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James A. Bassuk, PhD

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Overview

Research Description

My laboratory is developing recombinant proteins for use in the treatment of urinary tract diseases. These proteins are Fibroblast Growth Factor-10 (FGF-10) and Secreted Protein Acidic and Rich in Cysteine (SPARC). Bladder diseases cause widespread "quiet" suffering - especially for women.

For men, bladder cancer is the 4th leading cause of new cancer in the U.S. Incontinence is the #1 reason why our elderly enter nursing homes.

Understanding how the urothelium grows and differentiates is central to understanding a number of bladder diseases. Being able to modulate these processes will lead to improved treatment of urinary tract abnormalities in children and adults.

Research Focus Area

Genetics and Developmental Biology, Tissue Response to Injury

Research Funding

Grant TitleGrantorAmountAward Date
Directed differentiation of embryonic stem cells for urologic applicationsNIH Career Enhancement Award for Stem Cell Research $400,000.00July 1, 2010
Evaluation of Heterogeneity in Urothelial Cells in Interstitial CystitisNIH NIDDK $400,000.00Sept. 1, 2004

Additional Offices

Seattle Children's Research Institute
JMB - 5 - Center for Developmental Biology and Regenerative Medicine
1900 - 9th Ave
Seattle, WA 98101
206-884-1136

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