Profile

Karen D. Tsuchiya, MD

Karen D. Tsuchiya, MD

Pathology

On staff since March 2004

Children's Title: Program Director, Cytogenetics Laboratory; Program Director, Molecular Diagnostics

Academic Title: Associate Professor

Research Center: Center for Clinical and Translational Research

Overview

Board Certification(s)

Pathology - Anatomic
Clinical Cytogenetics
Clinical Molecular Genetics

Medical/Professional School

University of Michigan Medical School, Ann Arbor

Residency

Pathology - Anatomic, University of Washington School of Medicine, Seattle

Fellowship

Pathology - Clinical, University of Washington School of Medicine, Seattle
Clinical Cytogenetics, Case Western Reserve University School of Medicine, Cleveland

Research Focus Area

Translational Research

Publications

  • Hand M, Gray C, Glew G, Tsuchiya KD
    Mild phenotype in a patient with mosaic del(8p)/inv dup del(8p).
    American journal of medical genetics. Part A , 2010 Sept. 9
  • Bachmann-Gagescu R, Mefford HC, Cowan C, Glew GM, Hing AV, Wallace S, Bader PI, Hamati A, Reitnauer PJ, Smith R, Stockton DW, Muhle H, Helbig I, Eichler EE, Ballif BC, Rosenfeld J, Tsuchiya KD
    Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity.
    Genetics in medicine : official journal of the American College of Medical Genetics , 2010 Aug. 30
  • Tsuchiya KD, Shaffer LG, Aradhya S, Gastier-Foster JM, Patel A, Rudd MK, Biggerstaff JS, Sanger WG, Schwartz S, Tepperberg JH, Thorland EC, Torchia BA, Brothman AR
    Variability in interpreting and reporting copy number changes detected by array-based technology in clinical laboratories.
    Genetics in medicine : official journal of the American College of Medical Genetics , 2009 Dec. : 866-73
  • Yi Y, Nandana S, Case T, Nelson C, Radmilovic T, Matusik RJ, Tsuchiya KD
    Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer.
    Molecular Cytogenetics , 2009 Sept. 26 : 18
  • Ausch C, Kim YH, Tsuchiya KD, Dzieciatkowski S, Washington MK, Paraskeva C, Radich J, Grady WM
    Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA.
    Clinical chemistry , 2009 Aug. : 1559-63
  • Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM
    TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
    Gastroenterology , 2009 May : 1680-8.e7
  • Tsuchiya KD, Opheim KE, Hannibal MC, Hing AV, Glass IA, Raff ML, Norwood T, Torchia BA
    Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization.
    Molecular Cytogenetics , 2008 Apr, 21 : 7
  • Hatton BA, Villavicencio EH, Tsuchiya KD, Pritchard JI, Ditzler S, Pullar B, Hansen S, Knoblaugh SE, Lee D, Eberhart CG, Hallahan AR, Olson JM
    The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.
    Cancer research , 2008 Mar. 15 : 1768-76
  • Greene S, Hawkins DS, Rutledge JC, Tsuchiya KD, Douglas J, Ellenbogen RG, Avellino AM
    Pediatric intradural extramedullary synovial sarcoma: case report.
    Neurosurgery , 2006 Dec. : E1339; discussion E1339
  • Loeb KR, Kostner H, Firpo E, Norwood T, D Tsuchiya K, Clurman BE, Roberts JM
    A mouse model for cyclin E-dependent genetic instability and tumorigenesis.
    Cancer cell , 2005 July : 35-47
  • Filippova GN, Cheng MK, Moore JM, Truong JP, Hu YJ, Nguyen DK, Tsuchiya KD, Disteche CM
    Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.
    Developmental cell , 2005 Jan. : 31-42
  • Tsuchiya KD, Greally JM, Yi Y, Noel KP, Truong JP, Disteche CM
    Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse.
    Genome research , 2004 July : 1275-84
  • Kulnane LS, Lehman EJ, Hock BJ, Tsuchiya KD, Lamb BT
    Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts.
    Mammalian genome : official journal of the International Mammalian Genome Society , 2002 Apr, : 223-6