Profile

Stephen W. Standage, MD

Stephen W. Standage, MD

Critical Care, PICU

On staff since July 2011

Academic Title: Acting Assistant Professor

"Severe illness or injury is a devastating, often unanticipated event in the life of a child and their family. The tenacity, strength, resilience, and love demonstrated by the children, their family members, and care providers during these difficult times truly inspire me. I am driven each day, in both my clinical and research efforts, by a desire to improve the outcome for each child."

Stephen Standage, MD, is attending physician at Seattle Children’s Hospital and Harborview Medical Center and acting assistant professor of pediatrics at the University of Washington School of Medicine. He earned his MD at the University of Rochester, in Rochester, New York, and completed his pediatrics residency at The Children’s Hospital of Philadelphia. Dr. Standage completed his pediatric critical care fellowship training at Cincinnati Children’s Hospital.

Dr. Standage is a member of the University of Washington Center for Lung Biology and conducts his research at their South Lake Union facility. His laboratory work is directed at understanding the molecular mechanisms of the immune response in sepsis. Specifically, he is interested in how modulation of systemic inflammation can improve patient outcome in critical illness. Dr. Standage’s current investigations focus on macrophage biology and the nuclear hormone receptor PPAR alpha. He is a member of the American Academy of Pediatrics, the Society of Critical Care Medicine, the Shock Society, and the American Heart Association.

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

University of Rochester School of Medicine and Dentistry, Rochester

Residency

Pediatrics, Children's Hospital of Philadelphia, Philadelphia

Fellowship

Pediatric Critical Care Medicine, Cincinnati Children's Hospital, Cincinnati

Clinical Interests

Sepsis, systemic inflammatory response syndromes (SIRS), hemophagocytic lymphohistiocytosis (HLH), shock, and acute respiratory failure.

Research Description

I investigate the basic mechanisms of immune dysregulation in the body's response to severe infectious or inflammatory challenge with the goal to identify therapeutic interventions.

Publications

  • Basu RK, Standage SW, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Devarajan P, Goldstein SL, Wong HR
    Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.
    Critical care (London, England) , 2011 Nov. 18 : R273
  • Standage SW, Caldwell CC, Zingarelli B, Wong HR
    Reduced PPARα Expression is Associated With Decreased Survival and Increased Tissue Bacterial Load in Sepsis.
    Shock (Augusta, Ga.) , 2011 Nov. 15
  • Kilpatrick LE, Standage SW, Li H, Raj NR, Korchak HM, Wolfson MR, Deutschman CS
    Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC).
    Journal of leukocyte biology , 2011 Jan. : 3-10
  • Standage SW, Wong HR
    Biomarkers for pediatric sepsis and septic shock.
    Expert review of anti-infective therapy , 2011 Jan. : 71-9
  • Maffei FA, van der Jagt EW, Powers KS, Standage SW, Connolly HV, Harmon WG, Sullivan JS, Rubenstein JS
    Duration of mechanical ventilation in life-threatening pediatric asthma: description of an acute asphyxial subgroup.
    Pediatrics , 2004 Sept. : 762-7