Profile

David R. Beier, MD, PhD

David R. Beier, MD, PhD

Children's Title: Director, Center for Developmental Biology and Regenerative Medicine

Academic Title: Professor of Pediatrics, University of Washington

Research Center: Center for Developmental Biology and Regenerative Medicine

  • After my undergraduate education at Harvard University, I obtained my MD and PhD degrees in the Medical Scientist Training Program at the University of Washington, and was an intern in Pediatrics at Seattle Children's Hospital. I returned to Harvard Medical School for post-doctoral training in Dr. Philip Leder's lab, and also pursued clinical training in Medical Genetics. I joined the faculty of the HMS Dept. of Medicine in 1990 and became Professor in 2005.In 2012 I returned to Seattle as a Professor in Pediatrics and as the Director of the Center for Developmental Biology and Regenerative Medicine at the Seattle Children's Research Institute.

    My research has focused primarily on the use of genetic analysis in model systems as a means to understand human biology and disease. My efforts have provided insight into basic developmental processes, and have led to the identification of a number of human disease genes.

    My research is consistently forward looking, with the aim of marrying enabling genomic technology with innovative strategies of genetic analysis. I have endeavored to make these approaches accessible, and have led a number of community initiatives.

    • Beier DR
      High-resolution genetic localization of a modifying locus affecting disease severity in the juvenile cystic kidneys (jck) mouse model of polycystic kidney disease.
      27114383 Mammalian genome : official journal of the International Mammalian Genome Society , 2016 June - 2016 June : 27(5-6)191-9
    • Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O
      Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.
      27053712 Human molecular genetics , 2016 Apr, 5 - 2016 Apr, 5
    • Gallego-Llamas J, Timms AE, Pitstick R, Peters J, Carlson GA, Beier DR
      Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice.
      27441645 PloS one , 2016 - 2016 : 11(7)e0159377 PMCID: PMC4956170
    • Gallego-Llamas J, Timms AE, Geister KA, Lindsay A, Beier DR
      Variant mapping and mutation discovery in inbred mice using next-generation sequencing.
      26552429 BMC genomics , 2015 Nov. 9 - 2015 Nov. 9 : 16913 PMCID: PMC4640199
    • Tran PV, Talbott GC, Turbe-Doan A, Jacobs DT, Schonfeld MP, Silva LM, Chatterjee A, Prysak M, Allard BA, Beier DR
      Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models.
      24700869 Journal of the American Society of Nephrology : JASN , 2014 Oct. - 2014 Oct. : 25(10)2201-12 PMCID: PMC4178433
    • Herron BJ, Lu W, Rao C, Liu S, Peters H, Bronson RT, Justice MJ, McDonald JD, Beier DR
      Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.
      11818962 Nature genetics , 2002 Feb. - 2002 Feb. : 30(2)185-9

Overview

Medical/Professional School

University of Washington School of Medicine, Seattle
University of Washington School of Medicine, Seattle

About My Work

http://www.seattlechildrens.org/research/developmental-biology-regenerative-medicine/beier-lab/