Profile

Alpana Amalkant Waghmare, MD

Alpana Amalkant Waghmare, MD

Infectious Disease

On staff since July 2014

Research Center: Center for Clinical and Translational Research

  • My research is in the field of translational infectious diseases, with a particular focus on respiratory viral infections. My interest in viral infections in immunocompromised hosts stems from my experiences as a clinician, where I witnessed the impact of respiratory viral infections in vulnerable populations. I am currently focused on an often overlooked respiratory pathogen, human rhinovirus (HRV). Our data show that HRV is also now the most common cause of lower respiratory tract infection (LRTI) and leads to mortality rates similar to those seen with known pulmonary pathogens including respiratory syncytial virus (RSV), influenza virus and parainfluenza virus. I propose that viral and host factors may serve as biomarkers for disease severity and can provide needed risk stratification and management tools. Data generated in this research will provide the critical basis to develop rational prevention and treatment strategies for immunocompromised patients. Additionally, I am also involved in clinical trials for drug development to treat infections in this patient population.

  • Award Name Award Description Awarded By Award Date
    Macrae Foundation Young Investigator Award 2015
    Faculty Abstract Award Seattle Childrens Research Institute CCTR Science Day 2015
    Top paper in transplant ID IDweek 2015
    Joel Meyers Endowment Scholarship Award 2014
    Seattle Childrens Research Institute Clinical Research Scholar Intensive Path 2014
    IDWeek Trainee Travel Grant from Infectious Disease Society of America 2013
    National Institutes of Health Loan Repayment Program Recipient 2013
    IDWeek Trainee Travel Grant from Infectious Disease Society of America 2012
    Phi Beta Kappa Society Member 2003
    • Savage TJ, Kuypers J, Chu HY, Bradford MC, Buccat AM, Qin X, Klein EJ, Jerome KR, Englund JA, Waghmare A
      Enterovirus D-68 in Children Presenting for Acute Care in the Hospital Setting.
      29498483 Influenza and other respiratory viruses , 2018 Mar. 2
    • Ogimi C, Englund JA, Bradford MC, Qin X, Boeckh M, Waghmare A
      Characteristics and Outcomes of Coronavirus Infection in Children: The Role of Viral Factors and an Immunocompromised State.
      29447395 Journal of the Pediatric Infectious Diseases Society , 2018 Feb. 13
    • Waghmare A, Xie H, Kimball L, Yi J, Özkök S, Leisenring W, Cheng GS, Englund JA, Watkins TR, Chien JW, Boeckh M
      Supplemental Oxygen-Free Days in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus.
      28961971 The Journal of infectious diseases , 2017 Dec. 5 : 216(10)1235-1244
    • Ogimi C, Greninger AL, Waghmare AA, Kuypers JM, Shean RC, Xie H, Leisenring WM, Stevens-Ayers TL, Jerome KR, Englund JA, Boeckh M
      Prolonged Shedding of Human Coronavirus in Hematopoietic Cell Transplant Recipients: Risk Factors and Viral Genome Evolution.
      28838146 The Journal of infectious diseases , 2017 July 15 : 216(2)203-209
    • Waghmare A, Englund JA, Boeckh M
      Parainfluenza Virus 3-Specific T Cells: Opportunity for Intervention?
      28472318 The Journal of infectious diseases , 2017 July 15 : 216(2)147-149
    • Greninger AL, Waghmare A, Adler A, Qin X, Crowley JL, Englund JA, Kuypers JM, Jerome KR, Zerr DM
      Rule-Out Outbreak: 24-Hour Metagenomic Next-Generation Sequencing for Characterizing Respiratory Virus Source for Infection Prevention.
      28379561 Journal of the Pediatric Infectious Diseases Society , 2017 June 1 : 6(2)168-172
    • Ogimi C, Waghmare AA, Kuypers JM, Xie H, Yeung CC, Leisenring WM, Seo S, Choi SM, Jerome KR, Englund JA, Boeckh M
      Clinical Significance of Human Coronavirus in Bronchoalveolar Lavage Samples From Hematopoietic Cell Transplant Recipients and Patients With Hematologic Malignancies.
      28329354 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2017 June 1 : 64(11)1532-1539 PMCID: PMC5434339
    • Seo S, Waghmare A, Scott EM, Xie H, Kuypers JM, Hackman RC, Campbell AP, Choi SM, Leisenring WM, Jerome KR, Englund JA, Boeckh M
      Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality.
      28183847 Haematologica , 2017 June : 102(6)1120-1130 PMCID: PMC5451345
    • Waghmare A, Englund JA, Boeckh M
      How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation
      How I Treat: a Compendium for the Practicing Hematologist. 3rd ed , 2017
    • Waghmare A, Englund JA, Boeckh M
      How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation.
      26968533 Blood , 2016 June 2 : 127(22)2682-92 PMCID: PMC4891952
    • Waghmare A, Pergam SA, Jerome KR, Englund JA, Boeckh M, Kuypers J
      Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients.
      25593338 Blood , 2015 Mar. 12 : 125(11)1724-9 PMCID: PMC4357580
    • Vora S, Waghmare A, Zerr DM, Melvin AJ
      Life-threatening viral diseases and their treatment.
      Fuhrman and Zimmerman's Pediatric Critical Care, 5th edition , 2015
    • Waghmare A and Boeckh M
      Rhinovirus, Coronavirus, Enterovirus and Bocavirus after HCT or SOT
      Transplant Infections, 4th edition , 2015
    • Waghmare A, Wagner T, Andrews R, Smith S, Kuypers J, Moss R, Englund JA
      Successful treatment of parainfluenza virus respiratory tract infection with DAS181 in four immunocompromised children
      J Pediatr Inf Dis Soc , 2014
    • Kim YJ, Guthrie KA, Waghmare A, Walsh E, Falsey A, Kuypers J, Cent A, Englund JA, Boeckh M
      Respiratory syncytial virus in hematopoietic transplant recipients: factors determining progression from upper to lower respiratory tract disease
      24368837 J Infect Dis , 2014 : 209(8)1195-204
    • Waghmare A, Campbell AP, Xie H, Seo S, Kuypers J, Leisenring W, Jerome KR, Englund JA, Boeckh M
      Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes.
      24065324 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2013 Dec. : 57(12)1731-41 PMCID: PMC3840404
    • Eden A, Gaudet F, Waghmare A, Jaenisch R
      Chromosomal instability and tumors promoted by DNA hypomethylation
      12702868 Science , 2013 : 300(5618)455
    • Waghmare A, Xie H, Seo S, Kuypers J, Leisenring W, Englund JA, Boeckh M, Campbell AP
      Respiratory syncytial virus (RSV) in hematopoietic cell transplant (HCT) recipients: effect of RNA detection in blood and antiviral treatment on mortality
      ID Week , 2012 Oct. 17 - 2012 Oct. 21
    • Jordan N, Waghmare A, Abi-Ghanem AS, Moon A, Salvatore CM
      Systemic Mycobacterium avium complex infection during anti-tumor necrosis factor- therapy in a pediatric patient with Crohn's disease
      21694635 J Pediatr Gastroenterol Nutr , 2011
    • Robles DT, Leonard JL, Compton N, Waghmare A, McDonough KA, George E, Wolgamot G, Fleckman P
      Severe drug hypersensitivity reaction in a young woman treated with doxycycline.
      18332631 Dermatology (Basel, Switzerland) , 2008 : 217(1)23-6

  • Presentations Title Event Location Date
    Aspergillosis after respiratory viral infections Interscience Conference of Antimicrobial Agents and Chemotherapy/American Society of Microbiology Meeting Boston, MA June 20, 2016
    Update on respiratory viral infections in hematopoietic cell transplantation 7th Annual International Conference on Infections in Hematology and Stem Cell Transplantation Kazimierz Dolny, Poland May 7, 2015
    Antiviral therapy for respiratory viral infections in pediatric immunocompromised hosts Pediatric Academic Societies Annual Meeting San Diego, CA April 25, 2015
  • Grant Title Grantor Amount Award Date
    Viral and Host Biomarkers of Human Rhinovirus Disease Severity in Transplantation National Institutes of Health, National Institute of Allergy and Infectious Diseases $162,988 Dec. 11, 2014 - Nov. 30, 2019
    Viral factors of disease severity in human rhinovirus infection following transplantation Seattle Childrens Research Institute $44,773 July 1, 2014 - June 30, 2016

Overview

Board Certification(s)

Pediatrics
Pediatric Infectious Diseases

Medical/Professional School

University of Washington, Seattle

Residency

Pediatrics, NY Presbyterian / Weill Cornell Medical Center, New York

Fellowship

Pediatric Infectious Disease, Seattle Children's Hospital, Seattle