Profile

Philip G. Morgan, MD

Philip G. Morgan, MD

Anesthesia, Mitochondrial Medicine

On staff since June 2008

Children's Title: Program Director, Research

Research Center: Center for Developmental Therapeutics

Making A Difference

  • A Thriving Biomedical Community

    Partnering with UW and the Hutchinson Center for world-class science. ... cont.

  • Families Fuel Discovery

    Many rare and devastating diseases lack effective treatments or cures. The faith, funds and passion of families of our patients jump-start the search for answers that will help seriously ill children lead healthier lives. ... cont.

Overview

Board Certification(s)

Anesthesiology

Medical/Professional School

University of Colorado School of Medicine, Aurora
University of Colorado at Boulder, Boulder

Residency

Anesthesiology, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland

Fellowship

Pediatrics, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland
Anesthesiology, University of Washington, Seattle
Anesthesiology, University of Washington, Seattle

Research Description

We study the effects of genetic changes on mitochondrial function. Our primary work is in the nematode C. elegans. However, we are extending our studies to the effects of anesthetics on mitochondrial function in humans. We are also studying the mechanism of action of volatile anesthetics. These studies also focus on the genetic control of anesthetic sensitivity using the nematode C. elegans.

Lab URL

http://www.seattlechildrens.org/research/developmental-therapeutics/labs-programs/program-mitochondrial-biology/morgan-laboratory/

Research Focus Area

Pharmacology, Neuroscience / Neurodevelopment, Genetics and Developmental Biology

Awards and Honors

Award Name Award Description Awarded By Award Date
Best Abstracts, 2012 ASA 2012
Best Abstracts 2011 ASA Meeting 2011

Publications

  • Philip G. Morgan, MD
    Propofol compared to isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex
    J Cereb Blood Flow Metab , 2014 : 34(3)514-21
  • Philip G. Morgan, MD
    Novel Interactions between Mitochondrial Superoxide Dismutases and the Electron Transport Chain
    Aging Cell , 2013 : 12(6)239-50
  • Philip G. Morgan, MD
    Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
    Anesthesia and Analgesia , 2013 : 116185-189
  • Philip G. Morgan, MD
    mTOR Inhibition by Rapamycin Alleviates Mitochondrial Disease 1! in the Ndufs4 -/- Mouse Model of Leigh Syndrome
    Science , 2013 : epub ahead of print
  • Capacity for oxidative phosphorylation does not decline with age in mitochondria from Ndufs4 knockout mice
  • Region specific differences in oxidative phosphorylation in mitochondria from Ndufs4 knockout mice
  • Region specific differences in oxidative phosphorylation in mitochondria from Ndufs4 knockout mice
  • Capacity for oxidative phosphorylation does not decline with age in mitochondria from Ndufs4 knockout mice
  • Excitatory Synaptic Transmission is Depressed in a Mutant Mouse With Anesthetic Hypersensitivity
  • Glutamatergic Cell-Specific Mutations in Complex I Control Volatile Anesthetic Sensitivity
  • Sedensky MM, Morgan PG
    Genetics and the evolution of the anesthetic response.
    Anesthesia and analgesia , 2008 Sept. : 855-8
  • Falk MJ, Kayser EB, Morgan PG, Sedensky MM
    Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.
    Current biology : CB , 2006 Aug. 22 : 1641-5
  • Sedensky MM, Morgan PG
    Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.
    Experimental gerontology , 2006 Mar. : 237-45
  • Philip G. Morgan, MD
    Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
    Cell Metabolism : 18239-250
  • Philip G. Morgan, MD
    Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
    Clinicial Laboratory : 59655-60
  • Philip G. Morgan, MD
    Anesthetic considerations in patients with mitochondrial defects
    Pediatric Anesthesia : 23785-793
  • Philip G. Morgan, MD
    Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
    Clinicial Laboratory
  • Philip G. Morgan, MD
    Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
    Anesthesia and Analgesia
  • Philip G. Morgan, MD
    Anesthetic Mechanisms: The worm sheds light on anesthetic mechanisms
    Worm : 1(3)1-6
  • Philip G. Morgan, MD
    Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
    PLoS One : 7e42904

Presentations

Presentations Title Event Location Date
The interactions of anesthetics and perioperative medications with mitochondrial disease. United Mitochondrial Disease Foundation Newport Beach, CA June 11, 2013
Anesthetic care of patients with myotonia vs. mitochondrial disease International Anesthesia Research Society San Diego, CA May 5, 2013

Research Funding

Grant Title Grantor Amount Award Date
A mouse model linking mitochondrial function to anesthetic sensitivity. National Institute of Health Grant 2014 - 2018
Neurotoxic effects of volatile anesthetics NIH 2011 - 2014
ITHS Small Grant ITHS $20000