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J Lawrence Merritt II, MD

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J Lawrence Merritt II, MD

Biochemical Genetics, Genetics, Mitochondrial Medicine

On staff since July 2007

Research Center: Center for Clinical and Translational Research

Recommendations

AprilChandler, AZ08.13.12
Doctor Merritt is an amazing physician willing to go the extra mile searching for a diagnosis, treating the patient and working with parents in the process. We are forever grateful for his diligence in searching for the source of our son's issues. We were seen in a timely fashion for each appointment and never rushed through visits no matter how many questions we had. He is thoughtful and thorough and does not give up. He is a true asset to the field of Biochemical Genetics.
LisaLacey, WA12.31.11
Dr. Merritt LISTENS. He hears everything and responds and does not make us feel foolish for all of our questions that I'm sure he's heard a million times. I am so impressed that he is not threatened by patients researching and learning about their disorder, but encourages it. We are thankful to have been referred to him!
ShawneePhoenix, AZ08.31.11
Dr. Merritt has been our doctor for the past 2 1/2 years. Their is no one finer than him and his team. My son was sleepy and not doing normal day to day activities before meeting Dr. Merritt. After meeting him, Dr. Merritt and his team started him on the medicine that helped him have more energy and be able to play and have fun. My husband and I will be forever grateful to him. He is truly the best in his field. He is caring, compassionate, and truly loves what he does. I highly recommend him and his staff.
AmandaSeattle, WA04.04.11
Dr. Merritt is wonderful! He's super patient, has a great bedside manner and is fantastic with children. My daughter loves him....as do I! If you have a biochemical issue, I highly recommend seeing Dr. Merritt.
Recommend Dr. J Lawrence Merritt II

Overview

Board Certification(s)
Pediatrics
Clinical Biochemical Genetics
Clinical Genetics (MD)
Medical/Professional School
Loma Linda University, Loma Linda
Residency
Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria
Pediatrics, Mayo Clinic College of Medicine, Rochester
Medical Genetics, Mayo Clinic College of Medicine, Rochester
Fellowship
Medical Genetics, Mayo Clinic College of Medicine, Rochester
Clinical Biochemical Genetics, Mayo Clinic College of Medicine, Rochester
Clinical Interests

Treatment and management of individuals with inborn errors of metabolism, with an emphasis on fatty acid oxidation disorders and infants with abnormal newborn screening results.

Research Description

Areas of focus include newborn screening, urea cycle disorders, and fatty acid oxidation disorders

Research Focus Area

Translational Research

Publications

Newborn screening and renal disease: where we have been; where we are now; where we are going.
Pediatric nephrology (Berlin, Germany) , 2011 Sep 27
Ammonia control in children with urea cycle disorders (UCDs); phase 2 comparison of sodium phenylbutyrate and glycerol phenylbutyrate.
Molecular genetics and metabolism , 2011 Aug: 103(4)323-9
Establishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium.
Molecular genetics and metabolism , 2010: 100 Suppl 1S97-105
Establishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium.
Molecular genetics and metabolism , 2010: S97-105
A cognitively normal PDH-deficient 18-year-old man carrying the R263G mutation in the PDHA1 gene.
Journal of inherited metabolic disease , 2009 Jul 29
Biochemical correction of very long-chain acyl-CoA dehydrogenase deficiency following adeno-associated virus gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy , 2009 Mar: 17(3)425-9
Biochemical correction of very long-chain acyl-CoA dehydrogenase deficiency following adeno-associated virus gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy , 2009 Mar: 425-9
Chapter 26 Inherited Metabolic Disorders
Oxford American Handbood of Pediatrics , 2009: Oxford University Press; Oxford
Chapter 26 Inherited Metabolic Disorders
Oxford American Handbook of Pediatrics , 2009
Further clinical description of duplication of Williams-Beuren region presenting with congenital glaucoma and brachycephaly.
American journal of medical genetics. Part A , 2008 Apr 15: 146A(8)1055-8
Delineation of the cryptic 1qter deletion phenotype.
American journal of medical genetics. Part A , 2007 Mar 15: 143(6)599-603
Delineation of the cryptic 1qter deletion phenotype.
American journal of medical genetics. Part A , 2007 Mar 15: 599-603
Ornithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgery.
Archives of neurology , 2007 Jan: 64(1)126-8
Ornithine transcarbamylase deficiency presenting as encephalopathy during adulthood following bariatric surgery.
Archives of neurology , 2007 Jan: 126-8
In vitro characterization and in vivo expression of human very-long chain acyl-CoA dehydrogenase.
Molecular genetics and metabolism , 2006 Aug: 88(4)351-8
Extensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with TSC2 mutations.
American journal of medical genetics. Part A , 2006 Aug 1: 140(15)1669-72
In vitro characterization and in vivo expression of human very-long chain acyl-CoA dehydrogenase.
Molecular genetics and metabolism , 2006 Aug: 351-8
Extensive acrochordons and pancreatic islet-cell tumors in tuberous sclerosis associated with TSC2 mutations.
American journal of medical genetics. Part A , 2006 Aug 1: 1669-72
14q32.3 deletion syndrome with autism.
American journal of medical genetics. Part A , 2005 Feb 15: 99-100
Expression of cholera toxin B subunit oligomers in transgenic potato plants.
Transgenic research , 1997 Nov: 6(6)403-13

Presentations

Presentations TitleEventLocationDate
The Diagnosis of Genetic Disease. 3) Northwest Medical Laboratory Symposium. American Society for Clinical Laboratory Science, Region IX. Seattle, WAOct. 23, 2009
Newborn Screening: An Update on the Expansion. Pediatric Grand Rounds, Seattle Children's HospitalSeattle, WAJan. 29, 2009
Metabolic Disorders for all ages. WWAMI Visiting Professor Grand Rounds, 2 lectures. St. Lukes Regional Medical Center, Boise, ID and Mercy Medical Center, Nampa, IDSept. 24, 2008

Research Funding

Grant TitleGrantorAmountAward Date
Long Term Use of HPN-100 In Urea Cycle DisordersHyperion Inc. Oct. 5, 2010 - Oct. 14, 2013
Longitudinal Study of Urea Cycle Disorders, NIH, NICHD, ARRA Supplement3U54HD061221-06S1(Batshaw)Sept. 30, 2009 - Sept. 30, 2011
Urea Cycle Disorders Training Grant, OMalley Family Foundation Childrens Research Institute (Batshaw)Sept. 30, 2009 - July 31, 2011
A Phase 2, Fixed-Sequence, Open-Label, Switch-Over Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children 617 Years of Age with Urea Cycle Disorders, with a Long-Term Safety Extension (Hyperion Protocol HPN-100-005). FDA Phase II Clinical Study. Hyperion Inc.Aug. 6, 2009 - Aug. 4, 2011
Randomized Controlled Trial of Adjunct Hypothermia Treatment in Hyperammonemia and EncephalopathyNational Institutes of Health R01 grant submission, March 2009 (unfunded) 2009
Longitudinal Study of Urea Cycle Disorders, OMalley Family FoundationChildrens Research Institute (Batshaw) 2008 - 2012

Primary Office

Seattle Children's
MB.8.625 - Biochemical Genetics
4800 Sand Point Way NE
Seattle, WA 98105
206-987-3012

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