Sidney M. Gospe, MD, PhD

Sidney M. Gospe, MD, PhD


On staff since September 2000

Children's Title: Chief, Division of Neurology; Program Director, Neurology Education; Program Director, Neurology Residency

Academic Title: Herman and Faye Sarkowsky Endowed Chair Professor, Neurology and Pediatrics

Research Center: Center for Integrative Brain Research

  • Dr. Sidney M. Gospe, Jr. is the Head of the Division of Neurology at Children's and holds the Herman and Faye Sarkowsky Endowed Chair in Child Neurology at the University of Washington. He has over 25 years of experience in the evaluation and care of children with neurological and neuromuscular disorders.

    Dr. Gospe is a native of San Francisco and earned his BS and MS degrees from Stanford University. He then attended Duke University as a member of the MD-PhD program and completed his studies in 1981. His residency training in both pediatrics and child neurology was at Baylor College of Medicine in Houston (Texas Children's Hospital). Prior to his recruitment to Seattle Children's and the UW in 2000, Dr. Gospe was a member of the medical school faculties of the Albany Medical College and the University of California, Davis. At Children's, Dr. Gospe provides care to patients in the general neurology clinic and the neuromuscular clinic. He also conducts outreach clinics at several sites in Alaska. Dr. Gospe oversees the clinical, research and educational programs of the Division of Neurology. He has conducted basic neuroscience research in neurotoxicology (particularly regarding the effects of maternal exposure to toxicants on fetal brain development. His clinical research has focused on the natural history and genetic aspects of pyridoxine-dependent epilepsy.

    • Barbra Snohomish, WA 06.25.15

      Dr. Gospe has been my daughters doctor for over 3 years. He is wonderful, we love him. He listens, he explains, he's great.

    • Subramaniam Bangalore, India 06.23.15

      Dr. Sidney Gospe evaluated my son Santhosh, during the period 2005 to 2008 @ Seattle Children's. We have been fortunate to be with Dr. Gospe. His soft, gentle, and honest feedback has motivated us to reach out to the doctor for repeated followups in our quest for a diagnosis. My assignment ended and I had to return abruptly back to India due to my illness. Dr. Gospe has remained in our thoughts for his professionalism, care, and deep insights of my son's illness. Unfortunately, after we returned to India, my other son also diagnosed with Peripheral Neuropathy, same as Santhosh. But we couldn't approach Dr. Gospe from India for treatment and checkups.

    • Lexie Wenatchee WA 06.13.13

      Dr. Gospe is knowledgeable, kind and gentle.

    • Samantha Kingston, Ontario Canada 12.01.10

      I travelled to Seattle from Kingston, Ontario Canada with my two children to see Dr. Sidney Gospe. We chose Dr. Gospe because of his extensive knowledge in seizure disorders and Pyridoxine Dependency. I recommend this doctor to any parent who is dealing with a child who has neurological issues. Dr. Gospe is a very kind and knowledgable man and does everything he can to help. For us, it was well worth the long trip to see this specialist because there is no other neurologist that is comparable to Dr. Sidney Gospe. I felt confident that I was getting the correct answers and when he didn't know the answer to something he was honest about it and didn't pretend to know everything like many of the neurologists that we have seen in the past. We have seen many, many neurologists and Dr. Sidney Gospe is the best one we have ever encountered. You just can't go wrong with this incredible doctor. Samantha Knapp Ontario, Canada mom of 2 pyridoxine dependent children

  • Award Name Award Description Awarded By Award Date
    SEATTLE'S TOP DOCTOR - 2017 Seattle Magazine 2017
    SEATTLE MAGAZINE TOP DOCTOR - 2016 Seattle Magazine 2016
    Seattles Top Doctor 2016 Seattle Met Magazine 2016
    SEATTLE MAGAZINE TOP DOCTOR - 2015 Seattle Magazine 2015
    SEATTLE'S TOP DOCTOR - 2015 Seattle Met Magazine 2015
    SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
    SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014
    Parker Palmer Courage to Teach Award Accreditation Council for Graduate Medical Education 2014
    Seattle's Top Doc Seattle Met Magazine 2013
    Seattle Magazine Top Doctor - 2013 Seattle Magazine 2013
    U.S. News Top Doctor U.S. News and World Report 2012
    Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012
    The Best Doctors in America Listed in The Best Doctors in America 2008 - 2014
    Best Teaching Award UW Department of Neurology 2008
    Best Teaching Award UW Department of Neurology 2006
    Alpha Omega Alpha 1993
    • Tully HM, Dempsey JC, Ishak GE, Adam MP, Mink JW, Dobyns WB, Gospe SM Jr, Weiss A, Phillips JO, Doherty D
      Persistent figure-eight and side-to-side head shaking is a marker for rhombencephalosynapsis.
      24105968 Movement disorders : official journal of the Movement Disorder Society , 2013 Dec. : 28(14)2019-23
    • Jung S, Tran NT, Gospe SM Jr, Hahn SH
      Preliminary investigation of the use of newborn dried blood spots for screening pyridoxine-dependent epilepsy by LC-MS/MS.
      23953072 Molecular genetics and metabolism , 2013 Nov. : 110(3)237-40
    • Jansen LA, Hevner RF, Roden WH, Hahn SH, Jung S, Gospe Jr SM
      Glial localization of antiquitin: Implications for pyridoxine-dependent epilepsy.
      24122892 Annals of neurology , 2013 Oct.
    • Richardson RC, Tarleton JC, Bird TD, Gospe Jr SM
      Truncating CLCN1 mutations in myotonia congenita: Variable patterns of inheritance.
      23893571 Muscle and nerve , 2013 July
    • Segal MM, Williams MS, Gropman AL, Torres AR, Forsyth R, Connolly AM, El-Hattab AW, Perlman SJ, Samanta D, Parikh S, Pavlakis SG, Feldman LK, Betensky RA, Gospe SM Jr
      Evidence-Based Decision Support for Neurological Diagnosis Reduces Errors and Unnecessary Workup.
      23576414 Journal of child neurology , 2013 Apr,
    • Gospe, SM, Jr.
      Pyridoxine-dependent Epilepsy and Related Conditions
      P Pearl (Ed.) Metabolic Epilepsies , 2013 : 145-157
    • Mefford HC, Cook J, Gospe SM Jr
      Epilepsy due to 20q13.33 subtelomere deletion masquerading as pyridoxine-dependent epilepsy.
      23166088 American journal of medical genetics. Part A , 2012 Dec. : 158A(12)3190-5
    • van Karnebeek CD, Hartmann H, Jaggumantri S, Bok LA, Cheng B, Connolly M, Coughlin CR 2nd, Das AM, Gospe SM Jr, Jakobs C, van der Lee JH, Mercimek-Mahmutoglu S, Meyer U, Struys E, Sinclair G, Van Hove J, Collet JP, Plecko BR, Stockler S
      Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
      23022070 Molecular genetics and metabolism , 2012 Nov. : 107(3)335-44
    • Gospe SM Jr
      Natural history of pyridoxine-dependent epilepsy: tools for prognostication.
      22803601 Developmental medicine and child neurology , 2012 Sept. : 54(9)781-2
    • Tuschl K, Clayton PT, Gospe SM Jr, Gulab S, Ibrahim S, Singhi P, Aulakh R, Ribeiro RT, Barsottini OG, Zaki MS, Del Rosario ML, Dyack S, Price V, Rideout A, Gordon K, Wevers RA, Chong WK, Mills PB
      Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man.
      22341972 American journal of human genetics , 2012 Mar. : 90(3)457-66 PMCID: PMC3309187
    • Stockler S, Plecko B, Gospe SM Jr, Coulter-Mackie M, Connolly M, van Karnebeek C, Mercimek-Mahmutoglu S, Hartmann H, Scharer G, Struijs E, Tein I, Jakobs C, Clayton P, Van Hove JL
      Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.
      21704546 Molecular genetics and metabolism , 2011 Sept. : 104(1-2)48-60
    • Segal EB, Grinspan ZM, Mandel AM, Gospe SM Jr
      Biomarkers aiding diagnosis of atypical presentation of pyridoxine-dependent epilepsy.
      21397171 Pediatric neurology , 2011 Apr, : : 289-91
    • Gospe, SM, Jr.
      Pyridoxine-dependent epilepsy
      S Shorvon, R Guerrini, F. Andermann (Eds.) The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children , 2011 : 237-241
    • Martin ET, Kerin T, Christakis DA, Blume HK, Gospe SM Jr, Vinje J, Bowen MD, Gentsch J, Zerr DM
      Redefining outcome of first seizures by acute illness.
      21098153 Pediatrics , 2010 Dec. : : e1477-84
    • Soltanzadeh P, Friez MJ, Dunn D, von Niederhausern A, Gurvich OL, Swoboda KJ, Sampson JB, Pestronk A, Connolly AM, Florence JM, Finkel RS, Bönnemann CG, Medne L, Mendell JR, Mathews KD, Wong BL, Sussman MD, Zonana J, Kovak K, Gospe SM Jr, Gappmaier E, Taylor LE, Howard MT, Weiss RB, Flanigan KM
      Clinical and genetic characterization of manifesting carriers of DMD mutations.
      20630757 Neuromuscular disorders : NMD , 2010 Aug. : : 499-504
    • Gospe SM Jr
      Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.
      20412262 Developmental medicine and child neurology , 2010 July : : 602-3
    • Gospe SM Jr
      Neonatal vitamin-responsive epileptic encephalopathies.
      20184790 Chang Gung medical journal , 2010 Jan. : : 1-12
    • Sadilkova K, Gospe SM Jr, Hahn SH
      Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.
      19631689 Journal of neuroscience methods , 2009 Oct. : : 136-41
    • Basura GJ, Hagland SP, Wiltse AM, Gospe SM Jr
      Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry.
      18762976 European journal of pediatrics , 2009 June : : 697-704
    • Bennett CL, Chen Y, Hahn S, Glass IA, Gospe SM Jr
      Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients.
      19128417 Epilepsia , 2009 May : : 1167-75
    • Bamford NS, White KK, Robinett SA, Otto RK, Gospe SM Jr
      Neuromuscular hip dysplasia in Charcot-Marie-Tooth disease type 1A.
      19388151 Developmental medicine and child neurology , 2009 May : : 408-11
    • Gospe, SM, Jr
      Other organic chemicals
      MR Dobbs (Ed.) Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009 : 415-420
    • Firestone, JA, Gospe, SM, Jr.
      Organic solvents
      MR Dobbs (Ed.) Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009 : 401-414
    • Bouldin AA, Parisi MA, Laing N, Patterson K, Gospe SM Jr
      Variable presentation of nemaline myopathy: novel mutation of alpha actin gene.
      16967490 Muscle & nerve , 2007 Feb. : : 254-8
    • Gospe SM Jr
      Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment.
      16538088 Current opinion in neurology , 2006 Apr, : : 148-53
    • Barry PA, Lockridge KM, Salamat S, Tinling SP, Yue Y, Zhou SS, Gospe SM Jr, Britt WJ, Tarantal AF
      Nonhuman primate models of intrauterine cytomegalovirus infection.
      16391431 ILAR journal / National Research Council, Institute of Laboratory Animal Resources , 2006 : : 49-64
    • Gospe SM Jr, Bell RM
      Hospital pharmacy and emergency department availability of parenteral pyridoxine.
      16160662 Pediatric emergency care , 2005 Sept. : : 586-8
    • Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM Jr, Allpress AL, Christakis DA
      Nonfebrile illness seizures: a unique seizure category?
      15946338 Epilepsia , 2005 June : : 952-5
    • Allan WC, Gospe SM Jr
      Seizures, syncope, or breath-holding presenting to the pediatric neurologist--when is the etiology a life-threatening arrhythmia?
      15929459 Seminars in pediatric neurology , 2005 Mar. : : 2-9
    • Baynes K, Farias ST, Gospe SM Jr
      Pyridoxine-dependent seizures and cognition in adulthood.
      14580135 Developmental medicine and child neurology , 2003 Nov. : : 782-5
    • Gospe SM
      Pyridoxine-dependent seizures: findings from recent studies pose new questions.
      11955923 Pediatric neurology , 2002 Mar. : : 181-5

  • Grant Title Grantor Amount Award Date
    Awareness and Access to Care for Children and Youth with Epilepsy Health Resources and Services Administration $750,000.00 Sept. 1, 2009


Board Certification(s)

Neurology with Special Qualifications in Child Neu

Medical/Professional School

Duke University, Durham
Duke University, Durham


Pediatrics, Baylor College of Medicine, Houston
Child Neurology, Baylor College of Medicine, Houston

Clinical Interests

Pediatric neuromuscular disease, neurotoxicology, pyridoxine-dependent seizures

Research Description

I am currently conducting research in two areas:

(1) the effects of maternal exposure to second hand tobacco smoke on the neurologic development of the fetus

(2) the clinical and genetic aspects of pyridoxine-dependent seizures

Research Focus Area

Neuroscience / Neurodevelopment