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Scott J. Diede, MD, PhD

Scott J. Diede, MD, PhD


On staff since July 2008

Research Center: Center for Clinical and Translational Research

"To care for patients and their families with respect and compassion to the utmost of my abilities. It is a privilege to be a part of a patients health-care team and serve as a guide for patients and families during one of the most difficult times in their lives."


Board Certification(s)
Pediatric Hematology-Oncology
Medical/Professional School
University of Chicago, Chicago
University of Chicago, Chicago, Pathology - Clinical
Pediatrics, Seattle Children's Hospital, Seattle
Pediatric Hematology-Oncology, Seattle Children's Hospital, Seattle
Research Focus Area

Translational Research, Cancer

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Hyundai Hope on Wheels ScholarHyundai Hope on Wheels 2010
Young Investigator AwardAlex's Lemonade Stand Foundation for Childhood Cancer Research 2010 - 2012
Emily Dorfman Foundation for Children Basic Research FellowshipAmerican Brain Tumor Association 2010 - 2012
St. Baldrick's Foundation ScholarSt. Baldrick's Foundation 2010 - 2015
Child Health Research Center ScholarUniversity of Washington School of Medicine 2008 - 2011
Young Investigator AwardAmerican Society of Clinical Oncology 2008
Special Alternative Pathway in Pediatric Hematology and OncologyAmerican Board of Pediatrics 2005
Alpha Omega AlphaThe University of Chicago Pritzker School of Medicine, Chicago, IL 2003
Medical Scientists Training ProgramThe University of Chicago Pritzker School of Medicine, Chicago, IL 1992


Homology-mediated end-capping as a primary step of sister chromatid fusion in the breakage-fusion-bridge cycles.
Nucleic acids research , 2013 Nov 1: 41(21)9732-40
Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer.
Epigenetics : official journal of the DNA Methylation Society , 2013 Oct 9: 8(12)
TERT hypermethylation: biomarker in paediatric brain tumours.
The lancet oncology , May 2013: 14(6)447-8
Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors.
Molecular and cellular biology , Feb. 2013: 33(4)773-84
Genome-wide DNA methylation studies suggest distinct DNA methylation patterns in pediatric embryonal and alveolar rhabdomyosarcomas.
Epigenetics : official journal of the DNA Methylation Society , April 2012: 7(4)400-8
Assessment of palindromes as platforms for DNA amplification in breast cancer.
Genome research , Feb. 2012: 22(2)232-45
Genome-wide analysis of palindrome formation.
Nature genetics , April 2010: 42(4)279
DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences.
Proceedings of the National Academy of Sciences of the United States of America , Jan. 2010: 107(1)234-9
MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state.
Genes & development , March 2009: 23(6)694-707
A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20.
Human molecular genetics , Dec. 2008: 17(24)3847-53
EEL-1, a Hect E3 ubiquitin ligase, controls asymmetry and persistence of the SKN-1 transcription factor in the early C. elegans embryo.
Development (Cambridge, England) , June 2007: 134(12)2303-14
Reduced dosage of pos-1 suppresses Mex mutants and reveals complex interactions among CCCH zinc-finger proteins during Caenorhabditis elegans embryogenesis.
Genetics , Dec. 2006: 174(4)1933-45
Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
Current Biology , 2001: 11(17)1336-1340
The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
Nature Genetics , 2001: 27(1)64-67
All things must end: Telomere dynamics in yeast
Cold Spring Harbor Symposium on Quantitative Biology , 2000: 65281-296
Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerase and
Cell , 1999: 99(7)723-733
Expression of neurotrophins and the low-affinity NGF receptor in septal and hippocampal reaggregate cultures: Local physiologic effects of NGF synthesized in the septal region
Developmental Brain Research , 1992: 70(1)123-133

Research Funding

Grant TitleGrantorAmountAward Date
The Role of DNA Methylation in Pediatric CancerSt. Baldrick's Foundation $115,000/yearJuly 1, 2013 - June 30, 2015
The Role of Aberrant DNA Methylation in Pediatric RhabdomyosarcomaGo 4 the Goal Pediatric Cancer Foundation $100,000 2013 - 2015
The Role of DNA Methylation in Normal Muscle Development and Pediatric RhabdomyosarcomaHyundai Hope on Wheels $60,000Aug. 1, 2010 - July 31, 2011
The Role of DNA Methylation in Pediatric MedulloblastomaAmerican Brain Tumor Association $40,000/yearJuly 1, 2010 - June 30, 2012
The Role of DNA Methylation in Pediatric CancerAlex's Lemonade Stand Foundation for Cancer Research $40,000/yearJuly 1, 2010 - June 30, 2012
The Role of DNA Methylation in Pediatric CancerSt. Baldrick's Foundation $110,000/yearJuly 1, 2010 - June 30, 2013
DNA Palindrome Formation Promotes Genomic Instability in CancerAmerican Society of Clinical Oncology $50,000July 1, 2008 - June 30, 2009
DNA Palindrome Formation Promotes Genomic Instability in CancerUniversity of Washington Child Health Research Center $75,000/yearJuly 1, 2008 - June 30, 2011

Primary Office

Seattle Children's
MB.8.501 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105

Additional Offices

Fred Hutchinson Cancer Research Center
FHCRC Box 358080 - MS C3-168
PO Box 19024
Seattle, WA 98109-1024

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