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Serge Barcy, PhD

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Serge Barcy, PhD

Infectious Disease

Academic Title: Research Assistant Professor

Research Center: Center for Global Infectious Disease Research

Overview

Medical/Professional School
University Libre de Bruxelles, Bruxelles, Belgium
University Libre de Bruxelles, Bruxelles, Belgium
Fellowship
University Libre de Bruxelles, Bruxelles, Belgium
University of Washington, Seattle
Research Description

Dr. Barcy's research focuses on characterizing the effector mechanisms involved in the immune control of chronic viral infection. As an immunologist, he has acquired significant expertise and research experience in immunology, with emphasis on innate and acquired immune control of pathogenic and nonpathogenic infections. His contributions to various preclinical models of infectious diseases (HPV-16/18, HSV-1/2, KSHV/HHV-8) consist mainly in the discovery and preclinical development of therapeutics (antigenic epitopes, immune evasion mechanisms) for the treatment of infectious diseases, immune regulation, and tumor immunotherapy.

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
WaNPRC/ITHS Career Development Award 2010

Publications

Ets-1 is required for the activation of VEGFR3 during latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.
Journal of virology , June 2013: 87(12)6758-6768
Macaque homologs of EBV and KSHV show uniquely different associations with simian AIDS-related lymphomas.
PLoS pathogens , 2012: 8(10)e1002962
Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infection.
Journal of immunology (Baltimore, Md. : 1950) , March 2008: 180(5)3417-25
Longitudinal analysis of herpes simplex virus-specific CD4+ cell clonotypes in infected tissues and blood.
The Journal of infectious diseases , June 2005: 191(12)2012-21
Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , Sept. 2002: 35(5)518-25
Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome.
The Journal of infectious diseases , March 2002: 185(6)828-32
Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells
J Immunol , 2001: 166(10)6242-6249
Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes
J Immunol , 2000: 165(2)1146-1152
CD80 (B7-1) and CD86 (B7-2): potential targets for immunotherapy?
Res Immunol , 1995: 146(3)183-196
FcR cross-linking on monocytes results in impaired T cell stimulatory capacity
Int Immunol , 1995: 7(2)179-189
Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction
Eur J Immunol , 1994: 24(3)508-517
PATENT: New methods and compounds for the selective modulation of antigen-specific T-cell responsiveness
WO/1995/032734 ,

Presentations

Presentations TitleEventLocationDate
Neutralizing antibodies against cell to cell mediated virus transmissionUganda Programs Research-in-Progress meetingSeattle, WAJan. 24, 2013
KSHV virus spread by cell to cell mediated transmissionHerpesviruses Group MeetingSeattle, WAOct. 9, 2012
Discovery of novel herpesviruses homologues in nonhuman primatesInfectious Diseases Research ConferenceSeattle, WAMarch 6, 2012
Discovery of novel homologues of HHV6 and HHV7 in pig-tailed macaquesSTRIDE All Investigators MeetingSeattle, WANov. 17, 2011

Research Funding

Grant TitleGrantorAmountAward Date
Oral pathogenesis and host interactions of KSHV infection - P01 DE021954 (Rose)NIH/NIDCR $993,231 annual directsJune 1, 2011 - April 30, 2016

Primary Office

Seattle Children's Research Institute
JMB - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101
206-987-2073

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