Profile

William R.A. Osborne, PhD

William R.A. Osborne, PhD

Pediatrics-Inpatient

Academic Title: Research Professor, University of Washington

Research Center: Center for Genetics and Development

Overview

Awards and Honors

Award Name Award Description Awarded By Award Date
Henry Christian Memorial Award for Excellence in Clinical Research American Federation of Clinical Research 1992

Publications

  • Moralejo DH, Fuller JM, Rutledge EA, Van Yserloo B, Ettinger RA, Jensen R, Osborne W, Kwitek A, Lernmark A
    BB rat Gimap gene expression in sorted lymphoid T and B cells.
    Life sciences , 2011 Nov. 7 : 89(19-20)748-54
  • Moralejo D, Yanay O, Kernan K, Bailey A, Lernmark A, Osborne W
    Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats.
    Journal of bioscience and bioengineering , 2011 Apr, : 111(4)383-7
  • Yanay O, Moralejo D, Kernan K, Brzezinski M, Fuller JM, Barton RW, Lernmark A, Osborne WR
    Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1.
    The journal of gene medicine , 2010 June : 12(6)538-44
  • Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A
    Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
    Physiological genomics , 2010 Mar. 3 : 41(1)9-20
  • Sweet IR, Yanay O, Waldron L, Gilbert M, Fuller JM, Tupling T, Lernmark A, Osborne WR
    Treatment of diabetic rats with encapsulated islets.
    Journal of cellular and molecular medicine , 2008 Dec. : 12(6B)2644-50
  • Tatake RJ, O'Neill MM, Kennedy CA, Reale VD, Runyan JD, Monaco KA, Yu K, Osborne WR, Barton RW, Schneiderman RD
    Glucose-regulated insulin production from genetically engineered human non-beta cells.
    Life sciences , 2007 Oct. 13 : 81(17-18)1346-54
  • Brzezinski M, Yanay O, Waldron L, Barry SC, Osborne WR
    G-CSF-lentivirus administration in rats provided sustained elevated neutrophil counts and subsequent EPO-lentivirus administration increased hematocrits.
    The journal of gene medicine , 2007 July : 9(7)571-8
  • Fitzgerald SM, Goyal RK, Osborne WR, Roy JD, Wilson JW, Ferrell RE
    Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter.
    Human genetics , 2006 Apr, : 119(3)276-83
  • Yanay O, Brzezinski M, Christensen J, Liggitt D, Dale DC, Osborne WR
    An adult dog with cyclic neutropenia treated by lentivirus- mediated delivery of granulocyte colony-stimulating factor.
    Human gene therapy , 2006 Apr, : 17(4)464-9
  • Barry S, Brzezinski M, Yanay O, Seppen JE, Osborne WR
    Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery.
    The journal of gene medicine , 2005 Dec. : 7(12)1510-6
  • Yanay O, Barry SC, Flint LY, Brzezinski M, Barton RW, Osborne WR
    Long-term erythropoietin gene expression from transduced cells in bioisolator devices.
    Human gene therapy , 2003 Nov. 20 : 14(17)1587-93
  • Yanay O, Barry SC, Katen LJ, Brzezinski M, Flint LY, Christensen J, Liggitt D, Dale DC, Osborne WR
    Treatment of canine cyclic neutropenia by lentivirus-mediated G-CSF delivery.
    Blood , 2003 Sept. 15 : 102(6)2046-52
  • Katen LJ, Aprikyan AG, Dale DC, Osborne WR
    Cloning and sequencing of the canine neutrophil elastase cDNA.
    DNA sequence : the journal of DNA sequencing and mapping , 2002 Aug. : 13(4)221-3
  • Freitas AC, Bento FM, Ramesh N, Osborne WR, Han SW
    Modified blasticidin S resistance gene (bsrm) as a selectable marker for construction of retroviral vectors.
    Journal of biotechnology , 2002 Apr, 25 : 95(1)57-62

Research Funding

Grant Title Grantor Amount Award Date
Effect of Nutritional Factors on Macrophage Accumulation in Adipose Tissue NIH/NHLBI July 1, 2009 - June 30, 2014