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Laura A. Jansen, MD, PhD

Laura A. Jansen, MD, PhD

Neurology

On staff since August 2004

Academic Title: Assistant Professor of Neurology

Research Center: Center for Integrative Brain Research

Overview

Board Certification(s)
Neurology with Special Qualifications in Child Neu
Medical/Professional School
St Louis University School of Medicine - Academic Records, St Louis
Residency
Pediatrics, Washington University School of Medicine, St Louis
Child Neurology, Washington University School of Medicine, St Louis
Fellowship
Neurology, University College Hospital - London UK, London
Neurology, Washington University School of Medicine, St Louis
Clinical Interests

General child neurology, epilepsy, migraine

Research Description

My research involves investigation of abnormalities in ion channel function in brain specimens from children treated surgically for intractable seizures, with the goals of identifying causes of pediatric epilepsy and optimizing medical treatment of seizures.

Research Focus Area

Neuroscience / Neurodevelopment

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Morris-Coole Epilepsia PrizeILAE 2011
Philip R. Dodge Young Investigator AwardChild Neurology Society 2008

Publications

Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex.
Neuroscience letters , 2010 Oct 15: 167-72
Somatic mosaicism in Menkes disease suggests choroid plexus-mediated copper transport to the developing brain.
American journal of medical genetics. Part A , 2010 Oct: 2529-34
Impaired maturation of cortical GABA receptor expression in pediatric epilepsy.
Epilepsia , 2010 Feb 3
GABA(A) receptor properties in catastrophic infantile epilepsy.
Epilepsy research , 2008 Oct: 188-97
Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex.
Neurobiology of disease , 2007 Nov: 184-96
Additional evidence of a locus for complex febrile and afebrile seizures on chromosome 12q22-23.3.
Neurogenetics , 2007 Jan: 61-3
Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes.
Epilepsia , 2005 Dec: 1871-80
Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.
Annals of neurology , 2003 Aug: 251-6

Research Funding

Grant TitleGrantorAmountAward Date
Early-Life Seizures and the Development of GABAergic Inhibition in the Human BrainNIH NINDSJuly 1, 2011 - June 30, 2016

Primary Office

Seattle Children's
B-5552 - Neurology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2078

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