Dr. McAdams is a neonatologist with clinical experience in both developed and developing countries. He has been involved in volunteer medical humanitarianism work in developing countries including Mongolia, Zambia, Cambodia, and Uganda with a goal to improve neonatal outcomes globally. The inspiration for his scientific research derives from his clinical exposure to vulnerable newborns who have sustained lung and brain injuries.
Dr. McAdams research focuses on understanding early epigenetic mechanisms that may alter long-term lung and brain development. He is studying how in utero inflammatory signaling pathways affect gene expression in the developing lung in order to identify potential therapeutic windows to mitigate fetal and neonatal lung injury. Additionally, Dr. McAdams is investigating how pain and sedation medications commonly used in the NICU can alter levels of microRNAs, small non-coding RNA molecules that can regulate gene expression, in the neonatal brain. The goal of this work is to determine the potential neurodevelopmental impact of pain and sedation medicines to make sure these medicines are used in a safe and judicious manner in neonates. Dr. McAdams is also a strong advocate of improving care practices through the implementation of evidence-based practices with a current interest in advocating for delayed cord clamping in newborns to optimize neurodevelopmental outcomes.