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Philip G. Morgan, MD

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Philip G. Morgan, MD

Anesthesia, Mitochondrial Medicine

On staff since June 2008

Children's Title: Program Director, Research

Research Center: Center for Developmental Therapeutics

Making a Difference

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Overview

Board Certification(s)
Anesthesiology
Medical/Professional School
University of Colorado School of Medicine, Aurora
University of Colorado at Boulder, Boulder
Residency
Anesthesiology, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland
Fellowship
Pediatrics, University Hospitals of Cleveland Attn: Faculty Affairs, Cleveland
Anesthesiology, University of Washington, Seattle
Anesthesiology, University of Washington, Seattle
Research Description

We study the effects of genetic changes on mitochondrial function. Our primary work is in the nematode C. elegans. However, we are extending our studies to the effects of anesthetics on mitochondrial function in humans. We are also studying the mechanism of action of volatile anesthetics. These studies also focus on the genetic control of anesthetic sensitivity using the nematode C. elegans.

Lab URL

http://www.seattlechildrens.org/research/developmental-therapeutics/labs-programs/program-mitochondrial-biology/morgan-laboratory/

Research Focus Area

Pharmacology, Neuroscience / Neurodevelopment, Genetics and Developmental Biology

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Best Abstracts, 2012ASA 2012
Best Abstracts2011 ASA Meeting 2011

Publications

Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
Anesthesia and Analgesia , 2013: 116185-189
Genetics and the evolution of the anesthetic response.
Anesthesia and analgesia , 2008 Sep: 855-8
Mitochondrial complex I function modulates volatile anesthetic sensitivity in C. elegans.
Current biology : CB , 2006 Aug 22: 1641-5
Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants.
Experimental gerontology , 2006 Mar: 237-45
Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
PLoS One , : 7e42904
Anesthetic Mechanisms: The worm sheds light on anesthetic mechanisms
Worm , : 1(3)1-6
Early developmental exposure to volatile anesthetics causes behavioral defects in C. elegans
Anesthesia and Analgesia ,
Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
Clinicial Laboratory ,
Anesthetic considerations in patients with mitochondrial defects
Pediatric Anesthesia , : 23785-793
Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A Pilot Study
Clinicial Laboratory , : 59655-60
Novel Interactions between Mitochondrial Superoxide Dismutases and the Electron Transport Chain
Aging Cell, NA ,
Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure
Cell Metabolism , : 18239-250

Research Funding

Grant TitleGrantorAmountAward Date
Neurotoxic effects of volatile anestheticsNIH 2011 - 2013
ITHS Small GrantITHS $20000

Primary Office

Seattle Children's
MB.11.500.3 - Anesthesia Administration
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2518

Additional Offices

Seattle Children's Research Institute
JMB - 9 - Developmental Therapeutics
1900 - 9th Ave
Seattle, WA 98101

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