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Holly K. Tabor, PhD

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Holly K. Tabor, PhD

Bioethics

Children's Title: Treuman Katz Center for Pediatric Bioethics

Academic Title: Assistant Professor, Department of Pediatrics, Division of Bioethics, University of Washington School of Medicine

Research Center: Center for Clinical and Translational Research

"There are lots of opportunities for cross-disciplinary collaboration and partnership in Seattle. That’s exciting to me because collaboration leads to new ideas and new research—and to translation of research findings to help patients. "

Making a Difference

  • Mentoring Talented Junior Faculty

    An academic medical center and research institute, Seattle Children’s is dedicated to helping junior faculty establish research careers. Recently, several of our emerging genetics researchers have made significant contributions to their field.... cont.

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Overview

Research Description

I conduct research on ethical issues in genetic research on complex traits, particularly complex traits in children. Current projects include research on causal models in genetic research on autism and the interactions between researchers and advocacy groups in genetic research on complex traits, focusing on the field of autism and characterizing the perspectives of parents and adolescents across different contexts of pediatric genetic research about ethical and social issues, including parental permission and informed consent, return of results to families, sharing of samples and data, the meanings of genetic data and the potential benefits and risk. In addition, I am collaborating with researchers at the Center for Clinical Genomics to proactively identify and address ethical and social issues in ongoing complex disease research.

Research Focus Area

Behavioral / Mental Health

Publications

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome.
Nature genetics , 2010 Sep: 790-3
Exome sequencing identifies the cause of a mendelian disorder.
Nature genetics , 2010 Jan: 30-5
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
Nature genetics , 2008 Aug: 963-70
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Atherosclerosis , 2008 May: 136-44
Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.
Human genetics , 2008 May: 399-408
Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease.
American heart journal , 2007 Dec: 1035-42
Ethical implications of array comparative genomic hybridization in complex phenotypes: points to consider in research.
Genetics in medicine : official journal of the American College of Medical Genetics , 2007 Sep: 626-31
Candidate-gene approaches for studying complex genetic traits: practical considerations.
Nature reviews. Genetics , 2002 May: 391-7
Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families.
American journal of medical genetics , 2002 Jan 8: 24-30

Presentations

Presentations TitleEventLocationDate
Ethical and Social Challenges in a Whole Genome Sequencing Study of Two Families with a Rare DiseaseAmerican Society of Human Genetics Annual MeetingUnknownOct. 1, 2009
Not the Old Cast of Characters: Emerging Roles and Agendas for Advocacy in Biobanking and Clinical TranslationAmerican Society of Bioethics and Humanities Annual MeetingUnknownOct. 1, 2009
Clinical Integration of Direct-to-Consumer Personal Genome Testing: Perspectives, Experiences and ChallengesAmerican Society of Bioethics and Humanities Annual MeetingUnknownOct. 1, 2009
The Age of Personalized Genomics5th International DNA Sequencing ConferenceUnknownSept. 1, 2009
Ethical Challenges in Pediatric Bioethics: Balancing the Risks and BenefitsPediatric Academic Societies Annual MeetingUnknownMay 1, 2009
Copy Number Variants (CNVs): A New Frontier for Clinical Genetic Testing and CounselingAmerican College of Medical Genetics Annual Clinical MeetingUnknownMarch 1, 2009

Research Funding

Grant TitleGrantorAmountAward Date
NHLBI Lung Cohorts Sequencing ProjectNHLBI, NIHSept. 30, 2009 - Sept. 29, 2011
Next Generation Mendelian GeneticsNIHSept. 30, 2009 - Sept. 29, 2011
Ethical Approaches to Genotype-Driven Research RecruitmentRC-1 Challenge GrantSept. 30, 2009 - Sept. 29, 2011
Ethical and Social Issues in the Study of the Genetics of Complex TraitsNHGRI, NIHSept. 23, 2008 - Aug. 31, 2011
Institute of Translational Health Sciences: NIH Clinical and Translational Science Awards Institute of Translational Health SciencesSept. 17, 2007 - May 31, 2012

Primary Office

Seattle Children's Research Institute
C9S - 6 - Clinical and Translational Research
1900 - 9th Ave Bldg 1
Seattle, WA 98101
206-884-8929

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