Profile

Raj P. Kapur, MD, PhD

Raj P. Kapur, MD, PhD

Pathology, Reconstructive Pelvic Medicine

On staff since November 1992

Children's Title: Program Chief, Perinatal Autopsy; Program Director, Fetal Pathology Service; Program Director of Lab Medicine/Pathology Residency and Fellowship

Academic Title: Professor

Research Center: Center for Developmental Biology and Regenerative Medicine

Overview

Board Certification(s)

Pathology - Anatomic
Pediatric Pathology

Medical/Professional School

University of Southern California, Los Angeles

Residency

Pathology - Anatomic, University of Washington, Seattle

Fellowship

Pediatric Pathology, Seattle Children's Hospital, Seattle

Clinical Interests

Hirschsprung disease and related disorders, Fetal pathology

Research Focus Area

Translational Research

Publications

  • Kapur RP, Robertson SP, Hannibal MC, Finn LS, Morgan T, van Kogelenberg M, Loren DJ
    Diffuse abnormal layering of small intestinal smooth muscle is present in patients with FLNA mutations and x-linked intestinal pseudo-obstruction.
    20871226 The American journal of surgical pathology , 2010 Oct. : 1528-43
  • Juric-Sekhar G, Kapur RP, Glass IA, Murray ML, Parnell SE, Hevner RF
    Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III.
    20857301 Acta neuropathologica , 2010 Sept. 21
  • Swaminathan M, Kapur RP
    Counting myenteric ganglion cells in histologic sections: an empirical approach.
    20346481 Human pathology , 2010 Aug. : 1097-108
  • Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T
    The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group.
    20581236 Gut , 2010 July : 882-7
  • Quintana A, Kruse SE, Kapur RP, Sanz E, Palmiter RD
    Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.
    20534480 Proceedings of the National Academy of Sciences of the United States of America , 2010 June 15 : 10996-1001
  • Rudzinski ER, Kapur RP, Hevner RF
    Fetal akinesia deformation sequence with delayed skeletal muscle maturation and polymicrogyria: evidence for a hypoxic/ischemic pathogenesis.
    19968489 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2010 May : 192-201
  • Rudzinski E, Kapur RP
    PHOX2B Immunolocalization of the Candidate Human Retrotrapezoid Nucleus.
    19888871 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2009 Nov. 4
  • Kapur RP
    Practical pathology and genetics of Hirschsprung's disease.
    19782303 Seminars in pediatric surgery , 2009 Nov. : 212-23
  • Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T
    Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group.
    19360428 Acta neuropathologica , 2009 Aug. : 271-301
  • Suskind D, Wahbeh G, Murray K, Christie D, Kapur RP
    Collagenous gastritis, a new spectrum of disease in pediatric patients: two case reports.
    19829984 Cases journal , 2009 June 10 : 7511
  • Kapur RP, Correa H
    Architectural malformation of the muscularis propria as a cause for intestinal pseudo-obstruction: two cases and a review of the literature.
    18788889 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2009 Mar. : 156-64
  • Kapur RP, Reed RC, Finn LS, Patterson K, Johanson J, Rutledge JC
    Calretinin immunohistochemistry versus acetylcholinesterase histochemistry in the evaluation of suction rectal biopsies for Hirschsprung Disease.
    18442301 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2009 Jan. : 6-15
  • Weiss AH, Kelly JP, Kapur RP, Pendergrass T
    Retinal function and corresponding pathology in advanced retinoblastoma.
    19001217 Archives of ophthalmology , 2008 Nov. : 1507-12
  • Reed RC, Beischel L, Schoof J, Johnson J, Raff ML, Kapur RP
    Androgenetic/biparental mosaicism in an infant with hepatic mesenchymal hamartoma and placental mesenchymal dysplasia.
    18260692 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2008 Sept. : 377-83
  • Reed RC, Kapur RP
    Hepatic mesenchymal hamartoma: a disorder of imprinting.
    17990933 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2008 July : 264-5
  • Kruse SE, Watt WC, Marcinek DJ, Kapur RP, Schenkman KA, Palmiter RD
    Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.
    18396137 Cell metabolism , 2008 Apr, : 312-20
  • Mascher-Denen M, McPherson RJ, Kapur RP, Juul SE
    Characterization of developing bowel transplanted from transgenic erythropoietin receptor-deficient mouse embryos.
    17664892 Neonatology , 2008 : 56-63
  • Clarke CM, Plata C, Cole B, Tsuchiya K, La Spada AR, Kapur RP
    Visceral neuropathy and intestinal pseudo-obstruction in a murine model of a nuclear inclusion disease.
    18054568 Gastroenterology , 2007 Dec. : 1971-8
  • Kapur RP
    Achondrogenesis.
    17638434 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2007 July : 253-5
  • Souter VL, Parisi MA, Nyholt DR, Kapur RP, Henders AK, Opheim KE, Gunther DF, Mitchell ME, Glass IA, Montgomery GW
    A case of true hermaphroditism reveals an unusual mechanism of twinning.
    17165045 Human genetics , 2007 Apr, : 179-85
  • Hnasko TS, Hnasko RM, Sotak BN, Kapur RP, Palmiter RD
    Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia.
    17622754 Neuroendocrinology , 2007 : 48-57
  • Meier-Ruge WA, Bruder E, Kapur RP
    Intestinal neuronal dysplasia type B: one giant ganglion is not good enough.
    17163795 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2006 Nov. : 444-52
  • Kapur RP
    Does bcl2 immunostaining really help with pathological evaluation of intestinal pseudo-obstruction?
    16861987 The American journal of surgical pathology , 2006 Aug. : 1059; author reply 1059-62
  • Kapur RP
    Can we stop looking? Immunohistochemistry and the diagnosis of Hirschsprung disease.
    16753604 American journal of clinical pathology , 2006 July : 9-12
  • Howe DG, Clarke CM, Yan H, Willis BS, Schneider DA, McKnight GS, Kapur RP
    Inhibition of protein kinase A in murine enteric neurons causes lethal intestinal pseudo-obstruction.
    16329126 Journal of neurobiology , 2006 Feb. 15 : 256-72
  • Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP
    Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.
    16291166 Journal of pediatric surgery , 2005 Nov. : 1760-5
  • Siebert JR, Schoenecker KA, Resta RG, Kapur RP
    Holoprosencephaly and limb reduction defects: a consideration of Steinfeld syndrome and related conditions.
    15779021 American journal of medical genetics. Part A , 2005 May 1 : 381-92
  • Kapur RP
    Multiple endocrine neoplasia type 2B and Hirschsprung's disease.
    15880310 Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association , 2005 May : 423-31
  • Duthie MS, Kahn M, White M, Kapur RP, Kahn SJ
    Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection.
    15731095 Infection and immunity , 2005 Mar. : 1890-4
  • Kapur RP, Clarke CM, Doggett B, Taylor BE, Baldessari A, Parisi MA, Howe DG
    Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice.
    15803212 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2005 Mar. : 148-61
  • Duthie MS, Kahn M, White M, Kapur RP, Kahn SJ
    Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection.
    15618153 Infection and immunity , 2005 Jan. : 181-92
  • Siebert JR, Kapur RP, Resta RG, Luthy D
    Methods for induced abortion.
    15625178 Obstetrics and gynecology , 2005 Jan. : 221; author reply 221-2
  • Kapur RP, Yao Z, Iida MH, Clarke CM, Doggett B, Xing L, Boyce BF
    Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank.
    15355564 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research , 2004 Oct. : 1689-97
  • Clancy RM, Kapur RP, Molad Y, Askanase AD, Buyon JP
    Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block.
    14730614 Arthritis and rheumatism , 2004 Jan. : 173-82
  • Kapur RP
    Neuronal dysplasia: a controversial pathological correlate of intestinal pseudo-obstruction.
    14518065 American journal of medical genetics. Part A , 2003 Nov. 1 : 287-93
  • Parisi MA, Baldessari AE, Iida MH, Clarke CM, Doggett B, Shirasawa S, Kapur RP
    Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice.
    14598259 Gastroenterology , 2003 Nov. : 1428-40
  • Weldin J, Jack R, Dugaw K, Kapur RP
    Quercetin, an over-the-counter supplement, causes neuroblastoma-like elevation of plasma homovanillic acid.
    15018454 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2003 Nov. : 547-51
  • Clancy RM, Backer CB, Yin X, Kapur RP, Molad Y, Buyon JP
    Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block.
    12960355 Journal of immunology (Baltimore, Md. : 1950) , 2003 Sept. 15 : 3253-61
  • Souter VL, Kapur RP, Nyholt DR, Skogerboe K, Myerson D, Ton CC, Opheim KE, Easterling TR, Shields LE, Montgomery GW, Glass IA
    A report of dizygous monochorionic twins.
    12853588 The New England journal of medicine , 2003 July 10 : 154-8
  • Faye-Petersen OM, Kapur RP
    A little bit of everything: molecular genetics of congenital hyperinsulinism.
    12469235 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2003 Jan. : 3-5
  • Siebert JR, Kapur RP
    Rulers rule: present and future applications of cerebellar morphometry.
    12192428 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2002 Sept. : 422-4
  • Clancy RM, Askanase AD, Kapur RP, Chiopelas E, Azar N, Miranda-Carus ME, Buyon JP
    Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block.
    12165545 Journal of immunology (Baltimore, Md. : 1950) , 2002 Aug. 15 : 2156-63
  • Parisi MA, Kapur RP, Neilson I, Hofstra RM, Holloway LW, Michaelis RC, Leppig KA
    Hydrocephalus and intestinal aganglionosis: is L1CAM a modifier gene in Hirschsprung disease?
    11857550 American journal of medical genetics , 2002 Feb. 15 : 51-6