Profile

Holly K. Tabor, PhD

Holly K. Tabor, PhD

Bioethics

Children's Title: Treuman Katz Center for Pediatric Bioethics

Academic Title: Associate Professor, Division of Bioethics, Department of Pediatrics; Adjunct Assistant Professor, Department of Bioethics and Humanities, University of Washington School of Medicine

Research Center: Center for Clinical and Translational Research

"There are lots of opportunities for cross-disciplinary collaboration and partnership in Seattle. That’s exciting to me because collaboration leads to new ideas and new research—and to translation of research findings to help patients. "

Holly K. Tabor, PhD, is an assistant professor for the Treuman Katz Center for Pediatric Bioethics and assistant professor of pediatrics in the Division of Bioethics at the University of Washington School of Medicine. She earned her PhD in epidemiology, with a minor in genetics, at Stanford University School of Medicine. She was a senior scientist at the Stanford Human Genome Center, leading a group conducting candidate gene research on complex traits. She completed her postdoctoral training in bioethics at the Stanford Center for Biomedical Ethics in the Center for Research on Integration of Genetics and Ethics. She is the recipient of a K99/R00 Pathway to Independence award from the National Human Genome Research Institute at NIH on "Ethical and Social Issues in the Study of the Genetics of Complex Traits."

 She conducts research on ethical issues in genetic research on complex traits, particularly complex traits in children. Current projects include research on causal models in genetic research on autism and the interactions between researchers and advocacy groups in genetic research on complex traits, focusing on the field of autism and characterizing the perspectives of parents and adolescents across different contexts of pediatric genetic research about ethical and social issues, including parental permission and informed consent, return of results to families, sharing of samples and data, the meanings of genetic data and the potential benefits and risk. In addition, she is collaborating with researchers at the Center for Clinical Genomics to proactively identify and address ethical and social issues in ongoing complex disease research.

Making A Difference

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Overview

Research Description

I conduct research on ethical issues in genetic research on complex traits, particularly complex traits in children. Current projects include research on causal models in genetic research on autism and the interactions between researchers and advocacy groups in genetic research on complex traits, focusing on the field of autism and characterizing the perspectives of parents and adolescents across different contexts of pediatric genetic research about ethical and social issues, including parental permission and informed consent, return of results to families, sharing of samples and data, the meanings of genetic data and the potential benefits and risk. In addition, I am collaborating with researchers at the Center for Clinical Genomics to proactively identify and address ethical and social issues in ongoing complex disease research.

Research Focus Area

Behavioral / Mental Health

Publications

  • Chong JX, McMillin MJ, Shively KM, Beck AE, Marvin CT, Armenteros JR, Buckingham KJ, Nkinsi NT, Boyle EA, Berry MN, Bocian M, Foulds N, Uzielli ML, Haldeman-Englert C, Hennekam RC, Kaplan P, Kline AD, Mercer CL, Nowaczyk MJ, Klein Wassink-Ruiter JS, McPherson EW, Moreno RA, Scheuerle AE, Shashi V, Stevens CA, Carey JC, Monteil A, Lory P, Tabor HK, Smith JD, Shendure J, Nickerson DA, University of Washington Center for Mendelian Genomics, Bamshad MJ
    De Novo Mutations in NALCN Cause a Syndrome Characterized by Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay.
    American journal of human genetics , 2015 Mar. 5 : 96(3)462-73
  • Amendola LM, Dorschner MO, Robertson PD, Salama JS, Hart R, Shirts BH, Murray ML, Tokita MJ, Gallego CJ, Kim DS, Bennett JT, Crosslin DR, Ranchalis J, Jones KL, Rosenthal EA, Jarvik ER, Itsara A, Turner EH, Herman DS, Schleit J, Burt A, Jamal SM, Abrudan JL, Johnson AD, Conlin LK, Dulik MC, Santani A, Metterville DR, Kelly M, Foreman AK, Lee K, Taylor KD, Guo X, Crooks K, Kiedrowski LA, Raffel LJ, Gordon O, Machini K, Desnick RJ, Biesecker LG, Lubitz SA, Mulchandani S, Cooper GM, Joffe S, Richards CS, Yang Y, Rotter JI, Rich SS, O'Donnell CJ, Berg JS, Spinner NB, Evans JP, Fullerton SM, Leppig KA, Bennett RL, Bird T, Sybert VP, Grady WM, Tabor HK, Kim JH, Bamshad MJ, Wilfond B, Motulsky AG, Scott CR, Pritchard CC, Walsh TD, Burke W, Raskind WH, Byers P, Hisama FM, Rehm H, Nickerson DA, Jarvik GP
    Actionable exomic incidental findings in 6503 participants: challenges of variant classification.
    Genome research , 2015 Mar. : 25(3)305-15
  • Delgado F, Tabor HK, Chow PM, Conta JH, Feldman KW, Tsuchiya KD, Beck AE
    Single-nucleotide polymorphism arrays and unexpected consanguinity: considerations for clinicians when returning results to families.
    Genetics in medicine : official journal of the American College of Medical Genetics , 2014 Sept. 18
  • Yu JH, Crouch J, Jamal SM, Bamshad MJ, Tabor HK
    Attitudes of non-African American focus group participants toward return of results from exome and whole genome sequencing.
    American journal of medical genetics. Part A , 2014 Sept. : 164A(9)2153-60
  • Tabor HK, Auer PL, Jamal SM, Chong JX, Yu JH, Gordon AS, Graubert TA, O'Donnell CJ, Rich SS, Nickerson DA, NHLBI Exome Sequencing Project, Bamshad MJ
    Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results.
    American journal of human genetics , 2014 Aug. 7 : 95(2)183-93
  • McMillin MJ, Beck AE, Chong JX, Shively KM, Buckingham KJ, Gildersleeve HI, Aracena MI, Aylsworth AS, Bitoun P, Carey JC, Clericuzio CL, Crow YJ, Curry CJ, Devriendt K, Everman DB, Fryer A, Gibson K, Giovannucci Uzielli ML, Graham JM Jr, Hall JG, Hecht JT, Heidenreich RA, Hurst JA, Irani S, Krapels IP, Leroy JG, Mowat D, Plant GT, Robertson SP, Schorry EK, Scott RH, Seaver LH, Sherr E, Splitt M, Stewart H, Stumpel C, Temel SG, Weaver DD, Whiteford M, Williams MS, Tabor HK, Smith JD, Shendure J, Nickerson DA, University of Washington Center for Mendelian Genomics, Bamshad MJ
    Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.
    American journal of human genetics , 2014 May 1 : 94(5)734-44
  • Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ, Bamshad MJ, Nickerson DA, NHLBI GO Exome Sequencing Project
    Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset.
    Human molecular genetics , 2014 Apr, 15 : 23(8)1957-63
  • Yudell M, Tabor HK, Dawson G, Rossi J, Newschaffer C, Working Group in Autism Risk Communication and Ethics
    Priorities for autism spectrum disorder risk communication and ethics.
    Autism : the international journal of research and practice , 2013 Nov. : 17(6)701-22
  • Dorschner MO, Amendola LM, Turner EH, Robertson PD, Shirts BH, Gallego CJ, Bennett RL, Jones KL, Tokita MJ, Bennett JT, Kim JH, Rosenthal EA, Kim DS, National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project, Tabor HK, Bamshad MJ, Motulsky AG, Scott CR, Pritchard CC, Walsh T, Burke W, Raskind WH, Byers P, Hisama FM, Nickerson DA, Jarvik GP
    Actionable, pathogenic incidental findings in 1,000 participants' exomes.
    American journal of human genetics , 2013 Oct. 3 : 93(4)631-40
  • Holly K. Tabor, PhD
    Self-guided management of exome and whole-genome sequencing results: changing the results return model
    Genetics in Medicine , 2013 Sept. : 15(9)684-90
  • Yu JH, Jamal SM, Tabor HK, Bamshad MJ
    Self-guided management of exome and whole-genome sequencing results: changing the results return model.
    Genetics in medicine : official journal of the American College of Medical Genetics , 2013 Sept. : 15(9)684-90
  • Holly K. Tabor, PhD
    Attitudes of African Americans Toward Return of Results From Exome and Whole Genome Sequencing
    American Journal of Medical Genetics Part A , 2013 May : 161(5)1064-72
  • Yu JH, Crouch J, Jamal SM, Tabor HK, Bamshad MJ
    Attitudes of African Americans toward return of results from exome and whole genome sequencing.
    American journal of medical genetics. Part A , 2013 May : 161A(5)1064-72
  • Jamal SM, Yu JH, Chong JX, Dent KM, Conta JH, Tabor HK, Bamshad MJ
    Practices and policies of clinical exome sequencing providers: analysis and implications.
    American journal of medical genetics. Part A , 2013 May : 161A(5)935-50
  • Holly K. Tabor, PhD
    Practices and Policies of Clinical Exome Sequencing Providers: Analysis and Implications
    American Journal of Medical Genetics Part A , 2013 Apr, 22 : 161(5)935-50
  • Holly K. Tabor, PhD
    Mutations in KCTD1 cause scalp-ear-nipple syndrome
    American Journal of Human Genetics , 2013 Apr, 4 : 92(4)621-26
  • Tabor HK, Murray JC, Gammill HS, Kitzman JO, Snyder MW, Ventura M, Lewis AP, Qiu R, Simmons LE, Rubens CE, Santillan MK, Eichler EE, Cheng EY, Bamshad MJ, Shendure J
    Non-invasive fetal genome sequencing: opportunities and challenges.
    American journal of medical genetics. Part A , 2012 Oct. : 158A(10)2382-4
  • Holly K. Tabor, PhD
    Priorities for autism spectrum disorders risk communication and ethics
    Autism , 2012 Aug. 23
  • Holly K. Tabor, PhD
    Non-invasive Fetal Genome Sequencing: Opportunities and Challenges
    American Journal of Medical Genetics Part A , 2012 Aug. : 158A(10)2382-84
  • Holly K. Tabor, PhD
    Exome Sequencing of Extreme Phenotypes Identified DCTN4 as a Modifier of Chronic Pseudomonas Aeruginosa Infection in Cystic Fibrosis
    Nature Genetics , 2012 July 8 : 44(8)886-89
  • Holly K. Tabor, PhD
    Non-invasive whole-genome sequencing of a human fetus
    Science Translational Medicine , 2012 June 6 : 4(137)137ra76
  • Holly K. Tabor, PhD
    Informed Consent for Whole Genome Sequencing: A Qualitative Analysis of Participant Expectations and Perceptions of Risks, Benefits, and Harms
    American Journal of Medical Genetics Part A , 2012 June : 158A(6)1310-19
  • Holly K. Tabor, PhD
    Parent perspectives on pediatric genetic research and implications for genotype-driven research recruitment
    Journal of empirical research on human research ethics : JERHRE , 2011 Dec. : 6(4)41-52
  • Holly K. Tabor, PhD
    Genomics Really Gets Personal: How Exome and Whole Genome Sequencing Challenge the Ethical Framework of Human Genetics Research
    American Journal of Medical Genetics Part A , 2011 Dec. : 155A(12)2916-24
  • Holly K. Tabor, PhD
    Research Participants Perspectives on Genotype-driven Research Recruitment
    Journal of empirical research on human research ethics : JERHRE , 2011 Dec. : 6(4)3-20
  • Tabor HK, Berkman BE, Hull SC, Bamshad MJ
    Genomics really gets personal: how exome and whole genome sequencing challenge the ethical framework of human genetics research.
    American journal of medical genetics. Part A , 2011 Dec. : 2916-24
  • Holly K. Tabor, PhD
    Exome sequencing as a tool for Mendelian disease gene discovery
    Nature Reviews Genetics , 2011 Sept. 27 : 12(11)745-55
  • Holly K. Tabor, PhD
    The Autism Genetic Resource Exchange: Changing Pace, Priorities and Role in Discovery Science in Achieving Justice in Genome Translation: Rethinking the Pathway to Benefit
    Oxford University Press , 2011 Sept. : 56-71
  • Holly K. Tabor, PhD
    Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome
    American Journal of Medical Genetics Part A , 2011 July : 155A(7)1511-16
  • Hannibal MC, Buckingham KJ, Ng SB, Ming JE, Beck AE, McMillin MJ, Gildersleeve HI, Bigham AW, Tabor HK, Mefford HC, Cook J, Yoshiura K, Matsumoto T, Matsumoto N, Miyake N, Tonoki H, Naritomi K, Kaname T, Nagai T, Ohashi H, Kurosawa K, Hou JW, Ohta T, Liang D, Sudo A, Morris CA, Banka S, Black GC, Clayton-Smith J, Nickerson DA, Zackai EH, Shaikh TH, Donnai D, Niikawa N, Shendure J, Bamshad MJ
    Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome.
    American journal of medical genetics. Part A , 2011 July : 1511-6
  • Holly K. Tabor, PhD
    Bioethical Considerations in Autism Research and Translation: Present and Future in Autism Spectrum Disorders
    Oxford University Press , 2011 June : 1337-44
  • Tabor HK, Kelley M
    Challenges in the use of direct-to-consumer personal genome testing in children.
    The American journal of bioethics : AJOB , 2009 : 32-4

Presentations

Presentations Title Event Location Date
My46: An Innovative Web-based Approach to Managing Results HudsonAlpha Seminar Series, HudsonAlpha Institute for Biotechnology Huntsville, AL Nov. 28, 2012
Analysis of ESP 6500 Exomes for Results of Clinical Utility American Society of Human Genetics Annual Meeting San Francisco, CA Nov. 9, 2012
African American Attitudes Toward Exome and Whole Genome Sequencing American Society of Human Genetics Annual Meeting San Francisco, CA Nov. 8, 2012
My46: An Innovative Web-based Approach to Managing ES/WGS Results American Society of Human Genetics Annual Meeting San Francisco, CA Nov. 7, 2012
The Genome as a Resource: Self-directed Results Management in Genome Sequencing Studies NHGRI Sequencing Network Meeting Houston, TX Oct. 2, 2012
A Feasibility Study of Human Whole Genome Sequencing in the National Childrens Study: Return of Results National Childrens Study (NCS) Expanded Steering Committee Meeting Bethesda, MD Feb. 13, 2012
Innovative Approaches to Informed Consent and Return of Results from Exome and Whole Genome Sequencing Genomics and Randomized Trials Network (GARNET) Study Steering Committee meeting Washington, DC Dec. 14, 2011
Innovative Approaches to Informed Consent and Return of Results for Exome and Whole Genome Sequencing. University of California San Diego Institute for Genomic Medicine 2011 Symposium San Diego, CA Oct. 24, 2011
Consent and Return of Results from Whole Genome and Exome Sequencing Personal Genomes Meeting Cold Spring Harbor, NY Oct. 1, 2011
Understanding Ethical Implications of Genetic Testing and Research NIH Workshop: Ethical Legal and Social Implications of Autism Research, Interagency Autism Coordinating Committee Bethesda, MD Sept. 26, 2011
Ethical Challenges and Sociocultural Dimensions of Emerging Genomic Analyses: Data from Recent Studies of Exome/WGS ELSI 2011 Congress: Exploring the ELSI Universe Chapel Hill, NC April 14, 2011
Informed Consent and Return of Results from a Whole Genome Sequencing Study ELSI 2011 Congress: Exploring the ELSI Universe Chapel Hill, NC April 13, 2011
Ethical Implications of Return of Results in Pediatric Exome and Whole Genome Sequencing Studies; ELSI 2011 Congress: Exploring the ELSI Universe Chapel Hill, NC April 13, 2011
A Feasibility Study of Human Whole Genome Sequencing in the National Childrens Study: Return of Results National Childrens Study (NCS) Expanded Steering Committee Meeting Bethesda, MD Feb. 13, 2011

Research Funding

Grant Title Grantor Amount Award Date
UW Center for Mendelian Genetics NIH/NHGRI $24,667.00 Dec. 1, 2011
Innovative Approaches to Returning Results in Exome and Genome Sequencing Studies NIH/NHGRI $626,333.00 Sept. 30, 2011
Center for Genomics and Health Care Equality NIH/NHGRI $17,528.00 April 1, 2010
CSER RoRC Centralized Support Coordinating Center NIH/NHGRI $2,404.00 Sept. 23, 2008 - Aug. 31, 2011