Profile

Annika Mai Hofstetter, MD, PhD, MPH

Annika Mai Hofstetter, MD, PhD, MPH

On staff since September 2014

Academic Title: Assistant Professor

Research Center: Center for Clinical and Translational Research

"When my mom was seven years old, her brother died of polio. He was a healthy kid at the time, and the polio vaccine was developed just a few months later. Although over half a century has passed, we still face many challenges to vaccinating children against vaccine preventable diseases. My goal is to partner with parents, providers, public health officials and others to better understand these challenges and to improve timely receipt of needed vaccines in order to prevent serious complications and even death from diseases like polio."

  • Dr. Hofstetter is an attending physician at Seattle Childrens and an assistant professor of Pediatrics in the University of Washington Division of General Pediatrics and Hospital Medicine. She is certified with the American Board of Pediatrics and has been honored with multiple awards throughout her career, including a U.S. Fulbright Scholarship. Dr. Hofstetter serves as Region X Research Chair with the Academic Pediatric Association Continuity Research Network, is Co-Leader of the Maintenance of Certification Influenza Vaccination Project at Seattle Childrens and is a member of the Seattle Childrens Influenza Steering Committee.

    • Hofstetter AM, Lappetito L, Stockwell MS, Rosenthal SL
      Human Papillomavirus Vaccination of Adolescents with Chronic Medical Conditions: A National Survey of Pediatric Subspecialists.
      27542999 Journal of pediatric and adolescent gynecology , 2016 Aug. 16
    • Hofstetter AM, Ompad DC, Stockwell MS, Rosenthal SL, Soren K
      Human Papillomavirus Vaccination and Cervical Cytology Outcomes Among Urban Low-Income Minority Females.
      26974250 JAMA pediatrics , 2016 May 1 : 170(5)445-52
    • Siljehav V, Hofstetter AM, Leifsdottir K, Herlenius E
      Prostaglandin E2 Mediates Cardiorespiratory Disturbances during Infection in Neonates.
      26434370 The Journal of pediatrics , 2015 Dec. : 167(6)1207-13.e3
    • Hofstetter AM, DuRivage N, Vargas CY, Camargo S, Vawdrey DK, Fisher A, Stockwell MS
      Text message reminders for timely routine MMR vaccination: A randomized controlled trial.
      26424607 Vaccine , 2015 Oct. 26 : 33(43)5741-6
    • Hofstetter AM, Vargas CY, Camargo S, Holleran S, Vawdrey DK, Kharbanda EO, Stockwell MS
      Impacting delayed pediatric influenza vaccination: a randomized controlled trial of text message reminders.
      25812465 American journal of preventive medicine , 2015 Apr, : 48(4)392-401
    • Hofstetter AM, Barrett A, Stockwell MS
      Factors impacting influenza vaccination of urban low-income Latino children under nine years requiring two doses in the 2010-2011 season.
      25082482 Journal of community health , 2015 Apr, : 40(2)227-34 PMCID: PMC4314518
    • Hofstetter AM, LaRussa P, Rosenthal SL
      Vaccination of adolescents with chronic medical conditions: Special considerations and strategies for enhancing uptake.
      26212313 Human vaccines and immunotherapeutics , 2015 : 11(11)2571-81 PMCID: PMC4685675
    • Stockwell MS, Catallozzi M, Camargo S, Ramakrishnan R, Holleran S, Findley SE, Kukafka R, Hofstetter AM, Fernandez N, Vawdrey DK
      Registry-linked electronic influenza vaccine provider reminders: a cluster-crossover trial.
      25548331 Pediatrics , 2015 Jan. : 135(1)e75-82
    • Stockwell MS, Hofstetter AM, DuRivage N, Barrett A, Fernandez N, Vargas CY, Camargo S
      Text message reminders for second dose of influenza vaccine: a randomized controlled trial.
      25548329 Pediatrics , 2015 Jan. : 135(1)e83-91 PMCID: PMC4279072
    • Hofstetter AM, Rosenthal SL
      Factors impacting HPV vaccination: lessons for health care professionals.
      24965128 Expert review of vaccines , 2014 Aug. : 13(8)1013-26
    • Tsui J, Hofstetter AM, Soren K
      Cervical cytology screening among low-income, minority adolescents in New York City following the 2009 ACOG guidelines.
      24650625 Preventive medicine , 2014 June : 6381-6 PMCID: PMC4075324
    • Hofstetter AM, Stockwell MS, Al-Husayni N, Ompad D, Natarajan K, Rosenthal SL, Soren K
      HPV vaccination: are we initiating too late?
      24530404 Vaccine , 2014 Apr, 7 : 32(17)1939-45
    • Hofstetter AM, Jakob K, Klein NP, Dekker CL, Edwards KM, Halsey NA, Baxter R, Williams SE, Graham PL 3rd, LaRussa P
      Live vaccine use and safety in DiGeorge syndrome.
      24685951 Pediatrics , 2014 Apr, : 133(4)e946-54
    • Broutet N, Fruth U, Deal C, Gottlieb SL, Rees H, participants of the 2013 STI Vaccine Technical Consultation.
      Vaccines against sexually transmitted infections: the way forward.
      24480024 Vaccine , 2014 Mar. 20 : 32(14)1630-7
    • Hofstetter AM, Rosenthal SL
      Health care professional communication about STI vaccines with adolescents and parents.
      23791695 Vaccine , 2014 Mar. 20 : 32(14)1616-23
    • Hofstetter AM, Rosenthal SL, Stanberry LR
      Current thinking on genital herpes.
      24335720 Current opinion in infectious diseases , 2014 Feb. : 27(1)75-83
    • Hofstetter AM, Vargas CY, Kennedy A, Kitayama K, Stockwell MS
      Parental and provider preferences and concerns regarding text message reminder/recall for early childhood vaccinations.
      23624252 Preventive medicine , 2013 Aug. : 57(2)75-80
    • Hofstetter AM, Natarajan K, Rabinowitz D, Martinez RA, Vawdrey D, Arpadi S, Stockwell MS
      Timeliness of pediatric influenza vaccination compared with seasonal influenza activity in an urban community, 2004-2008.
      23678935 American journal of public health , 2013 July : 103(7)e50-8 PMCID: PMC3682625
    • Stockwell MS, Martinez RA, Hofstetter A, Natarajan K, Vawdrey DK
      Timeliness of 2009 H1N1 vaccine coverage in a low-income pediatric and adolescent population.
      21458606 Vaccine , 2013 Apr, 12 : 31(16)2103-7
    • Hofstetter AM, Natarajan K, Martinez RA, Rabinowitz D, Vawdrey DK, Stockwell MS
      Influenza vaccination coverage and timeliness among children requiring two doses, 2004-2009.
      23219757 Preventive medicine , 2013 Mar. : 56(3-4)165-70
    • Siljehav V, Olsson Hofstetter A, Jakobsson PJ, Herlenius E
      mPGES-1 and prostaglandin E2: vital role in inflammation, hypoxic response, and survival.
      22926547 Pediatric research , 2012 Nov. : 72(5)460-7 PMCID: PMC3647218
    • Hofstetter AO, Legnevall L, Herlenius E, Katz-Salamon M
      Cardiorespiratory development in extremely preterm infants: vulnerability to infection and persistence of events beyond term-equivalent age.
      18298775 Acta paediatrica (Oslo, Norway : 1992) , 2008 Mar. : 97(3)285-92
    • Hofstetter AO, Saha S, Siljehav V, Jakobsson PJ, Herlenius E
      The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.
      17535900 Proceedings of the National Academy of Sciences of the United States of America , 2007 June 5 : 104(23)9894-9 PMCID: PMC1877988
    • Hofstetter AO, Herlenius E
      Interleukin-1beta depresses hypoxic gasping and autoresuscitation in neonatal DBA/1lacJ mice.
      15766902 Respiratory physiology and neurobiology , 2005 Apr, 15 : 146(2-3)135-46
    • Olsson A, Kayhan G, Lagercrantz H, Herlenius E
      IL-1 beta depresses respiration and anoxic survival via a prostaglandin-dependent pathway in neonatal rats.
      12761362 Pediatric research , 2003 Sept. : 54(3)326-31

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

University of Washington, Seattle
Columbia University, New York, Epidemiology
Karolinska Institute, Stockholm

Residency

Pediatrics, Columbia University Medical Center, New York

Fellowship

Columbia University, New York

Clinical Interests

Dr. Hofstetter's research focuses on pediatric and adolescent vaccination, especially in high-risk populations. She has experience examining vaccination coverage, timeliness, and missed opportunities. She has worked on novel technology-based interventions aiming to improve vaccine uptake and reduce missed opportunities, including a recent text message vaccine reminder study targeting adolescents with chronic medical conditions. She also has a research interest in provider-parent vaccine communication and vaccine safety.