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Dana C. Matthews, MD

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Dana C. Matthews, MD

Hematology-Oncology

On staff since March 1988

Children's Title: Associate Professor, Pediatric Hematology/Oncology; Director, Clinical Hematology; Chair, Blood Usage Committee

Research Center: Center for Clinical and Translational Research

"Every time I walk into a clinic room to meet a new patient, I enjoy getting to know the patient and the parents, perhaps hearing a new language and learning something about what their life is like. I try hard to understand what they know, what they do not know, how I can best explain the diagnosis, and how we can work together most effectively to make decisions about diagnosis and treatment. I am profoundly fortunate to work with colleagues who are smart, warm and witty people as well as great clinicians. They care about our patients and about their colleagues on our team. Working together is stimulating, fun and gratifying."

Recommendations

RebeccaRichland, WA05.18.12
Dr. Matthews was warm, friendly and so helpful when she examined our failure-to-thrive baby. It's wonderful when a doctor who really knows their stuff also knows how to care for people. Thank you, Dr. Matthews.
MaureenBristow, VA12.14.11
Dr. Dana Matthews and her team are outstanding!!! We have been extremely confident in her ability to treat our son.
LynnSeattle, WA12.01.10
Dana is an amazing doctor that really has a handle on dealing not only with the patient but also with the families. She treats both sides with respect and I HIGHLY recommend her.
Recommend Dr. Dana Matthews

Overview

Board Certification(s)
Pediatric Hematology-Oncology
Pediatrics
Medical/Professional School
University of Washington School of Medicine, Seattle
Clinical Interests

Anemia, hemostasis, thrombosis, and autoimmune cytopenias

Research Description

My research interests include risk-based optimization of the treatment of pediatric thrombosis, and clinical outcomes in patients with hemophilia. In particular, I am participating in projects including an effort to characterize immune responses to factor VIII that result in inhibiting antibodies that significantly complicate the management of hemophilia A, and a prospective study of the development of inhibitors in young patients with hemophilia.

Additionally, I am interested in improving the outcome for pediatric patients with thrombosis by developing clinical trials for subgroups of patients with thrombosis.

Research Focus Area

Blood Disorders

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
U.S. News Top DoctorU.S. News and World Report 2012
Seattle Magazine Top Doctor - 2012Seattle Magazine Top Doctor - 2012Seattle Magazine 2012
Seattle Magazine Top Doctor - 2011Seattle Magazine Top Doctor - 2011Seattle Magazine 2011

Publications

Successful unrelated donor cord blood transplantation for Glanzmann's thrombasthenia.
Pediatric transplantation , 2009 Oct 22
Pretargeted radioimmunotherapy using anti-CD45 monoclonal antibodies to deliver radiation to murine hematolymphoid tissues and human myeloid leukemia.
Cancer research , 2009 Jan 1: 185-92
131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission.
Blood , 2006 Mar 1: 2184-91
Inferior vena cava thrombosis causing acute cauda equina syndrome. Case report.
Journal of neurosurgery , 2006 Jan: 46-9
Biodistribution of yttrium-90-labeled anti-CD45 antibody in a nonhuman primate model.
Clinical cancer research : an official journal of the American Association for Cancer Research , 2005 Jan 15: 787-94
High-dose radioimmunotherapy versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin lymphoma: a multivariable cohort analysis.
Blood , 2003 Oct 1: 2351-7
Conditionally cleavable radioimmunoconjugates: a novel approach for the release of radioisotopes from radioimmunoconjugates.
Bioconjugate chemistry , 2003 Sep-Oct: 927-33
Comparison of anti-CD20 and anti-CD45 antibodies for conventional and pretargeted radioimmunotherapy of B-cell lymphomas.
Blood , 2003 Mar 15: 2340-8
Use of radiolabeled antibodies in the treatment of childhood acute leukemia.
Pediatric transplantation , 2003: 89-94
Antibody-based therapy of human leukemia.
Current opinion in hematology , 2002 Jul: 316-21
High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma.
Blood , 2002 May 1: 3158-62

Research Funding

Grant TitleGrantorAmountAward Date
Mechanisms of Race-Based Differences in Factor VIII Immunogenicity in HemophiliaNational Institutes of HealthSept. 30, 2010

Primary Office

Seattle Children's
MB.8.501 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2106

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