Profile

Nam Gyun Kim, PhD

"What makes organs stop growing when they reach a certain size in the process of animal development? How organ size is regulated has been the fundamental question of biologists. Organ size control is a highly coordinated and complex process that relies on precisely controlled cell proliferation by cell density. This so-called contact inhibition of proliferation is a cellular mechanism that limits proliferation when cells reach confluence. It is a well-known property of normal differentiated tissues and needs to be tightly regulated during tissue morphogenesis, regeneration and wound healing process. Uncontrolled growth by the loss of contact inhibition of proliferation is a hallmark of solid tumors. The Hippo signaling pathway has been implicated in contact inhibition of proliferation as well as organ size control. It controls the activity of transcription factor YAP (Yes-associated protein) and TEAD (TEA domain family member). Recent studies identify the YAP/TEAD as a promoter of carcinogenesis as well as chemoresistance in various cancers including liver, breast and ovarian cancers. My goal at Seattle Children's Research Institute is to find a way to control the YAP-TEAD activity in cancer cells. I hope that it will provide an additional avenue for cancer therapy to prevent carcinogenesis and decrease chemoresistance."

  • Dr. Nam Gyun Kim received a PhD in Medical Sciences from Yonsei University College of Medicine, Seoul, Korea. He completed postdoctoral fellowships at the University of Michigan and the University of Virginia. He is currently an acting assistant professor as a member of Dr. Gumbiners research team within the Department of Pediatrics at the University of Washington School of Medicine and the Seattle Children's Research Institute's Center for Developmental Biology and Regenerative Medicine.

  • Award Name Award Description Awarded By Award Date
    GlaxoSmithKline award Korean Cancer Association 1999
    • Kim NG, Gumbiner BM
      Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
      26216901 The Journal of cell biology , 2015 Aug. 3 : 210(3)503-15 PMCID: PMC4523609
    • Gumbiner BM, Kim NG
      The Hippo-YAP signaling pathway and contact inhibition of growth.
      24532814 Journal of cell science , 2014 Feb. 15 : 127(Pt 4)709-17 PMCID: PMC3924201
    • Fan R, Kim NG, Gumbiner BM
      Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1.
      23359693 Proceedings of the National Academy of Sciences of the United States of America , 2013 Feb. 12 : 110(7)2569-74 PMCID: PMC3574943
    • Kim NH, Kim HS, Kim NG, Lee I, Choi HS, Li XY, Kang SE, Cha SY, Ryu JK, Na JM, Park C, Kim K, Lee S, Gumbiner BM, Yook JI, Weiss SJ
      p53 and microRNA-34 are suppressors of canonical Wnt signaling.
      22045851 Science signaling , 2011 Nov. 1 : 4(197)ra71 PMCID: PMC3447368
    • Kim NG, Koh E, Chen X, Gumbiner BM
      E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.
      21730131 Proceedings of the National Academy of Sciences of the United States of America , 2011 July 19 : 108(29)11930-5 PMCID: PMC3141988
    • Xu C, Kim NG, Gumbiner BM
      Regulation of protein stability by GSK3 mediated phosphorylation.
      19923896 Cell cycle (Georgetown, Tex.) , 2009 Dec. 15 : 8(24)4032-9 PMCID: PMC2824240
    • Kim NG, Xu C, Gumbiner BM
      Identification of targets of the Wnt pathway destruction complex in addition to beta-catenin.
      19289839 Proceedings of the National Academy of Sciences of the United States of America , 2009 Mar. 31 : 106(13)5165-70 PMCID: PMC2663984
    • You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H
      Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.
      17456004 PLoS biology , 2007 May : 5(5)e109 PMCID: PMC1854916
    • Koh KH, Kang HJ, Li LS, Kim NG, You KT, Yang E, Kim H, Kim HJ, Yun CO, Kim KS, Kim H
      Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas.
      16025146 Laboratory investigation; a journal of technical methods and pathology , 2005 Sept. : 85(9)1130-8
    • Kang HJ, Nam SW, Kim H, Rhee H, Kim NG, Kim H, Hyung WJ, Noh SH, Kim JH, Yun CO, Liu ET, Kim H
      Correlation of KIT and platelet-derived growth factor receptor alpha mutations with gene activation and expression profiles in gastrointestinal stromal tumors.
      15690055 Oncogene , 2005 Feb. 3 : 24(6)1066-74
    • Li LS, Kim NG, Kim SH, Park C, Kim H, Kang HJ, Koh KH, Kim SN, Kim WH, Kim NK, Kim H
      Chromosomal imbalances in the colorectal carcinomas with microsatellite instability.
      14507650 The American journal of pathology , 2003 Oct. : 163(4)1429-36 PMCID: PMC1868319
    • Choi YR, Kim H, Kang HJ, Kim NG, Kim JJ, Park KS, Paik YK, Kim HO, Kim H
      Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation.
      12727838 Cancer research , 2003 May 1 : 63(9)2188-93
    • Kim H, Kim YH, Kim SE, Kim NG, Noh SH, Kim H
      Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability.
      12692837 The Journal of pathology , 2003 May : 200(1)23-31
    • Chung KY, Kim NG, Li LS, Kim H, Kim H, Nam CM, Kim H, Shin DH
      Clinicopathologic characteristics related to the high variability of coding mononucleotide repeat sequences in tumors with high-microsatellite instability.
      12579286 Oncology reports , 2003 Mar. : 10(2)439-44
    • Chang J, Kim NG, Piao Z, Park C, Park KS, Paik YK, Lee WJ, Kim BR, Kim H
      Assessment of chromosomal losses and gains in hepatocellular carcinoma.
      12048165 Cancer letters , 2002 Aug. 28 : 182(2)193-202
    • Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H
      Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability.
      12140758 Oncogene , 2002 Aug. 1 : 21(33)5081-7
    • Park KS, Kim H, Kim NG, Cho SY, Choi KH, Seong JK, Paik YK
      Proteomic analysis and molecular characterization of tissue ferritin light chain in hepatocellular carcinoma.
      12029631 Hepatology (Baltimore, Md.) , 2002 June : 35(6)1459-66
    • Kim YH, Kim NG, Lim JG, Park C, Kim H
      Chromosomal alterations in paired gastric adenomas and carcinomas.
      11159202 The American journal of pathology , 2001 Feb. : 158(2)655-62 PMCID: PMC1850314
    • Kim NG, Choi YR, Baek MJ, Kim YH, Kang H, Kim NK, Min JS, Kim H
      Frameshift mutations at coding mononucleotide repeats of the hRAD50 gene in gastrointestinal carcinomas with microsatellite instability.
      11196187 Cancer research , 2001 Jan. 1 : 61(1)36-8
    • Baek MJ, Piao Z, Kim NG, Park C, Shin EC, Park JH, Jung HJ, Kim CG, Kim H
      p16 is a major inactivation target in hepatocellular carcinoma.
      10897001 Cancer , 2000 July 1 : 89(1)60-8
    • Kim NG, Chae JH, Choe SY, Kim CG
      Reporter constructs showing proper globin gene switching in cultured erythroid cell lines.
      10901166 Molecules and cells , 2000 June 30 : 10(3)281-8
    • Kim NG, Kim JJ, Ahn JY, Seong CM, Noh SH, Kim CB, Min JS, Kim H
      Putative chromosomal deletions on 9P, 9Q and 22Q occur preferentially in malignant gastrointestinal stromal tumors.
      10699941 International journal of cancer , 2000 Mar. 1 : 85(5)633-8
    • Kim NG, Roh JK, Kim JH, Chung WY, Park CS, Kim H
      Clonality analysis using methylation-specific polymerase chain reaction: a novel method for investigating tumor clonality.
      10616221 Laboratory investigation; a journal of technical methods and pathology , 1999 Dec. : 79(12)1727-9
    • Park KS, Kim NG, Kim JJ, Kim H, Ahn YH, Choi KY
      Differential regulation of MAP kinase cascade in human colorectal tumorigenesis.
      10584870 British journal of cancer , 1999 Dec. : 81(7)1116-21 PMCID: PMC2374318
    • Kim JJ, Baek MJ, Kim L, Kim NG, Lee YC, Song SY, Noh SH, Kim H
      Accumulated frameshift mutations at coding nucleotide repeats during the progression of gastric carcinoma with microsatellite instability.
      10496529 Laboratory investigation; a journal of technical methods and pathology , 1999 Sept. : 79(9)1113-20
    • Piao Z, Kim NG, Kim H, Park C
      Deletion mapping on the short arm of chromosome 8 in hepatocellular carcinoma.
      10378798 Cancer letters , 1999 Apr, 26 : 138(1-2)227-32

  • Presentations Title Event Location Date
    Src and FAK kinases integrate extracellular signaling to Hippo pathway Gordon Research Conference: Signaling by Adhesion Receptors Lewiston, ME June 25, 2014

Overview

Research Description

Dr. Nam Gyun Kim investigates the regulatory mechanisms of contact inhibition of proliferation, which inhibits cell division when the cell reaches their stationary density. It is important in embryonic development, tissue regeneration and organ size control, and the loss of contact inhibition of proliferation is a hallmark of solid tumors.