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Nigel S. Bamford, MD

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Nigel S. Bamford, MD

Neurology

On staff since October 2002

Academic Title: Associate Professor of Neurology, Adjunct Associate Professor of Pediatrics and Psychology

Research Center: Center for Integrative Brain Research

Recommendations

BreaNampa, ID07.24.12
Dr. Bamford is thorough and knowledgeable. Thanks to his careful diagnosis our sons have quality of life that they would not have otherwise had. We highly recommend him.
JuliaBellingham, Washington04.26.12
We found Dr. Bamford to be very thorough and thoughtful. I would recommend him highly.
Recommend Dr. Nigel Bamford

Overview

Board Certification(s)
Neurology with Special Qualifications in Child Neu
Pediatrics
Medical/Professional School
University of Utah School of Medicine, Salt Lake City
Residency
Pediatrics, Columbia Presbyterian Hospital, New York
Child Neurology, Neurological Institute, New York
Clinical Interests

Movement disorders, cortical and cerebellar dysgenesis, toxicology, drug addiction and withdrawal

Research Description

The Bamford laboratory studies synaptic function and regulation of presynaptic activity. Presently, we are concentrating on the effects of dopamine on corticostriatal projections. In particular, we are interested in how dopamine depletion, Huntington's disease and psychostimulant withdrawal affect the release of glutamate from cortical projections to the striatum.

Lab URL

http://depts.washington.edu/nigellab/

Research Focus Area

Neuroscience / Neurodevelopment

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Editorial Board, Pediatric NeurologyJournal of Pediatric Neurology 2012
Nominated, Seattle Childrens Hospital Center Family Choice AwardSeattle Childrens Hospital 2011
Nominated, Seattle Childrens Hospital Center Family Choice AwardSeattle Childrens Hospital 2006
Nominated, Seattle Childrens Hospital Center Family Choice AwardSeattle Childrens Hospital 2004
Teacher of the Year AwardDepartment of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, NY 2002
Young Investigator AwardChild Neurology Society 2002
Nominated, Teacher of the YearDepartment of Pediatrics, Babies and Childrens Hospital, NY, NY 2001
Best of the Best Scientific Presentation, Scientific Highlights Plenary SessionAmerican Academy of Neurology 2000
Neurological Sciences Academic Development AwardNIH 1997
First Place Resident Research CompetitionTri-State Pediatric Neurology Society 1996
Senior Pediatric Honors StudentUniversity of Utah Medical School 1992
Drew B. Meilstrup ScholarshipUniversity of Utah Medical School 1991
Josephine Beam Scholarship for Outstanding Scholastic AchievementUniversity of Utah 1988
Continuing Student Departmental Scholarship in Electrical EngineeringUniversity of Utah 1987
ASUTC Award for Outstanding Scholastic Achievement (4.0 GPA)Salt Lake Community College 1985
Junior College Transfer ScholarshipUniversity of Utah 1985 - 1987
Deans Departmental Scholarship in Electronic TechnologySalt Lake Community College 1984
Continuing Student Scholarship for Academic ExcellenceSalt Lake Community College 1984
Merit Scholarship for Academic ExcellenceSalt Lake Community College 1983
Eagle Scout, Bronze PalmBSA 1977

Publications

Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2013 Jun 19: 33(25)10405-26
Overinhibition of corticostriatal activity following prenatal cocaine exposure.
Annals of neurology , 2013 Mar: 73(3)355-69
Overinhibition of corticostriatal activity following prenatal cocaine exposure.
Annals of neurology , Nov. 2012
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors.
Nature neuroscience , Nov. 2012: 15(11)1547-55
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors.
Nature neuroscience , 2012 Nov: 15(11)1547-55
Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core.
The Journal of physiology , Aug. 2012: 590(Pt 16)3743-69
Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core.
The Journal of physiology , 2012 Aug 15: 590(Pt 16)3743-69
Prospective Trial of a Pediatric Ventricular Assist Device
New England Journal of Medicine , 2012: 367532-41
Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience , Nov. 2011: 31(47)17103-12
Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2011 Nov 23: 31(47)17103-12
Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization.
Proceedings of the National Academy of Sciences of the United States of America , March 2011: 108(10)4206-11
Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization.
Proceedings of the National Academy of Sciences of the United States of America , 2011 Mar 8: 108(10)4206-11
Imaging presynaptic exocytosis in corticostriatal slices.
Methods in molecular biology (Clifton, N.J.) , 2011: 793363-76
Imaging presynaptic exocytosis in corticostriatal slices.
Methods in molecular biology (Clifton, N.J.) , 2011: 793363-76
Alterations in Striatal Synaptic Function in Huntingtons and Parkinsons Diseases
In: Handbook of Basal Ganglia Structure and Function, a Decade of Progress , 2010: 607-623
Neuromuscular hip dysplasia in Charcot-Marie-Tooth disease type 1A.
Developmental medicine and child neurology , May 2009: 408-11
Neuromuscular hip dysplasia in Charcot-Marie-Tooth disease type 1A.
Developmental medicine and child neurology , 2009 May: 51(5)408-11
Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience , Feb. 2009: 29(8)2414-27
Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2009 Feb 25: 29(8)2414-27
The Corticostriatal Pathway in Parkinsons Disease
In: Cortico-subcortical Dynamics in Parkinsons Disease , 2009: 87-104
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration.
Neuron , April 2008: 89-103
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration.
Neuron , 2008 Apr 10: 58(1)89-103
Dopamine modulates release from corticostriatal terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience , Oct. 2004: 9541-52
Dopamine modulates release from corticostriatal terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2004 Oct 27: 24(43)9541-52
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.
Neuron , May 2004: 653-63
Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.
Neuron , 2004 May 27: 42(4)653-63
Congenital Guillain-Barr syndrome associated with maternal inflammatory bowel disease is responsive to intravenous immunoglobulin.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society , 2002: 115-9
Congenital Guillain-Barré syndrome associated with maternal inflammatory bowel disease is responsive to intravenous immunoglobulin.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society , 2002: 6(2)115-9
Varicella-Zoster Virus Retrobulbar Optic Neuritis in a Patient with Human Immunodeficiency Virus
Am J Ophthal , 1996: 122(4)586-588

Presentations

Presentations TitleEventLocationDate
Targeting GABA-A receptors for treatment of behaviors following prenatal cocaine exposureChild Neurology Society Annual MeetingAustin, TXOct. 2013
GABA Interneurons and Prenatal Cocaine; a little goes a long wayGrand Rounds, Neurological InstituteCoumbia UnivarsityFeb. 2013
Repeated Amphetamine Causes Long-Lasting Plasticity at Corticostriatal SynapsesWinter Conference on Brain ResearchSnowbird, UTJan. 2012
Lasting impressions of novel experience are encoded in basal ganglia circuitsChild Neurology Society Annual MeetingSavannah GAOct. 2011
Neurology Grand RoundsStanford UniversityNeuronal circuitry for attention, movements and very bad habitsMarch 2011
Prenatal cocaine exposure causes a GABA-dependent reversal in D2 dopamine receptor responses at corticostriatal synapsesWinter Conference on Brain ResearchKeystone, COJan. 2011
Effects of D2 dopamine receptors on corticostriatal synapsesThe Lieber Center for Schizophrenia Research and Treatment. Seminar SeriesColumbia UniversityOct. 2010
Behaviors are regulated by long-term synapse plasticity within the nucleus accumbens coreChild Neurology Society Annual MeetingProvidence, RIOct. 2010
D2 and D5 dopamine receptors in the dorsal striatum contribute to habit learning and substance abuseChild Neurology Society Annual MeetingProvidence, RIOct. 2010
Gestational cocaine exposure causes a GABAA-mediated reversal in D2 dopamine receptor responses at corticostriatal synapsesChild Neurology Society Annual MeetingProvidence, RIOct. 2010
Gestational cocaine exposure causes reversible plasticity at corticostriatal synapsesResearch SeminarUniversity of ChicagoJuly 2010
Anatomical and Functional Variations in Striatal Synaptic ControlChild Neurology Society Annual MeetingLouisville, TNOct. 2009
Huntington Mutation Produces Age-Dependent Alterations in Striatal Excitation in YAC128 transgenic miceChild Neurology Society Annual MeetingSanta Clara, CAOct. 2008
Biphasic changes of corticostriatal activity in the YAC128 mouse model of Huntingtons disease12th International Conference on In Vivo MethodsVancouver, BCAug. 2008
Methamphetamine Addiction Mechanism is IdentifiedBBC Radio World Service. Science in Action with John StewartApril 11, 2008
The Brain Circuitry in Drug AddictionBBC Radio 4. Leading Edge with Geoff WattsApril 10, 2008
Regulation of Glutamate Release in the Ventral StriatumWinter Conference on Brain ResearchJan. 2008
Methamphetamine Induces Locomotor Changes and Striatal Synaptic Plasticity that are Dependent on D1 Dopamine-ReceptorsChild Neurology Society Annual MeetingQubec City, CanadaOct. 2007
Glutamate Release in the Ventral Striatum is Mediated by D1 and D2 Receptor ActivityChild Neurology Society Annual MeetingQubec City, CanadaOct. 2007
Synaptic Mechanisms in Motor LearningNorth Pacific Pediatric Neurology ColloquiumSeattle, WAJune 2007
Dopamine Function in Models of Neurological and Psychiatric DisordersWinter Conference on Brain ResearchSteamboat Springs, COJan. 2006
Chronic Methamphetamine Mediates Long-Term Depression of Corticostriatal Release in the Dorsal StriatumChild Neurology Society Annual MeetingLos Angeles, CAAug. 2005
Presynaptic Regulation of Corticostriatal Terminals by Acetylcholine Unveiled During Amphetamine WithdrawalGordon Research ConferenceProctor Academy, NHJuly 2005
Synaptic Plasticity in Neonatal Psychostimulant WithdrawalPacific Northwest and Western Canada Pediatric Neurology ColloquiumVancouver BCMay 2005
Receptor Hypersensitivity in Dopamine DepletionNorth Pacific Pediatric Neurology ColloquiumSeattle, WAMay 2004
Psychostimulants Depress Cortical Excitation of the Striatum, an Effect Mediated by Presynaptic Corticostriatal D2 Dopamine ReceptorsChild Neurology Society Annual MeetingMiami FLOct. 2003
Corticostriatal Signaling in Huntingtons Disease Mutant MiceMental Retardation Research Center Research SeminarUCLA, CAJuly 2003
Presynaptic Activity of Corticostriatal Terminals is Regulated by D2 Dopamine ReceptorsChild Neurology Society Young Investigator Award LectureWashington DCOct. 2002
Defects in Cell Migration in Zellweger SyndromePediatric Grand RoundLincoln Medical and Mental Health Center, Bronx, NYMarch 2001
Neuronal Migration and Apoptosis in the Newborn Zellweger Transgenic MouseAmerican Academy of NeurologyMay 2000

Research Funding

Grant TitleGrantorAmountAward Date
Psychostimulant-induced changes in striatal cholinergic interneuron physiologyUniversity of Washington Alcohol and Drug Abuse Institute $, $ 2012 - 2014
Training in Molecular Pharmacology of Abused DrugsNIH $, $ 2009 - 2014
Dopamine-Induced Striatal Synaptic PlasticityNIH 2009 - 2010
Berlin Heart EXCOR Pediatric Ventricular Assist DeviceSeattle Childrens Hospital 2008 - 2009
Dopamine-Induced Striatal Synaptic PlasticiNIH $, $ 2007 - 2014
Gestational Cocaine Exposure Mediates Long-Term Changes in Striatal FunctionUniversity of Washington Alcohol and Drug Abuse Institute 2007 - 2009
Excitotoxic glutamatergic corticostriatal projections mediate striatal damage in Huntington's mutant miceUW Royalty Research Fund 2003 - 2004
Presynaptic activity of corticostriatal terminals is regulated by D2 dopamine receptorsChild Neurology Society Young Investigator Award 2002 - 2008
Neurological Sciences Academic Development AwardNIH 1997 - 2002

Primary Office

Seattle Children's
MB.7.420 - Neurology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2078

Additional Offices

University of Washington
UW Box 356465 - Neurology
1959 NE Pacific St
Seattle, WA 98195-6465
206-616-4149
Seattle Children's Bellevue Clinic and Surgery Center
CB-11
1500 - 116th Ave NE
Bellevue, WA 98004
425-454-4644

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