Skip to main content

Search
Profile

Marta Bull, PhD

|
Marta Bull, PhD

Infectious Disease

Academic Title: Research Assistant Professor, Pediatrics

Research Center: Center for Global Infectious Disease Research

Overview

Medical/Professional School
Washington State University, Pullman
North Carolina State Univeristy, Raleigh, Immunology
North Carolina State Univeristy, Raleigh, Immunology
Fellowship
University of Washington, Seattle
Research Description

Dr. Bull's primary research interest includes HIV at mucosal sites, primarily but not limited to the female genital tract. Her interest in the genital tract is threefold: (1) To better define immunological milieu at mucosal sites and how this pertains to HIV persistence at these sites, (2) to better define the viral dynamics and exchange between the genital tract, blood and other tissues, and (3) to evaluate the role of other chronic viruses - such as herpes simplex virus (HSV) 1, HSV-2, cytomegalovirus (CMV), and Epstein Barr virus - in HIV persistence. Specific areas currently under study include the cellular populations associated with HIV shedding from the female genital tract and immune mechanisms that promote HIV persistence at tissue sites as a barrier to a cure for HIV.

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
New Investigator AwardConference on Retroviruses and Opportunistic Infections (CROI) 2012
Research Travel AwardCenter for AIDS Research (CFAR) 2008
Loan Repayment AwardNational Institutes of Health (NIH) 2006 - 2008
Ruth L. Kirschstein National Research Service AwardUniversity of Washington STD/AIDS Research Training Program 2006 - 2008
Childrens Hospital Fellows Research Day AwardOral presentation, "HIV-1 Compartmentalization in the Female Genital Tract"Seattle Children's Research Institute 2006

Publications

Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.
The Journal of infectious diseases , April 2013: 207(8)1206-15
Monitoring of HIV type 1 DNA load and drug resistance in peripheral blood mononuclear cells during suppressive antiretroviral therapy does not predict virologic failure.
AIDS research and human retroviruses , 2012 Aug: 28(8)780-8
Transmitted HIV resistance to first-line antiretroviral therapy in Lima, Peru.
AIDS research and human retroviruses , April 2012: 28(4)333-8
Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis.
Journal of virology , Oct. 2010: 84(20)10812-9
Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations.
PloS one , Sept. 2009: 4(9)e7122
Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus.
Journal of virology , June 2009: 83(12)6020-8
Methods used to examine compartmentalization of viral populations between the genital tract and peripheral blood.
The Journal of infectious diseases , Aug. 2007: 196(3)493-4; author reply 494-5
Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trials.
Journal of immunological methods , April 2007: 322(1-2)57-69
Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies.
Veterinary immunology and immunopathology , May 2004: 99(1-2)25-37
B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion.
Veterinary immunology and immunopathology , April 2004: 98(3-4)203-14
Evaluation of T lymphocytes in captive african lions (Panthera leo) infected with feline immunodeficiency virus.
American journal of veterinary research , Oct. 2003: 64(10)1293-300
Feline immunodeficiency virus infection is characterized by B7+CTLA4+ T cell apoptosis.
The Journal of infectious diseases , April 2002: 185(8)1077-93
Polymorphic expression in the CD8alpha chain surface receptor of African lions (Panthera leo).
Veterinary immunology and immunopathology , Jan. 2002: 84(3-4)181-9

Research Funding

Grant TitleGrantorAmountAward Date
HIV-1 evolution in the female genital tract and traffickingNIH, R01 AI080439 (Frenkel)Sept. 15, 2010 - Dec. 31, 2015

Primary Office

Seattle Children's Research Institute
CW8-6 Child Health, Behavior and Development
2001 Eighth Ave
Seattle, WA 98121
206-884-7425
Seattle Children's Research Institute
JMB - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101
206-987-2073

Find a Doctor or Researcher

Find a Doctor or Researcher

Type the first or last name you are searching for or select a specialty.

Doctor or Researcher Name:

More search options