Profile

Akiko Shimamura, MD, PhD

Akiko Shimamura, MD, PhD

Hematology-Oncology

On staff since July 2007

Research Center: Center for Clinical and Translational Research

"Bone marrow failure is rare, so families often come to us not knowing whats wrong with their child. It makes a big difference when you can tell families and patients that this is what you have and this is what were going to do to try to make things better. It provides a sense of relief and hope. I like working with these patients because they deserve the same commitment to the best medical care as patients with more common diseases. The scientific advances from the study of marrow failure have deepened our understanding of blood diseases and cancers in the general population as well. I learn something new with every patient."

Recommendations

  • Ginger Monroe, WA 04.26.11

    Dr. Shimamura is a kind, caring, compassionate doctor. She has taken time to explain my child's disease to her in an age-appropriate manner without being patronizing. She also communicates well with me on a highly technical level. She also helps my child understand that she is expected to become more involved with owning her own care as she transitions to adulthood, and that resources are going to be available for her as and adult through the SCA and the UW Medical Center. We are so very fortunate to have one of the world's top authorities on Fanconi Anemia here in the Northwest.

Overview

Board Certification(s)

Pediatric Hematology-Oncology

Medical/Professional School

University of Rochester School of Medicine, Rochester
Johns Hopkins University School of Medicine, Baltimore

Residency

Pediatrics, Johns Hopkins University School of Medicine, Baltimore

Fellowship

Pediatric Hematology-Oncology, Children's Hospital Boston, Boston
Pediatric Hematology-Oncology, Children's Hospital Boston, Boston

Clinical Interests

Inherited bone marrow failure syndromes and aplastic anemia Shwachman-Diamond syndrome, Fanconi anemia and Diamond Blackfan anemia

Research Description

My research interests focus on hematopoiesis and leukemogenesis in the inherited marrow failure syndrome. My current studies investigate the role of ribosomal dysfunction in marrow failure and malignant transformation. I am also pursuing studies on translational control of gene expression in hematopoietic stem cells. Recent laboratory findings reported a role for mitotic spindle stabilization in genomic instability. I am a member of the scientific advisory board for the Shwachman-Diamond Syndrome Foundation and served as co-chair of the Fourth International Scientific Congress on Shwachman-Diamond Syndrome. I am also the principal investigator for the North American Shwachman-Diamond Syndrome Registry currently under development.

Research Focus Area

Cancer, Blood Disorders

Awards and Honors

Award Name Award Description Awarded By Award Date
Rare Disease Research Hall of Fame http://rarediseaseday.us/meet-the-community/researche-hall-of-fame/ National Organization for Rare Diseases (NORD) 2013
U.S. News Top Doctor U.S. News and World Report 2012
Seattle Top Doctors (Hematology), Seattle Magazine 2011
Golden Stethoscope Award (Hematology), Seattle Magazine 2010
"Guide to America's Top Pediatricians" Consumer's Research Council of America 2009
Harvard Medical School Scholars in Medicine Award 2000
David Abraham Fellowship 1997
Amy Clare Potter Fellowship 1997
Howard Hughes Medical Institute Physician Fellow 1997
V Foundation Scholar 1997
The Robert Kates Award (for excellence in clinical medicine and research) 1991
Alpha Omega Alpha 1990
Holtfreter Fellowship (for outstanding graduate work) 1986
Phi Beta Kappa 1983

Publications

  • Akiko Shimamura, MD, PhD
    Inherited Aplastic Anemia Syndromes
    In: Greer, J.P., Arber D.A., Glader, B.E., List, A.F., Means, R.T., Paraskevas, F., Rodgers, G.M., Foerster, J., eds. Wintrobe's Clinical Hematology. 13th ed. Philadelphia: Lippincott Williams and Wilkins , 2014
  • Myers KC, Bolyard AA, Otto B, Wong TE, Jones AT, Harris RE, Davies SM, Dale DC, Shimamura A
    Variable Clinical Presentation of Shwachman-Diamond Syndrome: Update from the North American Shwachman-Diamond Syndrome Registry.
    The Journal of Pediatrics , 2013 Dec.
  • Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, Vlachos A, Walkovich K, Wang W, Shimamura A
    Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC).
    Pediatric blood and cancer , 2013 Nov.
  • Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR
    Common variable immunodeficiency as the initial presentation of dyskeratosis congenita.
    The Journal of allergy and clinical immunology , 2013 July : 132(1)223-6
  • Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, Nakamura T, Schlaeger TM, Shimamura A, Daley GQ
    Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction.
    Cell stem cell , 2013 June : 12(6)727-36
  • Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D
    H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation.
    Cell reports , 2013 May : 3(5)1493-502
  • Myers KC, Davies SM, Shimamura A
    Clinical and molecular pathophysiology of Shwachman-Diamond syndrome: an update.
    Hematology/oncology clinics of North America , 2013 Feb. : 27(1)117-28, ix
  • Akiko Shimamura, MD, PhD
    Translational Profiling Reveals the elF2 kinase Pathway as a Mediator of Dexamethason Induced Apoptosis in Multiple Myeloma
    American Society of Hematology , 2013
  • Akiko Shimamura, MD, PhD
    ComprehensiveGenomic Evaluation for Inherited Bone Marrow Failure and Myelodysplastic Syndromes
    American Society of Hematology , 2013
  • Akiko Shimamura, MD, PhD
    Fanconi Anemia
    In Clinical Decision Support: Hematology, edited by Benz E.J., Berliner, N., Brodsky R., LaCasce A., Moake J. Decision Support in Medicine, LLC. Wilmington, DE www.decisionsupportinmedicine.com , 2013
  • Akiko Shimamura, MD, PhD
    Shwachman-Diamond Syndrome
    In Clincial Decision Support: Hematology, edited by Benz E.J., Berliner, N., Brodsky, R, LaCasce, A., Moake, J. Decision Support in Medicine, LLC. Wilmington, DE www.decisionsupportinmedicine.com , 2013
  • Burwick N, Coats SA, Nakamura T, Shimamura A
    Impaired ribosomal subunit association in Shwachman-Diamond syndrome.
    Blood , 2012 Dec. : 120(26)5143-52
  • Singh SA, Vlachos A, Morgenstern NJ, Ouansafi I, Ip W, Rommens JM, Durie P, Shimamura A, Lipton JM
    Breast cancer in a case of Shwachman Diamond syndrome.
    Pediatric blood and cancer , 2012 Nov. : 59(5)945-6
  • Kazenwadel J, Secker GA, Liu YJ, Rosenfeld JA, Wildin RS, Cuellar-Rodriguez J, Hsu AP, Dyack S, Fernandez CV, Chong CE, Babic M, Bardy PG, Shimamura A, Zhang MY, Walsh T, Holland SM, Hickstein DD, Horwitz MS, Hahn CN, Scott HS, Harvey NL
    Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.
    Blood , 2012 Feb. : 119(5)1283-91
  • Dror Y, Donadieu J, Koglmeier J, Dodge J, Toiviainen-Salo S, Makitie O, Kerr E, Zeidler C, Shimamura A, Shah N, Cipolli M, Kuijpers T, Durie P, Rommens J, Siderius L, Liu JM
    Draft consensus guidelines for diagnosis and treatment of Shwachman-Diamond syndrome.
    Annals of the New York Academy of Sciences , 2011 Dec. : 124240-55
  • Click ES, Cox B, Olson SB, Grompe M, Akkari Y, Moreau LA, Shimamura A, Sternen DL, Liu YJ, Leppig KA, Matthews DC, Parisi MA
    Fanconi anemia-like presentation in an infant with constitutional deletion of 21q including the RUNX1 gene.
    American journal of medical genetics. Part A , 2011 July : 155A(7)1673-9
  • Marro K, Otto R, Kolokythas O, Shimamura A, Sanders JE, McDonald GB, Friedman SD
    A simulation-based comparison of two methods for determining relaxation rates from relaxometry images.
    Magnetic resonance imaging , 2011 May : 29(4)497-506
  • Burwick N, Shimamura A, Liu JM
    Non-Diamond Blackfan anemia disorders of ribosome function: Shwachman Diamond syndrome and 5q- syndrome.
    Seminars in hematology , 2011 Apr, : 48(2)136-43
  • Huang JN, Shimamura A
    Clinical spectrum and molecular pathophysiology of Shwachman-Diamond syndrome.
    Current opinion in hematology , 2010 Nov.
  • Wong TE, Calicchio ML, Fleming MD, Shimamura A, Harris MH
    SBDS protein expression patterns in the bone marrow.
    Pediatric blood and cancer , 2010 Sept. : 546-9
  • Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A
    Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
    Stem cells (Dayton, Ohio) , 2010 July : 28(7)1186-95
  • Rosenberg PS, Zeidler C, Bolyard AA, Alter BP, Bonilla MA, Boxer LA, Dror Y, Kinsey S, Link DC, Newburger PE, Shimamura A, Welte K, Dale DC
    Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy.
    British journal of haematology , 2010 July : 196-9
  • Shimamura A, Alter BP
    Pathophysiology and management of inherited bone marrow failure syndromes.
    Blood reviews , 2010 May : 101-22
  • Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, Shimamura A, Daley GQ
    Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.
    Blood , 2010 Apr, : 3453-62
  • Sakamoto KM, Shimamura A, Davies SM
    Congenital disorders of ribosome biogenesis and bone marrow failure.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 Jan. : S12-7
  • Akiko Shimamura, MD, PhD
    Shwachman-Diamond Syndrome: A review of the clinical presentation, molecular pathogenesis, diagnosis, and treatment
    Hemmatol Oncol Clin North Am. Editor: Bagby, G. , 2009 : 23233-248
  • Akiko Shimamura, MD, PhD
    Inherited Aplastic Anemia Syndromes
    In: Greer, J.P., Foerster, J., Rodgers, G.M., Paraskevas, F., Glader, B.E., Arber DA, Means, RT eds. Wintrobe's Clincial Hematology. 12th ed. Philadelphia: Lippincott Williams and Wilkins , 2009 : 1173-1184
  • Akiko Shimamura, MD, PhD
    Acquired Aplastic Anemia and Pure Red Cell Aplasia
    In: Nathan, D.G., Orkin, S.H., Look, A.T., Ginsburg, D. Fisher, DE and Lux, SE, editors. Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition; Philadelphia: W.B. Saunders and Co. , 2009 : 275-306
  • Du HY, Pumbo E, Ivanovich J, An P, Maziarz RT, Reiss UM, Chirnomas D, Shimamura A, Vlachos A, Lipton JM, Goyal RK, Goldman F, Wilson DB, Mason PJ, Bessler M
    TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.
    Blood , 2009 Jan. : 309-16
  • Shimamura A
    Clinical approach to marrow failure.
    Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program , 2009 : 329-37
  • Vlachos A, Ball S, Dahl N, Alter BP, Sheth S, Ramenghi U, Meerpohl J, Karlsson S, Liu JM, Leblanc T, Paley C, Kang EM, Leder EJ, Atsidaftos E, Shimamura A, Bessler M, Glader B, Lipton JM
    Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference.
    British journal of haematology , 2008 Sept. : 859-76
  • Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ
    Disease-specific induced pluripotent stem cells.
    Cell , 2008 Sept. : 877-86
  • Shimamura A
    Diamond-Blackfan anemia: a new facet.
    Blood , 2008 Sept. : 1552-3
  • Kayed H, Bekasi S, Keleg S, Welsch T, Esposito I, Shimamura A, Michalski CW, Friess H, Kleeff J
    Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.
    Histology and histopathology , 2008 July : 819-26
  • Ganapathi KA, Shimamura A
    Ribosomal dysfunction and inherited marrow failure.
    British journal of haematology , 2008 May : 376-87
  • Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A
    Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.
    The Journal of clinical investigation , 2008 Apr, : 1511-8
  • Akiko Shimamura, MD, PhD
    "Treatment of Hematological Abnormalities in Fanconi Anemia" In Fanconi Anemia: Standards for Clinical Care, Fanconi Anemia Research Fund
    : 49-75
  • Akiko Shimamura, MD, PhD
    Inherited Aplastic Anemia Syndromes
    In: Greer, J.P., Foerster, J., Rodgers, G.M., Paraskevas, F., Glader, B.E., Arber DA, Means, RT eds. Wintrobe's Clinical Hematology. 12th ed. Philadelphia; Lippincott Williams and Wilkins , 2008 : 1173-1184
  • Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A
    The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.
    Blood , 2007 Sept. : 1458-65
  • Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD
    Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
    The Journal of clinical investigation , 2007 May : 1440-9
  • Shimamura A
    Shwachman-Diamond syndrome.
    Seminars in hematology , 2006 July : 178-88
  • Shimamura A
    Inherited bone marrow failure syndromes: molecular features.
    Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program , 2006 : 63-71
  • Austin KM, Leary RJ, Shimamura A
    The Shwachman-Diamond SBDS protein localizes to the nucleolus.
    Blood , 2005 Aug. : 1253-8
  • Soulier J, Leblanc T, Larghero J, Dastot H, Shimamura A, Guardiola P, Esperou H, Ferry C, Jubert C, Feugeas JP, Henri A, Toubert A, Socié G, Baruchel A, Sigaux F, D'Andrea AD, Gluckman E
    Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway.
    Blood , 2005 Feb. : 1329-36
  • Hirsch B, Shimamura A, Moreau L, Baldinger S, Hag-alshiekh M, Bostrom B, Sencer S, D'Andrea AD
    Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood.
    Blood , 2004 Apr, : 2554-9
  • Akiko Shimamura, MD, PhD
    Acquired and Inherited Aplastic Anemia Syndromes
    In: Greer, J.P., Foerster, J., Lukens, J.N., Rodgers, G.M., Paraskevas, F., Glader, B.E. Eds. Wintrobe's Clinical Hematology. 11th ed. Philadelphia: Lippincott Williams and Wilkins , 2004 : 1397-1420
  • Akiko Shimamura, MD, PhD
    Subtyping of Fanconi anemia patients: Implications for clincal management
    Blood , 2003 : 1023459-3459
  • Akiko Shimamura, MD, PhD
    "Treatment of Hematological Disorders" in Fanconi Anemia: Standards for Clinical Care
    Fanconi Anemia Research Fund , 2003 : 17-36
  • Akiko Shimamura, MD, PhD
    Acquired Bone Marrow Failure Syndromes
    In: Handin, R.I., Lux, S.E., Stossel, T.P., eds. Blood: Principles and Practice of Hematology, 2nd ed. Philadelpha: Lippincott Williams & Wilkins , 2003 : 273-318
  • Akiko Shimamura, MD, PhD
    Acquired Aplastic Anemia
    In: Nathan, D. G., Orkin, S. H., Look, A. T., and Ginsburg, D., editors. Nathan and Oski's Hematology on Infancy and Childhood, 6th Edition; Philadelphia: W.B Saunders and Co., , 2003 : 256-279
  • Shimamura A, Montes de Oca R, Svenson JL, Haining N, Moreau LA, Nathan DG, D'Andrea AD
    A novel diagnostic screen for defects in the Fanconi anemia pathway.
    Blood , 2002 Dec. : 4649-54
  • Akiko Shimamura, MD, PhD
    Structural Hemoglobinopathies
    In: Scharschmidt, B. F. editor. Pocket Medicine/Internal Medicine, Philadelphia; PocketMedicine.com, Inc., , 2001 - 2006
  • Akiko Shimamura, MD, PhD
    Disruption of 3-Phosphoinositide-Dependent Kinase 1 (PKD1) Signaling by the anti-tumorigenic and anti-proliferative agent N-a-tosyl-L-phenylalanyl chloromethyl ketone
    J. Biol.Chem. , 2001 : 276(15)12466-12475
  • Akiko Shimamura, MD, PhD
    RSK1 mediates a MEK/MAPK cell survival signal
    Curr. Biol. , 2000 : 10127-135
  • Akiko Shimamura, MD, PhD
    Distinct mathematical behavior of apoptotic versus non-apoptotic tumor cell death
    Int. J. Radiat. Oncol. Biol. Phys. , 1999 : 43(3)601-605
  • Akiko Shimamura, MD, PhD
    Low Molecular Weight Heparin
    Hematology/Oncology Clinics of North America , 1998 : 12(6)1251-1281
  • Akiko Shimamura, MD, PhD
    Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system
    J. Biol. Chem. , 1998 : 273(43)28378-28383
  • Akiko Shimamura, MD, PhD
    SMALL CELL SWEAT GLAND CARCINOMA IN CHILDHOOD
    Am. J. Surg. Path. , 1998 : 22(2)215-220
  • Akiko Shimamura, MD, PhD
    Fanconi Anemia
    In: /GeneReviews/ at GeneTests: Medical Genetics Information Resources [database online]. Copyright, University of Washington, Seattle. Available at www.genetests.org , 1997 - 2004
  • Akiko Shimamura, MD, PhD
    Transformation selective apoptosis in fibroblasts deprived of adhesion.
    J. Cell Biol. , 1997 : 138(4)901-011
  • Akiko Shimamura, MD, PhD
    p53 in Life and Death.
    Clinical Cancer Research. , 1996 : 2435-440
  • Akiko Shimamura, MD, PhD
    Respiratory syncytial virus as a cause of fever and petechiae in infants.
    Clinical Pediatrics , 1994 : 32(6)355-356
  • Akiko Shimamura, MD, PhD
    Assembly of chromatin with oocyte extracts
    Methods Enzymol. , 1989 : 170603-612
  • Akiko Shimamura, MD, PhD
    Histone H1 represses transcription from minichromosomes assembled in vitro.
    Mol. Cell. Biol. , 1989 : 95573-5584
  • Akiko Shimamura, MD, PhD
    The assembly of regularly spaced nucleosomes in the Xenopus oocyte S-150 extract is accompanied by deacetylation of histone H4.
    J. Biol. Chem. , 1989 : 26414524-14530
  • Akiko Shimamura, MD, PhD
    Assembly of chromatin with oocyte extracts.
    Methods Enzymol. , 1989 : 170603-612
  • Akiko Shimamura, MD, PhD
    Assembly and properties of chromatin containing histone H1.
    J. Mol. Biol. , 1989 : 209135-150
  • Akiko Shimamura, MD, PhD
    Assembly and properties of chromatin containing histone H1.
    J. Mol. Biol. , 1989 : 209135-150
  • Akiko Shimamura, MD, PhD
    Characterization of the repressed 5S DNA minchromosomes assembled in vitro with a high-speed supernatant of Xenopus laevis oocytes.
    Mol. Cell. Biol. , 1988 : 84257-4269
  • Akiko Shimamura, MD, PhD
    Characterization of the repressed 5S DNA minichromosomes assembled in vitro with a high-speed supernatant of Xenopus laevis oocytes.
    Mol. Cell. Biol. , 1988 : 84257-4269
  • Akiko Shimamura, MD, PhD
    Clinical Outcomes for Patients with Neutropenia Attributable to Mutations in the Gene for Neutrophil Elastase, ELANE
    Clinical Outcomes for Patients with Severe Chronic Neutropenia International Registry (SCNIR)
  • Akiko Shimamura, MD, PhD
    Cellular Basis of Hematopoiesis and Marrow Failure Syndromes. Chapter 2 In ASH-SAP Educational Book, 3rd Edition
  • Akiko Shimamura, MD, PhD
    Guidelines for Diagnostic Work-Up and management of bone marrow failure patients (for Vampire Handbook, a clinical reference for Children's Hospital hematologists)
  • Akiko Shimamura, MD, PhD
    Inherited Aplastic Anemia in Children
    In: UpToDate, Rose B.D. (Ed), UpToDate, Waltham, MA
  • Akiko Shimamura, MD, PhD
    Hemoglobins with Altered Oxygen Affinity
    In: Scharschmidt, B.F. editor. Pocket Medicine/Internal Medicine, Philadelphia; PocketMedicine.com, Inc., 2001, 2006.
  • Akiko Shimamura, MD, PhD
    Thalassemia
    In: Scharschmidt, B.F. editor. Pocket Medicine/Internal Medicine, Philadelphia; PocketMedicine.com, Inc., 2001, 2006

Presentations

Presentations Title Event Location Date
Invited Speaker Grand Rounds Boston Children's Hospital, Boston, MA 2014
Invited Speaker Scientific Congress on Shwachman-Diamond Syndrome University of Toronto, ON, Canada 2013
Invited Speaker Jackson Laboratories Bar Harbor, ME 2013
Invited Speaker 9th International Conference on Ribosome Synthesis Banff, Alberta, Canada 2012
Ribosomal Disorders in Marrow Failure Grand Rounds, Ribosomal Disorders in Marrow Failure Cincinnati Children's Hospital and Medical Center, Cincinnati, OH 2012
Invited Speaker Grand Rounds, Memorial Sloan Kettering Cancer Center New York, NY 2012
Invited Speaker 23rd Annual Fanconi Anemia Research Fund Scientific Symposium Barcelona, Spain 2011
Invited Speaker Red Cell Gordon Conference New Hampshire 2011
Shwachman-Diamond Syndrome Scientific Congress for Shwachman-Diamond Syndrome New York 2011
Fanconi Anemia Fanconi Anemia Family Meeting Camp Sunshine, ME 2011
Non-Transplant Treatment of Aplastic Anemia, PNH, and Constitutional Marrow Failure Aplastic Anemia and MDS International \ Aplastic Anemia and MDS International Foundation 2010
Presidential Symposium: Shwachman-Diamond Syndrome Japanese Society of Pediatric Hematology Osaka, Japan 2010
Shwachman Diamond Syndrome Shwachman Diamond Syndrome Family Meeting Camp Sunshine, ME 2010
Insights from inherited marrow failure syndromes, Anne T. Bass Endowed Lecture Pediatric Hematology/Oncology Stanford, Palo Alto, CA 2010
Insights from inherited marrow failure syndromes Grand Rounds, Pediatric Hematology/Oncology St. Jude, Mephis, TN 2010
Masquerade! The inherited marrow failure syndromes Grand Rounds, Seattle Children's Hospital Seattle, WA 2010
Shwachman-Diamond Syndrome BMT Tandem Meeting Orlando, FL 2010
Ribosomal disorders in marrow failure and malignancy AACR conference in Protein Translation and Cancer San Diego, CA 2010
Shwachman-Diamond Syndrome International Society of Experimental Hematology Athens, Greece 2009
Treatment and Pathogenesis of Inherited Marrow Failure Syndromes Japanese Pediatric MDS/Aplastic Anemia meeting Nagoya, Japan 2009
Clinical Apporach to Marrow Failure American Society of Hematology Education Session New Orleans, LA 2009
Shwachman-Diamond Syndrome and Translational research American Society of Pediatric Hematology/Oncology San Diego, CA 2009
Fanconi Anemia 101: An introduction to the science and medicine of Fanconi anemia Fanconi Anemia Research Fund Scientific Symposium Baltimore, MD 2009
Invited speaker Japanese Society of Hematology Kyoto, Japan 2008
Myelodysplastic Syndromes and Bone Marrow Failure European Society of Hematology Conference on Myelodysplastic Syndromes and Bone Marrow Failure Albufeira, Portugal 2008
Ribosomal Abnormalitities and Genomic Instability in Shwachman Diamond Syndrome Japanese Society of Hematology Kyoto, Japan 2008
Fanconi Anemia 101: An introduction of the science and medicine of Fanconi anemia Fanconi Anemia Research Fund Scientific Symposium Eugene, OR 2008
AML in Fanconi Anemia patients: Future Directions Fanconi Anemia Research Fund Eugene, OR 2008
Shwachman-Diamond Syndrome Shwachman-Diamond Syndrome family meeting Camp Sunshine, ME 2008
Fanconi Anemia Fanconi Anemia Family meeting Camp Sunshine, ME 2008
Severe Chronic Neturopenia Severe Chronic Neturopenia family meeting Seattle, WA 2008
Fanconi Anemia 101: An introduction to the sciene and medicine of Fanconi anemia Fanconi Anemia research Fund Scientific Symposium Eugene, OR 2008
AML in Fanconi Anemia Patients: Future Directions Fanconi Anemia Research Fund Scientific Symposium Eugene, OR 2008
Ribosomal Abnormalities in Shwachman-Diamond Syndrome NIDDK/NIH Workshop on Ribosomes and Their Role in Disease Bethesda, MD 2008
Fanconi anemia: Medical Management for Hematologic Issues Fanconi Anemia Family Meeting Camp Sunshine, Casco, ME 2008
Hematologic Issues In Shwachman-Diamond Syndrome Shwachman-Diamond Syndrome Family Meeting Camp Sunshine, Casco, ME 2008
The Decision to Transplant National Neutropenia Network Seattle, WA 2008
Diagnosis and Treatment of Bone Marow Failure Consensus Conference on Standards for Clnical Care of Fanconi Anemia Patients Chicago, IL 2008
"FA 101" Fanconi Anemia Scientific Conference Chicago, IL 2008
Ribosomal Dysfunction in Bone Marrow Failure Syndromes In the Hot Topics in Paediatric and Adolescent Cancer and Blood Diseases Conference Dublin, Ireland 2007
Hematologic Abnormalities in Shwachman-Diamond Syndrome 4th International Scientific Congress on Shwachman-Diamond Syndrome Boston, MA 2007
Shwachman-Diamond Syndrome the Myeloid Scientific Subcommittee Session, American Society of Hematology Orlando, FL 2006
Inherited Bone Marrow Failure Syndromes Marrow Failure Educational Session, American Society of Hematology Orlando, FL 2006
"FA 101" Fanconi Anemia Scientific Conference Bethesda, MD 2006
Shwachman-Diamond Syndrome Grand Rounds, Department of Hematology Johns Hopkins Hospital 2006
The SBDS Protein localizes to the nucleolus Shwachman-Diamond Syndrome Scientific Conference Cambridge, UK 2005
Diagnostic Evaluation of Bone Marrow Failure in Children American Society of Pediatric Hematology/Oncology Washington, D.C. 2005
FA monoubiquitination and FA pathway function Fanconi Anemia Scientific Conference Cambridge, MA 2004
Monoubiquitined FANCD2 is both necessary and sufficient for mitomycin C resistance in the absence of a functional Fanconi Anemia core complex American Society of Hematology San Diego, CA 2004
Intranuclear localization of the Shwachman-Diamond protein, SBDS: Functional Implications American Society of Pediatric Hematology/Oncology San Francisco, CA 2004
Variable SBDS Protein Expression in Shwachman-Diamond Patients: Implications for Pathogenesis American Society of Hematology San Diego, CA 2003
Analysis of the human FANCD2 gene Scientific Symposium, Fanconi Anemia Research Foundation Houston, TX 2003
Diagnosis and Treatment of Bone Marrow Failure Consensus Conference on Standards for Clinical Care of Fanconi Anemia Patients Chicago, IL 2003
The Fanconi Anemia Pathway Fanconi Anemia Family Meeting Camp Sunshine, Casco, ME 2003
The Fanconi Anemia DNA Repair Pathway Is Deficient in Acute Myeloid Leukemia Pediatric Academic Society Meeting Seatte. WA 2003
Clinical Approach to Bone Marrow Failure in Children American Society of Hematology Education Session on Marrow Failure American Society of Hematology 2002
Hematopoietic Stem Cell Biology and Plasticity RFA Hematopoietic Stem Cell Biology and Plasticity RFA Meeting NIH/NHLBI 2002
A Screen for Acquired Fanconi Anemia Pathways Defects in Acute Myeloid Leukemia American Society of Hematology meeting Philadelphia, PA 2002
The Fanconi anemia pathway: Clinical Implications Scientific Symposium, Fanconi Anemia Research Foundation Philadelphia, PA 2002
Fanconi Anemia Fanconi Anemia Cancer Symposium Chicago, IL 2002
Clinical applications of the FANCD2 monoubiquitination assay Pediatric Academic Society meeting Baltimore, MD 2002
Fancomi Anemia Fanconi Anemia Family Camp Lake Geneva, WI 2001
Signaling pathways regulating myeloid cell survival Severe Congenital Neutropenia International Registry Orlando, FL 2001

Research Funding

Grant Title Grantor Amount Award Date
R01 CA 181439-01 (Shimamura, Link) NIH / NCI $662,186 annual/3,342,968 total direct costs Dec. 1, 2014 - Nov. 30, 2019
U54 TE6376 (Deeg) Medical College of Wisconsin / NIH $123,905 annual direct costs July 1, 2014 - June 30, 2019
R01 DK098479-01 (Shimamura) NIH/NIDDK $250,000 annual direct costs April 1, 2014 - March 31, 2019
Department of Defense (Monnat) UW/Bone Marrow Failure Research Program Idea Development Award $, $7,500 annual direct costs March 1, 2014 - Feb. 28, 2017
Seattle Children's Hospital (Shimamura) Butterfly Guild $, $30,000 annual direct costs Jan. 10, 2014 - Jan. 9, 2015
R24 DK099808-01 (Shimamura) National Institutes of Health $972,703 annual direct costs Sept. 29, 2013 - Aug. 31, 2018
2013 Research Grant (Shimamura) Aplastic Anemia and MDS International Foundation $, $27, 273 annual direct costs July 1, 2013 - June 30, 2015
Seattle Children's Hospital (Shimamura) Aplastic Anemia Research Award $28,998 annual direct costs Feb. 1, 2013 - Jan. 31, 2014
Seattle Children's Hospital (Shimamura) Butterfly Guild $, $27,000 total direct costs Aug. 1, 2012 - July 31, 2013
1R24 DK093425 (Abkowitz) UW/NIH/NIDDK $75,000 total direct costs March 1, 2012 - Aug. 31, 2013
1 R03 A1092423 (Torgerson) Seattle Children's Hospital/NIH/NIAID $, $9,136 annual/$17,966 total direct costs Aug. 1, 2011 - July 31, 2013
St. Baldrick's Foundation (Shimamura) $100,000 total direct costs July 1, 2011 - June 30, 2012
Seattle Children's Hospital (Shimamura) Butterfly Guild $30,000 total direct costs June 15, 2011 - June 14, 2012
R24 AI049393-10 (Dale) UW/National Institutes of Health $18,445 annual direct costs Sept. 1, 2010 - Aug. 31, 2014
UL1 DE019582 (Scharenberg) Seattle Children's Hospital/NIH/NIDCR $73,575 annual / $122,625 total direct costs July 1, 2010 - June 30, 2012
1 RC1 DK087680 (Thomas) University of Cincinnati/NIH/NIDDK $, $79,564 annual / $157,395 total direct costs Sept. 30, 2009 - July 31, 2011
5 RC1HL100270 (Shimamura, Torok-Storb) NIH/NHLBI $348,636 annual / $679,696 total direct costs Sept. 30, 2009 - June 30, 2013
3 RO1 HL079582-06S1 (Shimamura) on Parent R01 Administrative Supplement NIH/NHLBI $190,174 total direct costs July 1, 2009 - June 3, 2011
Shwachman-Diamond America (Shimamura) Shwachman-Diamond Syndrome International Registry and Repository $10,000 total direct costs Jan. 1, 2009 - Nov. 30, 2014
5 P30 DK056465 (Shimamura) CCEH (NIDDK) $20,000 total direct costs Dec. 1, 2008 - Nov. 30, 2009
1 R03 AI079734 (Shimamura) NIH/NIAID $50,000 annual / $100,000 total direct costs Sept. 17, 2008 - Aug. 31, 2011
Shwachman-Diamond Syndrome Project, Ltd Shwachman-Diamond Syndrome International Registry and Repository $89,000 total direct costs July 1, 2008 - June 30, 2012
R13 HL088725-01 (Grand) NIH / NHLBI $ April 20, 2007 - March 31, 2008
200-2006-15969 CDC June 1, 2006 - Sept. 30, 2007
5R01 HL079582-11 (Shimamura) National Institutes of Health $250,000 annual direct costs Sept. 30, 2004 - May 31, 2014
R01 HL079582-11 (Shimamura) National Institutes of Health $250,000 annual direct costs Sept. 30, 2004 - May 31, 2014
5 K23 HL68632 (Shimamura) NIH / NHLBI $120,775 annual / $603,875 total July 5, 2002 - May 31, 2008
Private Donor (Shimamura) 2002 - 2007
Hood Foundation (Shimamura) 2001
Scholars in Medicine (Shimamura) 2001
5 P50 HL54785 (Nathan) NIH / NHLBI Sept. 1, 2000 - Aug. 31, 2005
Howard Hughes (Shimamura) 1997
V Foundation (Shimamura) 1997