Marta Bull, PhD

Marta Bull, PhD

Infectious Disease

Academic Title: Research Assistant Professor, Pediatrics

Research Center: Center for Global Infectious Disease Research

  • Award Name Award Description Awarded By Award Date
    New Investigator Award Conference on Retroviruses and Opportunistic Infections (CROI) 2012
    Research Travel Award Center for AIDS Research (CFAR) 2008
    Childrens Hospital Fellows Research Day Award Oral presentation, "HIV-1 Compartmentalization in the Female Genital Tract" Seattle Children's Research Institute 2006
    Ruth L. Kirschstein National Research Service Award University of Washington STD/AIDS Research Training Program 2006 - 2008
    Loan Repayment Award National Institutes of Health (NIH) 2006 - 2008
    • Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM
      Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.
      23315326 The Journal of infectious diseases , 2013 Apr, : 207(8)1206-15 PMCID: PMC3603533
    • Beck IA, Jang M, McKernan-Mullin J, Bull M, Wagner T, Huang S, Song LY, Nachman S, Krogstad P, Eshleman SH, Wiznia A, Frenkel LM
      Monitoring of HIV type 1 DNA load and drug resistance in peripheral blood mononuclear cells during suppressive antiretroviral therapy does not predict virologic failure.
      22081867 AIDS research and human retroviruses , 2012 Aug. : 28(8)780-8 PMCID: PMC3399556
    • Soria J, Bull M, Mitchell C, La Rosa A, Dross S, Kraft K, Coombs R, Ticona E, Frenkel L
      Transmitted HIV resistance to first-line antiretroviral therapy in Lima, Peru.
      21819256 AIDS research and human retroviruses , 2012 Apr, : 28(4)333-8 PMCID: PMC3316114
    • Gantt S, Carlsson J, Heath L, Bull ME, Shetty AK, Mutsvangwa J, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA, Mullins JI, Frenkel LM
      Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis.
      20660189 Journal of virology , 2010 Oct. : 84(20)10812-9 PMCID: PMC2950573
    • Bull M, Learn G, Genowati I, McKernan J, Hitti J, Lockhart D, Tapia K, Holte S, Dragavon J, Coombs R, Mullins J, Frenkel L
      Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations.
      19771165 PloS one , 2009 Sept. : 4(9)e7122 PMCID: PMC2741601
    • Bull ME, Learn GH, McElhone S, Hitti J, Lockhart D, Holte S, Dragavon J, Coombs RW, Mullins JI, Frenkel LM
      Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus.
      19339344 Journal of virology , 2009 June : 83(12)6020-8 PMCID: PMC2687376
    • Bull ME, Learn GH, Mullins JI, Frenkel LM
      Methods used to examine compartmentalization of viral populations between the genital tract and peripheral blood.
      17597465 The Journal of infectious diseases , 2007 Aug. : 196(3)493-4; author reply 494-5
    • Bull M, Lee D, Stucky J, Chiu YL, Rubin A, Horton H, McElrath MJ
      Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trials.
      17382342 Journal of immunological methods , 2007 Apr, : 322(1-2)57-69 PMCID: PMC1904432
    • Bull ME, Vahlenkamp TW, Dow JL, Collisson EW, Winslow BJ, Phadke AP, Tompkins MB, Tompkins WA
      Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies.
      15113651 Veterinary immunology and immunopathology , 2004 May : 99(1-2)25-37
    • Vahlenkamp TW, Bull ME, Dow JL, Collisson EW, Winslow BJ, Phadke AP, Tompkins WA, Tompkins MB
      B7+CTLA4+ T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion.
      15010229 Veterinary immunology and immunopathology , 2004 Apr, : 98(3-4)203-14
    • Bull ME, Kennedy-Stoskopf S, Levine JF, Loomis M, Gebhard DG, Tompkins WA
      Evaluation of T lymphocytes in captive african lions (Panthera leo) infected with feline immunodeficiency virus.
      14596469 American journal of veterinary research , 2003 Oct. : 64(10)1293-300
    • Tompkins MB, Bull ME, Dow JL, Ball JM, Collisson EW, Winslow BJ, Phadke AP, Vahlenkamp TW, Tompkins WA
      Feline immunodeficiency virus infection is characterized by B7+CTLA4+ T cell apoptosis.
      11930318 The Journal of infectious diseases , 2002 Apr, : 185(8)1077-93
    • Bull ME, Gebhard DG, Tompkins WA, Kennedy-Stoskopf S
      Polymorphic expression in the CD8alpha chain surface receptor of African lions (Panthera leo).
      11777533 Veterinary immunology and immunopathology , 2002 Jan. : 84(3-4)181-9

  • Grant Title Grantor Amount Award Date
    "University of Washington Center for AIDS Research" (CFAR) - P30 AI027757 (PI: King Holmes) NIH $11,528 subcontract annual direct costs June 1, 2013 - May 31, 2015


Medical/Professional School

Washington State University, Pullman
North Carolina State Univeristy, Raleigh, Immunology
North Carolina State Univeristy, Raleigh, Immunology


University of Washington, Seattle

Research Description

Dr. Bull's primary research interest includes HIV at mucosal sites, primarily but not limited to the female genital tract. Her interest in the genital tract is threefold: (1) To better define immunological milieu at mucosal sites and how this pertains to HIV persistence at these sites, (2) to better define the viral dynamics and exchange between the genital tract, blood and other tissues, and (3) to evaluate the role of other chronic viruses - such as herpes simplex virus (HSV) 1, HSV-2, cytomegalovirus (CMV), and Epstein Barr virus - in HIV persistence. Specific areas currently under study include the cellular populations associated with HIV shedding from the female genital tract and immune mechanisms that promote HIV persistence at tissue sites as a barrier to a cure for HIV.