Profile

Horacio Adrian Duarte, MD

Horacio Adrian Duarte, MD

Infectious Disease

On staff since July 2017

Language (Other than English): Spanish

"By providing health policy leaders with high-quality data, I hope to contribute to cost-effective health policy decisions that will prevent new HIV infections among newborns, adolescents, and adults, and improve the health of people living with HIV."

  • Dr. Horacio Duarte graduated from Harvard College, where he studied biological anthropology and developed an interest in global health and infectious diseases. After college, he pursued his MD at the University of Texas Medical School at Houston. During that time, he spent a year at the National Institutes of Health as a clinical research training program fellow, studying cardio-metabolic disease in HIV-infected adults, as well as treatment adherence in pediatric HIV patients in Latin America. In July 2011, he began his pediatric residency training at the University of Washington, where he also completed his pediatric infectious diseases fellowship. One of Dr. Duartes main research interests is using mathematical modeling and cost-effectiveness analysis to improve health policy and resource allocation decisions in low- and middle-income countries, with a current focus on HIV-related health outcomes.

    • Duarte HA, Panpradist N, Beck IA, Lutz B, Lai J, Kanthula RM, Kantor R, Tripathi A, Saravanan S, MacLeod IJ, Chung MH, Zhang G, Yang C, Frenkel LM
      Current Status of Point-of-Care Testing for Human Immunodeficiency Virus Drug Resistance.
      29040621 The Journal of infectious diseases , 2017 Dec. 1 : 216(suppl_9)S824-S828
    • Thiara DK, Liu CY, Raman F, Mangat S, Purdy JB, Duarte HA, Schmidt N, Hur J, Sibley CT, Bluemke DA, Hadigan C
      Abnormal Myocardial Function Is Related to Myocardial Steatosis and Diffuse Myocardial Fibrosis in HIV-Infected Adults.
      25964507 The Journal of infectious diseases , 2015 Nov. 15 : 212(10)1544-51 PMCID: PMC4621251
    • Duarte HA, Harris DR, Tassiopoulos K, Leister E, Negrini SF, Ferreira FF, Cruz ML, Pinto J, Allison S, Hazra R, NISDI PLACES Study Group.
      Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America.
      25743569 The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases , 2015 May : 19(3)263-71 PMCID: PMC4911806
    • Duarte H, Matta JR, Muldoon N, Masur H, Hadigan C, Gharib AM
      Non-calcified coronary plaque volume inversely related to CD4(+) T-cell count in HIV infection.
      22293714 Antiviral therapy , 2012 : 17(4)763-7 PMCID: PMC3777235
  • Grant Title Grantor Amount Award Date
    Pediatric Scientist Development Program Award NICHD July 1, 2015 - June 30, 2017

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

University of Texas Medical School at Houston, Houston

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Infectious Disease, University of Washington, Seattle

Research Description

Dr. Duarte's research applies methods from decision analysis, health economics, and infectious disease modeling to improve HIV-related health outcomes in sub-Saharan Africa. Currently, his research is focused on two major areas: HIV drug resistance and HIV prevention in young women.

1. HIV drug resistance: Since antiretroviral therapy became available in sub-Saharan Africa, the prevalence of pretreatment drug resistance has been increasing, which could threaten the effectiveness of antiretroviral therapy programs. Through mathematical modeling, Dr. Duarte is evaluating the cost-effectiveness of various diagnostic and treatment strategies, including drug resistance testing and the implementation of dolutegravir-based antiretroviral therapy, to improve HIV treatment and prevention efforts in Kenya.

2. HIV prevention in young women: In sub-Saharan Africa, young women ages 15 to 24 years old have a two- to four-fold higher risk of HIV infection than young men. There are multiple factors that may contribute to this, including: sexual partnerships with older men, higher levels of concurrency among male partners, earlier age of sexual debut among young women compared to young men, and lower rates of viral suppression among HIV-infected men than HIV-infected women. Using mathematical modeling and network analysis methods, Dr. Duarte is working to understand what proportion of the disparity in HIV incidence between young women and young men is explained by these various potential factors. In addition, he is evaluating the cost-effectiveness of different interventions aimed at addressing this disparity.