Profile

Kenneth A. Schenkman, MD

On staff since November 1998

Research Center: Center for Developmental Biology and Regenerative Medicine

Kenneth A. Schenkman, MD, PhD, is an attending physician in the Pediatric Intensive Care Units at Seattle Children’s Hospital and Harborview Medical Center. He is an Associate Professor of Pediatrics and Anesthesiology and Adjunct Associate Professor of Bioengineering at the University of Washington School of Medicine. Dr. Schenkman received his MD from Indiana University and completed a pediatrics residency at the Children’s Hospital of Pittsburgh, where he also served as Chief Resident.

He trained in pediatric critical care at Seattle Children’s and received a PhD in Bioengineering from the University of Washington. He has an active research program developing optical spectroscopic technologies for clinical assessment of intracellular oxygenation and mitochondrial function. Dr. Schenkman has been awarded a U.S. patent and filed four additional patent applications for his pioneering work on developing an intracellular oxygen monitor. Schenkman has published dozens of manuscripts and abstracts in the field of optical spectroscopy for physiologic and clinical applications, and has published several book chapters on pediatric critical care topics. He also has been an active reviewer for journals in the fields of medicine, physiology and biomedical optics.

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Overview
Publications
Research Funding

Overview

Board Certification(s): Pediatric Critical Care Medicine
Medical/Professional School: Indiana University School of Medicine, Indianapolis
Residency: Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh
Fellowship: Critical Care, Children's Hospital and Regional Medical Center, Seattle
Research Focus Area: Therapeutic Trials

Publications

Direct optical measurement of intraoperative myocardial oxygenation during congenital heart surgery.
ASAIO journal (American Society for Artificial Internal Organs : 1992) , 2011 Jul-Aug: 314-7

Simultaneous optical spectroscopic measurement of hemoglobin and myoglobin saturations and cytochrome aa3 oxidation in vivo.
Applied spectroscopy , 2010 Sep: 973-9

Mitochondrial function in vivo: spectroscopy provides window on cellular energetics.
Methods (San Diego, Calif.) , 2008 Dec: 312-8

Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.
Cell metabolism , 2008 Apr: 312-20

Clinical data collection in the information era.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2007 Nov: 588-9

Optical spectroscopy demonstrates elevated intracellular oxygenation in an endotoxic model of sepsis in the perfused heart.
Shock (Augusta, Ga.) , 2007 Jun: 695-700

Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra.
Applied spectroscopy , 2007 Jun: 665-9

Optical spectroscopy demonstrates elevated intracellular oxygenation in an endotoxic model of sepsis in the perfused heart.
Shock (Augusta, Ga.) , 2007 Jun: 695-700

Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra.
Applied spectroscopy , 2007 Jun: 665-9

Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children.
Critical care medicine , 2006 Aug: 2217-23

Cerebral oxygenation in neonatal and pediatric patients during veno-arterial extracorporeal life support.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2006 Mar: 154-8

Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle.
The Journal of physiology , 2005 Dec 1: 467-73

Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility.
American journal of physiology. Heart and circulatory physiology , 2005 May: H2062-7

Mitochondrial coupling in vivo in mouse skeletal muscle.
American journal of physiology. Cell physiology , 2004 Feb: C457-63

Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo.
American journal of physiology. Heart and circulatory physiology , 2003 Nov: H1900-8

Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation.
American journal of physiology. Heart and circulatory physiology , 2003 Nov: H1819-25

Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model.
American journal of physiology. Heart and circulatory physiology , 2003 Nov: H1826-36

Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo.
American journal of physiology. Heart and circulatory physiology , 2003 Nov: H1900-8

Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation.
American journal of physiology. Heart and circulatory physiology , 2003 Nov: H1819-25

Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model.
American journal of physiology. Heart and circulatory physiology , 2003 Nov: H1826-36

Bronchoesophageal fistula after gastrostomy tube removal by the "cut and push" method.
Gastrointestinal endoscopy , 2003 Jul: 134-7

An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart.
Proceedings of the National Academy of Sciences of the United States of America , 2002 Mar 19: 4073-8

Continuous measurement of oxygen consumption by pancreatic islets.
Diabetes technology & therapeutics , 2002: 661-72

Simultaneous optical spectroscopic measurement of hemoglobin and myoglobin saturations and cytochrome aa3 oxidation in vivo.
Applied spectroscopy , : : 973-9

Research Funding

Grant Title	Grantor	Amount	Award Date
Translational center for in vivo mitochondrial medicine	NIH	$1,798,509.00	Jan. 1, 2009
Noninvasive cellular oxygen monitor for shock	Coulter Foundation	$55,127.00	Jan. 1, 2009
Noninvasive Clinical Monitor for Early Detection of Shock	WA Life Sciences Discovery Fund	$150,000.00	Jan. 1, 2009
Cellular oxygenation in traumatic shock	Seattle Medic One Foundation	$106,291.00	Jan. 1, 2009
Noninvasive shock monitor for trauma and critically ill patients	UW Technology Gap Innovation Fund	$50,000.00	Jan. 1, 2008
MR and optical diagnosis of muscle metabolism and function	NIH	$1,678,900.00	Jan. 1, 2007

Primary Office

Seattle Children's

OB.10.625 - Critical Care
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2170

Additional Offices

University of Washington

UW Box 356320 - Pediatrics
1959 NE Pacific St

Seattle, WA 98195-6320

206-543-3373

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Kenneth A. Schenkman, MD

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