Profile

Allison A. Eddy, MD

On staff since July 1997

Children's Title: Chief, Division of Nephrology; Director, Center for Tissue and Cell Sciences

Academic Title: Professor, Pediatrics; Section Head, Nephrology

Research Center: Center for Tissue and Cell Sciences

Allison A. Eddy, MD, Chief of the Division of Nephrology at Seattle Children’s Hospital and a Professor of Pediatrics at the University of Washington School of Medicine is a graduate of McMaster University medical school and McGill University pediatric residency programs in Canada and the University of Minnesota fellowship program. Her particular clinical interest is in immune-mediated kidney diseases. She participates in outreach clinics in Alaska.

She served as the Director of the UW ACGME-accredited Pediatric Nephrology Fellowship Program from 1997-2008 and continues to serve as the director of the NIH-funded research fellowship training program in pediatric nephrology. Since 1985, Dr. Eddy has directed an independent basic science research program focusing on the cellular and molecular mechanisms of renal fibrosis. Her NIH-funded research program investigates cellular and molecular mechanisms of inflammation and fibrosis in chronic kidney disease. She also has active research funding from the Cystinosis Research Foundation and the Washington Global Health Alliance. The latter funds an epidemiological study in Kampala, Uganda.

In 2009, Dr. Eddy was elected to the Council of the International Society of Nephrology (only the second pediatric nephrologist in its 50-year history). She has served on several NIH Study Sections, and was Deputy Editor of the Journal of the American Society of Nephrology (JASN) from 2001-2007. Additionally, Dr. Eddy mentors junior pediatric clinician-scientists in other Divisions as part of her roles as Program Director of the University of Washington Child Health Research Center and Director of the Center for Tissue and Cell Biology at Seattle Children’s Research Institute.

Making a Difference

Healthy Kidneys/Healthy Lives
The quest to improve outcomes and train the next generation of providers drives our nationally ranked division of Nephrology. ... cont.

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Overview
Awards and Honors
Publications
Presentations
Research Funding

Overview

Board Certification(s): Pediatrics
Pediatric Nephrology
Medical/Professional School: McMaster University, Hamilton
Residency: McGill University, Montreal, Pediatrics
Fellowship: University of Minnesota Medical School, Minneapolis, Pediatric Nephrology
Clinical Interests: Progressive kidney disease, glomerulonephritis, interstitial nephritis
Research Description: Mechanisms of inflammation and fibrosis in progressive kidney disease. Our current studies are focused on the role of scavenger receptors and the family of serine proteases and their inhibitors.
Research Focus Area: Tissue Response to Injury

Awards and Honors

Award Name	Award Description	Awarded By	Award Date
	Robert O. Hickman Endowed Chair in Pediatric Nephrology - University of Washington	University of Washington	Jan. 1, 2009

Publications

Nicotinic acetylcholine receptor alpha1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.
Laboratory investigation; a journal of technical methods and pathology , 2010 Jul 26

A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis.
The Journal of biological chemistry , 2009 Oct 16: 29050-64

Serine proteases, inhibitors and receptors in renal fibrosis.
Thrombosis and haemostasis , 2009 Apr: 656-64

CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.
Journal of the American Society of Nephrology : JASN , 2009 Mar: 495-505

Macrophage diversity in renal injury and repair.
The Journal of clinical investigation , 2008 Nov: 3522-30

Urokinase and its receptors in chronic kidney disease.
Frontiers in bioscience : a journal and virtual library , 2008 May 1: 5462-78

Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury.
American journal of physiology. Renal physiology , 2007 Aug: F575-85

Endogenous urokinase lacks antifibrotic activity during progressive renal injury.
American journal of physiology. Renal physiology , 2007 Jul: F12-9

Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.
Journal of the American Society of Nephrology : JASN , 2007 Mar: 846-59

Chronic kidney disease progression.
Journal of the American Society of Nephrology : JASN , 2006 Nov: 2964-6

Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action.
Journal of the American Society of Nephrology : JASN , 2006 Nov: 2999-3012

Ramping up endogenous defences against chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association , 2006 May: 1174-7

Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.
Nephron. Experimental nephrology , 2006: e23-34

Can renal fibrosis be reversed?
Pediatric nephrology (Berlin, Germany) , 2005 Oct: 1369-75

Progression in chronic kidney disease.
Advances in chronic kidney disease , 2005 Oct: 353-65

Why is proteinuria an ominous biomarker of progressive kidney disease?
Kidney international. Supplement , 2004 Nov: S76-89

Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein.
Journal of the American Society of Nephrology : JASN , 2004 Aug: 2090-102

Expression of nephrin in acquired forms of nephrotic syndrome in childhood.
Pediatric nephrology (Berlin, Germany) , 2004 Mar: 300-5

Proteinuria and interstitial injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association , 2004 Feb: 277-81

Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria.
Nephron. Experimental nephrology , 2004: e123-35

Nephrotic syndrome in childhood.
Lancet , 2003 Aug 23: 629-39

Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.
Journal of the American Society of Nephrology : JASN , 2003 May: 1234-53

Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.
Journal of the American Society of Nephrology : JASN , 2003 May: 1254-71

Plasminogen activator inhibitor-1 and the kidney.
American journal of physiology. Renal physiology , 2002 Aug: F209-20

An introduction to frontiers in nephrology.
Journal of the American Society of Nephrology : JASN , 2002 Aug: 2185

Presentations

Presentations Title	Event	Location	Date
Lipid and macrophage abnormalities in chronic kidney disease (CKD)	CKD and CVD from the Vascular Viewpoint: Merging Basic and Clinical Sciences to Optimize Treatment Symposium. Pre-American Society of Nephrology Annual Meeting	San Diego CA	Oct. 1, 2009
Chronic kidney disease progression: will we ever be able to stop it?	4th Annual Western Canadian Kidney Research Symposium	Vancouver, BC	Oct. 1, 2009
Chronic kidney disease progression: will we ever be able to stop it?	Dr. Bernard Kaplan Festschrift, The Children’s Hospital of Philadelphia	Philadelphia	May 1, 2009
New insights into renal fibrosis	Renal Association and British Transplant Society joint meeting	Liverpool, UK	April 1, 2009
Nephrotic syndrome and Interstitial nephritis	University of Washington WWAMI	Spokane, WA	March 1, 2009
The kidney fibrosis puzzle: known and missing pieces	Northwestern University, Department of Pathology	Northwestern University	Feb. 1, 2009
Paediatric Preoperative Evaluation Regional Anaesthesia for Paediatric Spinal Surgery + Paediatric Problem-Based Learning	4th All Africa Anaesthesia Congress	Nairobi, Kenya	Jan. 1, 2009

Research Funding

Grant Title	Grantor	Amount	Award Date
Pediatric investigation for genetic factors associated with renal progression	National Institutes of Health	$Budget pending	Jan. 1, 2010
Cysteamine effects on extracellular matrix accumulation in chronic kidney disease	Cystinosis Research Foundation	$267,208.00	Jan. 1, 2007
Impact of Kidney Dysfunction on Mortality Rates in Ugandan Children Hospitalized with Acute Infections	Washington Global Health Alliance Pilot Grant	$75,000.00	Jan. 1, 2007
Molecular mechanisms in renal interstitial fibrosis	National Institutes of Health	$1,821,250.00	Jan. 1, 2004
Role of Renal Tubular Scavenger Receptors in Progressive Kidney Disease	National Institutes of Health	$782,600.00	Jan. 1, 2002

Primary Office

Seattle Children's

A-7931 - Nephrology
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2524

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Allison A. Eddy, MD

Making a Difference

Healthy Kidneys/Healthy Lives

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Overview

Awards and Honors

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