David J Rawlings, MD

David J Rawlings, MD

Immunology, Non-Malignant Transplant Program

On staff since October 2001

Children's Title: Director, Center for Immunity and Immunotherapies, Seattle Children’s Research Institute; Director, Program for Cell and Gene Therapy, Seattle Children’s Research Institute; Chief, Division of Immunology, Seattle Children's Hospital

Academic Title: Professor, Pediatrics

Research Title: Director, Center for Immunity and Immunotherapies, Seattle Children's Research Institute

Foundation Title: Children's Guild Association Endowed Chair in Pediatric Immunology Research

Research Center: Center for Immunity and Immunotherapies

"As a parent and a physician, I am continually amazed by the capacity of our patients and their families to adapt to the challenges of living with a chronic immune-system disease. As a physician-scientist, I am driven by the challenge to make this battle less difficult by whatever means possible now and in the future. And as a graying athlete, I see medical care as the ultimate team sport. Each day, I do my best to build and lead stronger teams teams that more quickly identify a diagnosis and the impact of immune disease and, most importantly, teams that build better and safer treatments and cures for these conditions."

  • Biography

    David J. Rawlings, MD, is chief in the Division of Immunology, overseeing the immunodeficiency clinic at Seattle Childrens Hospital. He is also director of the Center for Immunity and Immunotherapies leading the immunology research programs at Seattle Childrens Research Institute. Dr. Rawlings is professor of pediatrics and adjunct professor in the Department of Immunology at the University of Washington School of Medicine.

    He earned his MD with honors from the University of North Carolina School of Medicine and completed a residency and chief residency in pediatrics at the University of California, San Francisco. He was an intramural research fellow at the NIH and a senior fellow at the Howard Hughes Medical Institute, UCLA. He completed specialty training in pediatric rheumatology and immunology at Childrens Hospital Los Angeles and directed the pediatric rheumatology program at UCLA. Dr. Rawlings has been the recipient of many awards including election to the American Society for Clinical Investigation, Association of American Physicians, and the Childrens Hospital Guild Association Endowed Chair in Pediatric Immunology Research. Dr. Rawlings also co-directs the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap for Medical Research and focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. His publications include more than 90 peer-reviewed papers and many invited reviews. His primary research interests include dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. His laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders. He is also actively involved in collaborative studies with the bone marrow transplant team to design and test of new protocols for stem cell transplant in non-malignant disorders. Dr. Rawlings is a member of multiple regional and national organizations, an NIH study section member, and ad hoc reviewer for various grant programs and immunology journals.

  • Patient Testimonials

  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Tom Hansen Investigator in Pediatric Innovation Endowment Seattle Children's Research Institute Oct. 2018
    Washington State Leaders in Health Care Award for Leader in Medical Research Seattle Business Magazine - 2015
    Member American Pediatric Society 2009
    Children's Guild Association Endowed Chair in Pediatric Immunology 2008
    Member Association of American Physicians 2007
    Member American Society for Clinical Investigation 2001
    Scholar Award The Leukemia and Lymphoma Society 1999 - 2004
    Joan J. Drake Seed Grant for Excellence in Cancer Research 1998
    James S. McDonnell Scholar 1997 - 2000
    CHRC, HHMI, and Pennington Pediatric Faculty Research Awards 1996 - 1998
    Beatrice S. Kolliner Fellow Jonsson Comprehensive Cancer Center 1993
    Ellis Dresner Reserach Award Southern California Rheumatology Society 1993
    Physician's Scientist Award NIDDK, NIH 1993 - 1998
    Merle Carson Research Award Southwestern Pediatric Society 1992
  • Publications

    Manuscripts in Refereed Journals

    • 122. Hubbard N, Hagin D, Sommer K, Song Y, Khan I, Clough C, Ochs HD, Rawlings DJ*, Scharenberg AM, Torgerson TR
      Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome
      26903548 Blood, 2016 May 26 : 127(21):2513-22
      https://www.ncbi.nlm.nih.gov/pubmed/26903548

    Other Publications

    • 126. Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ
      Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation
      27837104 J Immunology, 2016 Dec 15 : 197(12)4529-4534 PMCID:PMC5147509
      https://www.ncbi.nlm.nih.gov/pubmed/27837104
    • Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ
      Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
      27837104 Journal of immunology (Baltimore, Md. : 1950), 2016 Dec 15 : 197(12)4529-4534 PMCID:PMC5147509
    • Jackson SW, Scharping NE, Jacobs HM, Wang S, Chait A, Rawlings DJ
      Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
      27837104 Journal of immunology (Baltimore, Md. : 1950), 2016 Dec 15 : 197(12)4529-4534 PMCID:PMC5147509
    • Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M
      NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
      27801679 The Journal of clinical investigation, 2016 Nov 1 : 126(11)4388 PMCID:PMC5096914
    • Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M
      NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
      27801679 The Journal of clinical investigation, 2016 Nov 1 : 126(11)4388 PMCID:PMC5096914
    • Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM
      High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.
      27203437 Molecular therapy : the journal of the American Society of Gene Therapy, 2016 Sep 29 : 24(9)1570-80 PMCID:PMC5113096
    • Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM
      High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins.
      27203437 Molecular therapy : the journal of the American Society of Gene Therapy, 2016 Sep 29 : 24(9)1570-80 PMCID:PMC5113096
    • Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ
      Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.
      27741222 Molecular therapy. Nucleic acids, 2016 Aug 23 : 5(8)e352 PMCID:PMC5023401
    • Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ
      Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.
      27741222 Molecular therapy. Nucleic acids, 2016 Aug 23 : 5(8)e352 PMCID:PMC5023401
    • Krishnamurty AT, Thouvenel CD, Portugal S, Keitany GJ, Kim KS, Holder A, Crompton PD, Rawlings DJ, Pepper M
      Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge.
      27473412 Immunity, 2016 Aug 16 : 45(2)402-14 PMCID:PMC5118370
    • Krishnamurty AT, Thouvenel CD, Portugal S, Keitany GJ, Kim KS, Holder A, Crompton PD, Rawlings DJ, Pepper M
      Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge.
      27473412 Immunity, 2016 Aug 16 : 45(2)402-14 PMCID:PMC5118370
    • Srinivasan R, Rawlings D, Wood CL, Cheetham T, Moreno AC, Mayhew A, Eagle M, Guglieri M, Straub V, Owen C, Bushby K, Sarkozy A
      Prophylactic oral bisphosphonate therapy in duchenne muscular dystrophy.
      26599341 Muscle and nerve, 2016 June : 54(1)79-85
    • Hubbard N, Hagin D, Sommer K, Song Y, Khan I, Clough C, Ochs HD, Rawlings DJ, Scharenberg AM, Torgerson TR
      Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome.
      26903548 Blood, 2016 May 26 : 127(21)2513-22
    • Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M
      NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
      27043286 The Journal of clinical investigation, 2016 May 2 : 126(5)1783-800 PMCID:PMC4855944
    • Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ
      B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.
      27069113 The Journal of experimental medicine, 2016 May 2 : 213(5)733-50 PMCID:PMC4854732
    • Jacobs HM, Thouvenel CD, Leach S, Arkatkar T, Metzler G, Scharping NE, Kolhatkar NS, Rawlings DJ, Jackson SW
      Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.
      27022196 Journal of immunology (Baltimore, Md. : 1950), 2016 May 1 : 196(9)3525-31 PMCID:PMC4868625
    • Grier AE, Burleigh S, Sahni J, Clough CA, Cardot V, Choe DC, Krutein MC, Rawlings DJ, Jensen MC, Scharenberg AM, Jacoby K
      pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.
      27093168 Molecular therapy. Nucleic acids, 2016 Apr 19 : 5e306 PMCID:PMC5014522
    • Partos TR, Cropper SJ, Rawlings D
      You Don't See What I See: Individual Differences in the Perception of Meaning from Visual Stimuli.
      26954696 PloS one, 2016 Mar 8 : 11(3)e0150615 PMCID:PMC4783041
    • Metzler G, Kolhatkar NS, Rawlings DJ
      BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.
      26605835 Current opinion in immunology, 2015 Dec. : 3746-53 PMCID:PMC4679457
    • Kolhatkar NS, Scharping NE, Sullivan JM, Jacobs HM, Schwartz MA, Khim S, Notarangelo LD, Thrasher AJ, Rawlings DJ, Jackson SW
      B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.
      26256668 European journal of immunology, 2015 Oct. : 45(10)2773-9 PMCID:PMC4679197
    • Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ
      Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.
      26424571 Science translational medicine, 2015 Sep 30 : 7(307)307ra156 PMCID:PMC4790757
    • Kolhatkar NS, Brahmandam A, Thouvenel CD, Becker-Herman S, Jacobs HM, Schwartz MA, Allenspach EJ, Khim S, Panigrahi AK, Luning Prak ET, Thrasher AJ, Notarangelo LD, Candotti F, Torgerson TR, Sanz I, Rawlings DJ
      Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.
      26371186 The Journal of experimental medicine, 2015 Sep 21 : 212(10)1663-77 PMCID:PMC4577851
    • Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD
      VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.
      26150117 BMC bioinformatics, 2015 Jul 7 : 16212 PMCID:PMC4493804
    • Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG
      The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
      26026062 Journal of immunology (Baltimore, Md. : 1950), 2015 Jul 1 : 195(1)246-56 PMCID:PMC4475445
    • Wang X, Shin SC, Chiang AF, Khan I, Pan D, Rawlings DJ, Miao CH
      Intraosseous delivery of lentiviral vectors targeting factor VIII expression in platelets corrects murine hemophilia A.
      25655313 Molecular therapy : the journal of the American Society of Gene Therapy, 2015 April : 23(4)617-26 PMCID:PMC4395783
    • Rawlings DJ, Dai X, Buckner JH
      The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.
      25795788 Journal of immunology (Baltimore, Md. : 1950), 2015 Apr 1 : 194(7)2977-84 PMCID:PMC4369788
    • Jackson SW, Kolhatkar NS, Rawlings DJ
      B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production.
      25679954 Current opinion in immunology, 2015 April : 3370-7 PMCID:PMC4397155
    • Jackson SW, Kolhatkar NS, Rawlings DJ
      B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production.
      25679954 Current opinion in immunology, 2015 Feb 10 : 33C70-77
    • Burroughs LM, Nemecek ER, Torgerson TR, Storer BE, Talano JA, Domm J, Giller RH, Shimamura A, Delaney C, Skoda-Smith S, Thakar MS, Baker KS, Rawlings DJ, Englund JA, Flowers ME, Deeg HJ, Storb R, Woolfrey AE
      Treosulfan-based conditioning and hematopoietic cell transplantation for nonmalignant diseases: a prospective multicenter trial.
      25196857 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014 Dec. : 20(12)1996-2003 PMCID:PMC4324724
    • Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP
      Intravenous injection of a foamy virus vector to correct canine SCID-X1.
      24642749 Blood, 2014 Jun 5 : 123(23)3578-84 PMCID:PMC4047497
    • Aubert M, Boyle NM, Stone D, Stensland L, Huang ML, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR
      In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease.
      24496438 Molecular therapy. Nucleic acids, 2014 Feb 4 : 3e146 PMCID:PMC3951911
    • Kuhar R, Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT
      Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.
      24121685 Nucleic acids research, 2013 Oct 10
    • Chen Y, Aardema J, Kale S, Whichard ZL, Awomolo A, Blanchard E, Chang B, Myers DR, Ju L, Tran R, Reece D, Christensen H, Boukour S, Debili N, Strom TS, Rawlings D, Vázquez FX, Voth GA, Zhu C, Kahr WH, Lam WA, Corey SJ
      Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
      23881916 Blood, 2013 Sep 5 : 122(10)1695-706 PMCID:PMC3765055
    • Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ
      Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORt and Ahr that leads to IL-17 production by activated B cells.
      23563688 Nature immunology, 2013 May : 14(5)514-22 PMCID:PMC3631452
    • Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ
      A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
      23619366 The Journal of clinical investigation, 2013 May 1 : 123(5)2024-36 PMCID:PMC3638909
    • Ferron M, Settembre C, Shimazu J, Lacombe J, Kato S, Rawlings DJ, Ballabio A, Karsenty G
      A RANKL-PKC-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
      23599343 Genes & development, 2013 Apr 15 : 27(8)955-69 PMCID:PMC3650231
    • Moreno-García ME, Sommer K, Rincon-Arano H, Brault M, Ninomiya-Tsuji J, Matesic LE, Rawlings DJ
      Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-B activation.
      23297344 Molecular and cellular biology, 2013 March : 33(6)1149-63 PMCID:PMC3592024
    • Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM
      Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
      22941364 Nature methods, 2012 Oct. : 9(10)973-5 PMCID:PMC3602999
    • Amezcua Vesely MC, Schwartz M, Bermejo DA, Montes CL, Cautivo KM, Kalergis AM, Rawlings DJ, Acosta-Rodríguez EV, Gruppi A
      FcRIIb and BAFF differentially regulate peritoneal B1 cell survival.
      22516957 Journal of immunology (Baltimore, Md. : 1950), 2012 May 15 : 188(10)4792-800 PMCID:PMC3361506
    • Astrakhan A, Sather BD, Ryu BY, Khim S, Singh S, Humblet-Baron S, Ochs HD, Miao CH, Rawlings DJ
      Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.
      22431569 Blood, 2012 May 10 : 119(19)4395-407 PMCID:PMC3362358
    • Andrews SF, Dai X, Ryu BY, Gulick T, Ramachandran B, Rawlings DJ
      Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells.
      22311635 European journal of immunology, 2012 May : 42(5)1327-36 PMCID:PMC3433238
    • Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON
      Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993.
      22442491 Journal of immunology (Baltimore, Md. : 1950), 2012 Apr 1 : 188(7)2936-47
    • Iseki M, Omori-Miyake M, Xu W, Sun X, Takaki S, Rawlings DJ, Ziegler SF
      Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
      22281511 International immunology, 2012 March : 24(3)183-95 PMCID:PMC3284690
    • Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL
      Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
      22291190 Journal of immunology (Baltimore, Md. : 1950), 2012 Mar 1 : 188(5)2065-9 PMCID:PMC3288200
    • Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
      Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
      22030463 The Journal of allergy and clinical immunology, 2012 Feb. : 129(2)559-62, 562.e1-2
    • Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP
      Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.
      22110042 Nucleic acids research, 2012 Jan. : 40(2)e14 PMCID:PMC3258163
    • Meyer-Bahlburg A, Rawlings DJ
      Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.
      22201817 Frontiers in bioscience (Landmark edition), 2012 Jan 1 : 171499-516 PMCID:PMC3601656
    • Habib T, Funk A, Rieck M, Brahmandam A, Dai X, Panigrahi AK, Luning Prak ET, Meyer-Bahlburg A, Sanda S, Greenbaum C, Rawlings DJ, Buckner JH
      Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.
      22105996 Journal of immunology (Baltimore, Md. : 1950), 2012 Jan 1 : 188(1)487-96 PMCID:PMC3670766
    • Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ
      Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
      21911364 Nucleic acids research, 2011 Nov. : 39(21)e143 PMCID:PMC3241668
    • Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
      WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
      21875954 The Journal of experimental medicine, 2011 Sep 26 : 208(10)2033-42 PMCID:PMC3182055
    • Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
      WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
      21875954 The Journal of experimental medicine, 2011 Sep 26 : 2033-42
    • Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ
      Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
      21911364 Nucleic acids research, 2011 Sep 12
    • Thornton J, Pye SR, O'Neill TW, Rawlings D, Francis RM, Symmons DP, Ashcroft DM, Foster HE
      Bone health in adult men and women with a history of juvenile idiopathic arthritis.
      21677004 The Journal of rheumatology, 2011 Aug. : 38(8)1689-93
    • Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM
      Tracking genome engineering outcome at individual DNA breakpoints.
      21743461 Nature methods, 2011 Jul 10 : 8(8)671-6 PMCID:PMC3415300
    • Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM
      Tracking genome engineering outcome at individual DNA breakpoints.
      21743461 Nature methods, 2011 Jul 10 : 671-6
    • Sather BD, Ryu BY, Stirling BV, Garibov M, Kerns HM, Humblet-Baron S, Astrakhan A, Rawlings DJ
      Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
      21139568 Molecular therapy : the journal of the American Society of Gene Therapy, 2011 March : 515-25
    • Sather BD, Ryu BY, Stirling BV, Garibov M, Kerns HM, Humblet-Baron S, Astrakhan A, Rawlings DJ
      Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
      21139568 Molecular therapy : the journal of the American Society of Gene Therapy, 2011 March : 19(3)515-25 PMCID:PMC3048182
    • Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR
      Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
      21399673 PloS one, 2011 Feb 9 : 6(2)e16825 PMCID:PMC3036713
    • Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR
      Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
      21399673 PloS one, 2011 Feb 9 : e16825
    • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
      Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
      20643476 The Journal of allergy and clinical immunology, 2010 Nov. : 126(5)1000-5 PMCID:PMC2962731
    • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
      Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
      20643476 The Journal of allergy and clinical immunology, 2010 Nov. : 1000-5
    • Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
      Galphaq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
      20624888 The Journal of experimental medicine, 2010 Aug 2 : 1775-89
    • Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
      G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
      20624888 The Journal of experimental medicine, 2010 Aug 2 : 1775-89
    • Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
      G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
      20624888 The Journal of experimental medicine, 2010 Aug 2 : 207(8)1775-89 PMCID:PMC2916136
    • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
      Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
      20643476 The Journal of allergy and clinical immunology, 2010 Jul 17
    • Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ
      B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
      20093406 Blood, 2010 Mar 18 : 2146-55
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      20093406 Blood, 2010 Mar 18 : 2146-55
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      The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty.
      20032523 Age and ageing, 2010 March : 39(2)234-9
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      20008554 Molecular and cellular biology, 2010 Feb. : 922-34
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      MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
      20008554 Molecular and cellular biology, 2010 Feb. : 30(4)922-34 PMCID:PMC2815576
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      CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
      20079667 Immunity, 2010 Jan 29 : 32(1)129-40
    • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
      CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
      20079667 Immunity, 2010 Jan 29 : 129-40
    • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
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      20079667 Immunity, 2010 Jan 29 : 129-40
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      Bone density of the femoral neck following Birmingham hip resurfacing.
      19995316 Acta orthopaedica, 2009 Dec. : 80(6)660-5 PMCID:PMC2823310
    • Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
      Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
      19917688 Journal of immunology (Baltimore, Md. : 1950), 2009 Dec 1 : 7362-70
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      Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
      20004776 The Journal of allergy and clinical immunology, 2009 Dec. : 1152-60.e12
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      Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
      20004776 The Journal of allergy and clinical immunology, 2009 Dec. : 124(6)1152-60.e12 PMCID:PMC2831471
    • Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
      Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
      19917688 Journal of immunology (Baltimore, Md. : 1950), 2009 Dec 1 : 183(11)7362-70 PMCID:PMC3433237
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      Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
      19917688 Journal of immunology (Baltimore, Md. : 1950), 2009 Dec 1 : 7362-70
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      Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
      20004776 The Journal of allergy and clinical immunology, 2009 Dec. : 1152-60.e12
    • Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
      Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
      19770362 Blood, 2009 Nov 12 : 4373-82
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      Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
      19770362 Blood, 2009 Nov 12 : 4373-82
    • Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
      Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
      19770362 Blood, 2009 Nov 12 : 114(20)4373-82 PMCID:PMC2777123
    • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
      CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
      19713458 Blood, 2009 Nov 5 : 4034-44
    • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
      CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
      19713458 Blood, 2009 Nov 5 : 114(19)4034-44 PMCID:PMC2774545
    • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
      CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
      19713458 Blood, 2009 Nov 5 : 4034-44
    • Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
      Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
      19733207 Experimental hematology, 2009 Nov. : 1353-63
    • Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
      Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
      19733207 Experimental hematology, 2009 Nov. : 1353-63
    • Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
      Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
      19733207 Experimental hematology, 2009 Nov. : 37(11)1353-63 PMCID:PMC2771582
    • Astrakhan A, Ochs HD, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
      19494259 Journal of immunology (Baltimore, Md. : 1950), 2009 Jun 15 : 182(12)7370-80 PMCID:PMC2830893
    • Astrakhan A, Ochs HD, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
      19494259 Journal of immunology (Baltimore, Md. : 1950), 2009 Jun 15 : 7370-80
    • Astrakhan A, Ochs HD, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
      19494259 Journal of immunology (Baltimore, Md. : 1950), 2009 Jun 15 : 7370-80
    • James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
      Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
      19471023 Science signaling, 2009 May 26 : ra25
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      Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
      19471023 Science signaling, 2009 May 26 : 2(72)ra25
    • James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
      Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
      19471023 Science signaling, 2009 May 26 : ra25
    • Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
      Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
      19299704 Journal of immunology (Baltimore, Md. : 1950), 2009 Apr 1 : 182(7)4065-75 PMCID:PMC3441183
    • Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
      Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
      19299704 Journal of immunology (Baltimore, Md. : 1950), 2009 Apr 1 : 4065-75
    • Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
      Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
      19299704 Journal of immunology (Baltimore, Md. : 1950), 2009 Apr 1 : 4065-75
    • Andrews SF, Rawlings DJ
      Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
      19234182 Journal of immunology (Baltimore, Md. : 1950), 2009 Mar 1 : 182(5)2868-78 PMCID:PMC2694130
    • Andrews SF, Rawlings DJ
      Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
      19234182 Journal of immunology (Baltimore, Md. : 1950), 2009 Mar 1 : 2868-78
    • Andrews SF, Rawlings DJ
      Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
      19234182 Journal of immunology (Baltimore, Md. : 1950), 2009 Mar 1 : 2868-78
    • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
      Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
      18952502 Clinical immunology (Orlando, Fla.), 2009 Feb. : 162-74
    • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
      Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
      18952502 Clinical immunology (Orlando, Fla.), 2009 Feb. : 162-74
    • Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
      Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
      19020005 Journal of the American Society of Nephrology : JASN, 2009 Jan. : 68-77
    • Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
      Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
      19020005 Journal of the American Society of Nephrology : JASN, 2009 Jan. : 68-77
    • Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
      Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
      19020005 Journal of the American Society of Nephrology : JASN, 2009 Jan. : 20(1)68-77 PMCID:PMC2615727
    • Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
      Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
      19009526 European journal of immunology, 2008 Dec. : 3411-25
    • Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
      Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
      19009526 European journal of immunology, 2008 Dec. : 38(12)3411-25 PMCID:PMC2734463
    • Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
      Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
      19009526 European journal of immunology, 2008 Dec. : 3411-25
    • Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
      Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
      18687984 Blood, 2008 Nov 15 : 4158-69
    • Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
      Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
      18687984 Blood, 2008 Nov 15 : 4158-69
    • Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
      Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
      18687984 Blood, 2008 Nov 15 : 112(10)4158-69 PMCID:PMC2582000
    • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
      Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
      18574023 Blood, 2008 Sep 1 : 1662-72
    • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
      Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
      18574023 Blood, 2008 Sep 1 : 112(5)1662-72 PMCID:PMC2518877
    • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
      Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
      18574023 Blood, 2008 Sep 1 : 1662-72
    • Chanen AM, Jovev M, Djaja D, McDougall E, Yuen HP, Rawlings D, Jackson HJ
      Screening for borderline personality disorder in outpatient youth.
      18684049 Journal of personality disorders, 2008 Aug. : 22(4)353-64
    • Meyer-Bahlburg A, Rawlings DJ
      B cell autonomous TLR signaling and autoimmunity.
      18295736 Autoimmunity reviews, 2008 Feb. : 7(4)313-6 PMCID:PMC2763483
    • Notarangelo LD, Rawlings DJ, Sullivan KE
      An exemplum of XLA.
      17974484 Clinical immunology (Orlando, Fla.), 2008 Feb. : 137-9
    • Notarangelo LD, Rawlings DJ, Sullivan KE
      An exemplum of XLA.
      17974484 Clinical immunology (Orlando, Fla.), 2008 Feb. : 126(2)137-9
    • Notarangelo LD, Rawlings DJ, Sullivan KE
      An exemplum of XLA.
      17974484 Clinical immunology (Orlando, Fla.), 2008 Feb. : 137-9
    • Meyer-Bahlburg A, Rawlings DJ
      B cell autonomous TLR signaling and autoimmunity.
      18295736 Autoimmunity reviews, 2008 Feb. : 313-6
    • Meyer-Bahlburg A, Rawlings DJ
      B cell autonomous TLR signaling and autoimmunity.
      18295736 Autoimmunity reviews, 2008 Feb. : 313-6
    • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
      Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
      18180309 The Journal of experimental medicine, 2008 Jan 21 : 155-68
    • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
      Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
      18180309 The Journal of experimental medicine, 2008 Jan 21 : 155-68
    • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
      Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
      18180309 The Journal of experimental medicine, 2008 Jan 21 : 205(1)155-68 PMCID:PMC2234381
    • Meyer-Bahlburg A, Khim S, Rawlings DJ
      B cell intrinsic TLR signals amplify but are not required for humoral immunity.
      18039950 The Journal of experimental medicine, 2007 Dec 24 : 204(13)3095-101 PMCID:PMC2150979
    • Meyer-Bahlburg A, Khim S, Rawlings DJ
      B cell intrinsic TLR signals amplify but are not required for humoral immunity.
      18039950 The Journal of experimental medicine, 2007 Dec 24 : 3095-101
    • Meyer-Bahlburg A, Khim S, Rawlings DJ
      B cell intrinsic TLR signals amplify but are not required for humoral immunity.
      18039950 The Journal of experimental medicine, 2007 Dec 24 : 3095-101
    • Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
      Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
      17998397 The Journal of cell biology, 2007 Nov 19 : 717-31
    • Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
      Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
      17998397 The Journal of cell biology, 2007 Nov 19 : 717-31
    • Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
      Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
      17998397 The Journal of cell biology, 2007 Nov 19 : 179(4)717-31 PMCID:PMC2080907
    • Scharenberg AM, Humphries LA, Rawlings DJ
      Calcium signalling and cell-fate choice in B cells.
      17853903 Nature reviews. Immunology, 2007 Oct. : 778-89
    • Scharenberg AM, Humphries LA, Rawlings DJ
      Calcium signalling and cell-fate choice in B cells.
      17853903 Nature reviews. Immunology, 2007 Oct. : 7(10)778-89 PMCID:PMC2743935
    • Scharenberg AM, Humphries LA, Rawlings DJ
      Calcium signalling and cell-fate choice in B cells.
      17853903 Nature reviews. Immunology, 2007 Oct. : 778-89
    • Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
      Novel suppressive function of transitional 2 B cells in experimental arthritis.
      17548625 Journal of immunology (Baltimore, Md. : 1950), 2007 Jun 15 : 7868-78
    • Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
      Novel suppressive function of transitional 2 B cells in experimental arthritis.
      17548625 Journal of immunology (Baltimore, Md. : 1950), 2007 Jun 15 : 7868-78
    • Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
      Novel suppressive function of transitional 2 B cells in experimental arthritis.
      17548625 Journal of immunology (Baltimore, Md. : 1950), 2007 Jun 15 : 178(12)7868-78
    • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
      Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
      17401368 Nature immunology, 2007 May : 522-31
    • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
      Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
      17401368 Nature immunology, 2007 May : 522-31
    • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
      Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
      17401368 Nature immunology, 2007 May : 8(5)522-31
    • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
      17218989 The Journal of clinical investigation, 2007 Feb. : 407-18
    • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
      17218989 The Journal of clinical investigation, 2007 Feb. : 407-18
    • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
      Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
      17218989 The Journal of clinical investigation, 2007 Feb. : 117(2)407-18 PMCID:PMC1764857
    • Rawlings DJ, Sommer K, Moreno-García ME
      The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
      17063183 Nature reviews. Immunology, 2006 Nov. : 799-812
    • Rawlings DJ, Sommer K, Moreno-García ME
      The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
      17063183 Nature reviews. Immunology, 2006 Nov. : 6(11)799-812
    • Rawlings DJ, Sommer K, Moreno-García ME
      The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
      17063183 Nature reviews. Immunology, 2006 Nov. : 799-812
    • Bartram SA, Peaston RT, Rawlings DJ, Walshaw D, Francis RM, Thompson NP
      Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
      17007022 World journal of gastroenterology : WJG, 2006 Sep 21 : 12(35)5680-6
    • Bartram SA, Peaston RT, Rawlings DJ, Walshaw D, Francis RM, Thompson NP
      Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
      17007022 World journal of gastroenterology : WJG, 2006 Sep 21 : 5680-6
    • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
      Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
      16507778 Blood, 2006 Jul 1 : 19-27
    • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
      Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
      16507778 Blood, 2006 Jul 1 : 19-27
    • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
      Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
      16507778 Blood, 2006 Jul 1 : 108(1)19-27 PMCID:PMC1895820
    • Poreh AM, Rawlings D, Claridge G, Freeman JL, Faulkner C, Shelton C
      The BPQ: a scale for the assessment of borderline personality based on DSM-IV criteria.
      16776554 Journal of personality disorders, 2006 June : 20(3)247-60
    • Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
      HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
      16782030 Immunity, 2006 June : 24(6)741-52 PMCID:PMC1779661
    • Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
      HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
      16782030 Immunity, 2006 June : 741-52
    • Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
      HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
      16782030 Immunity, 2006 June : 741-52
    • Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
      Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
      16802601 Advances in experimental medicine and biology, 2006 : 58489-106
    • Rawlings DJ
      The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
      16391533 EMBO reports, 2006 Jan. : 7(1)25-30 PMCID:PMC1369234
    • Aspray TJ, Stevenson P, Abdy SE, Rawlings DJ, Holland T, Francis RM
      Low bone mineral density measurements in care home residents--a treatable cause of fractures.
      16364932 Age and ageing, 2006 Jan. : 35(1)37-41
    • Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
      Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
      16802601 Advances in experimental medicine and biology, 2006 : 89-106
    • Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
      Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
      16802601 Advances in experimental medicine and biology, 2006 : 89-106
    • Rawlings DJ
      The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
      16391533 EMBO reports, 2006 Jan. : 25-30
    • Aspray TJ, Stevenson P, Abdy SE, Rawlings DJ, Holland T, Francis RM
      Low bone mineral density measurements in care home residents--a treatable cause of fractures.
      16364932 Age and ageing, 2006 Jan. : 37-41
    • Rawlings DJ
      The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
      16391533 EMBO reports, 2006 Jan. : 25-30
    • Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
      Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
      16356855 Immunity, 2005 Dec. : 561-74
    • Gleeson JF, Rawlings D, Jackson HJ, McGorry PD
      Early warning signs of relapse following a first episode of psychosis.
      16125373 Schizophrenia research, 2005 Dec 1 : 80(1)107-11
    • Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
      Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
      16356855 Immunity, 2005 Dec. : 561-74
    • Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
      Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
      16356855 Immunity, 2005 Dec. : 23(6)561-74
    • Pearce MS, Birrell FN, Francis RM, Rawlings DJ, Tuck SP, Parker L
      Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
      15911643 Journal of epidemiology and community health, 2005 June : 475-80
    • Pearce MS, Birrell FN, Francis RM, Rawlings DJ, Tuck SP, Parker L
      Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
      15911643 Journal of epidemiology and community health, 2005 June : 59(6)475-80 PMCID:PMC1757042
    • Murray JR, Cooke NJ, Rawlings D, Holland JP, McCaskie AW
      A reliable DEXA measurement technique for metal-on-metal hip resurfacing.
      16097541 Acta orthopaedica, 2005 April : 76(2)177-81
    • Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
      Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
      15743806 Molecular and cellular biology, 2005 March : 2073-84
    • Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
      CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
      15728476 Journal of immunology (Baltimore, Md. : 1950), 2005 Mar 1 : 2687-95
    • Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
      Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
      15743806 Molecular and cellular biology, 2005 March : 2073-84
    • Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
      Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
      15743806 Molecular and cellular biology, 2005 March : 25(6)2073-84 PMCID:PMC1061591
    • Rawlings D
      The IVF experience--a patient perspective.
      15799668 Australian family physician, 2005 March : 34(3)173
    • Gleeson JF, Rawlings D, Jackson HJ, McGorry PD
      Agreeableness and neuroticism as predictors of relapse after first-episode psychosis: a prospective follow-up study.
      15729105 The Journal of nervous and mental disease, 2005 March : 193(3)160-9
    • Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
      CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
      15728476 Journal of immunology (Baltimore, Md. : 1950), 2005 Mar 1 : 174(5)2687-95
    • Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
      CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
      15728476 Journal of immunology (Baltimore, Md. : 1950), 2005 Mar 1 : 2687-95
    • Schaller JL, Rawlings DB
      Escitalopram in adolescent major depression.
      16369311 MedGenMed : Medscape general medicine, 2005 Jan 31 : 7(1)6 PMCID:PMC1681392
    • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
      Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
      15642101 Genome biology, 2005 : R9
    • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
      Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
      15642101 Genome biology, 2005 : R9
    • David J. Rawlings, MD
      B-Cell Development
      Hematology: Basic Principles and Practice, 2005 : 119-133
    • David J. Rawlings, MD
      TSLP (Thymic stromal lymphopoietin)
      Enclyclopedia of Hormones, 2005
    • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
      Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
      15642101 Genome biology, 2005 : 6(1)R9 PMCID:PMC549070
    • Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
      Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
      15364915 The Journal of biological chemistry, 2004 Nov 12 : 47720-5
    • Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
      Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
      15364915 The Journal of biological chemistry, 2004 Nov 12 : 47720-5
    • Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
      Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
      15364915 The Journal of biological chemistry, 2004 Nov 12 : 279(46)47720-5
    • Schaller JL, Thomas J, Rawlings D
      Low-dose tiagabine effectiveness in anxiety disorders.
      15520630 MedGenMed : Medscape general medicine, 2004 Sep 17 : 6(3)8 PMCID:PMC1435649
    • Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
      ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
      15313175 Biochemical and biophysical research communications, 2004 Sep 10 : 74-81
    • Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
      ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
      15313175 Biochemical and biophysical research communications, 2004 Sep 10 : 74-81
    • Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
      ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
      15313175 Biochemical and biophysical research communications, 2004 Sep 10 : 322(1)74-81
    • Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
      Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
      15184383 The Journal of biological chemistry, 2004 Sep 3 : 279(36)37651-61
    • Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
      Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
      15184383 The Journal of biological chemistry, 2004 Sep 3 : 37651-61
    • Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
      Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
      15184383 The Journal of biological chemistry, 2004 Sep 3 : 37651-61
    • Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
      Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
      15142874 Blood, 2004 Sep 1 : 1281-90
    • Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
      Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
      15142874 Blood, 2004 Sep 1 : 104(5)1281-90
    • Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
      Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
      15142874 Blood, 2004 Sep 1 : 1281-90
    • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
      Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
      15233948 Molecular therapy : the journal of the American Society of Gene Therapy, 2004 July : 10(1)117-26
    • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
      Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
      15233948 Molecular therapy : the journal of the American Society of Gene Therapy, 2004 July : 117-26
    • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
      Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
      15233948 Molecular therapy : the journal of the American Society of Gene Therapy, 2004 July : 117-26
    • Boyce SH, Corfield AR, McGuffie AC, Stevenson J, Rawlings D
      Spontaneous tension pneumopericardium.
      15167184 European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2004 June : 11(3)181-4
    • Guo B, Su TT, Rawlings DJ
      Protein kinase C family functions in B-cell activation.
      15134787 Current opinion in immunology, 2004 June : 367-73
    • Guo B, Su TT, Rawlings DJ
      Protein kinase C family functions in B-cell activation.
      15134787 Current opinion in immunology, 2004 June : 367-73
    • Guo B, Su TT, Rawlings DJ
      Protein kinase C family functions in B-cell activation.
      15134787 Current opinion in immunology, 2004 June : 16(3)367-73
    • Su TT, Guo B, Wei B, Braun J, Rawlings DJ
      Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
      14962194 Immunological reviews, 2004 Feb. : 161-78
    • Su TT, Guo B, Wei B, Braun J, Rawlings DJ
      Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
      14962194 Immunological reviews, 2004 Feb. : 161-78
    • Su TT, Guo B, Wei B, Braun J, Rawlings DJ
      Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
      14962194 Immunological reviews, 2004 Feb. : 197161-78
    • David J. Rawlings, MD
      Predominant Antibody Deficiencies: X-linked Agammaglobulinemia
      Immunologic Disorders of Infants and Children, 2004 : 357-373
    • Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL
      BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
      14614854 Immunity, 2003 Nov. : 669-78
    • Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL
      BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
      14614854 Immunity, 2003 Nov. : 669-78
    • Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
      A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
      12881490 Proceedings of the National Academy of Sciences of the United States of America, 2003 Aug 5 : 9470-5
    • Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
      A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
      12881490 Proceedings of the National Academy of Sciences of the United States of America, 2003 Aug 5 : 9470-5
    • Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
      A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
      12881490 Proceedings of the National Academy of Sciences of the United States of America, 2003 Aug 5 : 100(16)9470-5 PMCID:PMC170942
    • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
      B cell developmental requirement for the G alpha i2 gene.
      12574334 Journal of immunology (Baltimore, Md. : 1950), 2003 Feb 15 : 1707-15
    • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
      B cell developmental requirement for the G alpha i2 gene.
      12574334 Journal of immunology (Baltimore, Md. : 1950), 2003 Feb 15 : 170(4)1707-15
    • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
      B cell developmental requirement for the G alpha i2 gene.
      12574334 Journal of immunology (Baltimore, Md. : 1950), 2003 Feb 15 : 1707-15
    • Clement WA, Graham I, Ablett M, Rawlings D, Dempster JH
      Intramuscular hemangioma of the posterior belly of the digastric muscle failing to highlight on magnetic resonance imaging.
      12450183 The Annals of otology, rhinology, and laryngology, 2002 Nov. : 111(11)1050-3
    • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
      Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
      12381789 Proceedings of the National Academy of Sciences of the United States of America, 2002 Oct 29 : 14392-7
    • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
      Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
      12381789 Proceedings of the National Academy of Sciences of the United States of America, 2002 Oct 29 : 99(22)14392-7 PMCID:PMC137894
    • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
      Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
      12381789 Proceedings of the National Academy of Sciences of the United States of America, 2002 Oct 29 : 14392-7
    • Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M
      A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.
      12235209 The Journal of experimental medicine, 2002 Sep 16 : 196(6)753-63 PMCID:PMC2194055
    • Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
      SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
      12176909 Blood, 2002 Sept. : : 1852-9
    • Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
      SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
      12176909 Blood, 2002 Sep 1 : 100(5)1852-9
    • Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
      SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
      12176909 Blood, 2002 Sep 1 : 1852-9
    • Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ
      PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
      12118249 Nature immunology, 2002 Aug. : 780-6
    • Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ
      PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
      12118249 Nature immunology, 2002 Aug. : 3(8)780-6
    • Su TT, Guo B, Rawlings DJ
      Emerging roles for PKC isoforms in immune cell function.
      14993374 Molecular interventions, 2002 June : 2(3)141-4
    • Su TT, Guo B, Rawlings DJ
      Emerging roles for PKC isoforms in immune cell function.
      14993374 Molecular interventions, 2002 June : 141-4
    • Su TT, Rawlings DJ
      Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
      11859095 Journal of immunology (Baltimore, Md. : 1950), 2002 Mar 1 : 2101-10
    • Su TT, Rawlings DJ
      Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
      11859095 Journal of immunology (Baltimore, Md. : 1950), 2002 Mar 1 : 168(5)2101-10
    • Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ
      PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
      11598012 The EMBO journal, 2001 Oct 15 : 5692-702
    • Ziegner UH, Ochs HD, Schanen C, Feig SA, Seyama K, Futatani T, Gross T, Wakim M, Roberts RL, Rawlings DJ, Dovat S, Fraser JK, Stiehm ER
      Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
      11295723 The Journal of pediatrics, 2001 April : 570-3
    • Said JW, Hoyer KK, French SW, Rosenfelt L, Garcia-Lloret M, Koh PJ, Cheng TC, Sulur GG, Pinkus GS, Kuehl WM, Rawlings DJ, Wall R, Teitell MA
      TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma.
      11304575 Laboratory investigation; a journal of technical methods and pathology, 2001 April : 555-64
    • Gallagher KT, Shaham B, Reiff A, Tournay A, Villablanca JP, Curran J, Nelson MD Jr, Bernstein B, Rawlings DJ
      Primary angiitis of the central nervous system in children: 5 cases.
      11296969 The Journal of rheumatology, 2001 March : 616-23
    • Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T
      Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
      10903718 Journal of immunology (Baltimore, Md. : 1950), 2000 Aug 1 : 1210-9
    • Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ
      Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
      10981967 Immunity, 2000 Aug. : 243-53
    • Goldman FD, Gilman AL, Hollenback C, Kato RM, Premack BA, Rawlings DJ
      Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties.
      10828029 Blood, 2000 Jun 1 : 3460-6
    • Gordon MS, Kato RM, Lansigan F, Thompson AA, Wall R, Rawlings DJ
      Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.
      10792036 Proceedings of the National Academy of Sciences of the United States of America, 2000 May 9 : 5504-9
    • Rawlings DJ
      Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.
      10370369 Clinical immunology (Orlando, Fla.), 1999 June : 243-53
    • Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI
      In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.
      10051622 Proceedings of the National Academy of Sciences of the United States of America, 1999 Mar 2 : 2221-6
    • Fluckiger AC, Sanz E, Garcia-Lloret M, Su T, Hao QL, Kato R, Quan S, de la Hera A, Crooks GM, Witte ON, Rawlings DJ
      In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells.
      9845515 Blood, 1998 Dec 15 : 4509-20
    • Satterthwaite AB, Rawlings DJ, Witte ON
      DSHP: a "power bar" for sustained immune responses?
      9811804 Proceedings of the National Academy of Sciences of the United States of America, 1998 Nov 10 : 13355-7
    • Fluckiger AC, Li Z, Kato RM, Wahl MI, Ochs HD, Longnecker R, Kinet JP, Witte ON, Scharenberg AM, Rawlings DJ
      Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
      9524120 The EMBO journal, 1998 Apr 1 : 1973-85
    • Reiff A, Rawlings DJ, Shaham B, Franke E, Richardson L, Szer IS, Bernstein BH
      Preliminary evidence for cyclosporin A as an alternative in the treatment of recalcitrant juvenile rheumatoid arthritis and juvenile dermatomyositis.
      9415655 The Journal of rheumatology, 1997 Dec. : 2436-43
    • Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, Rawlings DJ
      Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
      9326643 Proceedings of the National Academy of Sciences of the United States of America, 1997 Oct 14 : 11526-33
    • Li T, Rawlings DJ, Park H, Kato RM, Witte ON, Satterthwaite AB
      Constitutive membrane association potentiates activation of Bruton tyrosine kinase.
      9333013 Oncogene, 1997 Sep 18 : 1375-83
    • Rawlings DJ, Quan S, Hao QL, Thiemann FT, Smogorzewska M, Witte ON, Crooks GM
      Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro.
      8989909 Experimental hematology, 1997 Jan. : 66-72
    • Afar DE, Park H, Howell BW, Rawlings DJ, Cooper J, Witte ON
      Regulation of Btk by Src family tyrosine kinases.
      8668162 Molecular and cellular biology, 1996 July : 3465-71
    • Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON
      Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
      8630736 Immunity, 1996 May : 515-25
    • Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP
      Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
      8629002 Science (New York, N.Y.), 1996 Feb 9 : 822-5
    • Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM
      Impaired expansion of mouse B cell progenitors lacking Btk.
      7552995 Immunity, 1995 Sept. : 301-12
    • Rawlings DJ, Witte ON
      The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function.
      8520028 Seminars in immunology, 1995 Aug. : 237-46
    • Rawlings DJ, Quan SG, Kato RM, Witte ON
      Long-term culture system for selective growth of human B-cell progenitors.
      7533295 Proceedings of the National Academy of Sciences of the United States of America, 1995 Feb 28 : 1570-4
    • Faust EA, Rawlings DJ, Saffran DC, Witte ON
      Development of btk transgenic mice.
      7895510 Current topics in microbiology and immunology, 1995 : 363-70
    • Shahabuddin M, Rawlings DJ, Kaslow DC
      A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum: cDNA and primary protein structure.
      8086463 Biochimica et biophysica acta, 1994 Sep 13 : 191-4
    • Tsukada S, Rawlings DJ, Witte ON
      Role of Bruton's tyrosine kinase in immunodeficiency.
      7946052 Current opinion in immunology, 1994 Aug. : 623-30
    • Zhu Q, Zhang M, Rawlings DJ, Vihinen M, Hagemann T, Saffran DC, Kwan SP, Nilsson L, Smith CI, Witte ON, Chen SH, Ochs HD
      Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).
      7519238 The Journal of experimental medicine, 1994 Aug 1 : 461-70
    • Saffran DC, Parolini O, Fitch-Hilgenberg ME, Rawlings DJ, Afar DE, Witte ON, Conley ME
      Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.
      8164701 The New England journal of medicine, 1994 May 26 : 1488-91
    • Rawlings DJ, Witte ON
      Bruton's tyrosine kinase is a key regulator in B-cell development.
      8070812 Immunological reviews, 1994 April : 105-19
    • Rawlings DJ, Bernstein B, Rowland JM, Shaham B, Szer IS
      Prolonged course of illness in a child with malignant lymphoma mimicking sarcoidosis.
      8164220 The Journal of rheumatology, 1993 Sept. : 1583-7
    • Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, Cohen L, Mohr RN, Bazan JF, Howard M, Copeland NG
      Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.
      8332901 Science (New York, N.Y.), 1993 Jul 16 : 358-61
    • Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S
      Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
      8425221 Cell, 1993 Jan 29 : 279-90
    • Kaslow DC, Rawlings DJ
      Introducing restriction sites into double-stranded plasmid DNA.
      8386292 Methods in enzymology, 1993 : 295-301
    • Scharenberg AM, Hannibal MC, Torgerson T, Ochs HD, Rawlings DJ, Pagon RA, Bird TD, Dolan CR, Stephens K
      Common Variable Immune Deficiency Overview
      20301476 1993
    • Rawlings DJ, Fujioka H, Fried M, Keister DB, Aikawa M, Kaslow DC
      Alpha-tubulin II is a male-specific protein in Plasmodium falciparum.
      1484548 Molecular and biochemical parasitology, 1992 Dec. : 239-50
    • Rawlings DJ, Kaslow DC
      Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.
      1383389 The Journal of experimental medicine, 1992 Nov 1 : 1483-7
    • Rawlings DJ, Kaslow DC
      A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum.
      1740445 The Journal of biological chemistry, 1992 Feb 25 : 3976-82
    • Kaslow DC, Rawlings DJ
      Rapid method for introducing restriction sites into double stranded plasmid DNA.
      2557584 Nucleic acids research, 1989 Dec 11 : 10135
    • David J. Rawlings, MD
      Immunologic Basics of Hematology Part 2: B-Cell Immunity
      Hematology: Basic Principles and Practice. 5th Edition
  • Presentations

    Presentations Title Event Location Date
    Altered B Cell Signaling Orchestrates Loss of Tolerance and Systemic Autoimmunity University of Washington, Amgen Symposium Seattle, WA Nov 7, 2013
    New Insights into Normal and Dysregulated B Cell Function Jeffrey Modell Centers Summit Berlin, Germany Jul 17, 2013 - Jul 20, 2013
    Updates in Gene Therapy for PID Clinical Immunology Society Annual Meeting Miami, FL Apr 25, 2013 - Apr 28, 2013
    Seminaire dImmunologie, Hematologie et de Rhumatologie Pediatriques Pierre Royer Institut Paris, France Feb 19, 2013 - Feb 22, 2013
    A Novel, B Cell Intrinsic, IL17 B Program helps to control Trypanosoma Cruzi Infection Seattle BioMedical Research Institute Research Seminar Seattle, WA Dec 10, 2012
    Clinical Insights Derived from B-Cell Immunodeficiency Disorders American Society of Hematology Meeting San Diego, CA Dec 10, 2011 - Dec 11, 2011
    A Link between Innate and Adaptive Immunity Jeffrey Modell World Immunology Conference Rockefeller University; NY Jun 1, 2011 - Jun 5, 2011
    Viral Vectors for Gene Targeting and Homologous Recombination in Gene Therapy ASGCT 14th Annual Meeting Seattle, WA May 18, 2011 - May 22, 2011
    B Cells: New Insights into Normal versus Dysregulated Function 2011 Keystone Symposium Whistler, British Columbia, Canada Apr 12, 2011 - Apr 17, 2011
    B Cell homeostatis and activiation IUIS Expert Meeting on Primary Immunodeficiencies Dublin, Ireland Jun 3, 2009
    Improving Cellular Therapy for Primary Immune Deficiency Diseases - Recognition, Diagnosis and Management NIH Workshop Bethesda, MD May 20, 2009
    Antigen receptor driven NFkB signals in B cells- distinct inputs modulate activation, tolerance, and lymphoma development 50. University of Cincinnati, Cancer and Cell Biology Seminar Series Cincinnati, OH Apr 23, 2008 - Apr 24, 2008
    Role of PKC Signals in B Cell Activation, Survival and Malignancy Harvard Medical School Program in Immunology Seminar Series Boston, MA May 23, 2007
    Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced Signals Keystone Symposia "Biology of B Cells in Health and Disease (B5)" Banff, Alberta, Canada Feb 6, 2007 - Feb 11, 2007
    Gene Rx for WAS and XLA NIH Gene Therapy Conference, Gene Therapy for Inherited Immune Deficiencies: Advances and Safety Issues Bethesda, MD Sep 18, 2006 - Sep 19, 2006
    Gene Therapy of Primary Immunodeficiency Disorders UW Cystic Fibrosis Research Seminar Series Seattle, WA Dec 22, 2005
    Distinct signaling responses of transitional B cell subsets and their developmental consequences 7th Latin American Congress of Immunology Cordoba, Argentina Oct 2, 2005 - Oct 6, 2005
    Btk-dependent events controlling calcium and NF-kB signaling in B lymphocytes 3rd Lymphocyte Signal Transduction Workshop Crete, Greece May 27, 2005 - Jun 1, 2005
    Regulation of CARMA1-mediated NF-B signaling via PKC isoforms in B and T lymphocytes Cantoblanco Workshops Madrid, Spain May 22, 2005 - May 24, 2005
    Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced NF-kappaB Activation Keystone Symposia Steamboat Springs, Colorado Mar 28, 2005 - Apr 3, 2005
    Preclinical Gene Therapy Studies in XLA and WAS NIH Conference on Wiskott-Aldrich Syndrome Gene Therapy for Wiskott-Aldrich Syndrome Bethesda, MD Sep 22, 2004 - Sep 23, 2004
    Gene Therapy for Immunodeficiency Disease Progress, Challenges and Coming Trials Childrens Hospital and Regional Medical Center Seattle, Grand Aug 8, 2004
    The Role of BtK in B Cell Activation 12th International Congress of Immunology and 4th Annual Conference of FOCIS Montreal, Canada Jul 18, 2004 - Jul 23, 2004
    Molecular Events Controlling B Cell Receptor Dependent NfkappaB Activation Amgen Inc. and the University of Washington Department of Immunology Eighth Annual Joint Immunology Symposium Seattle, WA May 21, 2004
    Untangling the Pathways for Lymphocyte Activation American Association of Immunologists May 2003

Overview

Board Certification(s)

Pediatric Rheumatology

Medical/Professional School

University Of North Carolina School Of Medicine, Chapel Hill, NC

Residency

University of California at San Francisco School o, San Francisco, CA

Fellowship

Children's Hospital of Los Angeles, Los Angeles, CA
David Geffen School of Medicine at UCLA, Los Angeles, CA
Warren Magnuson Clinical Center/National Institute, Bethesda, MD

Research Description

My primary research interests include altered lymphoid B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. My laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders.

I am a member of multiple regional and national organizations, an NIH study section member, chairman for the USIDNET XLA patient registry, and ad hoc reviewer for various grant programs and immunology journals. I also co-direct the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. Northwest Genome Engineering Consortium (NGEC), http://research.seattlechildrens.org/ngec.

The Immunology research laboratories carry out basic, pre-clinical and clinical research. Primary immunodeficiency disorders (PIDD) represent some of the best candidate disorders for treatment via hematopoietic stem cell gene therapy, and our translational research programs include modeling of novel gene and cellular therapies. Our clinical program also participates in novel clinical trials for non myeloablative hematopoietic stem cell transplant in PIDD.

Research Focus Area

Immunology