Profile

Rachel Adria Katzenellenbogen, MD

Rachel Adria Katzenellenbogen, MD

Adolescent Medicine

On staff since July 2006

Academic Title: Associate Professor, Pediatrics-Section of Adolescent Medicine

Research Center: Center for Global Infectious Disease Research

"Adolescence is a time of transition a time when teenagers begin to decide who they are and what they want to become. As adults, we often look back at our lives and wish we had made smarter choices about our health, education and relationships. In my work with adolescents, I am focused on helping to highlight and define the range of choices they can make. The choices are theirs, and they are ones that should be made thoughtfully, deliberately and with a goal in mind. Seeing adolescents recognize the power they have in making their own choices and being in charge of their own lives is wonderful to witness. "

  • Rachel Katzenellenbogen, MD, is attending physician in adolescent medicine at Seattle Childrens Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her clinical interests include adolescent gynecology and STD management as well as general preventive medicine.

    Katzenellenbogen conducts NIH-sponsored research on high-risk human papillomavirus infection, which is linked to cervical cancer and is the most common sexually transmitted infection. For more information, please visit: http://www.seattlechildrens.org/katzenellenbogenlab/.

  • Award Name Award Description Awarded By Award Date
    Seattles Top Doctor 2016 Seattle Met Magazine 2016
    • Katzenellenbogen R
      Telomerase Induction in HPV Infection and Oncogenesis.
      28698524 Viruses , 2017 July 10 : 9(7) PMCID: PMC5537672
    • Katzenellenbogen RA
      Activation of telomerase by HPVs.
      27863966 Virus research , 2017 Mar. 2 : 23150-55
    • Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA
      Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.
      25723053 Virology , 2015 Apr, : 47850-60 PMCID: PMC4383269
    • Katzenellenbogen RA, Carter JJ, Stern JE, Butsch Kovacic MS, Mehta PA, Sauter SL, Galloway DA, Winer RL
      Skin and mucosal human papillomavirus seroprevalence in persons with Fanconi Anemia.
      25651924 Clinical and vaccine immunology : CVI , 2015 Apr, : 22(4)413-20 PMCID: PMC4375352
    • C Trimble and RA Katzenellenbogen
      The Biology of Cervical Squamous Neoplasia. Chapter in Pathology of the Female Reproductive Tract, 3rd edition. Eds. GL Mutter and J Prat
    • Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA
      NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
      24109236 Journal of virology , 2013 Dec. : 87(24)13741-50 PMCID: PMC3838236
    • Xu M, Katzenellenbogen RA, Grandori C, Galloway DA
      An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.
      24074563 Virology , 2013 Nov. : 446(1-2)17-24 PMCID: PMC3787310
    • Wong CA, Taylor JA, Wright JA, Opel DJ, Katzenellenbogen RA
      Missed opportunities for adolescent vaccination, 2006-2011.
      23809613 The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2013 Oct. : 53(4)492-7
    • Holder NA, Katzenellenbogen R, Middleman AB
      Human papillomavirus vaccines: factors that affect vaccine knowledge and delivery.
      23830089 The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2013 Sept. : 53(3)423-5
    • Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA
      Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes.
      20943973 Journal of virology , 2010 Dec. : 84(24)12934-44 PMCID: PMC3004306
    • Xu M, Katzenellenbogen RA, Grandori C, Galloway DA
      NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.
      20739528 Journal of virology , 2010 Nov. : 84(21)11461-9 PMCID: PMC2953198
    • RA Katzenellenbogen and DA Galloway
      Human Papillomavirus-Associated Cancers. Chapter One in Viral Oncology: Basic Science and Clinical Applications, Eds. K Khalili and KT Jeang
    • Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA
      NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.
      19369336 Journal of virology , 2009 July : 83(13)6446-56 PMCID: PMC2698580
    • Howie HL, Katzenellenbogen RA, Galloway DA
      Papillomavirus E6 proteins.
      19081593 Virology , 2009 Feb. : 324-34
    • Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, Gewin LC, Gafken PR, Galloway DA
      NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
      17267499 Journal of virology , 2007 Apr, : 81(8)3786-96 PMCID: PMC1866132
    • Katzenellenbogen R
      HEADSS: The "Review of Systems" for Adolescents.
      23249491 The virtual mentor : VM , 2005 Mar. 1 : 7(3)
    • Richardson LP, Katzenellenbogen R
      Childhood and adolescent depression: the role of primary care providers in diagnosis and treatment.
      15611721 Current problems in pediatric and adolescent health care , 2005 Jan. : 6-24

  • Presentations Title Event Location Date
    Speaker. "Human Papillomavirus Pathogenesis," 25h Annual Principles of STD/HIV Research Course Seattle, WA 2017
    Speaker. "Sexual Health in Adolescents," Update on the management of STDs and HIV prevention Seattle, WA 2016
    Speaker. "You Can Catch Cancer?!," Pacific Science Center Science Caf Kirkland, WA 2016
    Speaker. "Human Papillomavirus Pathogenesis," 24th Annual Principles of STD/HIV Research Course Seattle, WA 2016
    Speaker. "Global WACh: The role pediatrics plays in training and research across the lifecycle," Grand Rounds, Seattle Childrens Hospital Seattle, WA 2016
    Speaker. "HPV and Cancer: What you need to know to save a childs life," Grand Rounds, Seattle Childrens Hospital Seattle, WA 2016
    Speaker. "HPV E6 and NFX1-123 in telomerase, differentiation, and growth," Oral Health Sciences Lecture Series Seattle, WA 2015
    Speaker. "HPV and HPV Vaccines," Seattle Public Schools and King County Public Health Seattle, WA 2015
    Speaker. "Human Papillomavirus Pathogenesis," 23rd Annual Principles of STD/HIV Research Course Seattle, WA 2015
    Speaker. "HPV E6 and NFX1-123 in telomerase, growth, and differentiation," Richard King Mellon Foundation, Institute for Pediatric Research Seminar Pittsburgh, PA 2015
    Speaker. "Adolescent Drug and Alcohol Use," Waldorf High School Seattle, WA 2014
    Speaker. "International HPV Vaccine Rollout: Challenges and Outcomes," Global Oncology Lecture Series Seattle, WA 2014
    Speaker. "Human Papillomavirus Pathogenesis," 21st Annual Principles of STD/HIV Research Course Seattle, WA 2013
    Speaker. "Sexual Health in Adolescents," Update on the management of STDs and HIV prevention Portland, OR 2013
    Speaker. "Sexual Health in Adolescents," Update on the management of STDs and HIV prevention Seattle, WA 2012
    Speaker and panelist. "HeLa cells and cervical cancer: where are we today?" A Conversation with David (Sonny) Lacks, The Center for the Study of Justice in Society, Seattle University and Mt. Zion Baptist Church Seattle, WA 2012
    Speaker. "Human Papillomavirus Pathogenesis," 20th Annual Principles of STD/HIV Research Course Seattle, WA 2012
    Speaker. "STD in Adolescents: Special Concerns," STD Update Course Spokane, WA 2011
    Speaker. "Everything You Always Wanted to Know About Non-Genital Gonorrhea and Chlamydia Screening But Where Afraid to Ask," Society for Adolescent Health and Medicine Annual Meeting Seattle, WA 2011
    Speaker. "Human Papillomavirus Pathogenesis," 19th Annual Principles of STD/HIV Research Course Seattle, WA 2011
    Speaker. "HPV and Cervical Cancer: incidence and at-risk populations," in session "HeLa, HPV and Increased Participation of Minorities in Clinical Trials," 111th General Meeting for American Society for Microbiology New Orleans, LA 2011
    Speaker. "HPV Oncogenesis," 27th International Papillomavirus Conference and Clinical Workshop Berlin, Germany 2011
    Speaker. "STD in Adolescents: Special Concerns," STD Update Course Seattle, WA 2010
    Speaker. "Outpatient Management of Eating Disorders," WWAMI Visiting Professorship Port Angeles, WA 2010
    Speaker. "Abnormal Pap and HPV Update: Guidelines for Screening and Prevention," Contemporary Forums Adolescent Health Care Seattle, WA 2010
    Speaker. "HPV Case Conference and Update," King County Public Health STD clinic Seattle, WA 2010
    Speaker. "Shes All Grown Up Now: Consenting for the HPV Vaccine," Treuman Katz Center for Pediatric Bioethics conference Seattle, WA 2009
    Speaker. "STD in Adolescents: Special Concerns," STD Update Course Portland, OR 2009
    1. Speaker. "Taking the Opportunity to Talk with Teens about Sexuality," 18th Annual Pacific Northwest Nursing Conference, Shoreline, WA 2007
    Speaker. "Preventing Cancer by Vaccine!?: The Story of the HPV Vaccine," Grand Rounds, Seattle Childrens Hospital, Seattle, WA 2007
    Speaker. "HPV and other Vaccines Updates," 35th Annual Advances in Family Medicine and Primary Care CME, Seattle, WA 2007
    Speaker. "STD in Adolescents: Special Concerns," STD Update Course, Portland, OR 2007
  • Grant Title Grantor Amount Award Date
    "HIV integration-mediated modulation of immune regulation in HPV-associated cancers" - R01 CA206466 (PIs: Frenkel/Casper) NIH/NCI $441,435 annual direct costs Sept. 1, 2016 - Aug. 31, 2021
    "HPV E6 and NFX1-123 in differentiation, cell regulation, and cancer" - R01 CA172742-01A1 NIH/NCI $207,500 annual directs June 4, 2014 - May 31, 2019
    "Regulation of telomerase by NFX1" - K08 CA131171 NIH/NCI July 1, 2008 - June 30, 2013
    Telomerase Regulation by HPV E6, NFX1-123, and PABPCs NIH/NIAID $95,600.00 March 1, 2008

Overview

Board Certification(s)

Pediatrics
Adolescent Medicine

Medical/Professional School

Johns Hopkins University School of Medicine, Baltimore

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Adolescent Medicine, University of Washington, Seattle
University of Washington, Seattle

Research Description

Human papillomavirus (HPV) is the most common sexually transmitted infection, affecting more than 75 percent of the adult population. HPV is categorized as high-risk or low-risk, based on its association with cancer. Through dysregulation of normal cellular function, high-risk HPV blocks signals for DNA damage, programmed cell death, and cellular arrest, all as a part of its viral life cycle. I am studying the mechanism by which high-risk HPV activates telomerase, an enzyme found normally in stem cells and almost categorically activated in cancers, in order to understand how HPV drives cells to become malignant.

About My Work

http://www.seattlechildrens.org/research/global-infectious-disease-research/katzenellenbogen-lab/

Research Focus Area

Infectious Disease, Virology