Profile

Kenneth A. Schenkman, MD, PhD

Kenneth A. Schenkman, MD, PhD

Critical Care, PICU

On staff since November 1998

Research Center: Center for Clinical and Translational Research

Kenneth A. Schenkman, MD, PhD, is an attending physician in the Pediatric Intensive Care Units at Seattle Children’s Hospital and Harborview Medical Center. He is an Associate Professor of Pediatrics and Anesthesiology and Adjunct Associate Professor of Bioengineering at the University of Washington School of Medicine. Dr. Schenkman received his MD from Indiana University and completed a pediatrics residency at the Children’s Hospital of Pittsburgh, where he also served as Chief Resident.

He trained in pediatric critical care at Seattle Children’s and received a PhD in Bioengineering from the University of Washington. He has an active research program developing optical spectroscopic technologies for clinical assessment of intracellular oxygenation and mitochondrial function. Dr. Schenkman has been awarded a U.S. patent and filed four additional patent applications for his pioneering work on developing an intracellular oxygen monitor. Schenkman has published dozens of manuscripts and abstracts in the field of optical spectroscopy for physiologic and clinical applications, and has published several book chapters on pediatric critical care topics. He also has been an active reviewer for journals in the fields of medicine, physiology and biomedical optics.

Overview

Board Certification(s)

Pediatric Critical Care Medicine

Medical/Professional School

Indiana University School of Medicine, Indianapolis
University of Washington Department of Bioengineering, Seattle

Residency

Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh

Fellowship

Critical Care, Children's Hospital and Regional Medical Center, Seattle

Research Focus Area

Therapeutic Trials

Publications

  • Cohen GA, Permut LC, Arakaki LS, Ciesielski WA, McMullan DM, Parrish AR, Schenkman KA
    Direct optical measurement of intraoperative myocardial oxygenation during congenital heart surgery.
    ASAIO journal (American Society for Artificial Internal Organs : 1992) , 2011 July : 314-7
  • Arakaki LS, Ciesielski WA, Thackray BD, Feigl EO, Schenkman KA
    Simultaneous optical spectroscopic measurement of hemoglobin and myoglobin saturations and cytochrome aa3 oxidation in vivo.
    Applied spectroscopy , 2010 Sept. : 973-9
  • Amara CE, Marcinek DJ, Shankland EG, Schenkman KA, Arakaki LS, Conley KE
    Mitochondrial function in vivo: spectroscopy provides window on cellular energetics.
    Methods (San Diego, Calif.) , 2008 Dec. : 312-8
  • Amara CE, Marcinek DJ, Shankland EG, Schenkman KA, Arakaki LS, Conley KE
    Mitochondrial function in vivo: spectroscopy provides window on cellular energetics.
    Methods (San Diego, Calif.) , 2008 Dec. : 312-8
  • Kruse SE, Watt WC, Marcinek DJ, Kapur RP, Schenkman KA, Palmiter RD
    Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.
    Cell metabolism , 2008 Apr, : 312-20
  • Kruse SE, Watt WC, Marcinek DJ, Kapur RP, Schenkman KA, Palmiter RD
    Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.
    Cell metabolism , 2008 Apr, : 312-20
  • Schenkman KA
    Clinical data collection in the information era.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2007 Nov. : 588-9
  • Schenkman KA
    Clinical data collection in the information era.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2007 Nov. : 588-9
  • Schenkman KA, Arakaki LS, Ciesielski WA, Beard DA
    Optical spectroscopy demonstrates elevated intracellular oxygenation in an endotoxic model of sepsis in the perfused heart.
    Shock (Augusta, Ga.) , 2007 June : 695-700
  • Marcinek DJ, Amara CE, Matz K, Conley KE, Schenkman KA
    Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra.
    Applied spectroscopy , 2007 June : 665-9
  • Schenkman KA, Arakaki LS, Ciesielski WA, Beard DA
    Optical spectroscopy demonstrates elevated intracellular oxygenation in an endotoxic model of sepsis in the perfused heart.
    Shock (Augusta, Ga.) , 2007 June : 695-700
  • Marcinek DJ, Amara CE, Matz K, Conley KE, Schenkman KA
    Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra.
    Applied spectroscopy , 2007 June : 665-9
  • Roberts JS, Vavilala MS, Schenkman KA, Shaw D, Martin LD, Lam AM
    Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children.
    Critical care medicine , 2006 Aug. : 2217-23
  • Roberts JS, Vavilala MS, Schenkman KA, Shaw D, Martin LD, Lam AM
    Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children.
    Critical care medicine , 2006 Aug. : 2217-23
  • Ejike JC, Schenkman KA, Seidel K, Ramamoorthy C, Roberts JS
    Cerebral oxygenation in neonatal and pediatric patients during veno-arterial extracorporeal life support.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2006 Mar. : 154-8
  • Ejike JC, Schenkman KA, Seidel K, Ramamoorthy C, Roberts JS
    Cerebral oxygenation in neonatal and pediatric patients during veno-arterial extracorporeal life support.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2006 Mar. : 154-8
  • Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE
    Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle.
    The Journal of physiology , 2005 Dec. 1 : 467-73
  • Marcinek DJ, Schenkman KA, Ciesielski WA, Lee D, Conley KE
    Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle.
    The Journal of physiology , 2005 Dec. 1 : 467-73
  • Ejike JC, Arakaki LS, Beard DA, Ciesielski WA, Feigl EO, Schenkman KA
    Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility.
    American journal of physiology. Heart and circulatory physiology , 2005 May : H2062-7
  • Ejike JC, Arakaki LS, Beard DA, Ciesielski WA, Feigl EO, Schenkman KA
    Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility.
    American journal of physiology. Heart and circulatory physiology , 2005 May : H2062-7
  • Marcinek DJ, Schenkman KA, Ciesielski WA, Conley KE
    Mitochondrial coupling in vivo in mouse skeletal muscle.
    American journal of physiology. Cell physiology , 2004 Feb. : C457-63
  • Marcinek DJ, Schenkman KA, Ciesielski WA, Conley KE
    Mitochondrial coupling in vivo in mouse skeletal muscle.
    American journal of physiology. Cell physiology , 2004 Feb. : C457-63
  • Marcinek DJ, Ciesielski WA, Conley KE, Schenkman KA
    Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo.
    American journal of physiology. Heart and circulatory physiology , 2003 Nov. : H1900-8
  • Schenkman KA, Beard DA, Ciesielski WA, Feigl EO
    Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation.
    American journal of physiology. Heart and circulatory physiology , 2003 Nov. : H1819-25
  • Beard DA, Schenkman KA, Feigl EO
    Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model.
    American journal of physiology. Heart and circulatory physiology , 2003 Nov. : H1826-36
  • Marcinek DJ, Ciesielski WA, Conley KE, Schenkman KA
    Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo.
    American journal of physiology. Heart and circulatory physiology , 2003 Nov. : H1900-8
  • Schenkman KA, Beard DA, Ciesielski WA, Feigl EO
    Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation.
    American journal of physiology. Heart and circulatory physiology , 2003 Nov. : H1819-25
  • Beard DA, Schenkman KA, Feigl EO
    Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model.
    American journal of physiology. Heart and circulatory physiology , 2003 Nov. : H1826-36
  • Okpechi JC, Schenkman KA
    Bronchoesophageal fistula after gastrostomy tube removal by the "cut and push" method.
    Gastrointestinal endoscopy , 2003 July : 134-7
  • Okpechi JC, Schenkman KA
    Bronchoesophageal fistula after gastrostomy tube removal by the "cut and push" method.
    Gastrointestinal endoscopy , 2003 July : 134-7
  • Maier SK, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T, Catterall WA
    An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart.
    Proceedings of the National Academy of Sciences of the United States of America , 2002 Mar. 19 : 4073-8
  • Maier SK, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T, Catterall WA
    An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart.
    Proceedings of the National Academy of Sciences of the United States of America , 2002 Mar. 19 : 4073-8
  • Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, Callis JB
    Continuous measurement of oxygen consumption by pancreatic islets.
    Diabetes technology & therapeutics , 2002 : 661-72
  • Sweet IR, Khalil G, Wallen AR, Steedman M, Schenkman KA, Reems JA, Kahn SE, Callis JB
    Continuous measurement of oxygen consumption by pancreatic islets.
    Diabetes technology & therapeutics , 2002 : 661-72
  • Arakaki LS, Ciesielski WA, Thackray BD, Feigl EO, Schenkman KA
    Simultaneous optical spectroscopic measurement of hemoglobin and myoglobin saturations and cytochrome aa3 oxidation in vivo.
    Applied spectroscopy : : 973-9

Research Funding

Grant Title Grantor Amount Award Date
Translational center for in vivo mitochondrial medicine NIH $1,798,509.00 Jan. 1, 2009
Noninvasive cellular oxygen monitor for shock Coulter Foundation $55,127.00 Jan. 1, 2009
Noninvasive Clinical Monitor for Early Detection of Shock WA Life Sciences Discovery Fund $150,000.00 Jan. 1, 2009
Cellular oxygenation in traumatic shock Seattle Medic One Foundation $106,291.00 Jan. 1, 2009
Noninvasive shock monitor for trauma and critically ill patients UW Technology Gap Innovation Fund $50,000.00 Jan. 1, 2008
MR and optical diagnosis of muscle metabolism and function NIH $1,678,900.00 Jan. 1, 2007