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Ann J. Melvin, MD

Infectious Disease, Pediatrics-Inpatient

On staff since November 1993

Academic Title: Associate Professor, Pediatrics

Research Center: Center for Clinical and Translational Research

Ann J. Melvin, MD, MPH: Associate Professor of Pediatric Infectious Diseases. She is co-director of the Pediatric HIV program at SCH. Her research interests are in the antiretroviral management of HIV disease in children and prevention and management of complications of HIV treatment.

Dr. Melvin is co-principle investigator of the International Maternal Pediatric Adolescent Clinical Trials unit at the University of Washington, sponsored by the NIH, through which she is also chair or co-chair of several national and international research trials. She is also the co-director of the Regulatory Support and Bioethics Core of the Institute for Translational Health Sciences of the University of Washington. She collaborates with Drs. Englund, Frenkel, Corey, and Zerr.

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Overview
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Research Funding

Overview

Board Certification(s): Pediatric Infectious Diseases
Pediatrics
Medical/Professional School: Tulane University School of Medicine, New Orleans
Residency: Pediatrics, Children's Hospital and Regional Medical Center, Seattle
Clinical Interests: Prevention and treatment of pediatric HIV disease, research ethics
Research Focus Area: Translational Research

Publications

Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents.
AIDS (London, England) , 2009 Sep 10: 1893-901

Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment.
Journal of acquired immune deficiency syndromes (1999) , 2009 Sep 1: 17-24

Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses.
AIDS (London, England) , 2009 May 15: 923-8

Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era.
Archives of pediatrics & adolescent medicine , 2009 Feb: 164-71

Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study.
American journal of epidemiology , 2008 Jun 1: 1375-86

Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2008 Jun 1: 1751-60

Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children.
Journal of acquired immune deficiency syndromes (1999) , 2008 Apr 15: 607-14

Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy.
Antiviral therapy , 2008: 349-55

Effectiveness of antenatal group HIV voluntary counseling and testing services in rural India.
AIDS education and prevention : official publication of the International Society for AIDS Education , 2007 Jun: 187-97

Density-dependent decay in HIV-1 dynamics.
Journal of acquired immune deficiency syndromes (1999) , 2006 Mar: 266-76

Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women.
The Journal of infectious diseases , 2005 Dec 15: 2129-33

Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus.
Journal of virology , 2005 Aug: 9625-34

Rapid HIV type 1 testing of women presenting in late pregnancy with unknown HIV status in Lima, Peru.
AIDS research and human retroviruses , 2004 Oct: 1046-52

Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy.
Journal of virology , 2003 May: 5721-30

Efficacy and toxicity of antiretroviral therapy using 4 or more agents: application of a strategy for antiretroviral management in human immunodeficiency virus-infected children.
Archives of pediatrics & adolescent medicine , 2002 Jun: 568-73

Research Funding

Grant Title	Grantor	Amount	Award Date
Bone mineral density in tenofovir-exposed infants and young children	Gilead Sciences Phase4 program	$47,943.00	June 23, 2008
Bioethics core	NIH Cooperative Agreement	$1,583,701.00	June 1, 2008
International and Domestic Pediatric and Maternal HIV Studies Coordinating Center	NIH	$659,107.00	Dec. 16, 2007
Reservoirs of Drug-Resistant HIV-1 – US-India Collaborative Research Supplement	NIH	$58,907.00	March 1, 2005

Primary Office

Seattle Children's

MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2073

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Ann J. Melvin, MD

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