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Sidney M. Gospe, MD, PhD

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Sidney M. Gospe, MD, PhD

Neurology

On staff since September 2000

Children's Title: Chief, Division of Neurology; Program Director, Neurology Education; Program Director, Neurology Residency

Academic Title: Herman and Faye Sarkowsky Endowed Chair Professor, Neurology and Pediatrics

Research Center: Center for Integrative Brain Research

Recommendations

SamanthaKingston, Ontario Canada12.01.10
I travelled to Seattle from Kingston, Ontario Canada with my two children to see Dr. Sidney Gospe. We chose Dr. Gospe because of his extensive knowledge in seizure disorders and Pyridoxine Dependency. I recommend this doctor to any parent who is dealing with a child who has neurological issues. Dr. Gospe is a very kind and knowledgable man and does everything he can to help. For us, it was well worth the long trip to see this specialist because there is no other neurologist that is comparable to Dr. Sidney Gospe. I felt confident that I was getting the correct answers and when he didn't know the answer to something he was honest about it and didn't pretend to know everything like many of the neurologists that we have seen in the past. We have seen many, many neurologists and Dr. Sidney Gospe is the best one we have ever encountered. You just can't go wrong with this incredible doctor. Samantha Knapp Ontario, Canada mom of 2 pyridoxine dependent children
Recommend Dr. Sidney Gospe

Overview

Board Certification(s)
Neurology with Special Qualifications in Child Neu
Pediatrics
Medical/Professional School
Duke University, Durham
Duke University, Durham
Residency
Pediatrics, Baylor College of Medicine, Houston
Child Neurology, Baylor College of Medicine, Houston
Clinical Interests

Pediatric neuromuscular disease, neurotoxicology, pyridoxine-dependent seizures

Research Description

I am currently conducting research in two areas:

(1) the effects of maternal exposure to second hand tobacco smoke on the neurologic development of the fetus

(2) the clinical and genetic aspects of pyridoxine-dependent seizures

Research Focus Area

Neuroscience / Neurodevelopment

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
U.S. News Top DoctorU.S. News and World Report 2012
Seattle Magazine Top Doctor - 2012Seattle Magazine Top Doctor - 2012Seattle Magazine 2012
The Best Doctors in AmericaListed in The Best Doctors in America 2011
Seattle Magazine Top Doctor - 2011Seattle Magazine Top Doctor - 2011Seattle Magazine 2011
Best Teaching AwardUW Department of Neurology 2008
Best Teaching AwardUW Department of Neurology 2006
Alpha Omega Alpha 1993

Publications

Epilepsy due to 20q13.33 subtelomere deletion masquerading as pyridoxine-dependent epilepsy.
American journal of medical genetics. Part A , 2012 Dec: 158A(12)3190-5
Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Molecular genetics and metabolism , 2012 Nov: 107(3)335-44
Natural history of pyridoxine-dependent epilepsy: tools for prognostication.
Developmental medicine and child neurology , 2012 Sep: 54(9)781-2
Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man.
American journal of human genetics , 2012 Mar 9: 90(3)457-66
Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.
Molecular genetics and metabolism , 2011 Sep-Oct: 104(1-2)48-60
Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.
Molecular genetics and metabolism , 2011 Sep-Oct: 48-60
Biomarkers aiding diagnosis of atypical presentation of pyridoxine-dependent epilepsy.
Pediatric neurology , April 2011: : 289-91
Pyridoxine-dependent epilepsy
S Shorvon, R Guerrini, F. Andermann (Eds.) The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children , 2011: 237-241
Redefining outcome of first seizures by acute illness.
Pediatrics , Dec. 2010: : e1477-84
Clinical and genetic characterization of manifesting carriers of DMD mutations.
Neuromuscular disorders : NMD , Aug. 2010: : 499-504
Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.
Developmental medicine and child neurology , July 2010: : 602-3
Neonatal vitamin-responsive epileptic encephalopathies.
Chang Gung medical journal , Jan. 2010: : 1-12
Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.
Journal of neuroscience methods , Oct. 2009: : 136-41
Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry.
European journal of pediatrics , June 2009: : 697-704
Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients.
Epilepsia , May 2009: : 1167-75
Neuromuscular hip dysplasia in Charcot-Marie-Tooth disease type 1A.
Developmental medicine and child neurology , May 2009: : 408-11
Other organic chemicals
MR Dobbs (Ed.) Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009: 415-420
Organic solvents
MR Dobbs (Ed.) Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009: 401-414
Exposure to environmental tobacco smoke during pregnancy in rats yields less effect on indices of brain cell number and size than does postnatal exposure.
Reproductive toxicology (Elmsford, N.Y.) , Jan. 2009: : 22-7
Variable presentation of nemaline myopathy: novel mutation of alpha actin gene.
Muscle & nerve , Feb. 2007: : 254-8
Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment.
Current opinion in neurology , April 2006: : 148-53
Nonhuman primate models of intrauterine cytomegalovirus infection.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources , 2006: : 49-64
Hospital pharmacy and emergency department availability of parenteral pyridoxine.
Pediatric emergency care , Sept. 2005: : 586-8
Nonfebrile illness seizures: a unique seizure category?
Epilepsia , June 2005: : 952-5
Seizures, syncope, or breath-holding presenting to the pediatric neurologist--when is the etiology a life-threatening arrhythmia?
Seminars in pediatric neurology , March 2005: : 2-9
Pyridoxine-dependent seizures and cognition in adulthood.
Developmental medicine and child neurology , Nov. 2003: : 782-5
Pyridoxine-dependent seizures: findings from recent studies pose new questions.
Pediatric neurology , March 2002: : 181-5
Pyridoxine-Dependent Seizures
, 1993
Vitamin B6-Dependent Epilepsies
P Pearl (Ed.) Metabolic Epilepsies , : in press

Research Funding

Grant TitleGrantorAmountAward Date
Awareness and Access to Care for Children and Youth with EpilepsyHealth Resources and Services Administration $750,000.00Sept. 1, 2009

Primary Office

Seattle Children's
MB.7.420 - Neurology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2078

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