Profile

Marta Bull, PhD

Marta Bull, PhD

Infectious Disease

Academic Title: Research Assistant Professor, Pediatrics

Research Center: Center for Global Infectious Disease Research

Overview

Medical/Professional School

Washington State University, Pullman
North Carolina State Univeristy, Raleigh, Immunology
North Carolina State Univeristy, Raleigh, Immunology

Fellowship

University of Washington, Seattle

Research Description

Dr. Bull's primary research interest includes HIV at mucosal sites, primarily but not limited to the female genital tract. Her interest in the genital tract is threefold: (1) To better define immunological milieu at mucosal sites and how this pertains to HIV persistence at these sites, (2) to better define the viral dynamics and exchange between the genital tract, blood and other tissues, and (3) to evaluate the role of other chronic viruses - such as herpes simplex virus (HSV) 1, HSV-2, cytomegalovirus (CMV), and Epstein Barr virus - in HIV persistence. Specific areas currently under study include the cellular populations associated with HIV shedding from the female genital tract and immune mechanisms that promote HIV persistence at tissue sites as a barrier to a cure for HIV.

Awards and Honors

Award Name Award Description Awarded By Award Date
New Investigator Award Conference on Retroviruses and Opportunistic Infections (CROI) 2012
Research Travel Award Center for AIDS Research (CFAR) 2008
Childrens Hospital Fellows Research Day Award Oral presentation, "HIV-1 Compartmentalization in the Female Genital Tract" Seattle Children's Research Institute 2006
Ruth L. Kirschstein National Research Service Award University of Washington STD/AIDS Research Training Program 2006 - 2008
Loan Repayment Award National Institutes of Health (NIH) 2006 - 2008

Publications

  • Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM
    Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.
    The Journal of infectious diseases , 2013 Apr, : 207(8)1206-15
  • Beck IA, Jang M, McKernan-Mullin J, Bull M, Wagner T, Huang S, Song LY, Nachman S, Krogstad P, Eshleman SH, Wiznia A, Frenkel LM
    Monitoring of HIV type 1 DNA load and drug resistance in peripheral blood mononuclear cells during suppressive antiretroviral therapy does not predict virologic failure.
    AIDS research and human retroviruses , 2012 Aug. : 28(8)780-8
  • Soria J, Bull M, Mitchell C, La Rosa A, Dross S, Kraft K, Coombs R, Ticona E, Frenkel L
    Transmitted HIV resistance to first-line antiretroviral therapy in Lima, Peru.
    AIDS research and human retroviruses , 2012 Apr, : 28(4)333-8
  • Gantt S, Carlsson J, Heath L, Bull ME, Shetty AK, Mutsvangwa J, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA, Mullins JI, Frenkel LM
    Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis.
    Journal of virology , 2010 Oct. : 84(20)10812-9
  • Bull M, Learn G, Genowati I, McKernan J, Hitti J, Lockhart D, Tapia K, Holte S, Dragavon J, Coombs R, Mullins J, Frenkel L
    Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations.
    PloS one , 2009 Sept. : 4(9)e7122
  • Bull ME, Learn GH, McElhone S, Hitti J, Lockhart D, Holte S, Dragavon J, Coombs RW, Mullins JI, Frenkel LM
    Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus.
    Journal of virology , 2009 June : 83(12)6020-8
  • Bull ME, Learn GH, Mullins JI, Frenkel LM
    Methods used to examine compartmentalization of viral populations between the genital tract and peripheral blood.
    The Journal of infectious diseases , 2007 Aug. : 196(3)493-4; author reply 494-5
  • Bull M, Lee D, Stucky J, Chiu YL, Rubin A, Horton H, McElrath MJ
    Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trials.
    Journal of immunological methods , 2007 Apr, : 322(1-2)57-69
  • Bull ME, Vahlenkamp TW, Dow JL, Collisson EW, Winslow BJ, Phadke AP, Tompkins MB, Tompkins WA
    Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies.
    Veterinary immunology and immunopathology , 2004 May : 99(1-2)25-37
  • Vahlenkamp TW, Bull ME, Dow JL, Collisson EW, Winslow BJ, Phadke AP, Tompkins WA, Tompkins MB
    B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion.
    Veterinary immunology and immunopathology , 2004 Apr, : 98(3-4)203-14
  • Bull ME, Kennedy-Stoskopf S, Levine JF, Loomis M, Gebhard DG, Tompkins WA
    Evaluation of T lymphocytes in captive african lions (Panthera leo) infected with feline immunodeficiency virus.
    American journal of veterinary research , 2003 Oct. : 64(10)1293-300
  • Tompkins MB, Bull ME, Dow JL, Ball JM, Collisson EW, Winslow BJ, Phadke AP, Vahlenkamp TW, Tompkins WA
    Feline immunodeficiency virus infection is characterized by B7+CTLA4+ T cell apoptosis.
    The Journal of infectious diseases , 2002 Apr, : 185(8)1077-93
  • Bull ME, Gebhard DG, Tompkins WA, Kennedy-Stoskopf S
    Polymorphic expression in the CD8alpha chain surface receptor of African lions (Panthera leo).
    Veterinary immunology and immunopathology , 2002 Jan. : 84(3-4)181-9

Research Funding

Grant Title Grantor Amount Award Date
"University of Washington Center for AIDS Research" (CFAR) - P30 AI027757 (PI: King Holmes) NIH $11,528 subcontract annual direct costs June 1, 2013 - May 31, 2015
"HIV-1 evolution in the female genital tract and trafficking in the blood" - R01 AI091550 (PI: Frenkel) NIH $254,817 annual direct costs Jan. 21, 2011 - Dec. 31, 2015