Profile

Christine A. Gleason, MD

Christine A. Gleason, MD

Neonatology

On staff since January 1998

Academic Title: Professor of Pediatrics

"In 2009, I published a memoir about my early experiences in neonatology (Almost Home: Stories of Hope and the Human Spirit in the Neonatal ICU). In the last chapter, I describe what happened when I used an experimental therapy to try and save a very critically ill newborn baby. Miraculously, it worked, and the baby never looked back. I'll never forget that moment. I really feel that I have one of the best jobs in the world. I take care of sick babies and have an incredible team of people who work together to improve their outcomes; I get to teach the next generation of neonatal caregivers; and I've had opportunities to do research to advance neonatal care."

  • Dr. Gleason's primary clinical interest is in the care of high-risk newborns, especially those infants born at the "limits of viability" (23-24 weeks gestation). She interested in improving our clinical practices and in preventative or neuroprotective strategies in caring for these "micronates", who are at high risk for abnormal neurodevelopment outcome. Her research has focused on the developing brain, specifically the effects of drugs such as cocaine, alcohol and narcotics, for the past 25 years. More recently, she has studied the long-term effects of neonatal pain and stress and our attempts to ameliorate these effects with narcotics, such as morphine.

    Dr. Gleason's local teaching activities are focused on educating pediatric residents and neonatology fellows in the NICUs at Seattle Children's Hospital and UW Medical Center. Regionally, she teaches as a visiting professor in the WWAMI program and also does case reviews and presentations at regional hospitals. She chaired a subcommittee of the state's Perinatal Association, which revised the Levels of Neonatal-Perinatal Care guidelines for the State of Washington. Nationally, her teaching activities have focused on neonatal fellowship education and certification via her role on the neonatology sub-board of the American Board of Pediatrics. She also serves as co-editor of a major neonatal textbook (Avery's Diseases of the Newborn, released in 2012). In 2013, she will begin a 6-year term as Secretary-Treasurer of the American Pediatric Society.

  • Award Name Award Description Awarded By Award Date
    Secretary-Treasurer of the American Pediatric Society American Pediatric Society Jan. 1, 2014
    U.S. News Top Doctor U.S. News and World Report 2012
    Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012
    • Hays SL, Valieva OA, McPherson RJ, Juul SE, Gleason CA
      Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment.
      23026365 International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience , 2013 Feb. : 31(1)25-9 PMCID: PMC3525715
    • Mayock DE and Gleason CA
      Pain and sedation in the NICU
      NeoReviews , 2013 : 1422
    • Fleishman R, Gleason CA, Myaing M, Zhou C, Mangione-Smith R
      Evaluating patterns of morphine use in a single NICU after NEOPAIN
      Neonatology , 2013
    • Hays SL, McPherson RJ, Juul SE, Wallace G, Schindler AG, Chavkin C, Gleason CA
      Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis.
      22061798 Behavioural brain research , 2012 Feb. : 227(1)7-11 PMCID: PMC3494415
    • Gleason CA
      Intraventricular Hemorrhage
      Clinical Decision Support: Pediatrics , 2012
    • Back S, Hohimer W, Gleason CA
      Developmental physiology of the CNS
      Averys Diseases of the Newborn. 9th edition , 2012
    • Mayock DE, Gleason
      Management of neonatal pain and sedation, in Averys Diseases of the Newborn
      Averys Diseases of the Newborn, 9th edition , 2012
    • Wallen LD, Gleason CA
      Maternal substance abuse
      Averys Diseases of the Newborn, 9th edition , 2012
    • Gleason CA, Devaskar S (eds)
      Averys Diseases of the Newborn, 9th edition
      Averys Diseases of the Newborn, 9th edition. Philadelphia: Elsevier , 2012
    • Gleason CA
      Intraventricular Hemorrhage
      Clinical Decision Support: Pediatrics , 2012
    • Simon KE, Mondares RL, Born DE, Gleason CA
      The effects of binge alcohol exposure in the 2nd trimester on the estimated density of cerebral microvessels in near-term fetal sheep.
      18657528 Brain research , 2008 Sept. 22 : 123175-80 PMCID: PMC2583365
    • Laptook A, Tyson J, Shankaran S, McDonald S, Ehrenkranz R, Fanaroff A, Donovan E, Goldberg R, O'Shea TM, Higgins RD, Poole WK, National Institute of Child Health and Human Development Neonatal Research Network
      Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes.
      18762517 Pediatrics , 2008 Sept. : 122(3)491-9 PMCID: PMC2782681
    • Mayock DE, Ngai AC, Mondares RL, Gleason CA
      Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar function in third trimester fetal sheep.
      18640664 Brain research , 2008 Aug. 21 : 111-5
    • Juul SE, McPherson RJ, Bauer LA, Ledbetter KJ, Gleason CA, Mayock DE
      A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety.
      18676557 Pediatrics , 2008 Aug. : 383-91
    • Anderson DJ, Mondares RL, Born DE, Gleason CA
      The effect of binge fetal alcohol exposure on the number of vasoactive intestinal peptide-producing neurons in fetal sheep brain.
      17960055 Developmental neuroscience , 2008 : 30(4)276-84
    • Ngai AC, Mondares RL, Mayock DE, Gleason CA
      Fetal alcohol exposure alters cerebrovascular reactivity to vasoactive intestinal peptide in adult sheep.
      17630497 Neonatology , 2008 : 45-51
    • Anderson DJ, Mondares RL, Born DE, Gleason CA
      The effect of binge fetal alcohol exposure on the number of vasoactive intestinal peptide-producing neurons in fetal sheep brain.
      17960055 Developmental neuroscience , 2008 : 276-84
    • Mayock DE, Ness D, Mondares RL, Gleason CA
      Binge alcohol exposure in the second trimester attenuates fetal cerebral blood flow response to hypoxia.
      17341736 Journal of applied physiology (Bethesda, Md. : 1985) , 2007 Mar. : 972-7
    • McPherson RJ, Gleason C, Mascher-Denen M, Chan M, Kellert B, Juul SE
      A new model of neonatal stress which produces lasting neurobehavioral effects in adult rats.
      17596735 Neonatology , 2007 : 92(1)33-41
    • Mayock DE, Bennett R, Robinson RD, Gleason CA
      Dopamine does not limit fetal cerebrovascular responses to hypoxia.
      17209159 Journal of applied physiology (Bethesda, Md. : 1985) , 2007 Jan. : 130-4
    • Watari H, Born DE, Gleason CA
      Effects of first trimester binge alcohol exposure on developing white matter in fetal sheep.
      16549529 Pediatric research , 2006 Apr, : 59(4 Pt 1)560-4
    • Watari H, Born DE, Gleason CA
      Effects of first trimester binge alcohol exposure on developing white matter in fetal sheep.
      16549529 Pediatric research , 2006 Apr, : 560-4
    • Bookstein FL, Connor PD, Covell KD, Barr HM, Gleason CA, Sze RW, McBroom JA, Streissguth AP
      Preliminary evidence that prenatal alcohol damage may be visible in averaged ultrasound images of the neonatal human corpus callosum.
      16377456 Alcohol (Fayetteville, N.Y.) , 2005 July : 36(3)151-60
    • Bookstein FL, Connor PD, Covell KD, Barr HM, Gleason CA, Sze RW, McBroom JA, Streissguth AP
      Preliminary evidence that prenatal alcohol damage may be visible in averaged ultrasound images of the neonatal human corpus callosum.
      16377456 Alcohol (Fayetteville, N.Y.) , 2005 July : 151-60
    • Gleason CA, Back SA
      Developmental physiology of the central nervous system
      Averys Diseases of the Newborn, 8th edition. , 2005
    • 1. Chabra S and Gleason CA
      Gastroschisis:Embryology, Pathogenesis, Epidemiology
      NeoReviews 6 , 2005
    • Mayock DE, Gleason CA
      Cerebrovascular effects of rapid volume expansion in preterm fetal sheep.
      14681499 Pediatric research , 2004 Mar. : 395-9
    • Juul SE, McPherson RJ, Farrell FX, Jolliffe L, Ness DJ, Gleason CA
      Erytropoietin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high-dose recombinant erythropoietin.
      14639039 Biology of the neonate , 2004 : 85(2)138-44
    • Gleason CA, Robinson R, Harris AP, Mayock DE, Traystman RJ
      Cerebrovascular effects of intravenous dopamine infusions in fetal sheep.
      11796686 Journal of applied physiology (Bethesda, Md. : 1985) , 2002 Feb. : 717-24
    • Taeusch HW, Ballard RA, Gleason CA (eds)
      Averys Diseases of the Newborn, 8th edition
      Averys Diseases of the Newborn, 8th edition, Philadelphia: Elsevier Saunders

  • Presentations Title Event Location Date
    Organizing your CV UW Dept of Medicine Fellow's Course Seattle, WA July 15, 2014
    Caring for Preemies: Then, Now, and in the Future 35th Annual Duncan Seminar Seattle, WA 2014
    Tough Talks in the NICU: A Neonatologists Perspective" and "Healing You: The Power of Writing The Gravens Conference Clearwater, Florida 2014
    Clinical Experiences in Human Neonatal Critical Care: Pushing the Limits of Viability American College of Veterinary Internal Medicine (ACVIM) Annual Conference Seattle, WA 2013
    Current Research in Neonatal Stress and Neurodevelopment American College of Veterinary Internal Medicine (ACVIM) Annual Conference Seattle, WA 2013
    Organizing and preparing your CV: Showcasing your professional lifes story Pediatric Academic Societies Annual meeting Boston, MA 2012
    Telling Our NICU Stories: Reflective Medical Writing Contemporary Forums Perinatal-Neonatal Conference Jackson Hole, WY 2012
    Management of Neonatal Pain and Discomfort: Do We Know What We Are Doing? Contemporary Forums Perinatal-Neonatal Conference Jackson Hole, WY 2012
    Safe Births at Home: Oxymoron or Attainable Goal? Controversies in Neonatal-Perinatal Care Conference Series University of Washington, Seattle 2012
    Management of Neonatal Pain and Discomfort Regional Neonatal Grand Rounds Seattle Children's Hospital 2012
    Management of the Drug-Exposed Infant: Having a Plan and Executing it Seattle Childrens Hospital Seattle, WA 2011
    Effect of Vitamin A supplementation on Vitamin A status in extremely low birth weight neonates Pediatric Academic Societies Vancouver, BC 2010
    Neonatal morphine treatment stimulates hippocampal astrogliosis Pediatric Academic Societies Vancouver, BC 2010
    Increased left ventricular wall thickness in Sprague-Dawley rats: A change of heart? Pediatric Academic Societies Vancouver, BC 2010
    Intrauterine Drug Exposure: Whats a Pediatrician to Do AAP National Conference and Exhibition (NCE) San Francisco, CA 2010
    23. "Pain Management in the NICU: Do We Know What Were Doing?" and "Maternal Depression for Pediatricians: Why Worry?" Polish-American Pediatric Conference Rzeszow, Poland 2010
    Academic Neonatology Career Choices: Are You on the Right Track? Pediatric Academic Societies Meet the Professors Vancouver, BC 2010
    Management of the Drug-Affected Newborn 7th National Advanced Practice Neonatal Nurses Conference. San Francisco, CA 2010
    Management of the Drug-Affected Newborn 7th National Advanced Practice Neonatal Nurses Conference San Francisco, CA 2010
    Neonatal Sedation: Is there a good, better, best Neonatal Drug Therapy Conference - University of Washington School of Nursing Seattle, WA 2010
    Organizing your CV Faculty Development Days. University of Washington School of Medicine. Seattle, WA 2010
    Special Delivery: Taking Care of High-Risk Moms and Babies University of Washington Mini-Medical School Seattle, WA 2010
    Calming the Wild: Neonatal Sedation Today California Assoc.of Neonatologists (CAN) 16th annual conference Coronado, CA 2010
    Almost Home Stories of Hope and the Human Spirit in the NICU Jerry Elliott Memorial Lecture. Western Conference on Perinatal Research. Indian Wells, CA 2010
    Almost Home: Stories of Hope and the Human Spirit in the Neonatal ICU Seattle Town Hall lecture series Seattle, WA April 2009
    Treatment of Maternal Depression Neonatal Pharmacology Nursing Conference Seattle, WA March 21, 2009
    Microarray analysis of morphine treatment of stress in neonatal mouse hippocampus Pediatric Academic Societies Baltimore, MD 2009
    Vitamin A supplementation and incidence of BPD in ELBW infants: A single center experience Pediatric Academic Societies Baltimore, MD 2009
  • Grant Title Grantor Amount Award Date
    Neuropathology of Prenatal Alcohol Exposure Arc of Washington Trust Fund $50,067 July 1, 1999 - June 30, 2000
    Cerebrovascular effects of moderate prenatal alcohol exposure University of Washington Alcohol and Drug Abuse Institute $20,000 July 1, 1998 - June 30, 1999
    Neonatal outcomes after management of meconium-stained amniotic fluid Childrens Miracle Network Telethon Research Fund $10,696 Jan. 1, 1997 - Dec. 31, 1997
    Dopamine and volume expansion: Fetal cerebral responses NIH-NINDS $656,601 June 1, 1996 - May 31, 2000
    Increased level of a hematogenous photo sensitizer with decreased levels of Vitamin A and E may increase retinopathy in premature infants Pediatric Clinical Research Unit (PCRU) Grant $5,000 Dec. 1, 1994 - Dec. 1, 1996
    Mechanisms of regulation of cerebral blood flow (Project 4 Regulation of cerebral blood flow in the fetus) NIH-NINDS $575,950 Dec. 1, 1992 - Nov. 30, 1997
    Cocaine and cerebral blood flow: fetus, newborn and adult NIDA $570,619 Sept. 30, 1990 - Aug. 31, 1994
    Mechanisms of regulation of cerebral blood flow NIH-NINDS $2,462,337 Dec. 1, 1987 - Nov. 30, 1990

Overview

Board Certification(s)

Neonatal-Perinatal Medicine
Pediatrics

Medical/Professional School

University of Rochester School of Medicine and Dentistry, Rochester