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Karen D. Tsuchiya, MD

Karen D. Tsuchiya, MD


On staff since March 2004

Children's Title: Program Director, Cytogenetics Laboratory; Program Director, Molecular Diagnostics

Academic Title: Associate Professor

Research Center: Center for Clinical and Translational Research


Board Certification(s)
Pathology - Anatomic
Clinical Cytogenetics
Clinical Molecular Genetics
Medical/Professional School
University of Michigan Medical School, Ann Arbor
Pathology - Anatomic, University of Washington School of Medicine, Seattle
Pathology - Clinical, University of Washington School of Medicine, Seattle
Clinical Cytogenetics, Case Western Reserve University School of Medicine, Cleveland
Research Focus Area

Translational Research


Mild phenotype in a patient with mosaic del(8p)/inv dup del(8p).
American journal of medical genetics. Part A , 2010 Sep 9
Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity.
Genetics in medicine : official journal of the American College of Medical Genetics , 2010 Aug 30
Variability in interpreting and reporting copy number changes detected by array-based technology in clinical laboratories.
Genetics in medicine : official journal of the American College of Medical Genetics , 2009 Dec: 866-73
Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer.
Molecular Cytogenetics , 2009 Sep 26: 18
Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA.
Clinical chemistry , 2009 Aug: 1559-63
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
Gastroenterology , 2009 May: 1680-8.e7
Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization.
Molecular Cytogenetics , 2008 Apr 21: 7
The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.
Cancer research , 2008 Mar 15: 1768-76
Pediatric intradural extramedullary synovial sarcoma: case report.
Neurosurgery , 2006 Dec: E1339; discussion E1339
A mouse model for cyclin E-dependent genetic instability and tumorigenesis.
Cancer cell , 2005 Jul: 35-47
Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.
Developmental cell , 2005 Jan: 31-42
Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse.
Genome research , 2004 Jul: 1275-84
Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts.
Mammalian genome : official journal of the International Mammalian Genome Society , 2002 Apr: 223-6

Primary Office

Seattle Children's
OC.8.720 - Pathology Lab
4800 Sand Point Way NE
Seattle, WA 98105

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