Sidney M. Gospe, MD, PhD

Sidney M. Gospe, MD, PhD


On staff since September 2000

Children's Title: Chief, Division of Neurology; Program Director, Neurology Education; Program Director, Neurology Residency

Academic Title: Herman and Faye Sarkowsky Endowed Chair Professor, Neurology and Pediatrics

Research Center: Center for Integrative Brain Research

Dr. Sidney M. Gospe, Jr. is the Head of the Division of Neurology at Children's and holds the Herman and Faye Sarkowsky Endowed Chair in Child Neurology at the University of Washington. He has over 25 years of experience in the evaluation and care of children with neurological and neuromuscular disorders.

Dr. Gospe is a native of San Francisco and earned his BS and MS degrees from Stanford University. He then attended Duke University as a member of the MD-PhD program and completed his studies in 1981. His residency training in both pediatrics and child neurology was at Baylor College of Medicine in Houston (Texas Children's Hospital). Prior to his recruitment to Seattle Children's and the UW in 2000, Dr. Gospe was a member of the medical school faculties of the Albany Medical College and the University of California, Davis. At Children's, Dr. Gospe provides care to patients in the general neurology clinic and the neuromuscular clinic. He also conducts outreach clinics at several sites in Alaska. Dr. Gospe oversees the clinical, research and educational programs of the Division of Neurology. He has conducted basic neuroscience research in neurotoxicology (particularly regarding the effects of maternal exposure to toxicants on fetal brain development. His clinical research has focused on the natural history and genetic aspects of pyridoxine-dependent epilepsy.


  • Lexie Wenatchee WA 06.13.13

    Dr. Gospe is knowledgeable, kind and gentle.

  • Samantha Kingston, Ontario Canada 12.01.10

    I travelled to Seattle from Kingston, Ontario Canada with my two children to see Dr. Sidney Gospe. We chose Dr. Gospe because of his extensive knowledge in seizure disorders and Pyridoxine Dependency. I recommend this doctor to any parent who is dealing with a child who has neurological issues. Dr. Gospe is a very kind and knowledgable man and does everything he can to help. For us, it was well worth the long trip to see this specialist because there is no other neurologist that is comparable to Dr. Sidney Gospe. I felt confident that I was getting the correct answers and when he didn't know the answer to something he was honest about it and didn't pretend to know everything like many of the neurologists that we have seen in the past. We have seen many, many neurologists and Dr. Sidney Gospe is the best one we have ever encountered. You just can't go wrong with this incredible doctor. Samantha Knapp Ontario, Canada mom of 2 pyridoxine dependent children


Board Certification(s)

Neurology with Special Qualifications in Child Neu

Medical/Professional School

Duke University, Durham
Duke University, Durham


Pediatrics, Baylor College of Medicine, Houston
Child Neurology, Baylor College of Medicine, Houston

Clinical Interests

Pediatric neuromuscular disease, neurotoxicology, pyridoxine-dependent seizures

Research Description

I am currently conducting research in two areas:

(1) the effects of maternal exposure to second hand tobacco smoke on the neurologic development of the fetus

(2) the clinical and genetic aspects of pyridoxine-dependent seizures

Research Focus Area

Neuroscience / Neurodevelopment

Awards and Honors

Award Name Award Description Awarded By Award Date
SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014
Parker Palmer Courage to Teach Award Accreditation Council for Graduate Medical Education 2014
Seattle's Top Doc Seattle Met Magazine 2013
Seattle Magazine Top Doctor - 2013 Seattle Magazine 2013
U.S. News Top Doctor U.S. News and World Report 2012
Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012
The Best Doctors in America Listed in The Best Doctors in America 2008 - 2014
Best Teaching Award UW Department of Neurology 2008
Best Teaching Award UW Department of Neurology 2006
Alpha Omega Alpha 1993


  • Tully HM, Dempsey JC, Ishak GE, Adam MP, Mink JW, Dobyns WB, Gospe SM Jr, Weiss A, Phillips JO, Doherty D
    Persistent figure-eight and side-to-side head shaking is a marker for rhombencephalosynapsis.
    Movement disorders : official journal of the Movement Disorder Society , 2013 Dec. : 28(14)2019-23
  • Jung S, Tran NT, Gospe SM Jr, Hahn SH
    Preliminary investigation of the use of newborn dried blood spots for screening pyridoxine-dependent epilepsy by LC-MS/MS.
    Molecular genetics and metabolism , 2013 Nov. : 110(3)237-40
  • Jansen LA, Hevner RF, Roden WH, Hahn SH, Jung S, Gospe Jr SM
    Glial localization of antiquitin: Implications for pyridoxine-dependent epilepsy.
    Annals of neurology , 2013 Oct.
  • Richardson RC, Tarleton JC, Bird TD, Gospe Jr SM
    Truncating CLCN1 mutations in myotonia congenita: Variable patterns of inheritance.
    Muscle and nerve , 2013 July
  • Segal MM, Williams MS, Gropman AL, Torres AR, Forsyth R, Connolly AM, El-Hattab AW, Perlman SJ, Samanta D, Parikh S, Pavlakis SG, Feldman LK, Betensky RA, Gospe SM Jr
    Evidence-Based Decision Support for Neurological Diagnosis Reduces Errors and Unnecessary Workup.
    Journal of child neurology , 2013 Apr,
  • Gospe, SM, Jr.
    Pyridoxine-dependent Epilepsy and Related Conditions
    P Pearl (Ed.) Metabolic Epilepsies , 2013 : 145-157
  • Mefford HC, Cook J, Gospe SM Jr
    Epilepsy due to 20q13.33 subtelomere deletion masquerading as pyridoxine-dependent epilepsy.
    American journal of medical genetics. Part A , 2012 Dec. : 158A(12)3190-5
  • van Karnebeek CD, Hartmann H, Jaggumantri S, Bok LA, Cheng B, Connolly M, Coughlin CR 2nd, Das AM, Gospe SM Jr, Jakobs C, van der Lee JH, Mercimek-Mahmutoglu S, Meyer U, Struys E, Sinclair G, Van Hove J, Collet JP, Plecko BR, Stockler S
    Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
    Molecular genetics and metabolism , 2012 Nov. : 107(3)335-44
  • Gospe SM Jr
    Natural history of pyridoxine-dependent epilepsy: tools for prognostication.
    Developmental medicine and child neurology , 2012 Sept. : 54(9)781-2
  • Tuschl K, Clayton PT, Gospe SM Jr, Gulab S, Ibrahim S, Singhi P, Aulakh R, Ribeiro RT, Barsottini OG, Zaki MS, Del Rosario ML, Dyack S, Price V, Rideout A, Gordon K, Wevers RA, Chong WK, Mills PB
    Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man.
    American journal of human genetics , 2012 Mar. : 90(3)457-66
  • Stockler S, Plecko B, Gospe SM Jr, Coulter-Mackie M, Connolly M, van Karnebeek C, Mercimek-Mahmutoglu S, Hartmann H, Scharer G, Struijs E, Tein I, Jakobs C, Clayton P, Van Hove JL
    Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.
    Molecular genetics and metabolism , 2011 Sept. : 104(1-2)48-60
  • Segal EB, Grinspan ZM, Mandel AM, Gospe SM Jr
    Biomarkers aiding diagnosis of atypical presentation of pyridoxine-dependent epilepsy.
    Pediatric neurology , 2011 Apr, : : 289-91
  • Gospe, SM, Jr.
    Pyridoxine-dependent epilepsy
    S Shorvon, R Guerrini, F. Andermann (Eds.) The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children , 2011 : 237-241
  • Martin ET, Kerin T, Christakis DA, Blume HK, Gospe SM Jr, Vinje J, Bowen MD, Gentsch J, Zerr DM
    Redefining outcome of first seizures by acute illness.
    Pediatrics , 2010 Dec. : : e1477-84
  • Soltanzadeh P, Friez MJ, Dunn D, von Niederhausern A, Gurvich OL, Swoboda KJ, Sampson JB, Pestronk A, Connolly AM, Florence JM, Finkel RS, Bönnemann CG, Medne L, Mendell JR, Mathews KD, Wong BL, Sussman MD, Zonana J, Kovak K, Gospe SM Jr, Gappmaier E, Taylor LE, Howard MT, Weiss RB, Flanigan KM
    Clinical and genetic characterization of manifesting carriers of DMD mutations.
    Neuromuscular disorders : NMD , 2010 Aug. : : 499-504
  • Gospe SM Jr
    Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.
    Developmental medicine and child neurology , 2010 July : : 602-3
  • Gospe SM Jr
    Neonatal vitamin-responsive epileptic encephalopathies.
    Chang Gung medical journal , 2010 Jan. : : 1-12
  • Sadilkova K, Gospe SM Jr, Hahn SH
    Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.
    Journal of neuroscience methods , 2009 Oct. : : 136-41
  • Basura GJ, Hagland SP, Wiltse AM, Gospe SM Jr
    Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry.
    European journal of pediatrics , 2009 June : : 697-704
  • Bennett CL, Chen Y, Hahn S, Glass IA, Gospe SM Jr
    Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients.
    Epilepsia , 2009 May : : 1167-75
  • Bamford NS, White KK, Robinett SA, Otto RK, Gospe SM Jr
    Neuromuscular hip dysplasia in Charcot-Marie-Tooth disease type 1A.
    Developmental medicine and child neurology , 2009 May : : 408-11
  • Gospe, SM, Jr
    Other organic chemicals
    MR Dobbs (Ed.) Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009 : 415-420
  • Firestone, JA, Gospe, SM, Jr.
    Organic solvents
    MR Dobbs (Ed.) Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009 : 401-414
  • Bouldin AA, Parisi MA, Laing N, Patterson K, Gospe SM Jr
    Variable presentation of nemaline myopathy: novel mutation of alpha actin gene.
    Muscle & nerve , 2007 Feb. : : 254-8
  • Gospe SM Jr
    Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment.
    Current opinion in neurology , 2006 Apr, : : 148-53
  • Barry PA, Lockridge KM, Salamat S, Tinling SP, Yue Y, Zhou SS, Gospe SM Jr, Britt WJ, Tarantal AF
    Nonhuman primate models of intrauterine cytomegalovirus infection.
    ILAR journal / National Research Council, Institute of Laboratory Animal Resources , 2006 : : 49-64
  • Gospe SM Jr, Bell RM
    Hospital pharmacy and emergency department availability of parenteral pyridoxine.
    Pediatric emergency care , 2005 Sept. : : 586-8
  • Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM Jr, Allpress AL, Christakis DA
    Nonfebrile illness seizures: a unique seizure category?
    Epilepsia , 2005 June : : 952-5
  • Allan WC, Gospe SM Jr
    Seizures, syncope, or breath-holding presenting to the pediatric neurologist--when is the etiology a life-threatening arrhythmia?
    Seminars in pediatric neurology , 2005 Mar. : : 2-9
  • Baynes K, Farias ST, Gospe SM Jr
    Pyridoxine-dependent seizures and cognition in adulthood.
    Developmental medicine and child neurology , 2003 Nov. : : 782-5
  • Gospe SM
    Pyridoxine-dependent seizures: findings from recent studies pose new questions.
    Pediatric neurology , 2002 Mar. : : 181-5

Research Funding

Grant Title Grantor Amount Award Date
Awareness and Access to Care for Children and Youth with Epilepsy Health Resources and Services Administration $750,000.00 Sept. 1, 2009