Profile

Michele Shaffer, PhD

Michele Shaffer, PhD

Gastroenterology and Hepatology Research

Children's Title: Co-Director, Seattle Children's Core for Biomedical Statistics

Academic Title: Associate Professor of Pediatrics, Division of Gastroenterology

Research Center: Center for Clinical and Translational Research

"As a statistician, I participate in the design, monitoring, and analysis of research studies. I believe study design is fundamentally the most important element of conducting research it is the strong foundation on which the findings of the study will rest. My mission is to collaborate with pediatric researchers to design the best studies to address their research questions. In doing so we can speed the discovery of optimal care and new therapies, making meaningful improvements in child health."

  • Dr. Shaffer is a collaborative biostatistician with more than a decade of experience working with clinical investigators and physician scientists, including projects funded by the NIH and CDC. She was Associate Professor in the Department of Public Health Sciences, Division of Biostatistics and Bioinformatics with a joint appointment in the Department of Pediatrics at Penn State College of Medicine until 2012, when she left to join Seattle Childrens Research Institute and in 2013 the University of Washington Department of Pediatrics. She has expertise in the design and conduct of both longitudinal observational studies and clinical trials. She has experience with multicenter data coordination, serving as the PI of the Data Coordinating Center for the Prophylaxis of Early Adrenal Insufficiency to Prevent Chronic Lung Disease in the Tiny Baby (PROPHET) study and co-I of the Data Coordination and Analyses Center for the Community & Child Health Network, both funded by the NICHD. She has been active in Clinical and Translational Science Awards, both at Penn State and at the University of Washington and Seattle Childrens. She currently directs the Childrens Core for Biomedical Statistics which provides data management as well as study design and analyses for the support of basic science, translational, and clinical studies at Seattle Childrens. She has long-running collaborations for palliative care and gastroenterology studies. She has contributed to the statistical literature in the areas of missing or unobserved data, modeling studies in heterogeneous populations, and clustered data analysis. Her current research interests are n-of-1 clinical trials, design and analysis of studies of the microbiome, and use of machine learning methods for building predictive algorithms.

  • Award Name Award Description Awarded By Award Date
    Deans Award for Excellence in Teaching Penn State College of Medicine 2011
    • Suskind DL, Cohen SA, Brittnacher MJ, Wahbeh G, Lee D, Shaffer ML, Braly K, Hayden HS, Klein J, Gold B, Giefer M, Stallworth A, Miller SI
      Clinical and Fecal Microbial Changes With Diet Therapy in Active Inflammatory Bowel Disease.
      28030510 Journal of clinical gastroenterology , 2016 Dec. 27 - 2016 Dec. 27
    • Cunningham C, Cho E, Shaffer ML, Bradford MC, Palermo T
      Screening for Psychosocial and Family Risk in Pediatric Gastrointestinal Disorders.
      27875504 Journal of pediatric gastroenterology and nutrition , 2016 Dec. - 2016 Dec. : 63(6)e158-e162 PMCID: PMC5127394
    • Shaffer ML, D'Agata EM, Habtemariam D, Mitchell SL
      Examining the relationship between multidrug-resistant organism acquisition and exposure to antimicrobials in long-term care populations: a review.
      27751631 Annals of epidemiology , 2016 Nov. - 2016 Nov. : 26(11)810-815 PMCID: PMC5119547
    • Suskind DL, Wahbeh G, Cohen SA, Damman CJ, Klein J, Braly K, Shaffer M, Lee D
      Patients Perceive Clinical Benefit with the Specific Carbohydrate Diet for Inflammatory Bowel Disease.
      27638834 Digestive diseases and sciences , 2016 Nov. - 2016 Nov. : 61(11)3255-3260
    • Wahbeh GT, Lawless ME, Suskind DL, Shaffer ML, Cole B
      Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis.
      26465789 Journal of pediatric gastroenterology and nutrition , 2016 May - 2016 May : 62(5)728-33
    • Rosenberg AR, Bona K, Wharton CM, Bradford M, Shaffer ML, Wolfe J, Baker KS
      Adolescent and Young Adult Patient Engagement and Participation in Survey-Based Research: A Report From the "Resilience in Adolescents and Young Adults With Cancer" Study.
      26681427 Pediatric blood and cancer , 2016 Apr, - 2016 Apr, : 63(4)734-6 PMCID: PMC4755794
    • Obih C, Wahbeh G, Lee D, Braly K, Giefer M, Shaffer ML, Nielson H, Suskind DL
      Specific carbohydrate diet for pediatric inflammatory bowel disease in clinical practice within an academic IBD center.
      26655069 Nutrition (Burbank, Los Angeles County, Calif.) , 2016 Apr, - 2016 Apr, : 32(4)418-25
    • Williams O, DeSorbo A, Sawyer V, Apakama D, Shaffer M, Gerin W, Noble J
      Hip Hop HEALS: Pilot Study of a Culturally Targeted Calorie Label Intervention to Improve Food Purchases of Children.
      26272785 Health education and behavior : the official publication of the Society for Public Health Education , 2016 Feb. - 2016 Feb. : 43(1)68-75
    • Dufour AB, Shaffer ML, D'Agata EM, Habtemariam D, Mitchell SL
      Survival After Suspected Urinary Tract Infection in Individuals with Advanced Dementia.
      26613981 Journal of the American Geriatrics Society , 2015 Dec. - 2015 Dec. : 63(12)2472-2477 PMCID: PMC4688100
    • Givens JL, Spinella S, Ankuda CK, D'Agata E, Shaffer ML, Habtemariam D, Mitchell SL
      Healthcare Proxy Awareness of Suspected Infections in Nursing Home Residents with Advanced Dementia.
      26031905 Journal of the American Geriatrics Society , 2015 June - 2015 June : 63(6)1084-90 PMCID: PMC4478162
    • Roth CL, Eslamy H, Werny D, Elfers C, Shaffer ML, Pihoker C, Ojemann J, Dobyns WB
      Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity.
      25884561 Obesity (Silver Spring, Md.) , 2015 June - 2015 June : 23(6)1226-33 PMCID: PMC5029599
    • Suskind DL, Brittnacher MJ, Wahbeh G, Shaffer ML, Hayden HS, Qin X, Singh N, Damman CJ, Hager KR, Nielson H, Miller SI
      Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease.
      25647155 Inflammatory bowel diseases , 2015 Mar. : 21(3)556-63 PMCID: PMC4329080
    • Suskind DL, Brittnacher MJ, Wahbeh G, Shaffer ML, Hayden HS, Qin X, Singh N, Damman CJ, Hager KR, Nielson H, Miller SI
      Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease.
      25647155 Inflammatory bowel diseases , 2015 Mar. : 21(3)556-63 PMCID: PMC4329080
    • Suskind DL, Brittnacher MJ, Wahbeh G, Shaffer ML, Hayden HS, Qin X, Singh N, Damman CJ, Hager KR, Nielson H, Miller SI
      Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease.
      25647155 Inflammatory bowel diseases , 2015 Mar. - 2015 Mar. : 21(3)556-63 PMCID: PMC4329080
    • Fernandez-Mendoza J, Shaffer ML, Olavarrieta-Bernardino S, Vgontzas AN, Calhoun SL, Bixler EO, Vela-Bueno A
      Cognitive-emotional hyperarousal in the offspring of parents vulnerable to insomnia: a nuclear family study.
      24889269 Journal of sleep research , 2014 Oct. : 23(5)489-98
    • Mitchell SL, Shaffer ML, Loeb MB, Givens JL, Habtemariam D, Kiely DK, D'Agata E
      Infection management and multidrug-resistant organisms in nursing home residents with advanced dementia.
      25133863 JAMA internal medicine , 2014 Oct. : 174(10)1660-7 PMCID: PMC4188742
    • Mitchell SL, Shaffer ML, Loeb MB, Givens JL, Habtemariam D, Kiely DK, D'Agata E
      Infection management and multidrug-resistant organisms in nursing home residents with advanced dementia.
      25133863 JAMA internal medicine , 2014 Oct. - 2014 Oct. : 174(10)1660-7 PMCID: PMC4188742
    • Fernandez-Mendoza J, Shaffer ML, Olavarrieta-Bernardino S, Vgontzas AN, Calhoun SL, Bixler EO, Vela-Bueno A
      Cognitive-emotional hyperarousal in the offspring of parents vulnerable to insomnia: a nuclear family study.
      24889269 Journal of sleep research , 2014 Oct. - 2014 Oct. : 23(5)489-98
    • Bramley H, Mcfarland C, Lewis MM, Shaffer ML, Cilley R, Engbrecht B, Santos M, Rzucidlo S, Shirk B, Simmons L, Dias MS
      Short-term outcomes of sport- and recreation-related concussion in patients admitted to a pediatric trauma service.
      24790025 Clinical pediatrics , 2014 July - 2014 July : 53(8)784-90
    • Rosenberg AR, Wolfe J, Bradford MC, Shaffer ML, Yi-Frazier JP, Curtis JR, Syrjala KL, Baker KS
      Resilience and psychosocial outcomes in parents of children with cancer.
      24249426 Pediatric blood and cancer , 2014 Mar. - 2014 Mar. : 61(3)552-7 PMCID: PMC4066960
    • Lee EY, Sen S, Eslinger PJ, Wagner D, Shaffer ML, Kong L, Lewis MM, Du G, Huang X
      Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients.
      23932064 Parkinsonism & related disorders , 2013 Dec. : 19(12)1088-93 PMCID: PMC3858507
    • Lee EY, Sen S, Eslinger PJ, Wagner D, Shaffer ML, Kong L, Lewis MM, Du G, Huang X
      Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients.
      23932064 Parkinsonism & related disorders , 2013 Dec. : 19(12)1088-93 PMCID: PMC3858507
    • Lee EY, Sen S, Eslinger PJ, Wagner D, Shaffer ML, Kong L, Lewis MM, Du G, Huang X
      Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients.
      23932064 Parkinsonism and related disorders , 2013 Dec. - 2013 Dec. : 19(12)1088-93 PMCID: PMC3858507
    • Singareddy R, Krishnamurthy VB, Vgontzas AN, Fernandez-Mendoza J, Calhoun SL, Shaffer ML, Bixler EO
      Subjective and objective sleep and self-harm behaviors in young children: a general population study.
      23623452 Psychiatry research , 2013 Oct. 30 - 2013 Oct. 30 : 209(3)549-53 PMCID: PMC3742723
    • DeSorbo AL, Noble JM, Shaffer M, Gerin W, Williams OA
      The use of an audience response system in an elementary school-based health education program.
      23086554 Health education & behavior : the official publication of the Society for Public Health Education , 2013 Oct. : 40(5)531-5
    • Pejovic S, Basta M, Vgontzas AN, Kritikou I, Shaffer ML, Tsaoussoglou M, Stiffler D, Stefanakis Z, Bixler EO, Chrousos GP
      Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance.
      23941878 American journal of physiology. Endocrinology and metabolism , 2013 Oct. 1 - 2013 Oct. 1 : 305(7)E890-6 PMCID: PMC3798707
    • Meyers JM, Greecher CP, Shaffer ML, Shenberger JS
      Potential influence of total parenteral nutrition on body composition at discharge in preterm infants.
      23578184 The journal of maternal-fetal and neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians , 2013 Oct. - 2013 Oct. : 26(15)1548-53
    • DeSorbo AL, Noble JM, Shaffer M, Gerin W, Williams OA
      The use of an audience response system in an elementary school-based health education program.
      23086554 Health education and behavior : the official publication of the Society for Public Health Education , 2013 Oct. - 2013 Oct. : 40(5)531-5 PMCID: PMC5112758
    • Dolbier CL, Rush TE, Sahadeo LS, Shaffer ML, Thorp J, Community Child Health Network Investigators
      Relationships of race and socioeconomic status to postpartum depressive symptoms in rural African American and non-Hispanic white women.
      22961387 Maternal and child health journal , 2013 Sept. : 17(7)1277-87 PMCID: PMC3584227
    • Dolbier CL, Rush TE, Sahadeo LS, Shaffer ML, Thorp J, Community Child Health Network Investigators.
      Relationships of race and socioeconomic status to postpartum depressive symptoms in rural African American and non-Hispanic white women.
      22961387 Maternal and child health journal , 2013 Sept. - 2013 Sept. : 17(7)1277-87 PMCID: PMC3584227
    • Lloyd T, Shaffer ML, Christy S, Widome MD, Repke J, Weitekamp MR, Eslinger PJ, Bargainnier SS, Paul IM
      Health knowledge among the millennial generation.
      25170479 Journal of public health research , 2013 July 22 - 2013 July 22 : 2(1)38-41 PMCID: PMC4140324
    • Lewis MM, Du G, Kidacki M, Patel N, Shaffer ML, Mailman RB, Huang X
      Higher iron in the red nucleus marks Parkinson's dyskinesia.
      23177595 Neurobiology of aging , 2013 May - 2013 May : 34(5)1497-503 PMCID: PMC3570638
    • Lloyd T, Shaffer ML, Christy S, Widome MD, Repke J, Weitekamp MR, Eslinger PJ, Bargainnier SS, Paul IM
      Health knowledge among the millennial generation.
      25170479 Journal of public health research , 2013 Apr, 28 : 2(1)38-41 PMCID: PMC4140324
    • Terndrup TE, Ali S, Hulse S, Shaffer M, Lloyd T
      Multimedia education increases elder knowledge of emergency department care.
      23599848 The western journal of emergency medicine , 2013 Mar. - 2013 Mar. : 14(2)132-6 PMCID: PMC3628460
    • Fernandez-Mendoza J, Vgontzas AN, Liao D, Shaffer ML, Vela-Bueno A, Basta M, Bixler EO
      Response to poor sleep with normal sleep duration: a preventive effect on incident hypertension.
      23444458 Hypertension (Dallas, Tex. : 1979) , 2013 Feb. - 2013 Feb. : 61(2)e12
    • Mitchell SL, Shaffer ML, Kiely DK, Givens JL, D'Agata E
      The study of pathogen resistance and antimicrobial use in dementia: study design and methodology.
      22925431 Archives of gerontology and geriatrics , 2013 Jan. : 56(1)16-22 PMCID: PMC3502703
    • Mitchell SL, Shaffer ML, Kiely DK, Givens JL, D'Agata E
      The study of pathogen resistance and antimicrobial use in dementia: study design and methodology.
      22925431 Archives of gerontology and geriatrics , 2013 Jan. - 2013 Jan. : 56(1)16-22 PMCID: PMC3502703
    • Du G, Lewis MM, Sen S, Wang J, Shaffer ML, Styner M, Yang QX, Huang X
      Imaging nigral pathology and clinical progression in Parkinson's disease.
      23008179 Movement disorders : official journal of the Movement Disorder Society , 2012 Nov. : 27(13)1636-43 PMCID: PMC3510346
    • Du G, Lewis MM, Sen S, Wang J, Shaffer ML, Styner M, Yang QX, Huang X
      Imaging nigral pathology and clinical progression in Parkinson's disease.
      23008179 Movement disorders : official journal of the Movement Disorder Society , 2012 Nov. - 2012 Nov. : 27(13)1636-43 PMCID: PMC3510346
    • Thomas NJ, Guardia CG, Moya FR, Cheifetz IM, Markovitz B, Cruces P, Barton P, Segal R, Simmons P, Randolph AG, PALISI Network.
      A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure.
      22791092 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2012 Nov. - 2012 Nov. : 13(6)646-53
    • Fernandez-Mendoza J, Vgontzas AN, Liao D, Shaffer ML, Vela-Bueno A, Basta M, Bixler EO
      Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort.
      22892811 Hypertension , 2012 Oct. : 60(4)929-35 PMCID: PMC3679545
    • Ofoma U, He F, Shaffer ML, Naccarelli GV, Liao D
      Premature cardiac contractions and risk of incident ischemic stroke.
      23316293 Journal of the American Heart Association , 2012 Oct. : 1(5)e002519 PMCID: PMC3541607
    • Ofoma U, He F, Shaffer ML, Naccarelli GV, Liao D
      Premature cardiac contractions and risk of incident ischemic stroke.
      23316293 Journal of the American Heart Association , 2012 Oct. - 2012 Oct. : 1(5)e002519 PMCID: PMC3541607
    • Fernandez-Mendoza J, Vgontzas AN, Liao D, Shaffer ML, Vela-Bueno A, Basta M, Bixler EO
      Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort.
      22892811 Hypertension (Dallas, Tex. : 1979) , 2012 Oct. - 2012 Oct. : 60(4)929-35 PMCID: PMC3679545
    • Kiely DK, Shaffer ML, Mitchell SL
      Scales for the evaluation of end-of-life care in advanced dementia: sensitivity to change.
      22273800 Alzheimer disease and associated disorders , 2012 Oct. - 2012 Oct. : 26(4)358-63 PMCID: PMC3424399
    • Williams O, DeSorbo A, Noble J, Shaffer M, Gerin W
      Long-term learning of stroke knowledge among children in a high-risk community.
      22875089 Neurology , 2012 Aug. 21 - 2012 Aug. 21 : 79(8)802-6 PMCID: PMC3421152
    • Fernandez-Mendoza J, Vgontzas AN, Bixler EO, Singareddy R, Shaffer ML, Calhoun SL, Karataraki M, Vela-Bueno A, Liao D
      Clinical and polysomnographic predictors of the natural history of poor sleep in the general population.
      22547895 Sleep , 2012 May 1 - 2012 May 1 : 35(5)689-97 PMCID: PMC3321428
    • Geskey JM, Erdman HJ, Bramley HP, Williams RJ, Shaffer ML
      Superior mesenteric artery syndrome in intellectually disabled children.
      22453730 Pediatric emergency care , 2012 Apr, : 28(4)351-3
    • Geskey JM, Erdman HJ, Bramley HP, Williams RJ, Shaffer ML
      Superior mesenteric artery syndrome in intellectually disabled children.
      22453730 Pediatric emergency care , 2012 Apr, - 2012 Apr, : 28(4)351-3
    • Singareddy R, Vgontzas AN, Fernandez-Mendoza J, Liao D, Calhoun S, Shaffer ML, Bixler EO
      Risk factors for incident chronic insomnia: a general population prospective study.
      22425576 Sleep medicine , 2012 Apr, - 2012 Apr, : 13(4)346-53 PMCID: PMC3319648
    • Wang J, Shaffer ML, Eslinger PJ, Sun X, Weitekamp CW, Patel MM, Dossick D, Gill DJ, Connor JR, Yang QX
      Maturational and aging effects on human brain apparent transverse relaxation.
      22363767 PloS one , 2012 : 7(2)e31907 PMCID: PMC3283700
    • Du G, Lewis MM, Shaffer ML, Chen H, Yang QX, Mailman RB, Huang X
      Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
      22530017 PloS one , 2012 : 7(4)e35397 PMCID: PMC3328461
    • Du G, Lewis MM, Shaffer ML, Chen H, Yang QX, Mailman RB, Huang X
      Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.
      22530017 PloS one , 2012 - 2012 : 7(4)e35397 PMCID: PMC3328461
    • Wang J, Shaffer ML, Eslinger PJ, Sun X, Weitekamp CW, Patel MM, Dossick D, Gill DJ, Connor JR, Yang QX
      Maturational and aging effects on human brain apparent transverse relaxation.
      22363767 PloS one , 2012 - 2012 : 7(2)e31907 PMCID: PMC3283700
    • Vgontzas AN, Fernandez-Mendoza J, Bixler EO, Singareddy R, Shaffer ML, Calhoun SL, Liao D, Basta M, Chrousos GP
      Persistent insomnia: the role of objective short sleep duration and mental health.
      22215919 Sleep , 2012 Jan. 1 - 2012 Jan. 1 : 35(1)61-8 PMCID: PMC3242689
    • Ruth JL, Geskey JM, Shaffer ML, Bramley HP, Paul IM
      Evaluating communication between pediatric primary care physicians and hospitalists.
      21576183 Clinical pediatrics , 2011 Oct. - 2011 Oct. : 50(10)923-8
    • Du G, Lewis MM, Styner M, Shaffer ML, Sen S, Yang QX, Huang X
      Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease.
      21618607 Movement disorders : official journal of the Movement Disorder Society , 2011 Aug. 1 : 26(9)1627-32 PMCID: PMC3154471
    • Du G, Lewis MM, Styner M, Shaffer ML, Sen S, Yang QX, Huang X
      Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease.
      21618607 Movement disorders : official journal of the Movement Disorder Society , 2011 Aug. 1 - 2011 Aug. 1 : 26(9)1627-32 PMCID: PMC3154471
    • Sullivan SA, Leite KR, Shaffer ML, Birch LL, Paul IM
      Urban parents' perceptions of healthy infant growth.
      21357200 Clinical pediatrics , 2011 Aug. - 2011 Aug. : 50(8)698-703
    • Li X, Shaffer ML, Rodríguez-Colón SM, He F, Bixler EO, Vgontzas AN, Wolbrette DL, Wu C, Ball RW, Liao D
      Systemic inflammation and circadian rhythm of cardiac autonomic modulation.
      21444250 Autonomic neuroscience : basic & clinical , 2011 July 5 : 162(1-2)72-6 PMCID: PMC3111893
    • Li X, Shaffer ML, Rodríguez-Colón SM, He F, Bixler EO, Vgontzas AN, Wolbrette DL, Wu C, Ball RW, Liao D
      Systemic inflammation and circadian rhythm of cardiac autonomic modulation.
      21444250 Autonomic neuroscience : basic and clinical , 2011 July 5 - 2011 July 5 : 162(1-2)72-6 PMCID: PMC3111893
    • He F, Shaffer ML, Rodriguez-Colon S, Yanosky JD, Bixler E, Cascio WE, Liao D
      Acute effects of fine particulate air pollution on cardiac arrhythmia: the APACR study.
      21398201 Environmental health perspectives , 2011 July : 119(7)927-32 PMCID: PMC3222979
    • He F, Shaffer ML, Rodriguez-Colon S, Yanosky JD, Bixler E, Cascio WE, Liao D
      Acute effects of fine particulate air pollution on cardiac arrhythmia: the APACR study.
      21398201 Environmental health perspectives , 2011 July - 2011 July : 119(7)927-32 PMCID: PMC3222979
    • Givens JL, Prigerson HG, Kiely DK, Shaffer ML, Mitchell SL
      Grief among family members of nursing home residents with advanced dementia.
      21606897 The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry , 2011 June - 2011 June : 19(6)543-50 PMCID: PMC3101368
    • Li X, Shaffer ML, Rodriguez-Colon S, He F, Wolbrette DL, Alagona P Jr, Wu C, Liao D
      The circadian pattern of cardiac autonomic modulation in a middle-aged population.
      21240538 Clinical autonomic research : official journal of the Clinical Autonomic Research Society , 2011 June - 2011 June : 21(3)143-50 PMCID: PMC3093547
    • Tamburro RF, Shaffer ML, Hahnlen NC, Felker P, Ceneviva GD
      Care goals and decisions for children referred to a pediatric palliative care program.
      21438709 Journal of palliative medicine , 2011 May - 2011 May : 14(5)607-13
    • Dias MS, Shaffer ML, Iantosca MR, Hill KL Jr
      Variability among pediatric neurosurgeons in the threshold for ventricular shunting in asymptomatic children with hydrocephalus.
      21284457 Journal of neurosurgery. Pediatrics , 2011 Feb. : 7(2)134-42
    • Dias MS, Shaffer ML, Iantosca MR, Hill KL Jr
      Variability among pediatric neurosurgeons in the threshold for ventricular shunting in asymptomatic children with hydrocephalus.
      21284457 Journal of neurosurgery. Pediatrics , 2011 Feb. : 7(2)134-42
    • Dias MS, Shaffer ML, Iantosca MR, Hill KL Jr
      Variability among pediatric neurosurgeons in the threshold for ventricular shunting in asymptomatic children with hydrocephalus.
      21284457 Journal of neurosurgery. Pediatrics , 2011 Feb. - 2011 Feb. : 7(2)134-42
    • Liao D, Shaffer ML, He F, Rodriguez-Colon S, Wu R, Whitsel EA, Bixler EO, Cascio WE
      Fine particulate air pollution is associated with higher vulnerability to atrial fibrillation--the APACR study.
      21480044 Journal of toxicology and environmental health. Part A , 2011 - 2011 : 74(11)693-705 PMCID: PMC3082849
    • He F, Shaffer ML, Li X, Rodriguez-Colon S, Wolbrette DL, Williams R, Cascio WE, Liao D
      Individual-level PMâ‚‚.â‚… exposure and the time course of impaired heart rate variability: the APACR Study.
      20372190 Journal of exposure science and environmental epidemiology , 2011 Jan. - 2011 Jan. : 21(1)65-73 PMCID: PMC3647364
    • Rodríguez-Colón SM, Li X, Shaffer ML, He F, Bixler EO, Vgontzas AN, Cai J, Liao D
      Insulin resistance and circadian rhythm of cardiac autonomic modulation.
      21134267 Cardiovascular diabetology , 2010 Dec. 6 - 2010 Dec. 6 : 985 PMCID: PMC3017516
    • Kiely DK, Givens JL, Shaffer ML, Teno JM, Mitchell SL
      Hospice use and outcomes in nursing home residents with advanced dementia.
      21143437 Journal of the American Geriatrics Society , 2010 Dec. : 58(12)2284-91 PMCID: PMC3057929
    • Kiely DK, Givens JL, Shaffer ML, Teno JM, Mitchell SL
      Hospice use and outcomes in nursing home residents with advanced dementia.
      21143437 Journal of the American Geriatrics Society , 2010 Dec. - 2010 Dec. : 58(12)2284-91 PMCID: PMC3057929
    • He F, Shaffer ML, Rodriguez-Colon S, Bixler EO, Vgontzas AN, Williams RW, Wu R, Cascio WE, Liao D
      Acute effects of fine particulate air pollution on ST segment height: a longitudinal study.
      21059260 Environmental health : a global access science source , 2010 Nov. 8 : 968 PMCID: PMC2989950
    • He F, Shaffer ML, Rodriguez-Colon S, Bixler EO, Vgontzas AN, Williams RW, Wu R, Cascio WE, Liao D
      Acute effects of fine particulate air pollution on ST segment height: a longitudinal study.
      21059260 Environmental health : a global access science source , 2010 Nov. 8 - 2010 Nov. 8 : 968 PMCID: PMC2989950
    • Mitchell SL, Miller SC, Teno JM, Kiely DK, Davis RB, Shaffer ML
      Prediction of 6-month survival of nursing home residents with advanced dementia using ADEPT vs hospice eligibility guidelines.
      21045099 JAMA , 2010 Nov. 3 - 2010 Nov. 3 : 304(17)1929-35 PMCID: PMC3017367
    • Mitchell SL, Miller SC, Teno JM, Davis RB, Shaffer ML
      The advanced dementia prognostic tool: a risk score to estimate survival in nursing home residents with advanced dementia.
      20621437 Journal of pain and symptom management , 2010 Nov. : 40(5)639-51 PMCID: PMC2981683
    • Mitchell SL, Miller SC, Teno JM, Davis RB, Shaffer ML
      The advanced dementia prognostic tool: a risk score to estimate survival in nursing home residents with advanced dementia.
      20621437 Journal of pain and symptom management , 2010 Nov. - 2010 Nov. : 40(5)639-51 PMCID: PMC2981683
    • Rajasekaran S, Jones DP, Avent Y, Shaffer ML, Elbahlawan L, Henderson N, Barfield RC, Morrison RR, Tamburro RF
      Outcomes of hematopoietic stem cell transplant patients who received continuous renal replacement therapy in a pediatric oncology intensive care unit.
      20495504 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 Nov. - 2010 Nov. : 11(6)699-706
    • Carroll JK, Lewis BA, Marcus BH, Lehman EB, Shaffer ML, Sciamanna CN
      Computerized tailored physical activity reports. A randomized controlled trial.
      20621262 American journal of preventive medicine , 2010 Aug. - 2010 Aug. : 39(2)148-56 PMCID: PMC3140844
    • Givens JL, Jones RN, Shaffer ML, Kiely DK, Mitchell SL
      Survival and comfort after treatment of pneumonia in advanced dementia.
      20625013 Archives of internal medicine , 2010 July 12 : 170(13)1102-7 PMCID: PMC2914628
    • Givens JL, Jones RN, Shaffer ML, Kiely DK, Mitchell SL
      Survival and comfort after treatment of pneumonia in advanced dementia.
      20625013 Archives of internal medicine , 2010 July 12 - 2010 July 12 : 170(13)1102-7 PMCID: PMC2914628
    • Liao D, Shaffer ML, Rodriguez-Colon S, He F, Li X, Wolbrette DL, Yanosky J, Cascio WE
      Acute adverse effects of fine particulate air pollution on ventricular repolarization.
      20363686 Environmental health perspectives , 2010 July : 118(7)1010-5 PMCID: PMC2920900
    • Liao D, Shaffer ML, Rodriguez-Colon S, He F, Li X, Wolbrette DL, Yanosky J, Cascio WE
      Acute adverse effects of fine particulate air pollution on ventricular repolarization.
      20363686 Environmental health perspectives , 2010 July - 2010 July : 118(7)1010-5 PMCID: PMC2920900
    • Aucott SW, Watterberg KL, Shaffer ML, Donohue PK, PROPHET study group.
      Early cortisol values and long-term outcomes in extremely low birth weight infants.
      20010616 Journal of perinatology : official journal of the California Perinatal Association , 2010 July - 2010 July : 30(7)484-8 PMCID: PMC3586211
    • Tjia J, Rothman MR, Kiely DK, Shaffer ML, Holmes HM, Sachs GA, Mitchell SL
      Daily medication use in nursing home residents with advanced dementia.
      20406320 Journal of the American Geriatrics Society , 2010 May - 2010 May : 58(5)880-8 PMCID: PMC2910133
    • Laraway KA, Birch LL, Shaffer ML, Paul IM
      Parent perception of healthy infant and toddler growth.
      19745095 Clinical pediatrics , 2010 Apr, - 2010 Apr, : 49(4)343-9 PMCID: PMC3623679
    • Thomas NJ, Shaffer ML, Willson DF, Shih MC, Curley MA
      Defining acute lung disease in children with the oxygenation saturation index.
      19561556 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 Jan. : 11(1)12-7 PMCID: PMC2936504
    • Thomas NJ, Shaffer ML, Willson DF, Shih MC, Curley MA
      Defining acute lung disease in children with the oxygenation saturation index.
      19561556 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 Jan. : 11(1)12-7 PMCID: PMC2936504
    • Thomas NJ, Shaffer ML, Willson DF, Shih MC, Curley MA
      Defining acute lung disease in children with the oxygenation saturation index.
      19561556 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 Jan. - 2010 Jan. : 11(1)12-7 PMCID: PMC2936504
    • Mitchell SL, Teno JM, Kiely DK, Shaffer ML, Jones RN, Prigerson HG, Volicer L, Givens JL, Hamel MB
      The clinical course of advanced dementia.
      19828530 The New England journal of medicine , 2009 Oct. 15 - 2009 Oct. 15 : 361(16)1529-38 PMCID: PMC2778850
    • Sorond FA, Shaffer ML, Kung AL, Lipsitz LA
      Desferroxamine infusion increases cerebral blood flow: a potential association with hypoxia-inducible factor-1.
      19014354 Clinical science (London, England : 1979) , 2009 May - 2009 May : 116(10)771-9 PMCID: PMC2854553
    • Lowe J, MacLean PC, Shaffer ML, Watterberg K
      Early working memory in children born with extremely low birth weight: assessed by object permanence.
      19339284 Journal of child neurology , 2009 Apr, : 24(4)410-5 PMCID: PMC3071030
    • Lowe J, MacLean PC, Shaffer ML, Watterberg K
      Early working memory in children born with extremely low birth weight: assessed by object permanence.
      19339284 Journal of child neurology , 2009 Apr, - 2009 Apr, : 24(4)410-5 PMCID: PMC3071030
    • Shaffer ML, Hiriote S
      Analysis of time-to-event and duration outcomes in neonatal clinical trials with twin births.
      19027881 Contemporary clinical trials , 2009 Mar. - 2009 Mar. : 30(2)150-4 PMCID: PMC3606884
    • Shaffer ML, Kunselman AR, Watterberg KL
      Analysis of neonatal clinical trials with twin births.
      19245713 BMC medical research methodology , 2009 Feb. 26 : 912 PMCID: PMC2676314
    • Shaffer ML, Kunselman AR, Watterberg KL
      Analysis of neonatal clinical trials with twin births.
      19245713 BMC medical research methodology , 2009 Feb. 26 - 2009 Feb. 26 : 912 PMCID: PMC2676314
    • Kiely DK, Marcantonio ER, Inouye SK, Shaffer ML, Bergmann MA, Yang FM, Fearing MA, Jones RN
      Persistent delirium predicts greater mortality.
      19170790 Journal of the American Geriatrics Society , 2009 Jan. - 2009 Jan. : 57(1)55-61 PMCID: PMC2744464
    • Sorond FA, Serrador JM, Jones RN, Shaffer ML, Lipsitz LA
      The sit-to-stand technique for the measurement of dynamic cerebral autoregulation.
      18834658 Ultrasound in medicine and biology , 2009 Jan. - 2009 Jan. : 35(1)21-9 PMCID: PMC2680703
    • Aucott SW, Watterberg KL, Shaffer ML, Donohue PK, PROPHET Study Group
      Do cortisol concentrations predict short-term outcomes in extremely low birth weight infants?
      18829801 Pediatrics , 2008 Oct. : 122(4)775-81 PMCID: PMC3586215
    • Aucott SW, Watterberg KL, Shaffer ML, Donohue PK, PROPHET Study Group.
      Do cortisol concentrations predict short-term outcomes in extremely low birth weight infants?
      18829801 Pediatrics , 2008 Oct. - 2008 Oct. : 122(4)775-81 PMCID: PMC3586215
    • Tamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, Howard SC, Fiser RT, Schmidt JE, Sillos EM
      Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation.
      18446105 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2008 May : 9(3)270-7
    • Kesler H, Dias MS, Shaffer M, Rottmund C, Cappos K, Thomas NJ
      Demographics of abusive head trauma in the Commonwealth of Pennsylvania.
      18447667 Journal of neurosurgery. Pediatrics , 2008 May - 2008 May : 1(5)351-6
    • Tamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, Howard SC, Fiser RT, Schmidt JE, Sillos EM
      Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation.
      18446105 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2008 May - 2008 May : 9(3)270-7
    • Hillemeier MM, Weisman CS, Chase GA, Dyer AM, Shaffer ML
      Women's preconceptional health and use of health services: implications for preconception care.
      18211518 Health services research , 2008 Feb. - 2008 Feb. : 43(1 Pt 1)54-75 PMCID: PMC2323151
    • Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr
      Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents.
      18056558 Archives of pediatrics & adolescent medicine , 2007 Dec. : 161(12)1140-6
    • Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr
      Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents.
      18056558 Archives of pediatrics and adolescent medicine , 2007 Dec. - 2007 Dec. : 161(12)1140-6
    • Berry SD, Samelson EJ, Hannan MT, McLean RR, Lu M, Cupples LA, Shaffer ML, Beiser AL, Kelly-Hayes M, Kiel DP
      Second hip fracture in older men and women: the Framingham Study.
      17923597 Archives of internal medicine , 2007 Oct. 8 - 2007 Oct. 8 : 167(18)1971-6
    • Thomas NJ, Shaffer ML, Rzucidlo S, Shirk BJ, Dias MS
      Temporal factors and the incidence of physical abuse in young children: decreased nonaccidental trauma during Child Abuse Prevention Month.
      17923205 Journal of pediatric surgery , 2007 Oct. - 2007 Oct. : 42(10)1735-9
    • Stultz EE, Stokes JL, Shaffer ML, Paul IM, Berlin CM
      Extent of medication use in breastfeeding women.
      17903100 Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine , 2007 Sept. : 2(3)145-51
    • Stultz EE, Stokes JL, Shaffer ML, Paul IM, Berlin CM
      Extent of medication use in breastfeeding women.
      17903100 Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine , 2007 Sept. - 2007 Sept. : 2(3)145-51
    • Watterberg KL, Shaffer ML, Mishefske MJ, Leach CL, Mammel MC, Couser RJ, Abbasi S, Cole CH, Aucott SW, Thilo EH, Rozycki HJ, Lacy CB
      Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants.
      17606560 Pediatrics , 2007 July : 120(1)40-8
    • Watterberg KL, Shaffer ML, Mishefske MJ, Leach CL, Mammel MC, Couser RJ, Abbasi S, Cole CH, Aucott SW, Thilo EH, Rozycki HJ, Lacy CB
      Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants.
      17606560 Pediatrics , 2007 July - 2007 July : 120(1)40-8
    • Shaffer ML, Chinchilli VM
      Including multiple imputation in a sensitivity analysis for clinical trials with treatment failures.
      16877049 Contemporary clinical trials , 2007 Feb. - 2007 Feb. : 28(2)130-7
    • Shaffer ML, Watterberg KL
      Joint distribution approaches to simultaneously quantifying benefit and risk.
      17038184 BMC medical research methodology , 2006 Oct. 12 - 2006 Oct. 12 : 648 PMCID: PMC1630697
    • Cherry RA, Bradburn E, Carney DE, Shaffer ML, Gabbay RA, Cooney RN
      Do early ionized calcium levels really matter in trauma patients?
      17033540 The Journal of trauma , 2006 Oct. - 2006 Oct. : 61(4)774-9
    • Paul IM, Wai K, Jewell SJ, Shaffer ML, Varadan VV
      Evaluation of a new self-contained, ambulatory, objective cough monitor.
      17005042 Cough (London, England) , 2006 Sept. 27 : 27 PMCID: PMC1592112
    • Paul IM, Wai K, Jewell SJ, Shaffer ML, Varadan VV
      Evaluation of a new self-contained, ambulatory, objective cough monitor.
      17005042 Cough (London, England) , 2006 Sept. 27 - 2006 Sept. 27 : 27 PMCID: PMC1592112
    • Yoder KE, Shaffer ML, La Tournous SJ, Paul IM
      Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection.
      16928841 Clinical pediatrics , 2006 Sept. : 45(7)633-40
    • Yoder KE, Shaffer ML, La Tournous SJ, Paul IM
      Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection.
      16928841 Clinical pediatrics , 2006 Sept. - 2006 Sept. : 45(7)633-40
    • Paul IM, Eleoff SB, Shaffer ML, Bucher RM, Moyer KM, Gusic ME
      Improving influenza vaccination rates for children through year-round scheduling.
      16843256 Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association , 2006 July - 2006 July : 6(4)230-4
    • Vitale MA, Rzucidlo S, Shaffer ML, Ceneviva GD, Thomas NJ
      The impact of pediatric trauma in the Amish community.
      16615967 The Journal of pediatrics , 2006 Mar. : 148(3)359-65
    • Vitale MA, Rzucidlo S, Shaffer ML, Ceneviva GD, Thomas NJ
      The impact of pediatric trauma in the Amish community.
      16615967 The Journal of pediatrics , 2006 Mar. - 2006 Mar. : 148(3)359-65
    • Watterberg KL, Shaffer ML, Garland JS, Thilo EH, Mammel MC, Couser RJ, Aucott SW, Leach CL, Cole CH, Gerdes JS, Rozycki HJ, Backstrom C
      Effect of dose on response to adrenocorticotropin in extremely low birth weight infants.
      16159938 The Journal of clinical endocrinology and metabolism , 2005 Dec. - 2005 Dec. : 90(12)6380-5
    • Naeye RL, Shaffer ML
      Postnatal laboratory timers of antenatal hypoxemic-ischemic brain damage.
      16079907 Journal of perinatology : official journal of the California Perinatal Association , 2005 Oct. : 25(10)664-8
    • Naeye RL, Shaffer ML
      Postnatal laboratory timers of antenatal hypoxemic-ischemic brain damage.
      16079907 Journal of perinatology : official journal of the California Perinatal Association , 2005 Oct. - 2005 Oct. : 25(10)664-8
    • Liu W, Zhao W, Shaffer ML, Icitovic N, Chase GA
      Modelling clinical trials in heterogeneous samples.
      16007572 Statistics in medicine , 2005 Sept. 30 : 24(18)2765-75
    • Liu W, Zhao W, Shaffer ML, Icitovic N, Chase GA
      Modelling clinical trials in heterogeneous samples.
      16007572 Statistics in medicine , 2005 Sept. 30 - 2005 Sept. 30 : 24(18)2765-75
    • Dias MS, Smith K, DeGuehery K, Mazur P, Li V, Shaffer ML
      Preventing abusive head trauma among infants and young children: a hospital-based, parent education program.
      15805350 Pediatrics , 2005 Apr, - 2005 Apr, : 115(4)e470-7
    • Watterberg KL, Gerdes JS, Cole CH, Aucott SW, Thilo EH, Mammel MC, Couser RJ, Garland JS, Rozycki HJ, Leach CL, Backstrom C, Shaffer ML
      Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial.
      15574629 Pediatrics , 2004 Dec. - 2004 Dec. : 114(6)1649-57
    • Paul IM, Shaffer ML, Yoder KE, Sturgis SA, Baker MS, Berlin CM Jr
      Dose-response relationship with increasing doses of dextromethorphan for children with cough.
      15531013 Clinical therapeutics , 2004 Sept. : 26(9)1508-14
    • Paul IM, Shaffer ML, Yoder KE, Sturgis SA, Baker MS, Berlin CM Jr
      Dose-response relationship with increasing doses of dextromethorphan for children with cough.
      15531013 Clinical therapeutics , 2004 Sept. - 2004 Sept. : 26(9)1508-14
    • Paul IM, Yoder KE, Crowell KR, Shaffer ML, McMillan HS, Carlson LC, Dilworth DA, Berlin CM Jr
      Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents.
      15231978 Pediatrics , 2004 July - 2004 July : 114(1)e85-90
    • Liu W, Icitovic N, Shaffer ML, Chase GA
      The impact of population heterogeneity on risk estimation in genetic counseling.
      15228628 BMC medical genetics , 2004 June 30 : 518 PMCID: PMC449710
    • Liu W, Icitovic N, Shaffer ML, Chase GA
      The impact of population heterogeneity on risk estimation in genetic counseling.
      15228628 BMC medical genetics , 2004 June 30 - 2004 June 30 : 518 PMCID: PMC449710
    • Shaffer ML, Chinchilli VM
      Bayesian inference for randomized clinical trials with treatment failures.
      15083479 Statistics in medicine , 2004 Apr, 30 - 2004 Apr, 30 : 23(8)1215-28
    • Shaffer ML, Chinchilli VM
      A likelihood-based, counterfactual approach to accounting for treatment failures in clinical trials.
      12921395 Journal of biopharmaceutical statistics , 2003 Aug. : 13(3)481-94
    • Shaffer ML, Chinchilli VM
      A likelihood-based, counterfactual approach to accounting for treatment failures in clinical trials.
      12921395 Journal of biopharmaceutical statistics , 2003 Aug. - 2003 Aug. : 13(3)481-94

Overview

Medical/Professional School

Pennsylvania State University, University Park
Pennsylvania State University, University Park
Pennsylvania State University, University Park