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Rachel Adria Katzenellenbogen, MD

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Rachel Adria Katzenellenbogen, MD

Adolescent Medicine

On staff since July 2006

Academic Title: Assistant Professor, Pediatrics-Section of Adolescent Medicine

Research Center: Center for Global Infectious Disease Research

"Adolescence is a time of transition — a time when teenagers begin to decide who they are and what they want to become. As adults, we often look back at our lives and wish we had made smarter choices about our health, education and relationships. In my work with adolescents, I am focused on helping to highlight and define the range of choices they can make. The choices are theirs, and they are ones that should be made thoughtfully, deliberately and with a goal in mind. Seeing adolescents recognize the power they have in making their own choices and being in charge of their own lives is wonderful to witness. "

Making a Difference

  • Significant Recruits of 2010

    2010 was a banner year for recruiting at Seattle Children’s Research Institute as several nationally recognized researchers chose to continue their life’s work in Seattle.... cont.

Overview

Board Certification(s)
Pediatrics
Adolescent Medicine
Medical/Professional School
Johns Hopkins University School of Medicine, Baltimore
Residency
Pediatrics, University of Washington, Seattle
Fellowship
Adolescent Medicine, University of Washington, Seattle
University of Washington, Seattle
Research Description

Human papillomavirus (HPV) is the most common sexually transmitted infection, affecting more than 75 percent of the adult population. HPV is categorized as high-risk or low-risk, based on its association with cancer. Through dysregulation of normal cellular function, high-risk HPV blocks signals for DNA damage, programmed cell death, and cellular arrest, all as a part of its viral life cycle. I am studying the mechanism by which high-risk HPV activates telomerase, and enzyme found normally in stem cells and almost categorically activated in cancers, in order to understand how HPV drives cells to become malignant.

Lab URL

http://www.seattlechildrens.org/research/global-infectious-disease-research/katzenellenbogen-lab/

Research Focus Area

Infectious Disease, Virology

Publications

NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
Journal of virology , Dec. 2013: 87(24)13741-50
An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.
Virology , Nov. 2013: 446(1-2)17-24
Missed opportunities for adolescent vaccination, 2006-2011.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine , Oct. 2013: 53(4)492-7
Human papillomavirus vaccines: factors that affect vaccine knowledge and delivery.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine , Sept. 2013: 53(3)423-5
Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes.
Journal of virology , Dec. 2010: 12934-44
NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.
Journal of virology , Nov. 2010: 11461-9
NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.
Journal of virology , July 2009: 6446-56
Papillomavirus E6 proteins.
Virology , Feb. 2009: 324-34
NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
Journal of virology , April 2007: 3786-96
Childhood and adolescent depression: the role of primary care providers in diagnosis and treatment.
Current problems in pediatric and adolescent health care , Jan. 2005: 6-24

Research Funding

Grant TitleGrantorAmountAward Date
HPV E6 and NFX1-123 in differentiation, cell regulation, and cancer - R01 CA172742-01A1NIH/NCI $207,500 annual directsJune 4, 2014 - May 31, 2019
Regulation of telomerase by NFX1NIH/NCI $596,490.00July 1, 2008
Telomerase Regulation by HPV E6, NFX1-123, and PABPCsNIH/NIAID $95,600.00March 1, 2008

Primary Office

Seattle Children's Research Institute
JMB - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101
206-884-1082

Additional Offices

Seattle Children's
CSB-200 - Adolescent Medicine
PO Box 5371
Seattle, WA 98145-5005
206-987-2028
University of Washington
UW Box 356320 - Pediatrics
1959 NE Pacific St
Seattle, WA 98195-6320
206-987-2150

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