Profile

Christine A. Gleason, MD

Christine A. Gleason, MD

Neonatology

On staff since January 1998

Children's Title: Chief, Division of Neonatology; W. Alan Hodson Endowed Chair in Pediatrics

Academic Title: Professor of Pediatrics

"In 2009, I published a memoir about my early experiences in neonatology (Almost Home: Stories of Hope and the Human Spirit in the Neonatal ICU). In the last chapter, I describe what happened when I used an experimental therapy to try and save a very critically ill newborn baby. Miraculously, it worked, and the baby never looked back. I'll never forget that moment. I really feel that I have one of the best jobs in the world. I take care of sick babies and have an incredible team of people who work together to improve their outcomes; I get to teach the next generation of neonatal caregivers; and I've had opportunities to do research to advance neonatal care."

Dr. Gleason's primary clinical interest is in the care of high-risk newborns, especially those infants born at the "limits of viability" (23-24 weeks gestation). She interested in improving our clinical practices and in preventative or neuroprotective strategies in caring for these "micronates", who are at high risk for abnormal neurodevelopment outcome. Her research has focused on the developing brain, specifically the effects of drugs such as cocaine, alcohol and narcotics, for the past 25 years. More recently, she has studied the long-term effects of neonatal pain and stress and our attempts to ameliorate these effects with narcotics, such as morphine.

Dr. Gleason's local teaching activities are focused on educating pediatric residents and neonatology fellows in the NICUs at Seattle Children's Hospital and UW Medical Center. Regionally, she teaches as a visiting professor in the WWAMI program and also does case reviews and presentations at regional hospitals. She chaired a subcommittee of the state's Perinatal Association, which revised the Levels of Neonatal-Perinatal Care guidelines for the State of Washington. Nationally, her teaching activities have focused on neonatal fellowship education and certification via her role on the neonatology sub-board of the American Board of Pediatrics. She also serves as co-editor of a major neonatal textbook (Avery's Diseases of the Newborn, released in 2012). In 2013, she will begin a 6-year term as Secretary-Treasurer of the American Pediatric Society.

Overview

Board Certification(s)

Neonatal-Perinatal Medicine
Pediatrics

Medical/Professional School

University of Rochester School of Medicine and Dentistry, Rochester

Awards and Honors

Award Name Award Description Awarded By Award Date
Secretary-Treasurer of the American Pediatric Society American Pediatric Society Jan. 1, 2014
U.S. News Top Doctor U.S. News and World Report 2012
Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012

Publications

  • Hays SL, Valieva OA, McPherson RJ, Juul SE, Gleason CA
    Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience , 2013 Feb. : 31(1)25-9
  • Christine A. Gleason, MD
    Pain and sedation in the NICU
    NeoReviews , 2013 : 1422
  • Christine A. Gleason, MD
    Evaluating patterns of morphine use in a single NICU after NEOPAIN
    Neonatology , 2013
  • Hays SL, McPherson RJ, Juul SE, Wallace G, Schindler AG, Chavkin C, Gleason CA
    Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis.
    Behavioural brain research , 2012 Feb. : 227(1)7-11
  • Christine A. Gleason, MD
    Intraventricular Hemorrhage
    Clinical Decision Support: Pediatrics , 2012
  • Christine A. Gleason, MD
    Developmental physiology of the CNS
    Averys Diseases of the Newborn. 9th edition , 2012
  • Christine A. Gleason, MD
    Management of neonatal pain and sedation, in Averys Diseases of the Newborn
    Averys Diseases of the Newborn, 9th edition , 2012
  • Christine A. Gleason, MD
    Maternal substance abuse
    Averys Diseases of the Newborn, 9th edition , 2012
  • Christine A. Gleason, MD
    Averys Diseases of the Newborn, 9th edition
    Averys Diseases of the Newborn, 9th edition. Philadelphia: Elsevier , 2012
  • Christine A. Gleason, MD
    Intraventricular Hemorrhage
    Clinical Decision Support: Pediatrics , 2012
  • Simon KE, Mondares RL, Born DE, Gleason CA
    The effects of binge alcohol exposure in the 2nd trimester on the estimated density of cerebral microvessels in near-term fetal sheep.
    Brain research , 2008 Sept. 22 : 123175-80
  • Laptook A, Tyson J, Shankaran S, McDonald S, Ehrenkranz R, Fanaroff A, Donovan E, Goldberg R, O'Shea TM, Higgins RD, Poole WK, National Institute of Child Health and Human Development Neonatal Research Network
    Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes.
    Pediatrics , 2008 Sept. : 122(3)491-9
  • Mayock DE, Ngai AC, Mondares RL, Gleason CA
    Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar function in third trimester fetal sheep.
    Brain research , 2008 Aug. 21 : 111-5
  • Juul SE, McPherson RJ, Bauer LA, Ledbetter KJ, Gleason CA, Mayock DE
    A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety.
    Pediatrics , 2008 Aug. : 383-91
  • Anderson DJ, Mondares RL, Born DE, Gleason CA
    The effect of binge fetal alcohol exposure on the number of vasoactive intestinal peptide-producing neurons in fetal sheep brain.
    Developmental neuroscience , 2008 : 30(4)276-84
  • Ngai AC, Mondares RL, Mayock DE, Gleason CA
    Fetal alcohol exposure alters cerebrovascular reactivity to vasoactive intestinal peptide in adult sheep.
    Neonatology , 2008 : 45-51
  • Anderson DJ, Mondares RL, Born DE, Gleason CA
    The effect of binge fetal alcohol exposure on the number of vasoactive intestinal peptide-producing neurons in fetal sheep brain.
    Developmental neuroscience , 2008 : 276-84
  • Mayock DE, Ness D, Mondares RL, Gleason CA
    Binge alcohol exposure in the second trimester attenuates fetal cerebral blood flow response to hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985) , 2007 Mar. : 972-7
  • McPherson RJ, Gleason C, Mascher-Denen M, Chan M, Kellert B, Juul SE
    A new model of neonatal stress which produces lasting neurobehavioral effects in adult rats.
    Neonatology , 2007 : 92(1)33-41
  • Mayock DE, Bennett R, Robinson RD, Gleason CA
    Dopamine does not limit fetal cerebrovascular responses to hypoxia.
    Journal of applied physiology (Bethesda, Md. : 1985) , 2007 Jan. : 130-4
  • Watari H, Born DE, Gleason CA
    Effects of first trimester binge alcohol exposure on developing white matter in fetal sheep.
    Pediatric research , 2006 Apr, : 59(4 Pt 1)560-4
  • Watari H, Born DE, Gleason CA
    Effects of first trimester binge alcohol exposure on developing white matter in fetal sheep.
    Pediatric research , 2006 Apr, : 560-4
  • Bookstein FL, Connor PD, Covell KD, Barr HM, Gleason CA, Sze RW, McBroom JA, Streissguth AP
    Preliminary evidence that prenatal alcohol damage may be visible in averaged ultrasound images of the neonatal human corpus callosum.
    Alcohol (Fayetteville, N.Y.) , 2005 July : 36(3)151-60
  • Bookstein FL, Connor PD, Covell KD, Barr HM, Gleason CA, Sze RW, McBroom JA, Streissguth AP
    Preliminary evidence that prenatal alcohol damage may be visible in averaged ultrasound images of the neonatal human corpus callosum.
    Alcohol (Fayetteville, N.Y.) , 2005 July : 151-60
  • Christine A. Gleason, MD
    Developmental physiology of the central nervous system
    Averys Diseases of the Newborn, 8th edition. , 2005
  • Christine A. Gleason, MD
    Gastroschisis:Embryology, Pathogenesis, Epidemiology
    NeoReviews 6 , 2005
  • Mayock DE, Gleason CA
    Cerebrovascular effects of rapid volume expansion in preterm fetal sheep.
    Pediatric research , 2004 Mar. : 395-9
  • Juul SE, McPherson RJ, Farrell FX, Jolliffe L, Ness DJ, Gleason CA
    Erytropoietin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high-dose recombinant erythropoietin.
    Biology of the neonate , 2004 : 85(2)138-44
  • Gleason CA, Robinson R, Harris AP, Mayock DE, Traystman RJ
    Cerebrovascular effects of intravenous dopamine infusions in fetal sheep.
    Journal of applied physiology (Bethesda, Md. : 1985) , 2002 Feb. : 717-24
  • Christine A. Gleason, MD
    Averys Diseases of the Newborn, 8th edition
    Averys Diseases of the Newborn, 8th edition, Philadelphia: Elsevier Saunders

Presentations

Presentations Title Event Location Date
Organizing your CV UW Dept of Medicine Fellow's Course Seattle, WA July 15, 2014
Caring for Preemies: Then, Now, and in the Future 35th Annual Duncan Seminar Seattle, WA 2014
Tough Talks in the NICU: A Neonatologists Perspective" and "Healing You: The Power of Writing The Gravens Conference Clearwater, Florida 2014
Clinical Experiences in Human Neonatal Critical Care: Pushing the Limits of Viability American College of Veterinary Internal Medicine (ACVIM) Annual Conference Seattle, WA 2013
Current Research in Neonatal Stress and Neurodevelopment American College of Veterinary Internal Medicine (ACVIM) Annual Conference Seattle, WA 2013
Organizing and preparing your CV: Showcasing your professional lifes story Pediatric Academic Societies Annual meeting Boston, MA 2012
Telling Our NICU Stories: Reflective Medical Writing Contemporary Forums Perinatal-Neonatal Conference Jackson Hole, WY 2012
Management of Neonatal Pain and Discomfort: Do We Know What We Are Doing? Contemporary Forums Perinatal-Neonatal Conference Jackson Hole, WY 2012
Safe Births at Home: Oxymoron or Attainable Goal? Controversies in Neonatal-Perinatal Care Conference Series University of Washington, Seattle 2012
Management of Neonatal Pain and Discomfort Regional Neonatal Grand Rounds Seattle Children's Hospital 2012
Management of the Drug-Exposed Infant: Having a Plan and Executing it Seattle Childrens Hospital Seattle, WA 2011
Effect of Vitamin A supplementation on Vitamin A status in extremely low birth weight neonates Pediatric Academic Societies Vancouver, BC 2010
Neonatal morphine treatment stimulates hippocampal astrogliosis Pediatric Academic Societies Vancouver, BC 2010
Increased left ventricular wall thickness in Sprague-Dawley rats: A change of heart? Pediatric Academic Societies Vancouver, BC 2010
Intrauterine Drug Exposure: Whats a Pediatrician to Do AAP National Conference and Exhibition (NCE) San Francisco, CA 2010
23. "Pain Management in the NICU: Do We Know What Were Doing?" and "Maternal Depression for Pediatricians: Why Worry?" Polish-American Pediatric Conference Rzeszow, Poland 2010
Academic Neonatology Career Choices: Are You on the Right Track? Pediatric Academic Societies Meet the Professors Vancouver, BC 2010
Management of the Drug-Affected Newborn 7th National Advanced Practice Neonatal Nurses Conference. San Francisco, CA 2010
Management of the Drug-Affected Newborn 7th National Advanced Practice Neonatal Nurses Conference San Francisco, CA 2010
Neonatal Sedation: Is there a good, better, best Neonatal Drug Therapy Conference - University of Washington School of Nursing Seattle, WA 2010
Organizing your CV Faculty Development Days. University of Washington School of Medicine. Seattle, WA 2010
Special Delivery: Taking Care of High-Risk Moms and Babies University of Washington Mini-Medical School Seattle, WA 2010
Calming the Wild: Neonatal Sedation Today California Assoc.of Neonatologists (CAN) 16th annual conference Coronado, CA 2010
Almost Home Stories of Hope and the Human Spirit in the NICU Jerry Elliott Memorial Lecture. Western Conference on Perinatal Research. Indian Wells, CA 2010
Almost Home: Stories of Hope and the Human Spirit in the Neonatal ICU Seattle Town Hall lecture series Seattle, WA April 2009
Treatment of Maternal Depression Neonatal Pharmacology Nursing Conference Seattle, WA March 21, 2009
Microarray analysis of morphine treatment of stress in neonatal mouse hippocampus Pediatric Academic Societies Baltimore, MD 2009
Vitamin A supplementation and incidence of BPD in ELBW infants: A single center experience Pediatric Academic Societies Baltimore, MD 2009

Research Funding

Grant Title Grantor Amount Award Date
Neuropathology of Prenatal Alcohol Exposure Arc of Washington Trust Fund $50,067 July 1, 1999 - June 30, 2000
Cerebrovascular effects of moderate prenatal alcohol exposure University of Washington Alcohol and Drug Abuse Institute $20,000 July 1, 1998 - June 30, 1999
Neonatal outcomes after management of meconium-stained amniotic fluid Childrens Miracle Network Telethon Research Fund $10,696 Jan. 1, 1997 - Dec. 31, 1997
Dopamine and volume expansion: Fetal cerebral responses NIH-NINDS $656,601 June 1, 1996 - May 31, 2000
Increased level of a hematogenous photo sensitizer with decreased levels of Vitamin A and E may increase retinopathy in premature infants Pediatric Clinical Research Unit (PCRU) Grant $5,000 Dec. 1, 1994 - Dec. 1, 1996
Mechanisms of regulation of cerebral blood flow (Project 4 Regulation of cerebral blood flow in the fetus) NIH-NINDS $575,950 Dec. 1, 1992 - Nov. 30, 1997
Cocaine and cerebral blood flow: fetus, newborn and adult NIDA $570,619 Sept. 30, 1990 - Aug. 31, 1994
Mechanisms of regulation of cerebral blood flow NIH-NINDS $2,462,337 Dec. 1, 1987 - Nov. 30, 1990