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Rachel Adria Katzenellenbogen, MD

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Rachel Adria Katzenellenbogen, MD

Adolescent Medicine

On staff since July 2006

Academic Title: Assistant Professor, Pediatrics-Section of Adolescent Medicine

Research Center: Center for Childhood Infections and Prematurity Research

"Adolescence is a time of transition — a time when teenagers begin to decide who they are and what they want to become. As adults, we often look back at our lives and wish we had made smarter choices about our health, education and relationships. In my work with adolescents, I am focused on helping to highlight and define the range of choices they can make. The choices are theirs, and they are ones that should be made thoughtfully, deliberately and with a goal in mind. Seeing adolescents recognize the power they have in making their own choices and being in charge of their own lives is wonderful to witness. "

Making a Difference

  • Significant Recruits of 2010

    2010 was a banner year for recruiting at Seattle Children’s Research Institute as several nationally recognized researchers chose to continue their life’s work in Seattle.... cont.

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Overview

Board Certification(s)
Pediatrics
Adolescent Medicine
Medical/Professional School
Johns Hopkins University School of Medicine, Baltimore
Residency
Pediatrics, University of Washington, Seattle
Fellowship
Adolescent Medicine, University of Washington, Seattle
University of Washington, Seattle
Research Description

Human papillomavirus (HPV) is the most common sexually transmitted infection, affecting more than 75 percent of the adult population. HPV is categorized as high-risk or low-risk, based on its association with cancer. Through dysregulation of normal cellular function, high-risk HPV blocks signals for DNA damage, programmed cell death, and cellular arrest, all as a part of its viral life cycle. I am studying the mechanism by which high-risk HPV activates telomerase, and enzyme found normally in stem cells and almost categorically activated in cancers, in order to understand how HPV drives cells to become malignant.

Lab URL

http://www.seattlechildrens.org/katzenellenbogenlab

Research Focus Area

Infectious Disease, Virology

Publications

Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes.
Journal of virology , 2010 Dec: 12934-44
NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.
Journal of virology , 2010 Nov: 11461-9
NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.
Journal of virology , 2009 Jul: 6446-56
Papillomavirus E6 proteins.
Virology , 2009 Feb 20: 324-34
NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
Journal of virology , 2007 Apr: 3786-96
Childhood and adolescent depression: the role of primary care providers in diagnosis and treatment.
Current problems in pediatric and adolescent health care , 2005 Jan: 6-24

Research Funding

Grant TitleGrantorAmountAward Date
Regulation of telomerase by NFX1NIH/NCI $596,490.00July 1, 2008
Telomerase Regulation by HPV E6, NFX1-123, and PABPCsNIH/NIAID $95,600.00March 1, 2008

Primary Office

Seattle Children's
OB.9.640- Adolescent Medicine
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2028

Additional Offices

University of Washington
UW Box 356320 - Pediatrics
1959 NE Pacific St
Seattle, WA 98195-6320
206-543-3180
Seattle Children's Research Institute
C9S - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101
206-987-2073

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