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Arnold L. Smith, MD

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Arnold L. Smith, MD

Infectious Disease

On staff since October 1978

Research Center: Center for Childhood Infections and Prematurity Research

"I knew that infectious disease was the right choice for me when I cared for a newborn with an unusual case of bacterial meningitis. While caring for him, I recalled that this disease could be complicated by a brain abscess. I persuaded the radiologist to image his brain, even though there were no clinical indicators of an abscess. An abscess was identified and subsequently drained, and the infant recovered. His mother still sends me Christmas cards — 30 years later. Experiences like that motivate me to work to increase our understanding of childhood infections and to devise better ways of treating and ultimately preventing them."

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Overview

Research Description

The Smith lab seeks to understand the biology of Haemophilus influenzae, a ubiquitous bacterium in humans and the mechanisms it uses in producing mucosal disease of the respiratory tract and sporadic invasive disease. The current focus is on regulation of gene expression, which differs from strain-to-strain and is both stochastic and directed; the role of intermediary metabolism in virulence is emphasized. A wide variety of model systems and techniques is used to gain insight into this bacterium.

Research Focus Area

Infectious Disease

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Inventor of the YearUniversity of Washington 2009
Endowed Professorship for Training Pediatric Faculty in ResearchUniversity of Washington and Seattle Children's Hospital 2006
Paul di Sant Agnese Distinguished Scientific Achievement AwardCystic Fibrosis Foundation 2005
Maureen Andrews Award for MentoringSociety for Pediatric Research 2003
Robert Gans ProfessorshipMassachusetts General Hospital 2001
Service Award for Excellence in TeachingUniversity of Missouri-Columbia 2000
Outstanding Teacher AwardChildren's Hospital and Regional Medical Center 1991
Citation of Merit (outstanding achievement and meritorious service in medicine)University of Missouri Alumni Association 1988
Charles A. Janeway Award (excellence in clinical teaching) 1978

Publications

Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae.
PLoS pathogens , Jan. 2011: e1001247
Determination of capsulation status in Haemophilus influenzae by multiplex polymerase chain reaction.
Diagnostic microbiology and infectious disease , 2010 Mar: 235-40
Analysis of genetic relatedness of Haemophilus influenzae isolates by multilocus sequence typing.
Journal of bacteriology , 2008 Feb: 1473-83
Chloramphenicol is a substrate for a novel nitroreductase pathway in Haemophilus influenzae.
Antimicrobial agents and chemotherapy , 2007 Aug: 2820-9
Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior.
Trends in microbiology , 2007 Aug: 355-62
lgtC expression modulates resistance to C4b deposition on an invasive nontypeable Haemophilus influenzae.
Journal of immunology (Baltimore, Md. : 1950) , 2007 Jan 15: 1002-12
Sequence and functional analyses of Haemophilus spp. genomic islands.
Genome biology , 2007: R237
Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression.
Nucleic acids research , 2007: 5242-52
Role of lgtC in resistance of nontypeable Haemophilus influenzae strain R2866 to human serum.
Infection and immunity , 2006 Nov: 6226-35
Heterogeneity in tandem octanucleotides within Haemophilus influenzae lipopolysaccharide biosynthetic gene losA affects serum resistance.
Infection and immunity , 2006 Jun: 3408-14
Haemophilus influenzae luxS mutants form a biofilm and have increased virulence.
Microbial pathogenesis , 2005 Sep: 87-96
Characterization of genetic and phenotypic diversity of invasive nontypeable Haemophilus influenzae.
Infection and immunity , 2005 Sep: 5853-63
Certain site-directed, nonenzymatically active mutants of the Haemophilus influenzae P4 lipoprotein are able to elicit bactericidal antibodies.
Infection and immunity , 2005 Jul: 4454-7
Peptides selected for binding to a virulent strain of Haemophilus influenzae by phage display are bactericidal.
Antimicrobial agents and chemotherapy , 2005 Jul: 2972-8
Hypermutable Haemophilus influenzae with mutations in mutS are found in cystic fibrosis sputum.
Microbiology (Reading, England) , 2004 Sep: 2947-58
Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus.
BMC microbiology , 2004 Jul 26: 30
Inactivation of deoxyadenosine methyltransferase (dam) attenuates Haemophilus influenzae virulence.
Molecular microbiology , 2004 Jul: 651-64
Construction of a nontypeable Haemophilus influenzae-specific ectopic delivery vector.
Journal of microbiological methods , 2004 Jun: 421-4
In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich Medium.
Omics : a journal of integrative biology , 2004 Spring: 25-41
Recalcitrant otorrhea due to Pseudomonas biofilm.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery , 2003 Nov: 599-601
Chemically defined media for growth of Haemophilus influenzae strains.
Journal of clinical microbiology , 2003 Sep: 4408-10
Initial proteome analysis of model microorganism Haemophilus influenzae strain Rd KW20.
Journal of bacteriology , 2003 Aug: 4593-602
Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts.
American journal of respiratory and critical care medicine , 2003 May 15: 1374-9
Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration: lack of association in cystic fibrosis.
Chest , 2003 May: 1495-502
Prevalence and distribution of adhesins in invasive non-type b encapsulated Haemophilus influenzae.
Infection and immunity , 2003 Apr: 1635-42
Haemophilus influenzae Rd KW20 has virulence properties.
Journal of medical microbiology , 2003 Apr: 277-82
Montelukast pharmacokinetics in cystic fibrosis.
The Journal of pediatrics , 2003 Jan: 53-6
Bacteriophage HP2 of Haemophilus influenzae.
Journal of bacteriology , 2002 Dec: 6893-905
Murine beta-defensin-3 is an inducible peptide with limited tissue expression and broad-spectrum antimicrobial activity.
Shock (Augusta, Ga.) , 2002 Nov: 461-4
Acylation of the lipooligosaccharide of Haemophilus influenzae and colonization: an htrB mutation diminishes the colonization of human airway epithelial cells.
Infection and immunity , 2002 Aug: 4661-8
H. influenzae Consortium: integrative study of H. influenzae-human interactions.
Omics : a journal of integrative biology , 2002: 341-8

Primary Office

Seattle Children's Research Institute
C9S - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101
206-987-2073

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