2018

Trial to Assess Dual CAR T-Cell Therapy for Children, Young Adults With Leukemia

Trial to Assess Dual CAR T-Cell Therapy for Children, Young Adults With Leukemia

A trial is underway to evaluate the use of dual chimeric antigen receptor T-cell immunotherapy for children and young adults with relapsed or refractory CD19- and CD22-positive acute lymphoblastic leukemia. Dr. Rebecca Gardner, attending physician in the department of pediatric hematology-oncology at Seattle Children’s Hospital, and colleagues aim to reprogram CAR T cells to detect and destroy leukemia cells by targeting both the CD19 and CD22 proteins upfront. If the cancer evolves to no longer express CD19, the CAR T cells can still attack the cancer through the identification of the CD22 protein. HemOnc Today spoke with Gardner about the study, the rationale for this dual-targeting approach and the benefits it may confer.

About Seattle Children’s

Seattle Children’s mission is to provide hope, care and cures to help every child live the healthiest and most fulfilling life possible. Together, Seattle Children’s Hospital, Research Institute and Foundation deliver superior patient care, identify new discoveries and treatments through pediatric research, and raise funds to create better futures for patients.

Ranked as one of the top children’s hospitals in the country by U.S. News & World Report, Seattle Children’s serves as the pediatric and adolescent academic medical center for Washington, Alaska, Montana and Idaho – the largest region of any children’s hospital in the country. As one of the nation’s top five pediatric research centers, Seattle Children’s Research Institute is internationally recognized for its work in neurosciences, immunology, cancer, infectious disease, injury prevention and much more. Seattle Children’s Hospital and Research Foundation works with the Seattle Children’s Guild Association, the largest all-volunteer fundraising network for any hospital in the country, to gather community support and raise funds for uncompensated care and research. Join Seattle Children’s bold initiative – It Starts With Yes: The Campaign for Seattle Children’s – to transform children’s health for generations to come.

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