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Glen S. Tamura, MD, PhD

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Glen S. Tamura, MD, PhD

Hospital Medicine, Pediatrics-Inpatient

On staff since July 1990

Children's Title: Division Chief, Hospital Medicine

Academic Title: Associate Professor

"Being in the hospital with your sick child is a great challenge - I strive to insure your child's care is the best possible, that you are informed and involved in decision-making, and that team members communicate seamlessly with each other and with you."

Overview

Board Certification(s)
Pediatrics
Pediatric Infectious Diseases
Medical/Professional School
Stanford University , Stanford
Stanford University , Stanford
Residency
Pediatrics, University of Washington, School of Medicine, Seattle
Research Description

Pathogenesis of Group B Streptococcal disease (GBS, Streptococcus agalactiae).

GBS are the leading cause of meningitis and sepsis in neonates in the United States and Western Europe. Dr. Tamura's laboratory studies the molecular pathogenesis of group B Streptococcal (GBS) infections. We are particularly interested in the bacterial adhesins and their cognate epithelial cell receptors that are involved in mucosal colonization.

We have successfully identified fibronectin and cytokeratin 8 as potential epithelial cell receptors. We have also identified two fibronectin adhesins, one definnitively (ScpB, the Streptococcal C5a peptidase) and one tentatively (GlnP, the glutamine permease).

Both of these proteins have other functions by which they were originally defined. We are in the process of defining the role of the different activities of these genes in bacterial adherence both in vitro and in vivo.

GBS have the unusual property of being able to bind specifically to immobilized fibronectin (iFn) and not to soluble fibronectin (sFn). The adhesin ScpB shares this property.

We are also in the process of defining the structural basis for this specificity using a variety of cutting edge biophysical techniques, including surface plasmon resonance and atomic force microscopy.

Lab URL

http://myprofile.cos.com/gtamura

Research Focus Area

Host: Pathogen Interaction

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Seattle Magazine Top Doctor - 2013Seattle Magazine 2013
Named one of "Seattle's Top Doctors"Seattle Magazine 2006
Phi Beta Kappa 1980
Highest HonorsUniversity of California, Berkeley 1980
Medical Scientist Training Program 1980

Publications

Comprehension on family-centered rounds for limited English proficient families.
Academic pediatrics , 2013 May-Jun: 13(3)236-42
Where do medical students turn? The role of the assigned mentor in the fabric of support during medical school.
Teaching and learning in medicine , 2011 Apr: 23(2)112-7
Interactions of the streptococcal C5a peptidase with human fibronectin.
Acta biomaterialia , 2008 May: 504-13
Interactions of the streptococcal C5a peptidase with human fibronectin.
Acta biomaterialia , 2008 May: 4(3)504-13
Parental responses to involvement in rounds on a pediatric inpatient unit at a teaching hospital: a qualitative study.
Academic medicine : journal of the Association of American Medical Colleges , 2008 Mar: 292-7
Parental responses to involvement in rounds on a pediatric inpatient unit at a teaching hospital: a qualitative study.
Academic medicine : journal of the Association of American Medical Colleges , 2008 Mar: 83(3)292-7
Structure and reactivity of adsorbed fibronectin films on mica.
Biophysical journal , 2007 Oct 15: 2852-60
Atomic force microscopy and surface plasmon resonance investigation of fibronectin interactions with group B streptococci.
Biointerphases , 2007 Jun: 64-72
High-affinity interaction between fibronectin and the group B streptococcal C5a peptidase is unaffected by a naturally occurring four-amino-acid deletion that eliminates peptidase activity.
Infection and immunity , 2006 Oct: 5739-46
Use of glnQ as a counterselectable marker for creation of allelic exchange mutations in group B streptococci.
Applied and environmental microbiology , 2005 Jan: 587-90
A glutamine transport gene, glnQ, is required for fibronectin adherence and virulence of group B streptococci.
Infection and immunity , 2002 Jun: 2877-85
Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding.
Infection and immunity , 2002 Jun: 2869-76

Research Funding

Grant TitleGrantorAmountAward Date
R29 First Award 1998
Children's Health Research Grant 1994
Clinical Investigator Award (K08) 1994

Primary Office

Seattle Children's
MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE
Seattle, WA 98105
206-987-1918

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