Kimberly J. Riehle, MD

Kimberly J. Riehle, MD

General Surgery, Prenatal Diagnosis and Treatment

On staff since September 2010

Academic Title: Assistant Professor of Surgery and Pathology

"While liver tumors are rare in children, effective non-surgical treatments are few and far between. My research efforts are aimed at understanding how liver cancer develops in healthy children, and to develop cures for these patients. As a physician and a mom, I particularly enjoy helping children and their families get through tough situations, and appreciate the uniqueness of each child on whom I perform an operation."

• Biography

  Kimberly Riehle, MD, is an attending surgeon at Seattle Children's Hospital. She was born in Jefferson, Iowa and went to high school in Cedar Falls, Iowa. Both of her parents were teachers. She attended Washington University in St. Louis, double majoring in Chemistry and French. She received her medical degree from Emory University School of Medicine. Her clinical interests include helping families in difficult situations, including caring for babies with congenital anomalies and patients with cancer. She is also mom to son Jonah, who was born in 2004.

• Patient Testimonials

  • Maribeth Bethel, Alaska 10.28.16

    Kimbery is a very gifted and friendly doctor! She performed surgery on my 4 day old son,with professional opinions from chief surgeons, repairing my sons special type of CDH. She even came to talk to me before my son was born at UW to talk to me about my sons birth plan and his operation. She is very thorough and professional. Kimberly makes you feel comfortable from the second that you meet her, as though she is a friend you've known your whole life. Many thanks and blessings!

  • Alexis Kenmore, WA 08.28.15

    Dr. Riehle performed a hernia repair on my 6-year-old. She was incredibly kind, attentive and caring. She spoke directly to my daughter during appointments and also made me feel as comfortable as I possibly could be with a planned surgical procedure. We had three separate appointments including the day of surgery, and each time I felt that we were her top priority for the day. Dr. Riehle is smart, driven, energetic and compassionate. She has a special gift with children. Her patients are in excellent hands.

  • Carol Seattle 03.31.15

    Exceptional Surgeon With equal amounts of skill and compassion, Dr. Riehle transformed a scared, miserable emergency appendectomy patient back to my smiling 8 year-old son. She did this by covering his surgical incision with a specially cut star bandageat 3 am after a very busy Friday night in the ER. I heard there were 5 other appendectomy cases that evening, but I feel our experience would not be the same if Dr. Riehle had not given my son such personalized care and attention. My son looks back at his first ever hospital visit/stay and only remembers the cute bandage, eating popsicles and the wonderful staff that helped him heal. Many thanks!

  • Tina West Richland, WA 03.05.11

    Dr. Riehle performed surgery on my 16 year old son for his Chrons disease. She removed part of his small and large intestine plus his appendix. She was very personal and professional both before and after the surgery, always keeping us informed and explaining every detail very clearly. I felt she truly wanted what was best for my son and my son trusted her completely. I highly recommend her and feel very secure with her as a doctor.

  Recommend Dr. Kimberly J. Riehle

• Awards and Honors

  Award Name	Award Description	Awarded By	Award Date
  New Investigator Award		Fred Hutchinson Cancer Consortium	Dec. 2014
  American Surgical Association Foundation Fellowship Recipient		American Surgical Association	July 2013
  American College of Surgeons Louis C. Argenta Award Recipient		American College of Surgeons	July 2012
  Sydney Farber House Staff Award		Children's Hospital Boston	June 2010
  David Tapper Resident Teaching Award		University of Washington, Department of Surgery, Seattle WA	June 2008
  American College of Surgeons Forum on Fundamental Surgical Problems Resident/Fellow Excellence in Research Award		American College of Surgeons	Oct. 2006
  First Prize, Schilling Resident Research Symposium		Department of Surgery, University of Washington, Seattle, WA	Jan. 2006
  June 2004-July 2006: National Institutes of Health Loan Repayment Program Awardee in Pediatric Research		National Institutes of Health	June 2004 - July 2006
  American College of Surgeons Resident Research Scholarship		American College of Surgeons	June 2004 - July 2006

  Schilling Foundation Resident Research Scholarship		University of Washington	June 2004 - July 2006
  Gate Pharmaceutical Outstanding Student Award (Faculty Award for top student, medical school class)		Emory University School of Medicine, Atlanta, GA	May 2001
  Magna cum laude		Emory University, Atlanta, GA	May 2001
  Alpha Omega Alpha		Emory University School of Medicine, Atlanta, GA	Aug. 2000
  Solvay Pharmaceuticals Project Fund recipient		Emory University School of Medicine, Atlanta, GA	June 1998
  James L. Campbell Scholar in Medicine		Emory University School of Medicine, Atlanta, GA	Aug. 1997 - May 2001
  Summa cum laude		Washington University, St. Louis, MO	Dec. 1996
  Phi Beta Kappa		Washington University, St. Louis, MO	Dec. 1996

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• Publications

  • Riggle KM, Turnham R, Scott JD, Yeung RS, Riehle KJ
    Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma.
    26990031 Pediatric blood and cancer , 2016 Mar. 14
  • Riehle KJ, Riggle KM, Henry M
    Benign Ovarian Disorders
    1st edition of APSA Not A Textbook , 2016
  • Riehle KJ, Riggle KM, and Campbell JS
    The Priming and Progression Theory of Liver Regeneration
    1st edition of Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications , 2015
  • Riehle KJ, Yeh MM, Yu JJ, Kenerson HL, Harris WP, Park JO, Yeung RS
    mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma.
    24925055 Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc , 2015 Jan. : 28(1)103-10
  • Bahrami AJ, Gunaje JJ, Hayes BJ, Riehle KJ, Kenerson HL, Yeung RS, Stempien-Otero AS, Campbell JS, Mahoney WM Jr
    Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.
    25290689 PloS one , 2014 : 9(10)e108505 PMCID: PMC4188519
  • Kenerson HL, Yeh MM, Kazami M, Jiang X, Riehle KJ, McIntyre RL, Park JO, Kwon S, Campbell JS, Yeung RS
    Akt and mTORC1 have different roles during liver tumorigenesis in mice.
    23376645 Gastroenterology , 2013 May : 144(5)1055-65 PMCID: PMC3633657
  • Riehle KJ and Fausto N
    Mechanisms of Liver Injury
    1st edition of Clinical Pediatric Hepatology , 2013
  • Aarabi S, Sidhwa F, Riehle KJ, Chen Q, Mooney DP
    Pediatric appendicitis in New England: epidemiology and outcomes.
    21683207 Journal of pediatric surgery , 2011 June : 46(6)1106-14
  • Riehle KJ, Dan YY, Campbell JS, Fausto N
    New concepts in liver regeneration.
    21199532 Journal of gastroenterology and hepatology , 2011 Jan. : 203-12

  • Li J, Campbell JS, Mitchell C, McMahan RS, Yu X, Riehle KJ, Bumgarner RE, Fausto N
    Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in mice.
    19700759 The American journal of pathology , 2009 Sept. : 947-57
  • Langdale LA, Hoagland V, Benz W, Riehle KJ, Campbell JS, Liggitt DH, Fausto N
    Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury.
    18471922 Journal of hepatology , 2008 Aug. : 198-206
  • Riehle KJ, Campbell JS, McMahan RS, Johnson MM, Beyer RP, Bammler TK, Fausto N
    Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3.
    18158318 The Journal of experimental medicine , 2008 Jan. 21 : 91-103
  • Cheung RS, Brooling JT, Johnson MM, Riehle KJ, Campbell JS, Fausto N
    Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells.
    17698969 Carcinogenesis , 2007 Dec. : 2624-31
  • Campbell JS, Johnson MM, Bauer RL, Hudkins KL, Gilbertson DG, Riehle KJ, Yeh MM, Alpers CE, Fausto N
    Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis.
    17999742 Differentiation; research in biological diversity , 2007 Nov. : 843-52
  • Riehle KJ, Magnuson DK, Waldhausen JH
    Low recurrence rate after Gore-Tex/Marlex composite patch repair for posterolateral congenital diaphragmatic hernia.
    18022433 Journal of pediatric surgery , 2007 Nov. : 1841-4
  • Stoick-Cooper CL, Weidinger G, Riehle KJ, Hubbert C, Major MB, Fausto N, Moon RT
    Distinct Wnt signaling pathways have opposing roles in appendage regeneration.
    17185322 Development (Cambridge, England) , 2007 Feb. : 479-89
  • Campbell JS, Riehle KJ, Brooling JT, Bauer RL, Mitchell C, Fausto N
    Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4.
    16456013 Journal of immunology (Baltimore, Md. : 1950) , 2006 Feb. 15 : 2522-8
  • Fausto N, Campbell JS, Riehle KJ
    Liver regeneration.
    16447274 Hepatology (Baltimore, Md.) , 2006 Feb. : S45-53
  • Fausto N, Riehle KJ
    Mechanisms of liver regeneration and their clinical implications.
    15995805 Journal of hepato-biliary-pancreatic surgery , 2005 : 181-9
  • Rozycki GS, Tchorz KM, Riehle KJ, Hattaway A, Naidu DK
    A prospective study of a focused, surgeon-performed ultrasound examination for the detection of occult common femoral vein thrombosis in critically ill patients.
    15006884 Archives of surgery (Chicago, Ill. : 1960) , 2004 Mar. : 275-80

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• Presentations

  Presentations Title	Event	Location	Date
  Neonatal Intestinal Obstruction	Seattle Childrens Hospital Neonatal Intensive Care Unit Education Day	Seattle, WA	May 19, 2016
  Neurotensin enhances cell proliferation in fibrolamellar hepatocellular carcinoma	Schilling Foundation Research Symposium	Seattle, WA	2016
  Neurotensin enhances cell proliferation in fibrolamellar hepatocellular carcinoma	PRESENTATION: Riggle KM, Kenerson HL, Bauer R, Yeung RS, Riehle KJ	American Academy of Pediatrics, Section on Surgery, Washington, DC	Oct. 2015
  Neurotensin enhances cell proliferation in fibrolamellar hepatocellular carcinoma	PRESENTATION: Riggle KM, Kenerson HL, Yeung RS, Riehle KJ	Surgical Forum, American College of Surgeons Clinical Congress, Chicago, IL	Oct. 2015
  Pediatric Liver Cancers	Harkins Resident Education Symposium	Seattle, WA	Oct. 2015
  Neurotensin Enhances Hepatocyte Proliferation in Fibrolamellar Hepatocellular Carcinoma, PRESENTATION: Riggle KM, Kenerson HL, Yeung RS, Riehle KJ	Washington/Oregon Chapter of the American College of Surgeons	Suncadia, WA	June 2015
  Mechanisms of Pediatric Liver Cancers	University of Washington Department of Surgery Grand Rounds	Seattle, WA	May 6, 2015
  Characterization of a novel mutation in fibrolamellar hepatocellular carcinoma (presentation: Riggle KM, Kenerson HL, Bauer R, Kazami M, Yeung RS, Riehle KJ)	Academic Surgical Congress	Las Vegas, NV	2015
  Enhanced cyclic AMP induced protein kinase A activity in fibrolamellar hepatocellular carcinoma (presentation: Riggle KM, Kenerson HL, Bauer R, Kazami M, Yeung RS, Riehle KJ)	American Society of Clinical Oncology GI Symposium	San Francisco, CA	2015

  Enhanced cyclic AMP induced protein kinase A activity in fibrolamellar hepatocellular carcinoma (presentation: Riggle KM, Kenerson HL, Bauer R, Kazamii M, Yeung RS, Riehle KJ)	Schilling Foundation Research Symposium	Seattle, WA	2015
  Report to the American Surgical Association Foundation Executive Committee		San Diego, CA	2015
  Liver Regeneration: Past, Present, and Future.	Center for Developmental Biology and Regenerative Medicine Lecture Series	Seattle Childrens Research Institute	Dec. 20, 2013
  Long Gap Esophageal Atresia.	Operative Staff Educational Series	Seattle Childrens Hospital	March 5, 2013
  Fundamentals of Liver Regeneration	Grand Rounds	University of Washington Department of Surgery	May 2, 2012
  Regeneration in the Setting of Liver Fibrosis: Studies of 2/3 Partial Hepatectomy in Platelet-derived Growth Factor-C transgenic mice (poster presentation: Riehle KJ, Johansson F, Vaquero J, Bauer R, Fausto N, and Campbell JS)	American Association for the Study of Liver Diseases Meeting	San Francisco, CA	2011
  Deletion of Suppressor of Cytokine Signaling 3 is Protective Against Liver Ischemia-Reperfusion Injury (poster presentation: Riehle KJ, Hoagland V, Campbell JS, and Langdale LA.	American Association for the Study of Liver Diseases Meeting	San Francisco, CA	2011
  Low recurrence rate after Composite Patch Repair of Bochdalek Congenital Diaphragmatic Hernia (presentation: Riehle KJ, Magnuson D, Waldhausen JHT)	Washington State Chapter of the American College of Surgeons Meeting	Chelan, WA	2007
  Regulation of Liver Regeneration by Suppressors of Cytokine Signaling 3 (presentation: Riehle KJ, Croker BA, Campbell JS, and Fausto N)	2006 Schilling Resident Research Symposium	Seattle, WA	2006
  SOCS3 Negatively Regulates Hepatocyte Proliferation (poster presentation: Riehle KJ, McMahan RS, Campbell JS, Croker BA, and Fausto N)	University of Washington Department of Pathology Annual Retreat	Leavenworth, WA	2006
  Therapeutic Potential of Epithelial Progenitor Cells From Human Fetal Liver (presentation: Dan YY, Riehle KJ, Lazaro CA, Haque J, Campbell JS, and Fausto N)	Gastroenterological Society of Singapore Annual Scientific Meeting	Singapore	2006
  Regulation of Liver Regeneration by Suppressors of Cytokine Signaling 3 (presentation: Riehle KJ, McMahan RS, Croker BA, Campbell JS, and Fausto N)	American College of Surgeons Forum on Fundamental Surgical Problems	Chicago, IL	2006
  Distinct Wnt Signaling Pathways Have Opposing Roles in Appendage Regeneration (poster presentation: Stoick-Cooper C, Weidinger G, Riehle KJ, Hubbert C, Major MB, Nelson Fausto, and Randall T Moon)	Keystone Symposium	Snowbird, UT	2006
  LPS Signaling in Liver Regeneration (presentation: Riehle KJ, Campbell JS, Brooling JT, Fausto N)	2005 Schilling Resident Research Symposium	Seattle, WA	2005
  Isolation and Characterization of Multipotent Human Fetal Liver Progenitor Cells. (poster presentation: Dan YY, Riehle KJ, Lazaro CA, Campbell JS, and Fausto N)	2005 University of Washington Department of Pathology Annual Retreat	Leavenworth, WA	2005
  Liver Regeneration is Enhanced in Hepatocyte-specific Socs3 KO mice (poster presentation: Riehle KJ, Croker BA, Campbell JS, Hilton DJ, and Fausto N)	American Association for the Study of Liver Diseases Annual Meeting	San Francisco, CA	2005
  Isolation and Characterization of Multipotent Human Fetal Liver Progenitor Cells (presentation: Dan YY, Riehle KJ, Lazaro CA, Campbell JS, and Fausto N)	American Association for the Study of Liver Diseases Annual Meeting	San Francisco, CA	2005

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• Research Funding

  Grant Title	Grantor	Amount	Award Date
  Neurotensin in Fibrolamellar Hepatocellular Carcinoma	National Institutes of Health, National Cancer Institute		July 1, 2016
  University of Washington Royalty Research Fund	University of Washington	$40,000	March 2016
  Fred Hutchinson/University of Washington Cancer Consortium New Investigator Award	Fred Hutchinson/University of Washington Cancer Consortium	$95,495.00	Dec. 2014
  Improving Regeneration in the Fibrotic Liver	American Surgical Association Foundation Fellowship	$75,000/year	July 2013 - June 2015
  University of Washington Department of Surgery Research Reinvestment Fund	University of Washington, Department of Surgery	$50,000.00	Nov. 2012
  Improving Regeneration in the Fibrotic Liver	American College of Surgeons Louis C. Argenta Fellowship	$40,000.00/year	July 2012 - June 2013
  Mechanisms of Liver Regeneration, from , 2012	Seattle Childrens Hospital Discovery Fund	$15,000.00 one time gift	2012
  Liver Regeneration	50,000.00 one time private gift from Dr. Ann Delancey		2012
  Molecular Mechanisms of Liver Regeneration	Herbert Coe Foundation and Department of Surgery	$25,000.00/yr through June 2015