Profile

Matthew Speltz, PhD

Matthew Speltz, PhD

Psychiatry and Behavioral Health

On staff since May 1988

Children's Title: Clinic Chief, Outpatient Psychiatric Services; Co-chair, Physician Well-Being Subcommittee; Clinic Chief, Psychiatric Service, Bellevue (Interim)

Academic Title: Professor

Research Center: Center for Child Health, Behavior and Development

Making A Difference

Overview

Medical/Professional School

University of Missouri - Columbia School of Medicine, Columbia

Fellowship

Psychology, University of Washington School of Medicine, Seattle

Clinical Interests

Neurodevelopmental assessment of craniofacial disorders; psychiatric assessment and diagnosis of adolescent disorders; disruptive disorders; autism; anxiety disorders; behavioral medicine

Research Description

The Infant Learning Project is a 5-year prospective study funded by the National Institute of Dental and Craniofacial Research examining the neurobehavioral outcomes of infants with single-suture, non-syndromic craniosynstosis. Single-suture craniosynostosis is characterized by premature fusion of two, adjoining plates of the skull, which result in malformations and dysmorphology of the head in the absence of corrective surgery.

A total of 250 children with one of four types of single-suture synostosis (sagittal, metopic, right unilateral coronal and left unilateral coronal) are being recruited from four clinical centers across the U.S. (in Seattle, Chicago, St. Louis, and Atlanta). A case-matched comparison group of 250 normal healthy children is also being followed.

Participants are assessed at 3 time points - at time of enrollment (14 months of age or younger), at 18 months, and at 36 months. By following prospectively a relatively large sample of infants with and without targeted diagnoses of craniosynostosis (n = 500) and using a comprehensive battery of well-known standardized tests and neurocognitive tasks that can predict later learning and language disabilities, we hope to avoid the methodological problems experienced by past researchers.

Specific study aims are to:

(1) Characterize the neurobehavioral development and parental adjustment of infants with single-suture fusions, as compared to carefully matched, typically developing infants

(2) Examine relations between neurobehavioral development and degree of abnormality in bone and underlying brain tissue among children with craniosynostosis (using new CT scan measurement models)

(3) Examine relations between neurobehavioral development and presence of genetic mutations among children with unicoronal synostosis

(4) Develop predictive models of 36-month functional outcomes for all infants with craniosynostosis

(5) Determine relation between age of cranioplastic surgery and neurobehavioral development

Research Focus Area

Behavioral / Mental Health

Publications

  • Mefford HC, Shafer N, Antonacci F, Tsai JM, Park SS, Hing AV, Rieder MJ, Smyth MD, Speltz ML, Eichler EE, Cunningham ML
    Copy number variation analysis in single-suture craniosynostosis: multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis.
    American journal of medical genetics. Part A , 2010 Sept. : 2203-10
  • Rosenberg J, Kapp-Simon K, Starr J, Cradock M, Speltz M
    Mothers' and Fathers' Reports of Stress in Families of Infants with and without Single-Suture Craniosynostosis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2010 Aug. 19
  • Starr JR, Lin HJ, Ruiz-Correa S, Cunningham ML, Ellenbogen RG, Collett BR, Kapp-Simon KA, Speltz ML
    Little evidence of association between severity of trigonocephaly and cognitive development in infants with single-suture metopic synostosis.
    Neurosurgery , 2010 Aug. : 408-15; discussion 415-6
  • Collett BR, Leroux B, Speltz ML
    Language and early reading among children with orofacial clefts.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2010 May : 284-92
  • Collett BR, Stott-Miller M, Kapp-Simon KA, Cunningham ML, Speltz ML
    Reading in children with orofacial clefts versus controls.
    Journal of pediatric psychology , 2010 Mar. : 199-208
  • Speltz ML, Collett BR, Stott-Miller M, Starr JR, Heike C, Wolfram-Aduan AM, King D, Cunningham ML
    Case-control study of neurodevelopment in deformational plagiocephaly.
    Pediatrics , 2010 Mar. : e537-42
  • Cloonan YK, Kifle Y, Davis S, Speltz ML, Werler MM, Starr JR
    Sleep outcomes in children with hemifacial microsomia and controls: a follow-up study.
    Pediatrics , 2009 Aug. : e313-21
  • Werler MM, Starr JR, Cloonan YK, Speltz ML
    Hemifacial microsomia: from gestation to childhood.
    The Journal of craniofacial surgery , 2009 Mar. : 664-9
  • Ruiz-Correa S, Starr JR, Lin HJ, Kapp-Simon KA, Sze RW, Ellenbogen RG, Speltz ML, Cunningham ML
    New severity indices for quantifying single-suture metopic craniosynostosis.
    Neurosurgery , 2008 Aug. : 318-24; discussion 324-5
  • Toth K, Collett B, Kapp-Simon KA, Cloonan YK, Gaither R, Cradock MM, Buono L, Cunningham ML, Dawson G, Starr J, Speltz ML
    Memory and Response Inhibition in Young Children with Single-Suture Craniosynostosis.
    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence , 2007 Sept. 26 : 1-14
  • Ruiz-Correa S, Starr JR, Lin HJ, Kapp-Simon KA, Cunningham ML, Speltz ML
    Severity of skull malformation is unrelated to presurgery neurobehavioral status of infants with sagittal synostosis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2007 Sept. : 548-54
  • Starr JR, Kapp-Simon KA, Cloonan YK, Collett BR, Cradock MM, Buono L, Cunningham ML, Speltz ML
    Presurgical and postsurgical assessment of the neurodevelopment of infants with single-suture craniosynostosis: comparison with controls.
    Journal of neurosurgery , 2007 Aug. : 103-10
  • Speltz ML, Kapp-Simon K, Collett B, Keich Y, Gaither R, Cradock MM, Buono L, Cunningham ML
    Neurodevelopment of infants with single-suture craniosynostosis: presurgery comparisons with case-matched controls.
    Plastic and reconstructive surgery , 2007 May : 1874-81
  • Seto ML, Hing AV, Chang J, Hu M, Kapp-Simon KA, Patel PK, Burton BK, Kane AA, Smyth MD, Hopper R, Ellenbogen RG, Stevenson K, Speltz ML, Cunningham ML
    Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations.
    American journal of medical genetics. Part A , 2007 Apr, 1 : 678-86
  • Kapp-Simon KA, Speltz ML, Cunningham ML, Patel PK, Tomita T
    Neurodevelopment of children with single suture craniosynostosis: a review.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery , 2007 Mar. : 269-81
  • Ruiz-Correa S, Sze RW, Starr JR, Lin HT, Speltz ML, Cunningham ML, Hing AV
    New scaphocephaly severity indices of sagittal craniosynostosis: a comparative study with cranial index quantifications.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2006 Mar. : 211-21
  • Collett B, Breiger D, King D, Cunningham M, Speltz M
    Neurodevelopmental implications of "deformational" plagiocephaly.
    Journal of developmental and behavioral pediatrics : JDBP , 2005 Oct. : 379-89
  • Kapp-Simon KA, Leroux B, Cunningham M, Speltz ML
    Multisite study of infants with single-suture craniosynostosis: preliminary report of presurgery development.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2005 July : 377-84
  • Edwards TC, Patrick DL, Topolski TD, Aspinall CL, Mouradian WE, Speltz ML
    Approaches to craniofacial-specific quality of life assessment in adolescents.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2005 Jan. : 19-24
  • Speltz ML, Kapp-Simon KA, Cunningham M, Marsh J, Dawson G
    Single-suture craniosynostosis: a review of neurobehavioral research and theory.
    Journal of pediatric psychology , 2004 Dec. : 651-68
  • Endriga MC, Jordan JR, Speltz ML
    Emotion self-regulation in preschool-aged children with and without orofacial clefts.
    Journal of developmental and behavioral pediatrics : JDBP , 2003 Oct. : 336-44
  • McClellan JM, Speltz ML
    Psychiatric diagnosis in preschool children.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2003 Feb. : 127-8; author reply 128-30
  • Schwebel DC, Speltz ML, Jones K, Bardina P
    Unintentional injury in preschool boys with and without early onset of disruptive behavior.
    Journal of pediatric psychology , 2002 Dec. : 727-37
  • McClellan J, McCurry C, Speltz ML, Jones K
    Symptom factors in early-onset psychotic disorders.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2002 July : 791-8
  • Coy K, Speltz ML, Jones K
    Facial appearance and attachment in infants with orofacial clefts: a replication.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2002 Jan. : 66-72