khanna, MD

Overview

Board Certification(s)

Diagnostic Radiology

Medical/Professional School

K J Somaiya Medical College, Mumbai
L T M G Hospital - University of Mumbai, Mumbai, Radiology

Residency

L T M G Hospital - University of Mumbai, Mumbai, Radiology

Fellowship

Children's National Medical Center, Washington, Pediatric Radiology
University of Washington, Seattle, Neuroradiology

Clinical Interests

Pediatric Neuroimaging Pediatric Craniofacial and Head/Neck Imaging Fetal Neuroimaging

Research Description

My research focuses on the application of imaging to the following:

1. Magnetic Resonance Imaging (MRI) of murine medulloblastoma (and other pediatric brain tumor) models in the evaluation of experimental drugs. It has been our goal to use MRI as the end-point for this evaluation and to minimize the use of experimental animals as a consequence. We have also successfully employed a 3 Tesla clinical MRI scanner to obtain substantially high-resolution MR images of juvenile mice. These scanners are generally more accessible than the higher field-strength research magnets and we have fined-tuned basic murine brain imaging sequences, protocols and parameters such that we can use this technique for investigation of murine models of most forms of pediatric (and adult) CNS disease. Various post-processing tools are being employed in the segmentation and volumetric analysis of the imaging data.

2. Craniofacial Imaging of craniosynostosis and craniofacial syndromes in collaboration with the Craniofacial Medicine team at Seattle Children's Hospital. Current research includes:
(a) Investigation of metopic synostosis
(b) To examine and correlate physical and Computed Tomography (CT) phenotypes and genotypes in patient groups with midface hypoplasia and associated sutural synostoses in non Crouzon's patients using CT in humans and micro-CT in animal models
(c) To define physical and CT phenotypes in Oculofrontonasal Syndrome (OAFNS)

3. MRI and Diffusion Tensor Imaging (DTI) and Tractography in the evaluation of trigeminal neuralgia as there is a lack of adequate imaging-clinical correlation using conventional MRI. The hope is that identification of normal and abnormal trigeminal nerve fibers from the nucleus through potentially the three divisions of the nerve may help identify the precise site of abnormality and assist in management of this condition.

Research Focus Area

Translational Research, Neuroscience / Neurodevelopment, Imaging Science

Publications

Presentations