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Karen F. Murray, MD

Karen F. Murray, MD

Gastroenterology, Hepatology, Transplantation, Gastroenterology and Hepatology Research

On staff since November 1998

Children's Title: Division Chief of Pediatric Gastroenterology and Hepatology

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

"I love my work because I have so many opportunities to make a difference. Our team treats children with life-threatening diseases of the liver and digestive system that prevent them from realizing their full potential. It’s a complete thrill to give these kids and their families the care and compassion they need to achieve their life’s dreams. I also have the privilege of being a mentor. Educating the next generation of doctors and helping them meet their goals is a personal passion and vital to the future of medicine. And I’m excited to be involved in research about pediatric liver diseases and their treatment options, which we hope one day will enable us to prevent these terrible illnesses."

Karen F. Murray, MD, is division chief of the Pediatric Gastroenterology and Hepatology program at Seattle Children’s Hospital; she is program director of gastroenterology education; she is professor in the Department of Pediatrics at the University of Washington School of Medicine. She received her MD from Johns Hopkins School of Medicine and did a pediatrics residency and a chief resident year at Seattle Children’s.

She completed a clinical and research fellowship in gastroenterology and nutrition in the combined program at Children’s Hospital Boston and Massachusetts General Hospital, Harvard Medical School. Murray is certified in gastroenterology and transplant hepatology, and chairs the Gastroenterology Sub-board of the American Board of Pediatrics. In addition to clinical care in gastroenterology and transplantation, she has an active clinical research program in hepatology. Her main focus is in the treatment and pathophysiology of childhood liver disease, with focus on the treatment of hepatitis B and C viral infections, non-alcoholic fatty liver disease, and cholestatic liver diseases in childhood. Murray is past-president of Seattle Children’s medical staff. She is on the steering committees of three National Institute of Diabetes and Digestive and Kidney Diseases clinical research networks related to her research. She mentors pediatrics residents and speaks at Seattle Children’s noon conferences.

Recommendations

  • David Granite Falls, WA 10.25.11

    Dr Murray is an intelligent, compassionate doctor who truly cares for her patients. She communicates clearly to both children and parents. I am a parent of a teen daughter who has been under Dr Murray's care for about four years, and I highly recommend her.

Overview

Board Certification(s)

Pediatric Gastroenterology
Pediatrics
Pediatric Transplant Hepatology

Medical/Professional School

Johns Hopkins University School of Medicine, Baltimore

Residency

Pediatrics, Children's Hospital and Regional Medical Center, Seattle

Fellowship

Gastroenterology, Children's Hospital, Boston

Clinical Interests

Hepatitis B and C

Research Description

Clinical research in the pathogenesis of, epidemiology of, and treatment for viral hepatitis and other pediatric liver diseases.

Research Focus Area

Therapeutic Trials

Awards and Honors

Award Name Award Description Awarded By Award Date
1 of 2 Candidates for President of NASPGHAN Selected as 1 of 2 candidates for President of the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN), a society of approximately 3,000 members across the USA, Canada, and Mexico. NASPGHAN 2014
U.S. News Top Doctor U.S. News and World Report-ranked in top 1% 2012
Who's Who in America 2011
Best Doctors in America 2011
Seattle Magazine "Top Doctor" Seattle Magazine 2010 - 2014
International Association of Pediatricians 2010
Leading Physicians of the World International Association of Healthcare Professionals 2010
SEATTLE TOP DOCTORS Seattle Metropolitan Magazine 2010 - 2014
"Guide to America's Top Pediatricians" Consumer's Research Council of America 2009
Seattles Top Doctors Seattle Metropolitan Magazine 2006 - 2014
Seattle Magazine "Top Doctor" Seattle Magazine. 2006

Publications

  • Narkewicz MR, Rosenthal P, Schwarz KB, Drack A, Margolis T, Repka MX
    Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon.
    Journal of pediatric gastroenterology and nutrition , 2010 Aug. : 183-6
  • Richardson PG, Soiffer RJ, Antin JH, Uno H, Jin Z, Kurtzberg J, Martin PL, Steinbach G, Murray KF, Vogelsang GB, Chen AR, Krishnan A, Kernan NA, Avigan DE, Spitzer TR, Shulman HM, Di Salvo DN, Revta C, Warren D, Momtaz P, Bradwin G, Wei LJ, Iacobelli M, McDonald GB, Guinan EC
    Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 July : 1005-17
  • Wahbeh G, Rubens D, Katz JR, Seidel K, Rampersad SE, Murray KF
    Gastric contents in pediatric patients following bone marrow transplantation.
    Paediatric anaesthesia , 2010 July : 660-5
  • Sadilek M, Feldman K, Murray KF, Young M, Mazor S
    Detection of polyethylene glycol-based laxatives in stool.
    Journal of pediatric gastroenterology and nutrition , 2010 Mar. : 276-9
  • Laiko M, Murtazina R, Malyukova I, Zhu C, Boedeker EC, Gutsal O, O'Malley R, Cole RN, Tarr PI, Murray KF, Kane A, Donowitz M, Kovbasnjuk O
    Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3.
    Experimental cell research , 2010 Feb. 15 : 657-66
  • Mohan N, González-Peralta RP, Fujisawa T, Chang MH, Heller S, Jara P, Kelly D, Mieli-Vergani G, Shah U, Murray KF
    Chronic hepatitis C virus infection in children.
    Journal of pediatric gastroenterology and nutrition , 2010 Feb. : 123-31
  • Karen F. Murray, MD
    Fibrocystic diseases of the liver, 1st edition
    : 511 pages
  • Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J
    Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.
    Contemporary clinical trials , 2010 Jan. : 62-70
  • Narkewicz MR, Dell Olio D, Karpen SJ, Murray KF, Schwarz K, Yazigi N, Zhang S, Belle SH, Squires RH
    Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement.
    The Journal of pediatrics , 2009 Dec. : 801-806.e1
  • Knight C, Murray KF
    Hepatobiliary associations with inflammatory bowel disease.
    Expert review of gastroenterology & hepatology , 2009 Dec. : 681-91
  • Haber BA, Block JM, Jonas MM, Karpen SJ, London WT, McMahon BJ, Murray KF, Narkewicz MR, Rosenthal P, Schwarz KB
    Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B.
    Pediatrics , 2009 Nov. : e1007-13
  • Mieli-Vergani G, Heller S, Jara P, Vergani D, Chang MH, Fujisawa T, González-Peralta RP, Kelly D, Mohan N, Shah U, Murray KF
    Autoimmune hepatitis.
    Journal of pediatric gastroenterology and nutrition , 2009 Aug. : 158-64
  • Shah U, Kelly D, Chang MH, Fujisawa T, Heller S, González-Peralta RP, Jara P, Mieli-Vergani G, Mohan N, Murray KF
    Management of chronic hepatitis B in children.
    Journal of pediatric gastroenterology and nutrition , 2009 Apr, : 399-404
  • Rodrigue JR, Balistreri W, Haber B, Jonas MM, Mohan P, Molleston JP, Murray KF, Narkewicz MR, Rosenthal P, Smith LJ, Schwarz KB, Robuck P, Barton B, González-Peralta RP
    Impact of hepatitis C virus infection on children and their caregivers: quality of life, cognitive, and emotional outcomes.
    Journal of pediatric gastroenterology and nutrition , 2009 Mar. : 341-7
  • Malyukova I, Murray KF, Zhu C, Boedeker E, Kane A, Patterson K, Peterson JR, Donowitz M, Kovbasnjuk O
    Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis.
    American journal of physiology. Gastrointestinal and liver physiology , 2009 Jan. : G78-92
  • Murray KF, Hadzic N, Wirth S, Bassett M, Kelly D
    Drug-related hepatotoxicity and acute liver failure.
    Journal of pediatric gastroenterology and nutrition , 2008 Oct. : 395-405
  • McGinnis JK, Murray KF
    Infliximab for ulcerative colitis in children and adolescents.
    Journal of clinical gastroenterology , 2008 Sept. : 875-9
  • Murray KF, Shah U, Mohan N, Heller S, González-Peralta RP, Kelly D, Chang MH, Mieli-Vergani G, Jara P, Fujisawa T
    Chronic hepatitis.
    Journal of pediatric gastroenterology and nutrition , 2008 Aug. : 225-33
  • Bassett MD, Murray KF
    Biliary atresia: recent progress.
    Journal of clinical gastroenterology , 2008 July : 720-9
  • Hsu EK, Murray KF
    Hepatitis B and C in children.
    Nature clinical practice. Gastroenterology & hepatology , 2008 June : 311-20
  • Goodman ZD, Makhlouf HR, Liu L, Balistreri W, Gonzalez-Peralta RP, Haber B, Jonas MM, Mohan P, Molleston JP, Murray KF, Narkewicz MR, Rosenthal P, Smith LJ, Robuck PR, Schwarz KB
    Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial.
    Hepatology (Baltimore, Md.) , 2008 Mar. : 836-43
  • Suskind DL, Murray KF
    Increasing the mutation rate for Jagged1 mutations in patients with Alagille syndrome.
    Hepatology (Baltimore, Md.) , 2007 Aug. : 598-9
  • Murray KF
    Autoimmune hepatitis: are we using the right therapy?
    Journal of pediatric gastroenterology and nutrition , 2007 Jan. : 18-9
  • Murray KF, Rodrigue JR, González-Peralta RP, Shepherd J, Barton BA, Robuck PR, Schwarz KB
    Design of the PEDS-C trial: pegylated interferon +/- ribavirin for children with chronic hepatitis C viral infection.
    Clinical trials (London, England) , 2007 : 661-73
  • Squires RH Jr, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, Dhawan A, Rosenthal P, Rodriguez-Baez N, Murray KF, Horslen S, Martin MG, Lopez MJ, Soriano H, McGuire BM, Jonas MM, Yazigi N, Shepherd RW, Schwarz K, Lobritto S, Thomas DW, Lavine JE, Karpen S, Ng V, Kelly D, Simonds N, Hynan LS
    Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.
    The Journal of pediatrics , 2006 May : 652-658
  • Dinulos JG, Darmstadt GL, Len MK, Rutledge JC, Murray KF
    Infantile Crohn disease presenting with diarrhea and pyoderma gangrenosum.
    Pediatric dermatology , 2006 Jan. : 43-8
  • González-Peralta RP, Kelly DA, Haber B, Molleston J, Murray KF, Jonas MM, Shelton M, Mieli-Vergani G, Lurie Y, Martin S, Lang T, Baczkowski A, Geffner M, Gupta S, Laughlin M
    Interferon alfa-2b in combination with ribavirin for the treatment of chronic hepatitis C in children: efficacy, safety, and pharmacokinetics.
    Hepatology (Baltimore, Md.) , 2005 Nov. : 1010-8
  • Murray KF, Finn LS, Taylor SL, Seidel KD, Larson AM
    Liver histology and alanine aminotransferase levels in children and adults with chronic hepatitis C infection.
    Journal of pediatric gastroenterology and nutrition , 2005 Nov. : 634-8
  • Bousvaros A, Guandalini S, Baldassano RN, Botelho C, Evans J, Ferry GD, Goldin B, Hartigan L, Kugathasan S, Levy J, Murray KF, Oliva-Hemker M, Rosh JR, Tolia V, Zholudev A, Vanderhoof JA, Hibberd PL
    A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease.
    Inflammatory bowel diseases , 2005 Sept. : 833-9
  • Murray KF, Carithers RL Jr
    AASLD practice guidelines: Evaluation of the patient for liver transplantation.
    Hepatology (Baltimore, Md.) , 2005 June : 1407-32
  • Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Klein EJ, Tarr PI
    Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion.
    Pediatrics , 2005 June : e673-80
  • Murray KF, Lam D, Kowdley KV
    Current and future therapy in haemochromatosis and Wilson's disease.
    Expert opinion on pharmacotherapy , 2003 Dec. : 2239-51
  • Murray KF, Richardson LP, Morishima C, Owens JW, Gretch DR
    Prevalence of hepatitis C virus infection and risk factors in an incarcerated juvenile population: a pilot study.
    Pediatrics , 2003 Jan. : 153-7

Presentations

Presentations Title Event Location Date
"Drug-induced liver injury and liver failure in children” Taiwan Society of Pediatric Gastroenterology, Hepatology, and Nutrition annual meeting Taipei, Taiwan 2011
Concurrent Session III speaker: “Why do maintenance of certification?”; Faculty, 4th Hands on Endoscopy Course - Polypectomy Orlando, FL NASPGHAN Annual Meeting 2011
“Gastroenterology: Careers in Academic Pediatric Gastroenterology and Hepatology” Pediatric Academic Societies Vancouver, Canada 2010
“Biliary Atresia: Clinical Spectrum and Mechanisms of Disease"; • “New Treatments for Chronic B and C Hepatitis”; “State of the Art in Non-Alcoholic Steatohepatitis” International Symposium of Argentine Association for the Study of Liver Diseases (AAEEH) - International Guest Pediatric Hepatologist Buenos Aires, Argentina 2010

Research Funding

Grant Title Grantor Amount Award Date
A Phase 3, Randomized, Double-Blind Evaluation of the Antiviral Efficacy, Safety, and Tolerability of Tenofovir Disoproxil Fumarate Versus Placebo in Adolescents with Chronic Hepatitis B Infection Gilead Sciences, Inc. $56,849.00 Jan. 1, 2009
Limited Competition: Continuation of the Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN) NIH $225,207.00 Jan. 1, 2009
Childhood Liver Disease Research and Education Network Clinical Center in Seattle NIH NIDDK $1,557,754.00 Jan. 1, 2009
BARC CRN, Biliary atresia research consortium NIH NIDDK $95,266.00 Jan. 1, 2008
Clinical Research Network in Hepatitis B Virus NIH $311,878.00 Jan. 1, 2008
A phase 3 double-blind, randomized, placebo-controlled study of the safety and efficacy of Adefovir Dipivoxil in children and adolescents (age 2 to under 18) with chronic hepatitis B Gilead Sciences, Inc. $128,327.00 Jan. 1, 2004
Pegylated interferon + - ribavirin for children with HCV FDA-OPD-2002 Clinical Studies of Safety and Effectiveness of Orphan Products $99,650.00 Jan. 1, 2003
CD4+ T-cell immunity in mother-child pairs infected with hepatitis C virus Research Endorsement Fund $30,000.00 Jan. 1, 2002
Pediatric Acute liver failure study group NIH/NIDDK $16,000.00