Profile

Kevin B. Urdahl, MD, PhD

Kevin B. Urdahl, MD, PhD

Infectious Disease

On staff since November 2003

Academic Title: Assistant Professor, Pediatrics

Research Center: Center for Global Infectious Disease Research

Overview

Board Certification(s)

Pediatric Infectious Diseases

Medical/Professional School

University of Minnesota , Minneapolis

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Pediatric Infectious Disease, University of Washington, Seattle

Clinical Interests

Tuberculosis; Protective immunity against tuberculosis; Tuberculosis vaccines

Research Description

My laboratory is applying recently-developed immunologic tools to the study of tuberculosis in order to gain a better understanding of T lymphocyte-mediated mechanisms that promote protection against tuberculosis and also mechanisms that suppress immunity and help facilitate persistence of the pathogen. The overall goal of this research is to identify strategies that could contribute to the development of an effective vaccine.

Recently, my laboratory defined a role for a suppressive subset of T lymphocytes that dampens immunity and prevents the immune system from effectively eradicating the bacteria that causes tuberculosis.

Research Focus Area

Host: Pathogen Interaction

Publications

  • Curtis MM, Rowell E, Shafiani S, Negash A, Urdahl KB, Wilson CB, Way SS
    Fidelity of pathogen-specific CD4+ T cells to the Th1 lineage is controlled by exogenous cytokines, interferon-gamma expression, and pathogen lifestyle.
    Cell host & microbe , 2010 Aug. 19 : 163-73
  • Shafiani S, Tucker-Heard G, Kariyone A, Takatsu K, Urdahl KB
    Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis.
    The Journal of experimental medicine , 2010 July 5 : 1409-20
  • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ
    The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
    Nature immunology , 2009 June : 595-602
  • Scott-Browne JP, Shafiani S, Tucker-Heard G, Ishida-Tsubota K, Fontenot JD, Rudensky AY, Bevan MJ, Urdahl KB
    Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis.
    The Journal of experimental medicine , 2007 Sept. 3 : 2159-69
  • Urdahl KB, Liggitt D, Bevan MJ
    CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection.
    Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb. 15 : 1987-94
  • Urdahl KB, Sun JC, Bevan MJ
    Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells.
    Nature immunology , 2002 Aug. : 772-9