Profile

Philip G. Morgan, MD

Philip G. Morgan, MD

Anesthesia, Mitochondrial Medicine

On staff since June 2008

Children's Title: Interim Director, Center for Developmental Therapeutics

Academic Title: Professor in the Department of Anesthesiology and Pain Medicine, University of Washington

Research Center: Center for Developmental Therapeutics

Making a Difference

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Overview

Board Certification(s)

Anesthesiology

Medical/Professional School

University of Colorado School of Medicine, Aurora
University of Colorado at Boulder, Boulder

Residency

Anesthesiology, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland

Fellowship

Pediatrics, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland
Anesthesiology, University of Washington, Seattle
Anesthesiology, University of Washington, Seattle

Research Description

We study the effects of genetic changes on mitochondrial function. Our primary work is in the nematode C. elegans. However, we are extending our studies to the effects of anesthetics on mitochondrial function in humans. We are also studying the mechanism of action of volatile anesthetics. These studies also focus on the genetic control of anesthetic sensitivity using the nematode C. elegans.

About My Work

http://www.seattlechildrens.org/research/developmental-therapeutics/labs-programs/program-mitochondrial-biology/morgan-laboratory/

Research Focus Area

Pharmacology, Neuroscience / Neurodevelopment, Genetics and Developmental Biology

Awards and Honors

Award Name Award Description Awarded By Award Date
E I "Ted" Eger Lecture Western Anesthesia Residents Conference, Seattle, WA March 2015
Best Abstract United Mitochondrial Disease Foundation July 2014
Best Abstracts, 2012 ASA 2012
Best Abstracts 2011 ASA Meeting 2011

Publications

  • Higdon R, Kolker N, Bauman AT, Ilkayeva O, Newgard CB, Kolker E, Steele LM, Sedensky MM
    Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans
    Mitochondrion , 2015 : 2095-102
  • Dancy BM, Sedensky MM
    Mitochondrial bioenergetics and disease in Caenorhabditis elegans
    Front Biosci , 2015 : 20198-228
  • D’Almeida RE, Alberto MR, Sedensky MM, Isla MI
    Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
    Acta Parasitologica , 2015 : 60164-172
  • Eckenhoff RG
    Forward to the Past. Editorial
    Anesth Analg , 2015 : 120259-60
  • Hsieh V
    Muscle Disorders
    Smith’s Anesthesia for Infants and Children, ed. Peter Davis, Mosby , 2015
  • Hsieh V
    Myopathies of the Newborn
    Essentials of Anesthesia for Infants and Neonates, eds. Mary Ellen McCann, Kai Matthes & Christine Greco, Cambridge University Press , 2015
  • 2. Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R, Anselm I, Cohen BH, Falk MJ, Greene C, Gropman AL, Haas R, Hirano M, Sims K, Tarnopolsky M, Van Hove JL, Wolfe L, DiMauro S
    Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society
    doi: 10.1038/gim.2014.177 Genet Med , 2014 Dec. 11 : [Epub ahead of print]
  • Kajimoto M, Atkinson DB, Ledee DR, Kayser, EB, Morgan PG, Sedensky MM, Isern NG, Des Rosiers C, Portman MA
    Propofol compared to isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex
    J Cereb Blood Flow Metab , 2014 : 34(3)514-21
  • Kayser EB, Sedensky MM
    Brain regions prone to neurodegeneration in the Ndufs4 KO mouse yield synaptosomes with low capacity to respire
    UMDF , 2014
  • Dancy B, Sedensky MM
    A maladaptive glutathione S-transferase in mitochondrial dysfunction
    UMDF , 2014
  • Gentry KR, Na H-S, Brockway NL, Sedensky MM
    Inhibition of isoflurane-induced neurotoxicity
    ASA meeting , 2014
  • Jung S, Sedensky MM
    Molecular mechanisms of ketamine resistance in Ndufs4-KO mice
    ASA meeting , 2014
  • Philip G. Morgan, MD, Sedensky, M., Suthammarak, W., Opheim, E., Somerlot, B
    Novel Interactions between Mitochondrial Superoxide Dismutases and the Electron Transport Chain
    Aging Cell , 2013 : 12(6)239-50
  • Philip G. Morgan, MD, Gentry, K., Steele, L. M., Sedensky, M
    Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
    Anesthesia and Analgesia , 2013 : 116185-189
  • Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko B, Ramos FJ, Palmiter R, Rabinovitch P, Morgan PG, Sedensky MM, Kaeberlein M
    mTOR Inhibition by Rapamycin Alleviates Mitochondrial Disease 1! in the Ndufs4 -/- Mouse Model of Leigh Syndrome
    Science , 2013 : epub ahead of print
  • Morgan PG, Kayser EB, Sedensky MM
    Capacity for oxidative phosphorylation does not decline with age in mitochondria from Ndufs4 knockout mice
  • Sedensky MM, Kayser EB, Morgan PG
    Region specific differences in oxidative phosphorylation in mitochondria from Ndufs4 knockout mice
  • Morgan PG, Kayser EB, Sedensky MM
    Region specific differences in oxidative phosphorylation in mitochondria from Ndufs4 knockout mice
  • Kayser EB, Sedensky MM, Morgan PG
    Capacity for oxidative phosphorylation does not decline with age in mitochondria from Ndufs4 knockout mice
  • Sedensky MM, Morgan PG
    Excitatory Synaptic Transmission is Depressed in a Mutant Mouse With Anesthetic Hypersensitivity
  • Sedensky MM, Morgan PG
    Glutamatergic Cell-Specific Mutations in Complex I Control Volatile Anesthetic Sensitivity
  • Sedensky MM, Morgan PG
    Genetics and the evolution of the anesthetic response.
    18713894 Anesthesia and analgesia , 2008 Sept. : 855-8
  • Falk MJ, Kayser EB, Morgan PG, Sedensky MM
    Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.
    16920626 Current biology : CB , 2006 Aug. 22 : 1641-5
  • Sedensky MM, Morgan PG
    Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.
    16497463 Experimental gerontology , 2006 Mar. : 237-45
  • Karamanlidis, G., Tian, R., Sedensky, M., Kolwicz, S., Wang, W., Suthammarak, W., Lee, C. F., Garcia-Menendez, L., Gong, G
    Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
    Cell Metabolism : 18239-250
  • Philip G. Morgan, MD, Sedensky, M., Williams, M. A
    Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
    Clinicial Laboratory : 59655-60
  • Philip G. Morgan, MD, Niezgoda, J
    Anesthetic considerations in patients with mitochondrial defects
    Pediatric Anesthesia : 23785-793
  • Morgan, P., Qui, C., Havner, K., Abetew, D., Sedensky, M., Enquobahrie, D. A., Williams, M. A.
    Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
    Clinicial Laboratory
  • Morgan, P., Gentry, K. R., Steele, L. M., Sedensky, M.
    Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
    Anesthesia and Analgesia
  • Morgan, P., Singaram, V. K., Sedensky, M.
    Anesthetic Mechanisms: The worm sheds light on anesthetic mechanisms
    Worm : 1(3)1-6
  • Morgan, P., Quintana, A., Kruse, S. E., Palmiter, R. D., Sedensky, M.
    Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
    PLoS One : 7e42904

Presentations

Presentations Title Event Location Date
Anesthetic Sensitivity and Mitochondria 9th International Conference on Anesthetic Mechanisms Bonn, Germany June 18, 2015
Anesthetics and Mitochondria University of Washington, Mitochondrial Interest Group Seattle, WA May 1, 2015
Anesthetic Effects on Mitochondria University of Pennsylvania, Dept. Anesthesiology, Research in Progress Philadelphia, PA April 15, 2015
The role of mitochondrial dysfunction in aging and anesthetic behavior Pathology Presents Symposium Series, University of Washington Seattle, WA Nov. 19, 2014
The interactions of anesthetics and perioperative medications with mitochondrial disease. United Mitochondrial Disease Foundation Newport Beach, CA June 11, 2013
Anesthetic care of patients with myotonia vs. mitochondrial disease International Anesthesia Research Society San Diego, CA May 5, 2013

Research Funding

Grant Title Grantor Amount Award Date
A mouse model linking mitochondrial function to anesthetic sensitivity. National Institute of Health Grant 2014 - 2018
Neurotoxic effects of volatile anesthetics NIH 2011 - 2014
ITHS Small Grant ITHS $20000