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Akiko Shimamura, MD, PhD

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Akiko Shimamura, MD, PhD

Hematology-Oncology

On staff since July 2007

Research Center: Center for Clinical and Translational Research

"Bone marrow failure is rare, so families often come to us not knowing what’s wrong with their child. It makes a big difference when you can tell families and patients that this is what you have and this is what we’re going to do to try to make things better. It provides a sense of relief and hope. I like working with these patients because they deserve the same commitment to the best medical care as patients with more common diseases. The scientific advances from the study of marrow failure have deepened our understanding of blood diseases and cancers in the general population as well. I learn something new with every patient."

Recommendations

GingerMonroe, WA04.26.11
Dr. Shimamura is a kind, caring, compassionate doctor. She has taken time to explain my child's disease to her in an age-appropriate manner without being patronizing. She also communicates well with me on a highly technical level. She also helps my child understand that she is expected to become more involved with owning her own care as she transitions to adulthood, and that resources are going to be available for her as and adult through the SCA and the UW Medical Center. We are so very fortunate to have one of the world's top authorities on Fanconi Anemia here in the Northwest.
Recommend Dr. Akiko Shimamura

Overview

Board Certification(s)
Pediatric Hematology-Oncology
Medical/Professional School
University of Rochester School of Medicine, Rochester
Johns Hopkins University School of Medicine, Baltimore
Residency
Pediatrics, Johns Hopkins University School of Medicine, Baltimore
Fellowship
Pediatric Hematology-Oncology, Children's Hospital Boston, Boston
Pediatric Hematology-Oncology, Children's Hospital Boston, Boston
Clinical Interests

Inherited bone marrow failure syndromes and aplastic anemia Shwachman-Diamond syndrome, Fanconi anemia and Diamond Blackfan anemia

Research Description

My research interests focus on hematopoiesis and leukemogenesis in the inherited marrow failure syndrome. My current studies investigate the role of ribosomal dysfunction in marrow failure and malignant transformation. I am also pursuing studies on translational control of gene expression in hematopoietic stem cells. Recent laboratory findings reported a role for mitotic spindle stabilization in genomic instability. I am a member of the scientific advisory board for the Shwachman-Diamond Syndrome Foundation and served as co-chair of the Fourth International Scientific Congress on Shwachman-Diamond Syndrome. I am also the principal investigator for the North American Shwachman-Diamond Syndrome Registry currently under development.

Research Focus Area

Cancer, Blood Disorders

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
U.S. News Top DoctorU.S. News and World Report 2012
Seattle Magazine Top Doctor - 2011Seattle Magazine Top Doctor - 2011Seattle Magazine 2011

Publications

SBDS protein expression patterns in the bone marrow.
Pediatric blood & cancer , 2010 Sep: 546-9
Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy.
British journal of haematology , 2010 Jul: 196-9
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Stem cells (Dayton, Ohio) , 2010 Jul: 1186-95
Pathophysiology and management of inherited bone marrow failure syndromes.
Blood reviews , 2010 May: 101-22
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.
Blood , 2010 Apr 29: 3453-62
Congenital disorders of ribosome biogenesis and bone marrow failure.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 Jan: S12-7
Shwachman-Diamond syndrome: a review of the clinical presentation, molecular pathogenesis, diagnosis, and treatment.
Hematology/oncology clinics of North America , 2009 Apr: 233-48
TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.
Blood , 2009 Jan 8: 309-16
Clinical approach to marrow failure.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program , 2009: 329-37
Disease-specific induced pluripotent stem cells.
Cell , 2008 Sep 5: 877-86
Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference.
British journal of haematology , 2008 Sep: 859-76
Diamond-Blackfan anemia: a new facet.
Blood , 2008 Sep 1: 1552-3
Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.
Histology and histopathology , 2008 Jul: 819-26
Ribosomal dysfunction and inherited marrow failure.
British journal of haematology , 2008 May: 376-87
Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.
The Journal of clinical investigation , 2008 Apr: 1511-8
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.
Blood , 2007 Sep 1: 1458-65
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
The Journal of clinical investigation , 2007 May: 1440-9
Shwachman-Diamond syndrome.
Seminars in hematology , 2006 Jul: 178-88
Inherited bone marrow failure syndromes: molecular features.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program , 2006: 63-71
The Shwachman-Diamond SBDS protein localizes to the nucleolus.
Blood , 2005 Aug 15: 1253-8
Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway.
Blood , 2005 Feb 1: 1329-36
Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood.
Blood , 2004 Apr 1: 2554-9
Subtyping of Fanconi anemia patients: implications for clinical management.
Blood , 2003 Nov 1: 3459
A novel diagnostic screen for defects in the Fanconi anemia pathway.
Blood , 2002 Dec 15: 4649-54
Marrow failure.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program , 2002: 58-72

Primary Office

Fred Hutchinson Cancer Research Center
FHCRC Box 358080 - MS D2-100
PO Box 19024
Seattle, WA 98109-1024
206-667-6840

Additional Offices

Seattle Children's
MB.8.501 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2106

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