Profile

Xuan Qin, PhD

Xuan Qin, PhD

Pathology

Children's Title: Division Chief, Microbiology Laboratory

Academic Title: Associate Professor, UW Lab Medicine

Research Center: Center for Clinical and Translational Research

Overview

Medical/Professional School

Medical School of Southeast University, Nanjing, Jiangsu
SUNY Upstate Medical University, Syracuse, Molecular Genetic Pathology

Clinical Interests

I am a clinical microbiologist with thirty years of experience in medical microbiology and a specialist in molecular diagnosis of infectious diseases. I have held the Microbiology Laboratory directorship position at Seattle Children?s Hospital since January 1999. In this role, I have actively promoted the integration of ever advancing technologies: 1) I have personally developed and continue to improve a number of laboratory-developed tests (LDTs), such as real-time PCR assays for the diagnosis of pertussis whooping cough, shiga toxin-producing E. coli, and toxinogenic Clostridium difficile. 2) I also have personally developed molecular diagnostic panels for culture-negative infections that included major pediatric pathogens in invasive infections. 3) quantitative molecular measurements of CMV, EBV, and BK are among the most challenging LDTs that I have developed for the diagnosis and monitoring of these viral infections with precision for hospital services involving the care for immunocompromised patients. 4) our lab is among the first adopters of mega-multiplex molecular platforms for the diagnosis of large array of respiratory infections etiologies with rapid turnaround time. Since 2011, we have been able to use data generated from the 'mega'-multiplex platform for extensive analysis of their clinical disease associations, age-specific attack rates, and severity of illness; 5) I have played a significant role in updating our microbiology lab with cutting edge technologies using MALDI-TOF instrumentation which has significantly changed diagnostic paradigm of waiting for incubation to around-clock identification of pathogens as they multiply.

Research Description

I also have a passion in research, and my main interests include 1) antimicrobial resistance mechanisms including multidrug resistance in Enterobacteriaceae 2) symbiotic evolution of bacterial agents associated with chronic infections such as in airways of cystic fibrosis and their drug resistance by multicellularity, and 3) characterization of changing microbial ecology and microbial diversity using traditional culture method, DNA technology, and proteomic mass spectrometry. I have maintained many years of successful collaborations with my colleagues and appreciate the opportunity to work with many of the physician scientist at Seattle Children's Hospital.

Publications

  • Vornhagen J, Burnside K, Whidbey C, Berry J, Qin X, Rajagopal L
    Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to β-Lactam Antibiotics.
    26506394 Pathogens (Basel, Switzerland) , 2015 Oct. 22 - 2015 Oct. 22 : 4(4)708-21 PMCID: PMC4693160
  • Vornhagen J, Burnside K, Whidbey C, Berry J, Qin X, Rajagopal L
    Kinase Inhibitors that Increase the Sensitivity of Methicillin Resistant Staphylococcus aureus to β-Lactam Antibiotics.
    26506394 Pathogens (Basel, Switzerland) , 2015 Oct. 22 - 2015 Oct. 22 : 4(4)708-21 PMCID: PMC4693160
  • Qin X, Klein EJ, Galanakis E, Thomas AA, Stapp JR, Rich S, Buccat AM, Tarr PI
    Real-Time PCR Assay for Detection and Differentiation of Shiga Toxin-Producing Escherichia coli from Clinical Samples.
    25926491 Journal of clinical microbiology , 2015 July - 2015 July : 53(7)2148-53 PMCID: PMC4473226
  • Martin SW, Pawloski L, Williams M, Weening K, DeBolt C, Qin X, Reynolds L, Kenyon C, Giambrone G, Kudish K, Miller L, Selvage D, Lee A, Skoff TH, Kamiya H, Cassiday PK, Tondella ML, Clark TA
    Pertactin-negative Bordetella pertussis strains: evidence for a possible selective advantage.
    25301209 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2015 Jan. 15 - 2015 Jan. 15 : 60(2)223-7
  • Xuan Qin
    Resurgence of Whooping Cough and the Role of Laboratory Diagnosis. Invited Review. Clinical Microbiology News Letter
    Clinical Microbiology News Letter , 2015 : 37(9)
  • Mijatovic-Rustempasic S, Roy S, Sturgeon M, Rungsrisuriyachai K, Esona MD, Degroat D, Qin X, Cortese MM, Bowen MD
    Full-Genome Sequence of a Rare Human G3P[9] Rotavirus Strain.
    24675848 Genome announcements , 2014 Mar. 27 - 2014 Mar. 27 : 2(2) PMCID: PMC3968326
  • Johnson JR, Tchesnokova V, Johnston B, Clabots C, Roberts PL, Billig M, Riddell K, Rogers P, Qin X, Butler-Wu S, Price LB, Aziz M, Nicolas-Chanoine MH, Debroy C, Robicsek A, Hansen G, Urban C, Platell J, Trott DJ, Zhanel G, Weissman SJ, Cookson BT, Fang FC, Limaye AP, Scholes D, Chattopadhyay S, Hooper DC, Sokurenko EV
    Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.
    23288927 The Journal of infectious diseases , 2013 Mar. 15 - 2013 Mar. 15 : 207(6)919-28 PMCID: PMC3571447
  • Qin X, Zerr DM, McNutt MA, Berry JE, Burns JL, Kapur RP
    Pseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patients.
    22964251 Antimicrobial agents and chemotherapy , 2012 Nov. - 2012 Nov. : 56(11)5971-81 PMCID: PMC3486535
  • Liu Y, Zhang B, Cao Q, Huang W, Shen L, Qin X
    Two clinical strains of Klebsiella pneumoniae carrying plasmid-borne blaIMP-4, blaSHV-12, and armA isolated at a Pediatric Center in Shanghai, China.
    19164142 Antimicrobial agents and chemotherapy , 2009 Apr, - 2009 Apr, : 53(4)1642-4 PMCID: PMC2663070
  • Qin X, Zerr DM, Weissman SJ, Englund JA, Denno DM, Klein EJ, Tarr PI, Kwong J, Stapp JR, Tulloch LG, Galanakis E
    Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
    18765688 Antimicrobial agents and chemotherapy , 2008 Nov. - 2008 Nov. : 52(11)3909-14 PMCID: PMC2573145
  • Xuan Qin
    Diagnostic Microbiology Using Real-time PCR Based on FRET Technology. Advanced Techniques in diagnostic Microbiology
    Advanced Techniques in Diagnostic Microbiology , 2006
  • Denno DM, Stapp JR, Boster DR, Qin X, Clausen CR, Del Beccaro KH, Swerdlow DL, Braden CR, Tarr PI
    Etiology of diarrhea in pediatric outpatient settings.
    15702043 The Pediatric infectious disease journal , 2005 Feb. - 2005 Feb. : 24(2)142-8
  • Qin X, Abe PM, Weissman SJ, Manning SC
    Extrapulmonary Legionella micdadei infection in a previously healthy child.
    12508793 The Pediatric infectious disease journal , 2002 Dec. - 2002 Dec. : 21(12)1174-6