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Karen F. Murray, MD

Karen F. Murray, MD

Gastroenterology, Hepatology, Transplantation, Gastroenterology and Hepatology Research

On staff since November 1998

Children's Title: Division Chief of Pediatric Gastroenterology and Hepatology

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

"I love my work because I have so many opportunities to make a difference. Our team treats children with life-threatening diseases of the liver and digestive system that prevent them from realizing their full potential. It’s a complete thrill to give these kids and their families the care and compassion they need to achieve their life’s dreams. I also have the privilege of being a mentor. Educating the next generation of doctors and helping them meet their goals is a personal passion and vital to the future of medicine. And I’m excited to be involved in research about pediatric liver diseases and their treatment options, which we hope one day will enable us to prevent these terrible illnesses."


DavidGranite Falls, WA10.25.11
Dr Murray is an intelligent, compassionate doctor who truly cares for her patients. She communicates clearly to both children and parents. I am a parent of a teen daughter who has been under Dr Murray's care for about four years, and I highly recommend her.
Recommend Dr. Karen Murray


Board Certification(s)
Pediatric Gastroenterology
Pediatric Transplant Hepatology
Medical/Professional School
Johns Hopkins University School of Medicine, Baltimore
Pediatrics, Children's Hospital and Regional Medical Center, Seattle
Gastroenterology, Children's Hospital, Boston
Clinical Interests

Hepatitis B and C

Research Description

Clinical research in the pathogenesis of, epidemiology of, and treatment for viral hepatitis and other pediatric liver diseases.

Research Focus Area

Therapeutic Trials

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
SEATTLE MAGAZINE TOP DOCTOR - 2014Seattle Magazine 2014
SEATTLE'S TOP DOCTOR - 2014Seattle Metropolitan Magazine 2014
Seattle Magazine Top Doctor - 2013Seattle Magazine 2013
Seattle's Top Doc Met Magazine 2013
Seattle Magazine Top Doctor - 2012Seattle Magazine Top Doctor - 2012Seattle Magazine 2012
U.S. News Top DoctorU.S. News and World Report 2012
Best Doctors in America 2011
Who's Who in America 2011
Leading Physicians of the WorldInternational Association of Healthcare Professionals 2010
International Association of Pediatricians 2010
"Guide to America's Top Pediatricians"Consumer's Research Council of America 2009
Seattle's Top DoctorSeattle Metropolitan MagazineJan. 1, 2009
Seattle’s Top DoctorsSeattle Metropolitan Magazine 2006 - 2010


Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon.
Journal of pediatric gastroenterology and nutrition , 2010 Aug: 183-6
Gastric contents in pediatric patients following bone marrow transplantation.
Paediatric anaesthesia , July 2010: 660-5
Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 Jul: 1005-17
Detection of polyethylene glycol-based laxatives in stool.
Journal of pediatric gastroenterology and nutrition , 2010 Mar: 276-9
Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3.
Experimental cell research , 2010 Feb 15: 657-66
Chronic hepatitis C virus infection in children.
Journal of pediatric gastroenterology and nutrition , 2010 Feb: 123-31
Fibrocystic diseases of the liver, 1st edition
, 2010: 511 pages
Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.
Contemporary clinical trials , 2010 Jan: 62-70
Hepatobiliary associations with inflammatory bowel disease.
Expert review of gastroenterology & hepatology , 2009 Dec: 681-91
Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement.
The Journal of pediatrics , 2009 Dec: 801-806.e1
Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B.
Pediatrics , 2009 Nov: e1007-13
Autoimmune hepatitis.
Journal of pediatric gastroenterology and nutrition , 2009 Aug: 158-64
Management of chronic hepatitis B in children.
Journal of pediatric gastroenterology and nutrition , 2009 Apr: 399-404
Impact of hepatitis C virus infection on children and their caregivers: quality of life, cognitive, and emotional outcomes.
Journal of pediatric gastroenterology and nutrition , 2009 Mar: 341-7
Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis.
American journal of physiology. Gastrointestinal and liver physiology , 2009 Jan: G78-92
Drug-related hepatotoxicity and acute liver failure.
Journal of pediatric gastroenterology and nutrition , 2008 Oct: 395-405
Infliximab for ulcerative colitis in children and adolescents.
Journal of clinical gastroenterology , 2008 Sep: 875-9
Chronic hepatitis.
Journal of pediatric gastroenterology and nutrition , 2008 Aug: 225-33
Biliary atresia: recent progress.
Journal of clinical gastroenterology , 2008 Jul: 720-9
Hepatitis B and C in children.
Nature clinical practice. Gastroenterology & hepatology , 2008 Jun: 311-20
Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial.
Hepatology (Baltimore, Md.) , 2008 Mar: 836-43
Increasing the mutation rate for Jagged1 mutations in patients with Alagille syndrome.
Hepatology (Baltimore, Md.) , 2007 Aug: 598-9
Design of the PEDS-C trial: pegylated interferon +/- ribavirin for children with chronic hepatitis C viral infection.
Clinical trials (London, England) , 2007: 661-73
Autoimmune hepatitis: are we using the right therapy?
Journal of pediatric gastroenterology and nutrition , 2007 Jan: 18-9
Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.
The Journal of pediatrics , 2006 May: 652-658
Infantile Crohn disease presenting with diarrhea and pyoderma gangrenosum.
Pediatric dermatology , 2006 Jan-Feb: 43-8
Liver histology and alanine aminotransferase levels in children and adults with chronic hepatitis C infection.
Journal of pediatric gastroenterology and nutrition , 2005 Nov: 634-8
Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics.
Hepatology (Baltimore, Md.) , 2005 Nov: 1010-8
A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease.
Inflammatory bowel diseases , 2005 Sep: 833-9
Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion.
Pediatrics , 2005 Jun: e673-80
AASLD practice guidelines: Evaluation of the patient for liver transplantation.
Hepatology (Baltimore, Md.) , 2005 Jun: 1407-32
Current and future therapy in haemochromatosis and Wilson's disease.
Expert opinion on pharmacotherapy , 2003 Dec: 2239-51
Prevalence of hepatitis C virus infection and risk factors in an incarcerated juvenile population: a pilot study.
Pediatrics , 2003 Jan: 153-7


Presentations TitleEventLocationDate
Concurrent Session III speaker: “Why do maintenance of certification?”; Faculty, 4th Hands on Endoscopy Course - PolypectomyOrlando, FLNASPGHAN Annual Meeting 2011
"Drug-induced liver injury and liver failure in children”Taiwan Society of Pediatric Gastroenterology, Hepatology, and Nutrition annual meetingTaipei, Taiwan 2011
“Biliary Atresia: Clinical Spectrum and Mechanisms of Disease"; • “New Treatments for Chronic B and C Hepatitis”; “State of the Art in Non-Alcoholic Steatohepatitis”International Symposium of Argentine Association for the Study of Liver Diseases (AAEEH) - International Guest Pediatric HepatologistBuenos Aires, Argentina 2010
“Gastroenterology: Careers in Academic Pediatric Gastroenterology and Hepatology”Pediatric Academic SocietiesVancouver, Canada 2010

Research Funding

Grant TitleGrantorAmountAward Date
Childhood Liver Disease Research and Education Network Clinical Center in SeattleNIH NIDDK $1,557,754.00Jan. 1, 2009
Limited Competition: Continuation of the Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN)NIH $225,207.00Jan. 1, 2009
A Phase 3, Randomized, Double-Blind Evaluation of the Antiviral Efficacy, Safety, and Tolerability of Tenofovir Disoproxil Fumarate Versus Placebo in Adolescents with Chronic Hepatitis B InfectionGilead Sciences, Inc. $56,849.00Jan. 1, 2009
Clinical Research Network in Hepatitis B VirusNIH $311,878.00Jan. 1, 2008
BARC CRN, Biliary atresia research consortiumNIH NIDDK $95,266.00Jan. 1, 2008
A phase 3 double-blind, randomized, placebo-controlled study of the safety and efficacy of Adefovir Dipivoxil in children and adolescents (age 2 to under 18) with chronic hepatitis BGilead Sciences, Inc. $128,327.00Jan. 1, 2004
Pegylated interferon + - ribavirin for children with HCVFDA-OPD-2002 Clinical Studies of Safety and Effectiveness of Orphan Products $99,650.00Jan. 1, 2003
CD4+ T-cell immunity in mother-child pairs infected with hepatitis C virusResearch Endorsement Fund $30,000.00Jan. 1, 2002
Pediatric Acute liver failure study groupNIH/NIDDK $16,000.000101.05

Primary Office

Seattle Children's
OB.9.620.1 - Gastroenterology and Hepatology
4800 Sand Point Way NE
Seattle, WA 98105

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