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On CAR-T’s Edge, Seattle Researchers Plot to Bypass Novartis Therapy

On CAR-T’s Edge, Seattle Researchers Plot to Bypass Novartis Therapy

It’s not a stretch to say that Greta Oberhofer is alive thanks to the genetically modified cell therapy called CAR-T. But the Novartis CAR-T wasn’t what cured Greta; her parents enrolled her in a study for a different CAR-T program, at Seattle Children’s Hospital, which was accepting patients as young as a year old. Three years later with no relapse, Greta is one of the lucky ones. The dim outlook for many others, however, has spurred Drs. Mike Jensen, Rebecca Gardner, Colleen Annesley, and their colleagues to press on with more cutting-edge versions of CAR-T that they hope in a few years are not just replacements for the Novartis therapy, but alternatives to bone marrow transplants.

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Seattle Children’s mission is to provide hope, care and cures to help every child live the healthiest and most fulfilling life possible. Together, Seattle Children’s Hospital, Research Institute and Foundation deliver superior patient care, identify new discoveries and treatments through pediatric research, and raise funds to create better futures for patients.

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