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Holly K. Tabor, PhD

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Holly K. Tabor, PhD

Bioethics

Children's Title: Treuman Katz Center for Pediatric Bioethics

Academic Title: Associate Professor, Division of Bioethics, Department of Pediatrics; Adjunct Assistant Professor, Department of Bioethics and Humanities, University of Washington School of Medicine

Research Center: Center for Clinical and Translational Research

"There are lots of opportunities for cross-disciplinary collaboration and partnership in Seattle. That’s exciting to me because collaboration leads to new ideas and new research—and to translation of research findings to help patients. "

Making a Difference

  • Mentoring Talented Junior Faculty

    An academic medical center and research institute, Seattle Children’s is dedicated to helping junior faculty establish research careers. Recently, several of our emerging genetics researchers have made significant contributions to their field.... cont.

Overview

Research Description

I conduct research on ethical issues in genetic research on complex traits, particularly complex traits in children. Current projects include research on causal models in genetic research on autism and the interactions between researchers and advocacy groups in genetic research on complex traits, focusing on the field of autism and characterizing the perspectives of parents and adolescents across different contexts of pediatric genetic research about ethical and social issues, including parental permission and informed consent, return of results to families, sharing of samples and data, the meanings of genetic data and the potential benefits and risk. In addition, I am collaborating with researchers at the Center for Clinical Genomics to proactively identify and address ethical and social issues in ongoing complex disease research.

Research Focus Area

Behavioral / Mental Health

Publications

Single-Nucleotide Polymorphism Arrays and Unexpected Consanguinity: Considerations for Clinicians When Returning Results to Families
Genetics in Medicine , Sept. 18, 2014
Attitudes of Non-African American Focus Group Participants Toward Return of Results From Exome and Whole Genome Sequencing
American Journal of Medical Genetics , Sept. 2014: 164(9)2153-60
Pathogenic Variants for Mendelian and Complex Traits in Exomes of 6,517 European and African Americans: Implications For the Return of Incidental Results
American Journal of Human Genetics , Aug. 7, 2014: 95(2)183-93
"We Don't Know Her History, Her Background": Adoptive Parents' Perspectives on Whole Genome Sequencing Results
Journal of Genetic Counseling , July 12, 2014
Attitudes of Genetics Professionals Toward the Return of Incidental Results From Exome and Whole-Genome Sequencing
American Journal of Human Genetics , July 3, 2014: 95(1)77-84
Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.
American Journal of Human Genetics , May 1, 2014: 94(5)734-44
Quantifying Rare, Deleterious Variation in 12 Human Cytochrome P450 Drug-Metabolism Genes in a Large-Scale Exome Dataset
Human Molecular Genetics , April 15, 2014: 23(8)1957-63
Actionable, Pathogenic Incidental Findings in 1,000 Participants' Exomes.
American Journal of Human Genetics , Oct. 3, 2013: 93(4)631-40
Self-guided management of exome and whole-genome sequencing results: changing the results return model
Genetics in Medicine , Sept. 2013: 15(9)684-90
Attitudes of African Americans Toward Return of Results From Exome and Whole Genome Sequencing
American Journal of Medical Genetics Part A , May 2013: 161(5)1064-72
Practices and Policies of Clinical Exome Sequencing Providers: Analysis and Implications
American Journal of Medical Genetics Part A , April 22, 2013: 161(5)935-50
Mutations in KCTD1 cause scalp-ear-nipple syndrome
American Journal of Human Genetics , April 4, 2013: 92(4)621-26
Priorities for autism spectrum disorders risk communication and ethics
Autism , Aug. 23, 2012
Non-invasive Fetal Genome Sequencing: Opportunities and Challenges
American Journal of Medical Genetics Part A , Aug. 2012: 158A(10)2382-84
Exome Sequencing of Extreme Phenotypes Identified DCTN4 as a Modifier of Chronic Pseudomonas Aeruginosa Infection in Cystic Fibrosis
Nature Genetics , July 8, 2012: 44(8)886-89
Non-invasive whole-genome sequencing of a human fetus
Science Translational Medicine , June 6, 2012: 4(137)137ra76
Informed Consent for Whole Genome Sequencing: A Qualitative Analysis of Participant Expectations and Perceptions of Risks, Benefits, and Harms
American Journal of Medical Genetics Part A , June 2012: 158A(6)1310-19
Research Participants Perspectives on Genotype-driven Research Recruitment
Journal of empirical research on human research ethics : JERHRE , Dec. 2011: 6(4)3-20
Genomics Really Gets Personal: How Exome and Whole Genome Sequencing Challenge the Ethical Framework of Human Genetics Research
American Journal of Medical Genetics Part A , Dec. 2011: 155A(12)2916-24
Parent perspectives on pediatric genetic research and implications for genotype-driven research recruitment
Journal of empirical research on human research ethics : JERHRE , Dec. 2011: 6(4)41-52
Exome sequencing as a tool for Mendelian disease gene discovery
Nature Reviews Genetics , Sept. 27, 2011: 12(11)745-55
The Autism Genetic Resource Exchange: Changing Pace, Priorities and Role in Discovery Science in Achieving Justice in Genome Translation: Rethinking the Pathway to Benefit
Oxford University Press , Sept. 2011: 56-71
Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome
American Journal of Medical Genetics Part A , July 2011: 155A(7)1511-16
Bioethical Considerations in Autism Research and Translation: Present and Future in Autism Spectrum Disorders
Oxford University Press , June 2011: 1337-44

Presentations

Presentations TitleEventLocationDate
My46: An Innovative Web-based Approach to Managing ResultsHudsonAlpha Seminar Series, HudsonAlpha Institute for BiotechnologyHuntsville, ALNov. 28, 2012
Analysis of ESP 6500 Exomes for Results of Clinical UtilityAmerican Society of Human Genetics Annual MeetingSan Francisco, CANov. 9, 2012
African American Attitudes Toward Exome and Whole Genome SequencingAmerican Society of Human Genetics Annual MeetingSan Francisco, CANov. 8, 2012
My46: An Innovative Web-based Approach to Managing ES/WGS ResultsAmerican Society of Human Genetics Annual MeetingSan Francisco, CANov. 7, 2012
The Genome as a Resource: Self-directed Results Management in Genome Sequencing StudiesNHGRI Sequencing Network MeetingHouston, TXOct. 2, 2012
A Feasibility Study of Human Whole Genome Sequencing in the National Childrens Study: Return of ResultsNational Childrens Study (NCS) Expanded Steering Committee MeetingBethesda, MDFeb. 13, 2012
Innovative Approaches to Informed Consent and Return of Results from Exome and Whole Genome SequencingGenomics and Randomized Trials Network (GARNET) Study Steering Committee meetingWashington, DCDec. 14, 2011
Innovative Approaches to Informed Consent and Return of Results for Exome and Whole Genome Sequencing.University of California San Diego Institute for Genomic Medicine 2011 SymposiumSan Diego, CAOct. 24, 2011
Consent and Return of Results from Whole Genome and Exome SequencingPersonal Genomes MeetingCold Spring Harbor, NYOct. 1, 2011
Understanding Ethical Implications of Genetic Testing and ResearchNIH Workshop: Ethical Legal and Social Implications of Autism Research, Interagency Autism Coordinating CommitteeBethesda, MDSept. 26, 2011
Ethical Challenges and Sociocultural Dimensions of Emerging Genomic Analyses: Data from Recent Studies of Exome/WGSELSI 2011 Congress: Exploring the ELSI UniverseChapel Hill, NCApril 14, 2011
Ethical Implications of Return of Results in Pediatric Exome and Whole Genome Sequencing Studies;ELSI 2011 Congress: Exploring the ELSI UniverseChapel Hill, NCApril 13, 2011
Informed Consent and Return of Results from a Whole Genome Sequencing StudyELSI 2011 Congress: Exploring the ELSI UniverseChapel Hill, NCApril 13, 2011
A Feasibility Study of Human Whole Genome Sequencing in the National Childrens Study: Return of ResultsNational Childrens Study (NCS) Expanded Steering Committee MeetingBethesda, MDFeb. 13, 2011

Research Funding

Grant TitleGrantorAmountAward Date
UW Center for Mendelian GeneticsNIH/NHGRI $24,667.00Dec. 1, 2011
Innovative Approaches to Returning Results in Exome and Genome Sequencing StudiesNIH/NHGRI $626,333.00Sept. 30, 2011
Center for Genomics and Health Care EqualityNIH/NHGRI $17,528.00April 1, 2010
CSER RoRC Centralized Support Coordinating CenterNIH/NHGRI $2,404.00Sept. 23, 2008 - Aug. 31, 2011

Primary Office

Seattle Children's Research Institute
JMB - 6 - Clinical and Translational Research
1900 - 9th Ave
Seattle, WA 98101
206-884-8929

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