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Dolena Ledee, PhD

Dolena Ledee, PhD

Cardiology

Research Center: Center for Integrative Brain Research

"Research is asking and searching, and my passion is trying to figure out what we dont yet understand. Cardiovascular disease is a leading cause of mortality and morbidity in the U.S., and my goal is to better understand the molecular changes involved with the hope that therapies can be developed to help people achieve optimal health."

  • Dolena Ledee, PhD, is a principal investigator at Seattle Childrens Research Institute and a research assistant professor at the University of Washington. She has won a variety of awards including the Fellows Award for Research Excellence from the National Institutes of Health. She earned her PhD from the Ohio State University, her MAE from the University of the Virgin Islands, and her BA from Jacksonville University.

Overview

Research Description

Dolena Ledee, PhD, studies the developmental changes in the heart due to age and hormone status. She is leading projects that investigate the molecular basis for gene expression changes in the heart due to age and the role that thyroid hormones and their receptors play in this process. Thyroid hormone dysfunction exerts profound effects on cardiovascular function and increases in the general population with age. The primary mode of action for thyroid hormones occur via thyroid hormone receptors; therefore, understanding how thyroid hormone receptors are regulated can yield insights that open the door to therapies that prevent dysfunction and disease.