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David R. Beier, MD, PhD

David R. Beier, MD, PhD


Children's Title: Director, Center for Developmental Biology and Regenerative Medicine

Academic Title: Professor

Research Center: Center for Developmental Biology and Regenerative Medicine


Medical/Professional School
University of Washington School of Medicine, Seattle
University of Washington School of Medicine, Seattle

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Life and Health Insurance Medical Research Fund FellowshipHarvard Medical School 1993 - 1996
Damon Runyon-Walter Winchell Cancer Fund Clinical Scientist FellowshipGenetics Department, Harvard Medical School 1986 - 1987
Graduate School DissertationBiochemistry Department, University of Washington 1983 - 1983
Dreyfus FellowshipHarvard University 1976 - 1976
Mellon FellowshipWestern Psychiatric Institute and Clinic, Pittsburgh Medical School 1975 - 1975
Harvard UniversityHarvard Scholarship 1974 - 1976
ScholarshipMountain Memorial Sloan-Kettering Cancer Research Institute 1973 - 1973


Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain.
The Journal of comparative neurology , 2013 Feb 15: 521(3)677-96
Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.
Journal of the American Society of Nephrology : JASN , 2013 Jan: 24(1)100-12
Mutation mapping and identification by whole-genome sequencing.
Genome research , 2012 Aug: 22(8)1541-8
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
The Journal of cell biology , 2012 Jun 11: 197(6)789-800
Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo.
PLoS genetics , 2011 Sep: 7(9)e1002224
The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated.
Proceedings of the National Academy of Sciences of the United States of America , 2011 Aug 2: 108(31)12787-92
A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.
Neural development , 2011 Jan 7: 63
A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development.
PloS one , 2010 Dec 16: 5(12)e14375
Genome-wide identification of mouse congenital heart disease loci.
Human molecular genetics , 2010 Aug 15: 19(16)3105-13
Prdm16 is required for normal palatogenesis in mice.
Human molecular genetics , 2010 Mar 1: 19(5)774-89
Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.
The New England journal of medicine , 2010 Jan 21: 362(3)206-16
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Nature genetics , 2008 Apr: 40(4)403-10
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Genome research , 2006 Mar: 16(3)436-40
Fog2 is required for normal diaphragm and lung development in mice and humans.
PLoS genetics , 2005 Jul: 1(1)58-65
Interacting genetic loci cause airway hyperresponsiveness.
Physiological genomics , 2005 Mar 21: 21(1)105-11
A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.
Development (Cambridge, England) , 2002 Dec: 129(24)5839-46
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.
Nature genetics , 2002 Feb: 30(2)185-9


Presentations TitleEventLocationDate
Inviited LectureMontreal Symposium on Genetics and Infectious DiseasesMontreal, Canada 2011
Invited LectureMouse Molecular GeneticsHinxton, UK 2011
Invited lectureCedars Sinai HospitalLos Angeles, CA 2011
LectureBroad Institute, Medical and Population Genetics ProgramCambridge, MA 2011
Invited LectureMCDB Dept, CU BoulderBoulder, CO 2010
Invited LectureSecond International Conference of Functional Annotation of the Mammalian GenomeBanff, Canada 2009

Research Funding

Grant TitleGrantorAmountAward Date
Genetic Analysis of Disease Modifiers of the Cystogenic Kinase Nek8NIDDK 2010 - 2013
Genetic analysis of an asthma-related trait in miceNHLBI 2010 - 2014
Analysis of Neurodevelopment Using Mouse MutagenesisNINDS 2008 - 2013
Mutagenesis and Murine Embryonic DevelopmentNICHD 1998 - 2015

Primary Office

Seattle Children's Research Institute
JMB - 5 - Center for Developmental Biology and Regenerative Medicine
1900 - 9th Ave
Seattle, WA 98101

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