Profile

Karen Marie Chisholm, MD, PhD

Karen Marie Chisholm, MD, PhD

Pathology

On staff since July 2015

Children's Title: Anatomic Pathologist

Academic Title: Clinical Assistant Professor, University of Washington

  • Award Name Award Description Awarded By Award Date
    Gordon F. Vawter Pathologist-in-Training award Presentation: "Evaluation of serial urine viral cultures for the diagnosis of cytomegalovirus infection in neonates and infants" Society for Pediatric Pathology Sept. 2013
    Perinatal Pathology award Presentation: "Diagnosis of congenital CMV using PCR performed on formalin-fixed, paraffin-embedded placental tissue" Society for Pediatric Pathology Oct. 2012
    Gordon F. Vawter Pathologist-in-Training award Presentation: "Beta adrenergic receptor expression in pediatric vascular lesions" Gordon F. Vawter Pathologist-in-Training award Feb. 2011
    • Hoffmann JC, Chisholm KM, Cherry A, Chen J, Arber DA, Natkunam Y, Warnke RA, Ohgami RS
      An analysis of MYC and EBV in diffuse large B-cell lymphomas associated with angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma not otherwise specified.
      26772393 Human pathology , 2016 : 489-17
    • Chisholm KM, Folkins AK
      Placental and Clinical Characteristics of Term Small-for-Gestational-Age Neonates: A Case-Control Study.
      26368794 Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society , 2016 : 19(1)37-46
    • Chisholm KM and Heerema-McKenney AE
      PRAME immunohistochemical staining in Transient Abnormal Myelopoiesis and Myeloid leukemia associated with Down syndrome.
      25887863 Annals of Clinical and Laboratory Science , 2015 : 45(2)121-127
    • Chisholm KM, Merker JD, Gotlib JR, Gitana G, Lefterova M, Zehnder JL, George TI, Arber DA, and Ohgami RS
      Mast cells in systemic mastocytosis have distinctly brighter CD45 expression by flow cytometry
      25780004 American Journal of Clinical Pathology. , 2015 : 143527-534
    • Schulz S, Chisholm KM, Zhao H, Kalish F, Yang Y, Wong RJ, Stevenson DK
      Heme oxygenase-1 confers protection and alters T cell populations in a model of neonatal intestinal inflammation
      25665053 Pediatric Research , 2015 : 77(5)640-648
    • Chisholm KM, Bangs D, Bacchi CE, Molina Kirsch H, Cherry A, and Natkunam Y
      Expression profiles of MYC protein and MYC gene rearrangement in lymphomas
      25581730 American Journal of Surgical Pathology , 2015 : 39(3)294-303
    • Chisholm KM and Heerema-McKenney AE
      Fetal thrombotic vasculopathy: significance in liveborn children using proposed Society for Pediatric Pathology diagnostic criteria
      25321333 American Journal of Surgical Pathology , 2015 : 39(2)274-280
    • Chisholm KM, Longacre TA
      Utility of Peripherin Versus MAP-2 and Calretinin in the Evaluation of Hirschsprung Disease.
      26469323 Applied immunohistochemistry and molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry , 2015
    • Chisholm KM, Aziz N, McDowell MJ, Guo F, Srinivas N, Guttierrez K, Folkins A, and Pinsky BA
      Evaluation of serial urine viral cultures for the diagnosis of Cytomegalovirus infection in neonates and infants
      24617645 Pediatric and Developmental Pathology , 2014 : 39(2)274-280
    • Ohgami RS, Chisholm KM, Ma L, Arber DA
      E-cadherin is a specific marker for erythroid differentiation and has utility, in combination with CD117 and CD34, for enumerating myeloblasts in hematopoietic neoplasms
      24713736 American Journal of Clinical Pathology , 2014 : 141656-664
    • Chisholm KM and Heerema-McKenney AE
      Erythroid nuclear irregularities: a review of fetal and neonatal autopsies and correlation with clinical features
      24695468 Annals of Clinical and Laboratory Science , 2014 : 44(1)10-18
    • Chisholm KM, Getsinger D, Vaughan W, Hwang P, and Banaei N
      Pretreatment of sinus aspirates with dithiothreitol improves yield of fungal cultures in patients with chronic sinusitis.
      24124079 International Forum of Allergy & Rhinology , 2013 : 3(12)992-996
    • Schulz S, Wong RJ, Jang KY, Kalish F, Chisholm KM, Zhao H, Vreman HJ, Sylvester KS, Stevenson DK. 2013
      Heme Oxygenase-1 deficiency promotes the development of necrotizing enterocolitis-like intestinal injury in a newborn mouse model
      23578787 American Journal of Physiology - Gastrointestinal and Liver Physiology , 2013 : 304G991-G1001
    • Dharajiya N, Chisholm KM, Dietz L, Richards CS, Kharrazi M, and Schrijver I
      Identification of the CFTR p.Phe508del founder mutation in the absence of a polythymidine 9T allele in a Hispanic Patient
      23017188 Clinical Genetics , 2013 : 83(6)598-599
    • Kraneburg UM, Rinsky LA, Chisholm KM, and Khosla RK
      Emergency surgical treatment of an ulcerative and hemorrhagic congenital/infantile fibrosarcoma of the lower leg: case report and literature review
      22568962 Journal of Pediatric Orthopaedics B , 2013 : 22(3)228-232
    • Folkins AK, Chisholm KM, Guo F, McDowell M, Aziz N, and Pinsky BA
      Diagnosis of Congenital CMV using PCR performed on formalin-fixed, paraffin-embedded placental tissue
      23797721 American Journal of Surgical Pathology , 2013 : 37(9)1413-1420
    • Chisholm KM, Chang KW, Truong MT, Kwok S, West R, and Heerema-McKenney AE
      Beta-Adrenergic Receptor Expression in Vascular Tumors
      22743651 Modern Pathology , 2012 : 25(11)1446-1451
    • Kim MJJ, Wapnir IL, Ikeda DM, Chisholm KM, Do Y, and Daniel BL
      MRI enhancement correlates with high grade desmoid tumor of breast
      22716922 The Breast Journal , 2012 : 18(4)374-376
    • Chisholm KM, Hsu C, Kim M, Rangaswami A, and Hazard FKG
      Congenital Pancreatoblastoma: A case report and review of the literature
      22278199 Journal of Pediatric Hematology/Oncology , 2012 : 34(4)310-315
    • Chisholm KM, Aubert SD, Freese KP, Zakian VA, King M-C, and Welcsh PL
      A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements reveals a role for PIF1.
      22347400 PLoS ONE , 2012 : 7(2)e30748
    • Chisholm KM, Wan Y, Li R, Montgomery KD, Chang H, and West RB
      Detection of long non-coding RNA in archival tissue: correlation with Polycomb protein expression in primary and metastatic breast carcinoma
      23133536 PLoS One , 2012 : 7(10)e47998
    • Murphy JD, Chisholm KM, Daly ME, Wiegner EA, Truong D, Iagaru A, Maxim PG, Loo BW, Graves EE, Kaplan MJ, Kong C, and Le Q-T
      Correlation between metabolic tumor volume and pathologic tumor volume in squamous cell carcinoma of the oral cavity.
      21665308 Radiotherapy and Oncology , 2011 : 101(3)356-361
    • Pierce S, Chisholm KM, Lynch E, Lee MK, Walsh T, Opitz JM, Li W, Klevit RE, and King M-C
      Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault Syndrome.
      21464306 PNAS , 2011 : 108(16)6543-6548
    • Chisholm KM and Harruff RC
      Elderly deaths due to ground level falls
      20938326 American Journal of Forensic Medicine and Pathology , 2010 : 31350-354
    • Pierce SB, Walsh T, Chisholm KM, Lee MK, Thornton AM, Fiumara A, Opitz JM, Levy-Lahad E, Klevit RE, and King M-C
      Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia in Perrault syndrome
      20673864 American Journal of Human Genetics , 2010 : 87282-288
    • Chisholm KM, Goff MA, Garcia R, King M-C, and Swisher EM
      Genomic structure of chromosome 17 deletions in BRCA1 associated ovarian cancers
      18474296 Cancer Genetics and Cytogenetics. , 2008 : 18341-48
    • Seligman LM, Chisholm KM, Chevalier BS, Chadsey MS, Edwards ST, Savage JH, and Veillet AL
      Mutations altering the cleavage specificity of a homing endonuclease
      12202772 Nucleic Acids Research , 2002 : 3(17)3870-3879

  • Presentations Title Event Location Date
    Primary lymphoma of bone in the pediatric population Society for Pediatric Pathology Boston March 2015
    Immunohistochemical profile of MYC protein in pediatric small round blue cell tumors SPP/PPS Joint Meeting Birmingham, UK Sept. 2014
    Expression profile of MYC protein in lymphoma subtypes United States and Canadian Academy of Pathology San Diego March 2014
    Evaluation of serial urine viral cultures for the diagnosis of Cytomegalovirus infection in neonates and infants Society for Pediatric Pathology Salt Lake City Sept. 2013
    Diagnosis of congenital CMV using PCR performed on formalin-fixed, paraffin-embedded placental tissue Society for Pediatric Pathology Houston Oct. 2012
    Dyserythropoiesis: a review of fetal and neonatal autopsies and correlation with clinical features Society for Pediatric Pathology Vancouver, BC March 2012
    Fetal thrombotic vasculopathy: significance in liveborn children Society for Pediatric Pathology Vancouver, BC March 2012
    Correlation of preterm infant morbidities with placenta histology Society for Pediatric Pathology Vancouver, BC March 2012
    Beta adrenergic receptor expression in pediatric vascular lesions Society for Pediatric Pathology San Antonio Feb. 2011
    Acute erythroleukemia (AEL): The COG AML0531 experience Society for Pediatric Pathology San Antonio Feb. 2011
    Acute megakaryoblastic leukemia (AMkL): The COG AML0531 experience Society for Pediatric Pathology San Antonio Feb. 2011

Overview

Board Certification(s)

Pathology - Anatomic
Hematology
Pathology - Clinical
Pediatric Pathology

Medical/Professional School

University of Washington, Seattle

Residency

Pathology - Anatomic, Stanford University School of Medicine, Stanford

Fellowship

Hematopathology, Stanford University School of Medicine, Stanford
Pediatric Pathology, Boston Children's Hospital, Boston