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Kevin B. Urdahl, MD, PhD

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Kevin B. Urdahl, MD, PhD

Infectious Disease

On staff since November 2003

Academic Title: Assistant Professor, Pediatrics

Research Center: Center for Global Infectious Disease Research

Overview

Board Certification(s)
Pediatric Infectious Diseases
Medical/Professional School
University of Minnesota , Minneapolis
Residency
Pediatrics, University of Washington, Seattle
Fellowship
Pediatric Infectious Disease, University of Washington, Seattle
Clinical Interests

Tuberculosis; Protective immunity against tuberculosis; Tuberculosis vaccines

Research Description

My laboratory is applying recently-developed immunologic tools to the study of tuberculosis in order to gain a better understanding of T lymphocyte-mediated mechanisms that promote protection against tuberculosis and also mechanisms that suppress immunity and help facilitate persistence of the pathogen. The overall goal of this research is to identify strategies that could contribute to the development of an effective vaccine.

Recently, my laboratory defined a role for a suppressive subset of T lymphocytes that dampens immunity and prevents the immune system from effectively eradicating the bacteria that causes tuberculosis.

Research Focus Area

Host: Pathogen Interaction

Publications

Fidelity of pathogen-specific CD4+ T cells to the Th1 lineage is controlled by exogenous cytokines, interferon-gamma expression, and pathogen lifestyle.
Cell host & microbe , 2010 Aug 19: 163-73
Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis.
The Journal of experimental medicine , 2010 Jul 5: 1409-20
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology , 2009 Jun: 595-602
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis.
The Journal of experimental medicine , 2007 Sep 3: 2159-69
CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection.
Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb 15: 1987-94
Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells.
Nature immunology , 2002 Aug: 772-9

Primary Office

Seattle Children's
MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2073

Additional Offices

Seattle Biomedical Research Institute
307 Westlake Ave N
Suite 500
Seattle, WA 98109-5219
206-256-7200

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