Profile

K Scott Baker, MD, MS

K Scott Baker, MD, MS

Hematology-Oncology

On staff since April 2009

Children's Title: Director, Pediatric Blood and Marrow Transplant Program and Cancer Survivor Program

Academic Title: Professor of Pediatrics

Research Center: Center for Clinical and Translational Research

"As a physician involved in the field of blood and marrow transplantation, I have the opportunity to offer patients and parents hope for the cure of many potentially life-threatening diseases both malignant and nonmalignant. That fact, along with the intensity of transplant as a treatment, creates a strong bond between physician and patient. The reward for doing this comes many years later, when I receive a high-school or college graduation announcement and realize that what I did gave that person a chance for life."

K. Scott Baker, MD, MS is a Member in the Clinical Research Division of the Fred Hutchinson Cancer Research Center (FHCRC), Professor in the Department of Pediatrics at the University of Washington in Seattle Washington, and an attending physician for Pediatric Hematology/Oncology and Bone Marrow Transplantation at Seattle Children's Hospital. Dr. Baker is the Director of the Cancer Survivorship Program at Seattle Children's Hospital, FHCRC and the Seattle Cancer Care Alliance.

This program is one of only eight centers in the US designated by the Lance Armstrong Foundation as a LIVESTRONG Survivorship Center of Excellence. He is a nationally recognized expert in the field of hematopoietic cell transplantation (HCT) and in cancer survivorship and serves on the Cancer Control and Late Effects steering committee of the Childrens Oncology Group and is a member of the Late Effects and Health Policy Committees for the Center for International Blood and Marrow Transplant Research.

Dr. Baker's research interests are in the acute and long term-effects of HCT and are focused on the study of treatment related acute and long-term complications in survivors after transplant. This research forms the basis for his current grant support in which the incidence, risk factors, and characteristics of cardiac, pulmonary, renal, endocrine, reproductive late effects and quality of life outcomes in survivors are being studied. Additional studies are examining the "metabolic syndrome" and the early development of cardiovascular risk factors and diabetes in HCT survivors.

Dr. Baker is the principal investigator for FHCRC and the Seattle Children's Hospital for participation in the multi-institutional Childhood Cancer Survivor Study which follows nearly 20,000 childhood cancer survivors. This study has made a tremendous number of scientific discoveries regarding the long term outcomes in survivors after childhood cancer.

Dr. Baker also serves as the principal investigator for several HCT clinical trials, particularly for treatment of children with hemophagoytic lymphohistiocytosis (HLH), Langerhans Cell Histiocytosis (LCH) and other primary immune deficiencies. For these patients, a novel type of transplantation that is designed to make HCT for patients with these disorders safer by utilizing a reduced intensity transplant preparative regimen is being investigated.

Recommendations

  • Yalonda Maple Grove, MN 06.02.11

    I absolutely adore Dr.Baker. We were very sad as a family to have lost him as our physician but realized that his expertise and commitment were needed in other areas as well. He was our primary physician during 2 BMT's for our oldest daughter and she is doing remarkably well!! He is very knowledgeable, stays on top of the latest research and is very caring. The team at Seattle Children's Hospital is very lucky to have him on board. Yalonda Tate

Overview

Board Certification(s)

Pediatric Hematology-Oncology

Medical/Professional School

University of Nebraska College of Medicine, Omaha

Residency

Pediatrics, University of Nebraska Medical Center, Omaha

Fellowship

Pediatric Hematology-Oncology, Cincinnati Children's Hospital, Cincinnati

Clinical Interests

Hematopoietic cell transplantation for non-malignant hematologic diseases, immune deficiencies, and histiocytic disorders; cord blood transplantation, long term complications of cancer therapy. Etiology and risk factors for late effects in survivors after hematopoietic cell transplantation, metabolic syndrome and cardiovascular risk in cancer survivors.

Research Focus Area

Translational Research

Publications

  • McAvoy S, Baker KS, Mulrooney D, Blaes A, Arora M, Burns LJ, Majhail NS
    Corticosteroid dose as a risk factor for avascular necrosis of the bone after hematopoietic cell transplantation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 Sept. : 1231-6
  • Armenian SH, Sun CL, Teh JB, Arora M, Baker KS, Francisco L, Forman SJ, Bhatia S
    Ethnic differences in chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study.
    Cancer , 2010 Sept. 1 : 4152-9
  • Sun CL, Francisco L, Kawashima T, Leisenring W, Robison LL, Baker KS, Weisdorf DJ, Forman SJ, Bhatia S
    Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study.
    Blood , 2010 July 23
  • Chow EJ, Simmons JH, Roth CL, Baker KS, Hoffmeister PA, Sanders JE, Friedman DL
    Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 May 31
  • Hoffmeister PA, Hingorani SR, Storer BE, Baker KS, Sanders JE
    Hypertension in long-term survivors of pediatric hematopoietic cell transplantation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 Apr, : 515-24
  • Baker KS, Bresters D, Sande JE
    The burden of cure: long-term side effects following hematopoietic stem cell transplantation (HSCT) in children.
    Pediatric clinics of North America , 2010 Feb. : 323-42
  • Baker KS, Armenian S, Bhatia S
    Long-term consequences of hematopoietic stem cell transplantation: current state of the science.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 Jan. : S90-6
  • Smith AR, Gross TG, Baker KS
    Transplant outcomes for primary immunodeficiency disease.
    Seminars in hematology , 2010 Jan. : 79-85
  • Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi RJ, Yeazel M, Beiraghi S, Hudson MM, Sklar CA, Robison LL, Baker KS
    Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study.
    Cancer , 2009 Dec. 15 : 5817-27
  • Baker KS, Davies SM, Majhail NS, Hassebroek A, Klein JP, Ballen KK, Bigelow CL, Frangoul HA, Hardy CL, Bredeson C, Dehn J, Friedman D, Hahn T, Hale G, Lazarus HM, LeMaistre CF, Loberiza F, Maharaj D, McCarthy P, Setterholm M, Spellman S, Trigg M, Maziarz RT, Switzer G, Lee SJ, Rizzo JD
    Race and socioeconomic status influence outcomes of unrelated donor hematopoietic cell transplantation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2009 Dec. : 1543-54
  • Majhail NS, Challa TR, Mulrooney DA, Baker KS, Burns LJ
    Hypertension and diabetes mellitus in adult and pediatric survivors of allogeneic hematopoietic cell transplantation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2009 Sept. : 1100-7
  • Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman DS, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ
    Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2009 Aug. 1 : 3634-41
  • Yi JS, Moertel CL, Baker KS
    Homozygous alpha-thalassemia treated with intrauterine transfusions and unrelated donor hematopoietic cell transplantation.
    The Journal of pediatrics , 2009 May : 766-8
  • Hunger SP, Loh KM, Baker KS, Schultz KR
    Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2009 Jan. : 79-83
  • Thomas IH, Donohue JE, Ness KK, Dengel DR, Baker KS, Gurney JG
    Bone mineral density in young adult survivors of acute lymphoblastic leukemia.
    Cancer , 2008 Dec. 1 : 3248-56
  • Prasad PK, Sun CL, Baker KS, Francisco L, Forman S, Bhatia S, Shankar SM
    Health care utilization by adult Hispanic long-term survivors of hematopoietic stem cell transplantation: report from the Bone Marrow Transplant Survivor Study.
    Cancer , 2008 Nov. 15 : 2724-33
  • Krishnamurti L, Kharbanda S, Biernacki MA, Zhang W, Baker KS, Wagner JE, Wu CJ
    Stable long-term donor engraftment following reduced-intensity hematopoietic cell transplantation for sickle cell disease.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2008 Nov. : 1270-8
  • Robien K, Ness KK, Klesges LM, Baker KS, Gurney JG
    Poor adherence to dietary guidelines among adult survivors of childhood acute lymphoblastic leukemia.
    Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology , 2008 Nov. : 815-22
  • Johnson L, Orchard PJ, Baker KS, Brundage R, Cao Q, Wang X, Langer E, Farag-El Maasah S, Ross JA, Remmel R, Jacobson PA
    Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation.
    Journal of clinical pharmacology , 2008 Sept. : 1052-62
  • Harker-Murray PD, Thomas AJ, Wagner JE, Weisdorf D, Luo X, DeFor TE, Verneris MR, Dusenbery KE, MacMillan ML, Tolar J, Baker KS, Orchard PJ
    Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2008 June : 685-92
  • Baker KS, Fraser CJ
    Quality of life and recovery after graft-versus-host disease.
    Best practice & research. Clinical haematology , 2008 June : 333-41
  • Perez-Albuerne ED, Eapen M, Klein J, Gross TJ, Lipton JM, Baker KS, Woolfrey A, Kamani N
    Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemia.
    British journal of haematology , 2008 Apr, : 216-23
  • Dengel DR, Ness KK, Glasser SP, Williamson EB, Baker KS, Gurney JG
    Endothelial function in young adult survivors of childhood acute lymphoblastic leukemia.
    Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology , 2008 Jan. : 20-5
  • Ness KK, Baker KS, Dengel DR, Youngren N, Sibley S, Mertens AC, Gurney JG
    Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia.
    Pediatric blood & cancer , 2007 Dec. : 975-81
  • Perkins JL, Kunin-Batson AS, Youngren NM, Ness KK, Ulrich KJ, Hansen MJ, Petryk A, Steinberger J, Anderson FS, Baker KS
    Long-term follow-up of children who underwent hematopoeitic cell transplant (HCT) for AML or ALL at less than 3 years of age.
    Pediatric blood & cancer , 2007 Dec. : 958-63
  • Bhatia S, Francisco L, Carter A, Sun CL, Baker KS, Gurney JG, McGlave PB, Nademanee A, O'Donnell M, Ramsay NK, Robison LL, Snyder D, Stein A, Forman SJ, Weisdorf DJ
    Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study.
    Blood , 2007 Nov. 15 : 3784-92
  • Gurney JG, Donohue JE, Ness KK, O'Leary M, Glasser SP, Baker KS
    Health knowledge about symptoms of heart attack and stroke in adult survivors of childhood acute lymphoblastic leukemia.
    Annals of epidemiology , 2007 Oct. : 778-81
  • Majhail NS, Ness KK, Burns LJ, Sun CL, Carter A, Francisco L, Forman SJ, Bhatia S, Baker KS
    Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor study.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2007 Oct. : 1153-9
  • Adamkiewicz TV, Szabolcs P, Haight A, Baker KS, Staba S, Kedar A, Chiang KY, Krishnamurti L, Boyer MW, Kurtzberg J, Wagner JE, Wingard JR, Yeager AM
    Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experience.
    Pediatric transplantation , 2007 Sept. : 641-4
  • Shankar SM, Carter A, Sun CL, Francisco L, Baker KS, Gurney JG, Weisdorf DG, Forman SJ, Robison LL, Grant M, Bhatia S
    Health care utilization by adult long-term survivors of hematopoietic cell transplant: report from the Bone Marrow Transplant Survivor Study.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology , 2007 Apr, : 834-9
  • Brunstein CG, Baker KS, Wagner JE
    Umbilical cord blood transplantation for myeloid malignancies.
    Current opinion in hematology , 2007 Mar. : 162-9
  • Baker KS, Ness KK, Steinberger J, Carter A, Francisco L, Burns LJ, Sklar C, Forman S, Weisdorf D, Gurney JG, Bhatia S
    Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study.
    Blood , 2007 Feb. 15 : 1765-72
  • Fraser CJ, Bhatia S, Ness K, Carter A, Francisco L, Arora M, Parker P, Forman S, Weisdorf D, Gurney JG, Baker KS
    Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study.
    Blood , 2006 Oct. 15 : 2867-73
  • Gurney JG, Ness KK, Sibley SD, O'Leary M, Dengel DR, Lee JM, Youngren NM, Glasser SP, Baker KS
    Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia.
    Cancer , 2006 Sept. 15 : 1303-12
  • Kharbanda S, Panoskaltsis-Mortari A, Haddad IY, Blazar BR, Orchard PJ, Cornfield DN, Grewal SS, Peters C, Regelmann WE, Milla CE, Baker KS
    Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disorders.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2006 Apr, : 430-7
  • Gurney JG, Ness KK, Rosenthal J, Forman SJ, Bhatia S, Baker KS
    Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: results from the Bone Marrow Transplant Survivor study.
    Cancer , 2006 Mar. 15 : 1402-8
  • Petryk A, Bergemann TL, Polga KM, Ulrich KJ, Raatz SK, Brown DM, Robison LL, Baker KS
    Prospective study of changes in bone mineral density and turnover in children after hematopoietic cell transplantation.
    The Journal of clinical endocrinology and metabolism , 2006 Mar. : 899-905
  • Fraser CJ, Hirsch BA, Dayton V, Creer MH, Neglia JP, Wagner JE, Baker KS
    First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation.
    Blood , 2005 Dec. 15 : 4377-80
  • Baker KS, Loberiza FR Jr, Yu H, Cairo MS, Bolwell BJ, Bujan-Boza WA, Camitta BM, Garcia JJ, Ho WG, Liesveld JL, Maharaj D, Marks DI, Schultz KR, Wiernik P, Zander AR, Horowitz MM, Keating A, Weisdorf DJ
    Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United States.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2005 Oct. 1 : 7032-42
  • Ness KK, Bhatia S, Baker KS, Francisco L, Carter A, Forman SJ, Robison LL, Rosenthal J, Gurney JG
    Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor study.
    Archives of pediatrics & adolescent medicine , 2005 Aug. : 706-13
  • Punyko JA, Mertens AC, Gurney JG, Yasui Y, Donaldson SS, Rodeberg DA, Raney RB, Stovall M, Sklar CA, Robison LL, Baker KS
    Long-term medical effects of childhood and adolescent rhabdomyosarcoma: a report from the childhood cancer survivor study.
    Pediatric blood & cancer , 2005 June 15 : 643-53
  • Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, Baker KS, Fung H, Gurney JG, McGlave PB, Nademanee A, Ramsay NK, Stein A, Weisdorf DJ, Forman SJ
    Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study.
    Blood , 2005 June 1 : 4215-22
  • Peters A, Manivel JC, Dolan M, Gulbahce HE, Baker KS, Verneris MR
    Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2005 June : 484-5
  • Punyko JA, Mertens AC, Baker KS, Ness KK, Robison LL, Gurney JG
    Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluation.
    Cancer , 2005 Apr, 1 : 1475-83
  • Ness KK, Oakes JM, Punyko JA, Baker KS, Gurney JG
    Prevalence of the metabolic syndrome in relation to self-reported cancer history.
    Annals of epidemiology , 2005 Mar. : 202-6
  • Kumar A, Saltzman D, Shukula M, Lewis V, Wendorf R, Sauer M, Neglia J, Baker KS, Macmillan M, Steiner ME
    Diagnostic peritoneal lavage for assessing acute abdomen in pediatric oncology and stem cell transplantation patients.
    Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology , 2004 Dec. : 824-6
  • Baker KS, Gurney JG, Ness KK, Bhatia R, Forman SJ, Francisco L, McGlave PB, Robison LL, Snyder DS, Weisdorf DJ, Bhatia S
    Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study.
    Blood , 2004 Sept. 15 : 1898-906
  • Barnett SJ, Weisdorf-Schindle S, Baker KS, Saltzman DA
    Spontaneous liver rupture in a child with graft-versus-host disease.
    Journal of pediatric surgery , 2004 Sept. : e1-3
  • Gulbahce HE, Pambuccian SE, Jessurun J, Woodard P, Steiner ME, Manivel JC, Hite S, Ramsay NK, Baker KS
    Pulmonary nodular lesions in bone marrow transplant recipients: impact of histologic diagnosis on patient management and prognosis.
    American journal of clinical pathology , 2004 Feb. : 205-10
  • Serna DS, Lee SJ, Zhang MJ, Baker S, Eapen M, Horowitz MM, Klein JP, Rizzo JD, Loberiza FR Jr
    Trends in survival rates after allogeneic hematopoietic stem-cell transplantation for acute and chronic leukemia by ethnicity in the United States and Canada.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2003 Oct. 15 : 3754-60
  • Gulbahce HE, Baker KS, Kumar P, Kjeldahl K, Pambuccian SE
    Atypical cells in bronchoalveolar lavage specimens from bone marrow transplant recipients. A potential pitfall.
    American journal of clinical pathology , 2003 July : 101-6
  • Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL
    New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2003 Apr, 1 : 1352-8
  • Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM, Qualman SJ, Wharam MD, Donaldson SS, Maurer HM, Meyer WH, Baker KS, Paidas CN, Crist WM
    Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2003 Jan. 1 : 78-84
  • Baker KS, Anderson JR, Lobe TE, Wharam MD, Qualman SJ, Raney RB, Ruymann FB, Womer RB, Meyer WH, Link MP, Crist WM
    Children from ethnic minorities have benefited equally as other children from contemporary therapy for rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2002 Nov. 15 : 4428-33
  • Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, Zhang J, Wan X, Baker KS, Sorensen P, Barr FG
    Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes.
    Genes, chromosomes & cancer , 2002 Mar. : 310-21
  • Baker KS, Wagner JE
    Novel conditioning regimens and nonmyeloablative stem cell transplants.
    Current opinion in pediatrics , 2002 Feb. : 17-22

Presentations

Presentations Title Event Location Date
Cancer Survivorship and Implementing Care Plans Montana Cancer Control Coalition Helena, MT Nov. 5, 2009
Models of Survivorship Care 1st Annual Survivorship Symposium: Cancer Survivorship and Health Disparities George Washington Cancer Institute - Washington, DC Oct. 15, 2009
Special Considerations and Complications Related to Long-Term Outcomes in Infants after HCT American Society Blood and Marrow Transplant San Diego, CA Feb. 12, 2009

Research Funding

Grant Title Grantor Amount Award Date
Abdominal aorta intima-media thickness: a measure of early subclinical atherosclerosis Minnesota Medical Foundation $12,000.00 Aug. 15, 2008
Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP) NIAID $75,000.00 May 1, 2007
Metabolic Syndrome Following Transplant for Leukemia NIH/NCI $1,497,680.00 Aug. 15, 2006
Metabolic Syndrome in Childhood Cancer Survivors NIH/NCI $2,317,865.00 April 1, 2006
FHCRC Survivorship Program Lance Armstrong Foundation $1,700,054.00 Jan. 1, 2006
Pediatric Cancer Epidemiology Training Grant National Institutes of Health $1,115,934.00 Sept. 30, 2004