Profile

Franck K. Kalume, PhD

Franck K. Kalume, PhD

Research Center: Center for Integrative Brain Research

"Two years ago, my nephew suddenly passed away, shortly after he went to sleep one evening. He was suffering from epilepsy and was having nocturnal seizures. Ironically, I had just concluded my first project on sudden unexpected death in epilepsy (SUDEP). This tragic event has immensely motivated me to continue working toward understanding the mechanisms of this condition and discovering novel approaches for its prevention."

Publications

  • Kalume F
    Sudden unexpected death in Dravet syndrome: respiratory and other physiological dysfunctions.
    Respiratory physiology & neurobiology , 2013 Nov. 1 : 189(2)324-8
  • Cheah CS, Westenbroek RE, Roden WH, Kalume F, Oakley JC, Jansen LA, Catterall WA
    Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.
    Channels (Austin, Tex.) , 2013 Nov. 1 : 7(6)468-72
  • Kalume F, Westenbroek RE, Cheah CS, Yu FH, Oakley JC, Scheuer T, Catterall WA
    Sudden unexpected death in a mouse model of Dravet syndrome.
    The Journal of clinical investigation , 2013 Apr, 1 : 123(4)1798-808
  • Cheah CS, Yu FH, Westenbroek RE, Kalume FK, Oakley JC, Potter GB, Rubenstein JL, Catterall WA
    Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.
    Proceedings of the National Academy of Sciences of the United States of America , 2012 Sept. 4 : 109(36)14646-51
  • Dutton SB, Sawyer NT, Kalume F, Jumbo-Lucioni P, Borges K, Catterall WA, Escayg A
    Protective effect of the ketogenic diet in Scn1a mutant mice.
    Epilepsia , 2011 Nov. : 52(11)2050-6
  • Oakley JC, Kalume F, Catterall WA
    Insights into pathophysiology and therapy from a mouse model of Dravet syndrome.
    Epilepsia , 2011 Apr, : 52 Suppl 259-61
  • Catterall WA, Kalume F, Oakley JC
    NaV1.1 channels and epilepsy.
    The Journal of physiology , 2010 June 1 : 588(Pt 11)1849-59
  • Oakley JC, Kalume F, Yu FH, Scheuer T, Catterall WA
    Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy.
    Proceedings of the National Academy of Sciences of the United States of America , 2009 Mar. 10 : 106(10)3994-9
  • Kalume F, Yu FH, Westenbroek RE, Scheuer T, Catterall WA
    Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience , 2007 Oct. 10 : 27(41)11065-74
  • Yu FH, Mantegazza M, Westenbroek RE, Robbins CA, Kalume F, Burton KA, Spain WJ, McKnight GS, Scheuer T, Catterall WA
    Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.
    Nature neuroscience , 2006 Sept. : 9(9)1142-9
  • Kalume F, Lee SM, Morcos Y, Callaway JC, Levin MC
    Molecular mimicry: cross-reactive antibodies from patients with immune-mediated neurologic disease inhibit neuronal firing.
    Journal of neuroscience research , 2004 July 1 : 77(1)82-9
  • Levin MC, Lee SM, Kalume F, Morcos Y, Dohan FC Jr, Hasty KA, Callaway JC, Zunt J, Desiderio D, Stuart JM
    Autoimmunity due to molecular mimicry as a cause of neurological disease.
    Nature medicine , 2002 May : 8(5)509-13