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Franck K. Kalume, PhD

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Franck K. Kalume, PhD

Research Center: Center for Integrative Brain Research

"Two years ago, my nephew suddenly passed away, shortly after he went to sleep one evening. He was suffering from epilepsy and was having nocturnal seizures. Ironically, I had just concluded my first project on sudden unexpected death in epilepsy (SUDEP). This tragic event has immensely motivated me to continue working toward understanding the mechanisms of this condition and discovering novel approaches for its prevention."

Publications

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.
Channels (Austin, Tex.) , 2013 Nov 1: 7(6)468-72
Sudden unexpected death in Dravet syndrome: respiratory and other physiological dysfunctions.
Respiratory physiology & neurobiology , 2013 Nov 1: 189(2)324-8
Sudden unexpected death in a mouse model of Dravet syndrome.
The Journal of clinical investigation , 2013 Apr 1: 123(4)1798-808
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.
Proceedings of the National Academy of Sciences of the United States of America , 2012 Sep 4: 109(36)14646-51
Protective effect of the ketogenic diet in Scn1a mutant mice.
Epilepsia , 2011 Nov: 52(11)2050-6
Insights into pathophysiology and therapy from a mouse model of Dravet syndrome.
Epilepsia , 2011 Apr: 52 Suppl 259-61
NaV1.1 channels and epilepsy.
The Journal of physiology , 2010 Jun 1: 588(Pt 11)1849-59
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy.
Proceedings of the National Academy of Sciences of the United States of America , 2009 Mar 10: 106(10)3994-9
Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2007 Oct 10: 27(41)11065-74
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.
Nature neuroscience , 2006 Sep: 9(9)1142-9
Molecular mimicry: cross-reactive antibodies from patients with immune-mediated neurologic disease inhibit neuronal firing.
Journal of neuroscience research , 2004 Jul 1: 77(1)82-9
Autoimmunity due to molecular mimicry as a cause of neurological disease.
Nature medicine , 2002 May: 8(5)509-13

Primary Office

Seattle Children's Research Institute
JMB -10 - Integrative Brain Research
1900 - 9th Ave
Seattle, WA 98101
206-884-1085

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