Stephen W. Standage, MD

On staff since July 2011

Academic Title: Acting Assistant Professor

"Severe illness or injury is a devastating, often unanticipated event in the life of a child and their family. The tenacity, strength, resilience, and love demonstrated by the children, their family members, and care providers during these difficult times truly inspire me. I am driven each day, in both my clinical and research efforts, by a desire to improve the outcome for each child."

Stephen Standage, MD, is attending physician at Seattle Children’s Hospital and Harborview Medical Center and acting assistant professor of pediatrics at the University of Washington School of Medicine. He earned his MD at the University of Rochester, in Rochester, New York, and completed his pediatrics residency at The Children’s Hospital of Philadelphia. Dr. Standage completed his pediatric critical care fellowship training at Cincinnati Children’s Hospital.

Dr. Standage is a member of the University of Washington Center for Lung Biology and conducts his research at their South Lake Union facility. His laboratory work is directed at understanding the molecular mechanisms of the immune response in sepsis. Specifically, he is interested in how modulation of systemic inflammation can improve patient outcome in critical illness. Dr. Standage’s current investigations focus on macrophage biology and the nuclear hormone receptor PPAR alpha. He is a member of the American Academy of Pediatrics, the Society of Critical Care Medicine, the Shock Society, and the American Heart Association.

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Overview
Publications

Overview

Board Certification(s): Pediatrics
Medical/Professional School: University of Rochester School of Medicine, Rochester
Residency: Pediatrics, Children's Hospital of Philadelphia, Philadelphia
Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital, Cincinnati
Clinical Interests: Sepsis, systemic inflammatory response syndromes (SIRS), hemophagocytic lymphohistiocytosis (HLH), shock, and acute respiratory failure.
Research Description: I investigate the basic mechanisms of immune dysregulation in the body's response to severe infectious or inflammatory challenge with the goal to identify therapeutic interventions.

Publications

Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.
Critical care (London, England) , 2011 Nov 18: R273

Reduced PPARα Expression is Associated With Decreased Survival and Increased Tissue Bacterial Load in Sepsis.
Shock (Augusta, Ga.) , 2011 Nov 15

Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC).
Journal of leukocyte biology , 2011 Jan: 3-10

Biomarkers for pediatric sepsis and septic shock.
Expert review of anti-infective therapy , 2011 Jan: 71-9

Duration of mechanical ventilation in life-threatening pediatric asthma: description of an acute asphyxial subgroup.
Pediatrics , 2004 Sep: 762-7

Primary Office

Seattle Children's

OB.10.625 - Critical Care
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2170

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Seattle Children’s provides healthcare for the special needs of children regardless of race, sex, creed, ethnicity or disability. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.

4800 Sand Point Way NE

Seattle

98105

206-987-2000

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