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Suzanne Skoda-Smith, MD

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Suzanne Skoda-Smith, MD

Immunology

On staff since August 2008

Academic Title: Associate Professor, Assistant Program Director of the UWSOM Allergy and Immunology Fellowship Training Program

Research Center: Center for Immunity and Immunotherapies

"I was on my way home from a conference when I heard my name shouted out. I turned to discover the parents of a young boy I had done a bone marrow transplant on for severe combined immunodeficiency disease several years earlier. His parents were security agents, working the late shift at the airport. I remembered they had lost their young daughter to the same disease. After a gigantic bear hug from both of them, I got to see their sons Little League picture and learned that he is a talented skateboarder as well. I flew home feeling that what I have learned as an immunologist was put to good use."

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Overview

Board Certification(s)
Pediatrics
Allergy and Immunology
Medical/Professional School
University of Miami - Jackson Memorial Medical Center, Miami
Residency
Pediatrics, University of Florida, Gainsville
Fellowship
Allergy and Immunology, Children's Hospital of Alabama, Birmingham
Clinical Interests

Primary Immunodeficiency Diseases, Hematopoetic Stem Cell Transplantation for Immunodeficiency, Secondary Immunodeficiency associated with Solid Organ Transplantation Clinical care for patients with primary immunodeficiencies

Research Description

My clinical research has been focused on the delivery of care and new therapies to patients with primary immunodeficiency diseases, particularly those needing hematopoetic stem cell transplantation. I am particularly interested in how to bring the promise of new therapies currently in the laboratory setting, to reality in the clinical care arena. I also interface with clinicians skilled in the care of solid organ transplant patients who experience secondary immunodeficiency as a consequence of their transplant therapies.

Research Focus Area

Translational Research, Solid Organ Transplantation, Stem Cell Transplantation

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
K30, Masters Candidate in the Advanced Postgraduate Program in Clinical InvestigationUniversity of Florida 2000 - 2001
Dixon Post-Doctorate Fellowship 1995 - 1997
National Research Service Award (NRSA) Training GrantUniversity of Alabama at Birmingham 1994 - 1995
AΩA 1990
Medical School Trustee ScholarshipUniveristy of Miami 1986 - 1990

Publications

Outcomes and Duration of Pneumocystis jiroveci Pneumonia Therapy in Infants With Severe Combined Immunodeficiency.
The Pediatric infectious disease journal , Aug. 2011
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , July 2010
Postgrafting Immune Suppression Combined with Nonmyeloablative
, March 2010
Subcutaneous immunoglobulin replacement therapy in the treatment of patients with primary immunodeficiency disease.
Therapeutics and clinical risk management , Feb. 2010: 1-10
Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases.
Journal of clinical immunology , 2006 May: 26(3)265-73
Using the pneumococcal conjugate vaccine PCV7 (Prevnar) to evaluate the functional antibody response in adults with recurrent sinopulmonary infections.
, March 2006
Systemic Epstein-Barr virus infection associated with membranous nephropathy in children.
Clinical nephrology , 2006 Mar: 65(3)160-4
Systemic Epstein-Barr virus infection-associated membranous nephropathy.
, Nov. 2005
A new kindred with X-lined lympho-proliferative disease
, Nov. 2004
Octagam 5%, an intravenous IgG product, is efficacious and well tolerated in subjects with primary immunodeficiency diseases.
Journal of clinical immunology , 2004 May: 24(3)309-14
Persistent perianal abscess in early infancy as a presentation of autoimmune neutropenia.
Journal of perinatology : official journal of the California Perinatal Association , July 2003: 428-30
Profiling the non-adherent adolescent heart transplant recipient.
, April 2003
Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).
Vox sanguinis , April 2003: 202-10
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Nature , Sept. 2002: 395-9
Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report.
Transplantation , March 2002: 907-10
Impact of lymphoproliferative disorders after pediatric liver transplant: a single center ten-year experience.
, Oct. 2001
Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab.
Bone marrow transplantation , Feb. 2001: 329-32
Pharmacokinetics of a novel IVIG preparation.
, 2001
Distinct T-cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of Zap-70.
, 2001
Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
Journal of immunology (Baltimore, Md. : 1950) , Jan. 2001: 656-61
Donor leukocyte infusions after bone marrow transplantation in children: series from a single institution and review of the literature.
International Journal of Pediatric Hematology/Oncology 7 , 2001: 71-79
Current management in child neurology
Vasculitis , 2001
Failure of combined costimulatory blockade in animal transplant model.
Nature medicine , Feb. 2000: 115
Adoptive immunotherapy in children compared to adults.
, May 1999
Thalidomide in children undergoing bone marrow transplantation: series at a single institution and review of the literature.
Pediatrics , April 1999: e44
Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
Archives of pathology & laboratory medicine , Sept. 1997: 996-9
Alpha 1-antitrypsin deficiency in a child with X-linked lymphoproliferative disease.
Archives of pathology & laboratory medicine , 1997 Sep: 121(9)996-9
Reversed phosphorylation T-cell receptor subunits following stimulation of lymphocytes from an immunodeficient patient.
, Feb. 1997
CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children.
AIDS (London, England) , Nov. 1996: 1477-84
Angioedema following dust mite exposure presenting as suspected food allergy.
, Feb. 1996
Rituximab Administration in Second Trimester of Pregnancy for Kidney Transplant Rejection Results in Suppression of Neonatal B-Cell Development
,
Anti-CD20 monoclonal antibody for the treatment of post-transplant lymphoproliferative disease in a pediatric heart transplant recipient.
,

Presentations

Presentations TitleEventLocationDate
From 1952 to 2012: The Impact and Evolution of Diagnostics in Allergy and Immunology6th Annual Alvin D. Wert Lecture in Pediatric Allergy, OHSUPortland, ORDec. 8, 2011
Identifying Primary Immunodeficiencies: Present and FutureLegacy Continuing Medical Education: Current Topics in Pediatrics ConferencePortland, ORNov. 19, 2011
Parent Education Meeting for Persons and Families Living with Primary Immunodeficiency DiseasesImmune Deficiency FoundationSeattle, WASept. 10, 2011
RASopathies and Other Shard ConditionsHematology/Oncology Friday AM Research ConferenceSeattle, WAMay 13, 2011
Severe Combined Immunodeficiency DiseaseAdvance Oncology Day, Seattle Children's HospitalSeattle, WAFeb. 23, 2009
Primary Immunodeficiency for the Hematologist/Oncologist Primary Immunodeficiency for the Hematologist-OncologistResearch Seminar, Seattle Children's HospitalSeattle, WA 2009
Severe Combined Immunodeficiency DiseaseAdvanced Oncology Day, Seattle Children's HospitalSeattle, WAJan. 1, 2009
Non-Malignant Review Board PresentationSeattle Cancer Care AllianceSeattle, WASept. 2009
Morbid/Mortality discussion on recent SCID patientFred Hutchinson Cancer Research CenterSeattle, WANov. 14, 2008
Clinical Approach to Children with Immune Deficiency Disease15th Annual Care of the Sick Child ConferenceOrlando, FLNov. 2007
Antibiotic and Antifungal Therapy in Primary Immune DeficiencyImmune Deficiency Foundation 3rd National ConferenceOrlando, FLJune 2005
Peripheral Blood Stem Cell Transplantation for Severe Combined Immunodeficiency DiseaseChildren's Hospital of Cincinnati, Division of Pediatric Hematology and OncologyCincinnati, OHJan. 2002
Clues in the Diagnosis of Primary ImmunodeficiencyAmerican College of Osteopathic Pediatricians Spring ConventionNaples, FLJune 2001
Emerging Infectious Diseases29th Annual Florida Pediatric Alumni Association MeetingAmelia Island, GAApril 1998
Invited speakerImmune Deficiency Foundation regional conferences 1998 - 2005

Research Funding

Grant TitleGrantorAmountAward Date
Lentiviral Gene Therapy of X-linked AgammaglobulinemiaNIH/NIAID $, $Sept. 23, 2009
Lentiviral Gene Therapy for Wiskott-Aldrich SyndromeNIH/NIAID $, $March 1, 2008 - Feb. 28, 2013

Primary Office

Seattle Children's
MA.7.226 - Infectious Disease/Immunology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2482

Additional Offices

Seattle Children's Research Institute
C9S - 7 - Immunology
1900 - 9th Ave
Seattle, WA 98101
206-987-2482

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